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1. DOL Issues Guidance On AI And Worker Well-Being Best Practices

Author

Wang, Alice H.

Subjects
United States. Department of Labor -- Labor relations -- Powers and duties, Artificial intelligence -- Usage -- Management, Business enterprises -- Technology application -- Human resource management, Company business management, Artificial intelligence, Technology application, Company personnel management, Business, international
Abstract

> On October 16, 2024, the U.S. Department of Labor (DOL) published Artificial Intelligence and Worker Well-Being: Principles and Best Practices for Developers and Employers. This document expands upon guidance [...]

Published
2024

2. Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

Author

Berndt, Sonja I, Skibola, Christine F, Joseph, Vijai, Camp, Nicola J, Nieters, Alexandra, Wang, Zhaoming, Cozen, Wendy, Monnereau, Alain, Wang, Sophia S, Kelly, Rachel S, Lan, Qing, Teras, Lauren R, Chatterjee, Nilanjan, Chung, Charles C, Yeager, Meredith, Brooks-Wilson, Angela R, Hartge, Patricia, Purdue, Mark P, Birmann, Brenda M, Armstrong, Bruce K, Cocco, Pierluigi, Zhang, Yawei, Severi, Gianluca, Zeleniuch-Jacquotte, Anne, Lawrence, Charles, Burdette, Laurie, Yuenger, Jeffrey, Hutchinson, Amy, Jacobs, Kevin B, Call, Timothy G, Shanafelt, Tait D, Novak, Anne J, Kay, Neil E, Liebow, Mark, Wang, Alice H, Smedby, Karin E, Adami, Hans-Olov, Melbye, Mads, Glimelius, Bengt, Chang, Ellen T, Glenn, Martha, Curtin, Karen, Cannon-Albright, Lisa A, Jones, Brandt, Diver, W Ryan, Link, Brian K, Weiner, George J, Conde, Lucia, Bracci, Paige M, Riby, Jacques, Holly, Elizabeth A, Smith, Martyn T, Jackson, Rebecca D, Tinker, Lesley F, Benavente, Yolanda, Becker, Nikolaus, Boffetta, Paolo, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, McKay, James, Staines, Anthony, Rabe, Kari G, Achenbach, Sara J, Vachon, Celine M, Goldin, Lynn R, Strom, Sara S, Lanasa, Mark C, Spector, Logan G, Leis, Jose F, Cunningham, Julie M, Weinberg, J Brice, Morrison, Vicki A, Caporaso, Neil E, Norman, Aaron D, Linet, Martha S, De Roos, Anneclaire J, Morton, Lindsay M, Severson, Richard K, Riboli, Elio, Vineis, Paolo, Kaaks, Rudolph, Trichopoulos, Dimitrios, Masala, Giovanna, Weiderpass, Elisabete, Chirlaque, María-Dolores, Vermeulen, Roel CH, Travis, Ruth C, Giles, Graham G, Albanes, Demetrius, Virtamo, Jarmo, Weinstein, Stephanie, Clavel, Jacqueline, Zheng, Tongzhang, Holford, Theodore R, Offit, Kenneth, Zelenetz, Andrew, Klein, Robert J, Spinelli, John J, and Bertrand, Kimberly A

Subjects
Biological Sciences, Genetics, Lymphatic Research, Cancer Genomics, Cancer, Hematology, Prevention, Lymphoma, Rare Diseases, Human Genome, Case-Control Studies, Chromosomes, Human, Pair 2, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Recombination, Genetic, Risk, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls. In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P=1.22×10(-14)), 18q21.33 (BCL2, P=7.76×10(-11)), 11p15.5 (C11orf21, P=2.15×10(-10)), 4q25 (LEF1, P=4.24×10(-10)), 2q33.1 (CASP10 or CASP8 (CASP10/CASP8), P=2.50×10(-9)), 9p21.3 (CDKN2B-AS1, P=1.27×10(-8)), 18q21.32 (PMAIP1, P=2.51×10(-8)), 15q15.1 (BMF, P=2.71×10(-10)) and 2p22.2 (QPCT, P=1.68×10(-8)), as well as an independent signal at an established locus (2q13, ACOXL, P=2.08×10(-18)). We also found evidence for two additional promising loci below genome-wide significance at 8q22.3 (ODF1, P=5.40×10(-8)) and 5p15.33 (TERT, P=1.92×10(-7)). Although further studies are required, the proximity of several of these loci to genes involved in apoptosis suggests a plausible underlying biological mechanism.

Published
2013

4. Update On California's Efforts To Regulate The Use Of AI In Employment Decision-Making

Author

Wang, Alice H.

Subjects
California. State Assembly -- Powers and duties, Artificial intelligence -- Laws, regulations and rules -- Usage, Employee selection -- Laws, regulations and rules -- Technology application, Bills, Legislative -- Laws, regulations and rules, Government regulation, Hiring, Artificial intelligence, Technology application, Business, international
Abstract

California's Civil Rights Council has revised proposed regulations governing the use of automated-decision systems. A proposed bill, AB 331, would impose obligations on employers to evaluate the impact of an [...]

Published
2023

5. California Seeks To Ban Criminal Background Checks For Most Private Sector Employers

Author

Wang, Alice H.

Subjects
Employers -- Laws, regulations and rules, Private sector -- Laws, regulations and rules, Employee recruitment -- Laws, regulations and rules, Government regulation, Business, international
Abstract

Lawmakers in Sacramento seek to outright ban criminal background checks by most private sector employers in California in a bill that would scrap California's existing fair chance law and replace [...]

Published
2023

6. Data from Germline Variation in Apoptosis Pathway Genes and Risk of Non–Hodgkin's Lymphoma

Author

Kelly, Jennifer L., primary, Novak, Anne J., primary, Fredericksen, Zachary S., primary, Liebow, Mark, primary, Ansell, Stephen M., primary, Dogan, Ahmet, primary, Wang, Alice H., primary, Witzig, Thomas E., primary, Call, Timothy G., primary, Kay, Neil E., primary, Habermann, Thomas M., primary, Slager, Susan L., primary, and Cerhan, James R., primary

Published
2023
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7. Data from Mapping of the IRF8 Gene Identifies a 3′UTR Variant Associated with Risk of Chronic Lymphocytic Leukemia but not Other Common Non-Hodgkin Lymphoma Subtypes

Author

Slager, Susan L., primary, Achenbach, Sara J., primary, Asmann, Yan W., primary, Camp, Nicola J., primary, Rabe, Kari G., primary, Goldin, Lynn R., primary, Call, Timothy G., primary, Shanafelt, Tait D., primary, Kay, Neil E., primary, Cunningham, Julie M., primary, Wang, Alice H., primary, Weinberg, J. Brice, primary, Norman, Aaron D., primary, Link, Brian K., primary, Leis, Jose F., primary, Vachon, Celine M., primary, Lanasa, Mark C., primary, Caporaso, Neil E., primary, Novak, Anne J., primary, and Cerhan, James R., primary

Published
2023
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8. Supplementary Table 5 from Mapping of the IRF8 Gene Identifies a 3′UTR Variant Associated with Risk of Chronic Lymphocytic Leukemia but not Other Common Non-Hodgkin Lymphoma Subtypes

Author

Slager, Susan L., primary, Achenbach, Sara J., primary, Asmann, Yan W., primary, Camp, Nicola J., primary, Rabe, Kari G., primary, Goldin, Lynn R., primary, Call, Timothy G., primary, Shanafelt, Tait D., primary, Kay, Neil E., primary, Cunningham, Julie M., primary, Wang, Alice H., primary, Weinberg, J. Brice, primary, Norman, Aaron D., primary, Link, Brian K., primary, Leis, Jose F., primary, Vachon, Celine M., primary, Lanasa, Mark C., primary, Caporaso, Neil E., primary, Novak, Anne J., primary, and Cerhan, James R., primary

Published
2023
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9. Supplementary Table 3 from Mapping of the IRF8 Gene Identifies a 3′UTR Variant Associated with Risk of Chronic Lymphocytic Leukemia but not Other Common Non-Hodgkin Lymphoma Subtypes

Author

Slager, Susan L., primary, Achenbach, Sara J., primary, Asmann, Yan W., primary, Camp, Nicola J., primary, Rabe, Kari G., primary, Goldin, Lynn R., primary, Call, Timothy G., primary, Shanafelt, Tait D., primary, Kay, Neil E., primary, Cunningham, Julie M., primary, Wang, Alice H., primary, Weinberg, J. Brice, primary, Norman, Aaron D., primary, Link, Brian K., primary, Leis, Jose F., primary, Vachon, Celine M., primary, Lanasa, Mark C., primary, Caporaso, Neil E., primary, Novak, Anne J., primary, and Cerhan, James R., primary

Published
2023
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10. Supplementary Table 1 from Germline Variation in Apoptosis Pathway Genes and Risk of Non–Hodgkin's Lymphoma

Author

Kelly, Jennifer L., primary, Novak, Anne J., primary, Fredericksen, Zachary S., primary, Liebow, Mark, primary, Ansell, Stephen M., primary, Dogan, Ahmet, primary, Wang, Alice H., primary, Witzig, Thomas E., primary, Call, Timothy G., primary, Kay, Neil E., primary, Habermann, Thomas M., primary, Slager, Susan L., primary, and Cerhan, James R., primary

Published
2023
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11. Supplementary Figure 1 from Mapping of the IRF8 Gene Identifies a 3′UTR Variant Associated with Risk of Chronic Lymphocytic Leukemia but not Other Common Non-Hodgkin Lymphoma Subtypes

Author

Slager, Susan L., primary, Achenbach, Sara J., primary, Asmann, Yan W., primary, Camp, Nicola J., primary, Rabe, Kari G., primary, Goldin, Lynn R., primary, Call, Timothy G., primary, Shanafelt, Tait D., primary, Kay, Neil E., primary, Cunningham, Julie M., primary, Wang, Alice H., primary, Weinberg, J. Brice, primary, Norman, Aaron D., primary, Link, Brian K., primary, Leis, Jose F., primary, Vachon, Celine M., primary, Lanasa, Mark C., primary, Caporaso, Neil E., primary, Novak, Anne J., primary, and Cerhan, James R., primary

Published
2023
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12. Supplementary Table 1 from Mapping of the IRF8 Gene Identifies a 3′UTR Variant Associated with Risk of Chronic Lymphocytic Leukemia but not Other Common Non-Hodgkin Lymphoma Subtypes

Author

Slager, Susan L., primary, Achenbach, Sara J., primary, Asmann, Yan W., primary, Camp, Nicola J., primary, Rabe, Kari G., primary, Goldin, Lynn R., primary, Call, Timothy G., primary, Shanafelt, Tait D., primary, Kay, Neil E., primary, Cunningham, Julie M., primary, Wang, Alice H., primary, Weinberg, J. Brice, primary, Norman, Aaron D., primary, Link, Brian K., primary, Leis, Jose F., primary, Vachon, Celine M., primary, Lanasa, Mark C., primary, Caporaso, Neil E., primary, Novak, Anne J., primary, and Cerhan, James R., primary

Published
2023
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13. Supplementary Table 4 from Mapping of the IRF8 Gene Identifies a 3′UTR Variant Associated with Risk of Chronic Lymphocytic Leukemia but not Other Common Non-Hodgkin Lymphoma Subtypes

Author

Slager, Susan L., primary, Achenbach, Sara J., primary, Asmann, Yan W., primary, Camp, Nicola J., primary, Rabe, Kari G., primary, Goldin, Lynn R., primary, Call, Timothy G., primary, Shanafelt, Tait D., primary, Kay, Neil E., primary, Cunningham, Julie M., primary, Wang, Alice H., primary, Weinberg, J. Brice, primary, Norman, Aaron D., primary, Link, Brian K., primary, Leis, Jose F., primary, Vachon, Celine M., primary, Lanasa, Mark C., primary, Caporaso, Neil E., primary, Novak, Anne J., primary, and Cerhan, James R., primary

Published
2023
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14. Supplementary Table 2 from Mapping of the IRF8 Gene Identifies a 3′UTR Variant Associated with Risk of Chronic Lymphocytic Leukemia but not Other Common Non-Hodgkin Lymphoma Subtypes

Author

Slager, Susan L., primary, Achenbach, Sara J., primary, Asmann, Yan W., primary, Camp, Nicola J., primary, Rabe, Kari G., primary, Goldin, Lynn R., primary, Call, Timothy G., primary, Shanafelt, Tait D., primary, Kay, Neil E., primary, Cunningham, Julie M., primary, Wang, Alice H., primary, Weinberg, J. Brice, primary, Norman, Aaron D., primary, Link, Brian K., primary, Leis, Jose F., primary, Vachon, Celine M., primary, Lanasa, Mark C., primary, Caporaso, Neil E., primary, Novak, Anne J., primary, and Cerhan, James R., primary

Published
2023
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17. ARTIFICIAL INTELLIGENCE AS A LESS DISCRIMINATORY ALTERNATIVE.

Author

King, Allan G. and Wang, Alice H.

Subjects
*DISPARATE impact (Law), *ARTIFICIAL intelligence, *EMPLOYMENT of minorities, *EMPLOYEE selection, *ANTI-discrimination laws
Abstract

This Article considers the role of the "less discriminatory alternative" (LDA) in disparate impact litigation under Title VII of the Civil Rights Act and related statutes. The question posed is: has assigning the burden ofproof of identifying LDAs to plaintiffs resulted in the adoption of these alternatives? The answer is no. But well-meaning employers have been reluctant to adopt practices that might increase the presence of minority employees in the workplace because the anti-discrimination laws prohibit reverse discrimination. This Article discusses the legal constraints that impinge on employers who wish to unilaterally search for and adopt an LDA, and explains how artificial intelligence (predictive analytics, specifically) can prove helpful. Artificial intelligence may improve the accuracy of employee selections and, by constraining the algorithm regarding its analysis of seed data but not selections themselves, can lawfully enhance the presence ofminorities and women in the workplace. [ABSTRACT FROM AUTHOR]

Published
2023

24. CXCR5 polymorphisms in non-Hodgkin lymphoma risk and prognosis

Author

Charbonneau, Bridget, Wang, Alice H., Maurer, Matthew J., Asmann, Yan W., Zent, Clive S., Link, Brian K., Ansell, Stephen M., Weiner, George J., Ozsan, Nazan, Feldman, Andrew L., Witzig, Thomas E., Cunningham, Julie M., Dogan, Ahmet, Habermann, Thomas M., Slager, Susan L., Novak, Anne J., and Cerhan, James R.

Published
2013
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27. Salary Negotiation Can Provide Affirmative Defense To Equal Pay Act Claim As 'Factor Other Than Sex'

Author

Wang, Alice H.

Subjects
Wages -- Negotiation, mediation and arbitration -- Laws, regulations and rules -- Demographic aspects, Government regulation, Salary, Business, international, Equal Pay Act of 1963
Abstract

A female applicant applies for a position that was widely advertised. During her interview she insists on being paid $100,000. The employer agrees to her salary demand although it employs [...]

Published
2021

30. Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes

Author

Slager, Susan L., Camp, Nicola J., Conde, Lucia, Shanafelt, Tait D., Achenbach, Sara J., Rabe, Kari G., Kay, Neil E., Novak, Anne J., Call, Timothy G., Bracci, Paige M., Sille, Fenna M. C., Sanchez, Sylvia, Akers, Nicholas K., Cunningham, Julie M., Serie, Daniel J., McDonnell, Shannon K., Leis, Jose F., Wang, Alice H., Weinberg, Brice J., Glenn, Martha, Link, Brian, Vachon, Celine M., Lanasa, Mark C., Skibola, Christine F., and Cerhan, James R.

Published
2012
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42. PRRC2A and BCL2L11 gene variants influence risk of non-Hodgkin lymphoma: results from the InterLymph consortium

Author

Nieters, Alexandra, Conde, Lucia, Slager, Susan L., Brooks-Wilson, Angela, Morton, Lindsay, Skibola, Danica R., Novak, Anne J., Riby, Jacques, Ansell, Stephen M., Halperin, Eran, Shanafelt, Tait D., Agana, Luz, Wang, Alice H., De Roos, Anneclaire J., Severson, Richard K., Cozen, Wendy, Spinelli, John, Butterbach, Katja, Becker, Nikolaus, de Sanjose, Silvia, Benavente, Yolanda, Cocco, Pierluigi, Staines, Anthony, Maynadié, Marc, Foretova, Lenka, Boffetta, Paolo, Brennan, Paul, Lan, Qing, Zhang, Yawei, Zheng, Tongzhang, Purdue, Mark, Armstrong, Bruce, Kricker, Anne, Vajdic, Claire M., Grulich, Andrew, Smith, Martyn T., Bracci, Paige M., Chanock, Stephen J., Hartge, Patricia, Cerhan, James R., Wang, Sophia S., Rothman, Nathaniel, and Skibola, Christine F.

Published
2012
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44. Tumor Budding in Colorectal Carcinoma

Author

Graham, Rondell P., primary, Vierkant, Robert A., additional, Tillmans, Lori S., additional, Wang, Alice H., additional, Laird, Peter W., additional, Weisenberger, Daniel J., additional, Lynch, Charles F., additional, French, Amy J., additional, Slager, Susan L., additional, Raissian, Yassaman, additional, Garcia, Joaquin J., additional, Kerr, Sarah E., additional, Eun Lee, Hee, additional, Thibodeau, Stephen N., additional, Cerhan, James R., additional, Limburg, Paul J., additional, and Smyrk, Thomas C., additional

Published
2015
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45. Genetic variation in BAFF is associated with an increased risk of developing B-cell non-Hodgkin lymphoma

Author

Novak, Anne J., Slager, Susan L., Fredericksen, Zachary S., Wang, Alice H., Manske, Michelle M., Ziesmer, Steven, Liebow, Mark, Macon, William R., Dillon, Stacey R., Witzig, Thomas E., Cerhan, James R, and Ansell, Stephen M.

Subjects
Adult, Lymphoma, B-Cell, Genetic Variation, Enzyme-Linked Immunosorbent Assay, Iowa, Polymorphism, Single Nucleotide, Article, Alternative Splicing, Young Adult, Wisconsin, Gene Frequency, immune system diseases, Risk Factors, hemic and lymphatic diseases, Case-Control Studies, B-Cell Activating Factor, Humans
Abstract

Elevated B-cell-activating factor (BAFF; TNFSF13B) levels have been found in patients with B-cell malignancies and autoimmune diseases, suggesting that it may play a pathogenic role. We previously found that a single nucleotide polymorphism (SNP) in the TNFSF13B promoter resulted in increased transcription, suggesting that genetic variation in TNFSF13B may influence its expression. We therefore wanted to determine if genetic variation in TNFSF13B is associated with high BAFF levels and non-Hogkin lymphoma (NHL) risk. We genotyped 9 tagSNPs within TNFSF13B in a clinic-based study of 441 NHL cases and 475 matched controls and evaluated the association of individual SNPs with risk of NHL; 3 tagSNPs were significant (P0.05). When categorized into low-, moderate-, and high-risk groups based on risk alleles, we found the permutation-corrected odds ratio for the trend to be 1.43 (P = 0.0019) for risk of B-cell NHL, 1.69 (P = 0.0093) for diffuse large B-cell lymphoma, 1.43 (P = 0.029) for follicular lymphoma, and 1.06 (P = 0.21) for chronic lymphocytic leukemia/small lymphocytic lymphoma. The mean serum BAFF level in those who carried the low-risk alleles was 2 ng/mL compared with 4.3 ng/mL in those with the high-risk alleles (P = 0.02). Taken together, our data suggest that genetic variation in the TNFSF13B gene is significantly associated with NHL risk and elevated serum BAFF levels.

Published
2009

46. Associations between Environmental Exposures and Incident Colorectal Cancer by ESR2 Protein Expression Level in a Population-Based Cohort of Older Women

Author

Tillmans, Lori S., primary, Vierkant, Robert A., additional, Wang, Alice H., additional, Samadder, Niloy Jewel, additional, Lynch, Charles F., additional, Anderson, Kristin E., additional, French, Amy J., additional, Haile, Robert W., additional, Harnack, Lisa J., additional, Potter, John D., additional, Slager, Susan L., additional, Smyrk, Thomas C., additional, Thibodeau, Stephen N., additional, Cerhan, James R., additional, and Limburg, Paul J., additional

Published
2015
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47. Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

Author

Berndt, Sonja I., Skibola, Christine F., Joseph, Vijai, Camp, Nicola J., Nieters, Alexandra, Wang, Zhaoming, Cozen, Wendy, Monnereau, Alain, Wang, Sophia S., Kelly, Rachel S., Lan, Qing, Teras, Lauren R., Chatterjee, Nilanjan, Chung, Charles C., Yeager, Meredith, Brooks-Wilson, Angela R., Hartge, Patricia, Purdue, Mark P., Birmann, Brenda M., Armstrong, Bruce K., Cocco, Pierluigi, Zhang, Yawei, Severi, Gianluca, Zeleniuch-Jacquotte, Anne, Lawrence, Charles, Burdette, Laurie, Yuenger, Jeffrey, Hutchinson, Amy, Jacobs, Kevin B., Call, Timothy G., Shanafelt, Tait D., Novak, Anne J., Kay, Neil E., Liebow, Mark, Wang, Alice H., Smedby, Karin E., Adami, Hans-Olov, Melbye, Mads, Glimelius, Bengt, Chang, Ellen T., Glenn, Martha, Curtin, Karen, Cannon-Albright, Lisa A., Jones, Brandt, Diver, W. Ryan, Link, Brian K., Weiner, George J., Conde, Lucia, Bracci, Paige M., Riby, Jacques, Holly, Elizabeth A., Smith, Martyn T., Jackson, Rebecca D., Tinker, Lesley F., Benavente, Yolanda, Becker, Nikolaus, Boffetta, Paolo, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, McKay, James, Staines, Anthony, Rabe, Kari G., Achenbach, Sara J., Vachon, Celine M., Goldin, Lynn R., Strom, Sara S., Lanasa, Mark C., Spector, Logan G., Leis, Jose F., Cunningham, Julie M., Weinberg, J. Brice, Morrison, Vicki A., Caporaso, Neil E., Norman, Aaron D., Linet, Martha S., De Roos, Anneclaire J., Morton, Lindsay M., Severson, Richard K., Riboli, Elio, Vineis, Paolo, Kaaks, Rudolph, Trichopoulos, Dimitrios, Masala, Giovanna, Weiderpass, Elisabete, Chirlaque, Mara-Dolores, Vermeulen, Roel C. H., Travis, Ruth C., Giles, Graham G., Albanes, Demetrius, Virtamo, Jarmo, Weinstein, Stephanie, Clavel, Jacqueline, Zheng, Tongzhang, Holford, Theodore R., Offit, Kenneth, Zelenetz, Andrew, Klein, Robert J., Spinelli, John J., Bertrand, Kimberly A., Laden, Francine, Giovannucci, Edward, Kraft, Peter, Kricker, Anne, Turner, Jenny, Vajdic, Claire M., Ennas, Maria Grazia, Ferri, Giovanni M., Miligi, Lucia, Liang, Liming, Sampson, Joshua, Crouch, Simon, Park, Ju-Hyun, North, Kari E., Cox, Angela, Snowden, John A., Wright, Josh, Carracedo, Angel, Lopez-Otin, Carlos, Bea, Silvia, Salaverria, Itziar, Martin-Garcia, David, Campo, Elias, Fraumeni, Joseph F., Jr., de Sanjose, Silvia, Hjalgrim, Henrik, Cerhan, James R., Chanock, Stephen J., Rothman, Nathaniel, Slager, Susan L., Berndt, Sonja I., Skibola, Christine F., Joseph, Vijai, Camp, Nicola J., Nieters, Alexandra, Wang, Zhaoming, Cozen, Wendy, Monnereau, Alain, Wang, Sophia S., Kelly, Rachel S., Lan, Qing, Teras, Lauren R., Chatterjee, Nilanjan, Chung, Charles C., Yeager, Meredith, Brooks-Wilson, Angela R., Hartge, Patricia, Purdue, Mark P., Birmann, Brenda M., Armstrong, Bruce K., Cocco, Pierluigi, Zhang, Yawei, Severi, Gianluca, Zeleniuch-Jacquotte, Anne, Lawrence, Charles, Burdette, Laurie, Yuenger, Jeffrey, Hutchinson, Amy, Jacobs, Kevin B., Call, Timothy G., Shanafelt, Tait D., Novak, Anne J., Kay, Neil E., Liebow, Mark, Wang, Alice H., Smedby, Karin E., Adami, Hans-Olov, Melbye, Mads, Glimelius, Bengt, Chang, Ellen T., Glenn, Martha, Curtin, Karen, Cannon-Albright, Lisa A., Jones, Brandt, Diver, W. Ryan, Link, Brian K., Weiner, George J., Conde, Lucia, Bracci, Paige M., Riby, Jacques, Holly, Elizabeth A., Smith, Martyn T., Jackson, Rebecca D., Tinker, Lesley F., Benavente, Yolanda, Becker, Nikolaus, Boffetta, Paolo, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, McKay, James, Staines, Anthony, Rabe, Kari G., Achenbach, Sara J., Vachon, Celine M., Goldin, Lynn R., Strom, Sara S., Lanasa, Mark C., Spector, Logan G., Leis, Jose F., Cunningham, Julie M., Weinberg, J. Brice, Morrison, Vicki A., Caporaso, Neil E., Norman, Aaron D., Linet, Martha S., De Roos, Anneclaire J., Morton, Lindsay M., Severson, Richard K., Riboli, Elio, Vineis, Paolo, Kaaks, Rudolph, Trichopoulos, Dimitrios, Masala, Giovanna, Weiderpass, Elisabete, Chirlaque, Mara-Dolores, Vermeulen, Roel C. H., Travis, Ruth C., Giles, Graham G., Albanes, Demetrius, Virtamo, Jarmo, Weinstein, Stephanie, Clavel, Jacqueline, Zheng, Tongzhang, Holford, Theodore R., Offit, Kenneth, Zelenetz, Andrew, Klein, Robert J., Spinelli, John J., Bertrand, Kimberly A., Laden, Francine, Giovannucci, Edward, Kraft, Peter, Kricker, Anne, Turner, Jenny, Vajdic, Claire M., Ennas, Maria Grazia, Ferri, Giovanni M., Miligi, Lucia, Liang, Liming, Sampson, Joshua, Crouch, Simon, Park, Ju-Hyun, North, Kari E., Cox, Angela, Snowden, John A., Wright, Josh, Carracedo, Angel, Lopez-Otin, Carlos, Bea, Silvia, Salaverria, Itziar, Martin-Garcia, David, Campo, Elias, Fraumeni, Joseph F., Jr., de Sanjose, Silvia, Hjalgrim, Henrik, Cerhan, James R., Chanock, Stephen J., Rothman, Nathaniel, and Slager, Susan L.

Abstract

Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls. In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P = 1.22 x 10(-14)), 18q21.33 (BCL2, P = 7.76 x 10(-11)), 11p15.5 (C11orf21, P = 2.15 x 10(-10)), 4q25 (LEF1, P = 4.24 x 10(-10)), 2q33.1 (CASP10 or CASP8 (CASP10/CASP8), P = 2.50 x 10(-9)), 9p21.3 (CDKN2B-AS1, P = 1.27 x 10(-8)), 18q21.32 (PMAIP1, P = 2.51 x 10(-8)), 15q15.1 (BMF, P = 2.71 x 10(-10)) and 2p22.2 (QPCT, P = 1.68 x 10(-8)), as well as an independent signal at an established locus (2q13, ACOXL, P = 2.08 x 10(-18)). We also found evidence for two additional promising loci below genome-wide significance at 8q22.3 (ODF1, P = 5.40 x 10(-8)) and 5p15.33 (TERT, P = 1.92 x 10(-7)). Although further studies are required, the proximity of several of these loci to genes involved in apoptosis suggests a plausible underlying biological mechanism.

Published
2013
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48. Associations between Cigarette Smoking, Hormone Therapy, and Folate Intake with Incident Colorectal Cancer by TP53 Protein Expression Level in a Population-Based Cohort of Older Women

Author

Tillmans, Lori S., primary, Vierkant, Robert A., additional, Wang, Alice H., additional, Jewel Samadder, N., additional, Lynch, Charles F., additional, Anderson, Kristin E., additional, French, Amy J., additional, Haile, Robert W., additional, Harnack, Lisa J., additional, Potter, John D., additional, Slager, Susan L., additional, Smyrk, Thomas C., additional, Thibodeau, Stephen N., additional, Cerhan, James R., additional, and Limburg, Paul J., additional

Published
2014
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50. Abstract 3652: Hormone therapy and incident colorectal cancer risk by ER beta protein expression level in a population-based cohort of older women.

Author

Tillmans, Lori S., primary, Vierkant, Robert A., additional, Wang, Alice H., additional, Lynch, Charles F., additional, Anderson, Kristin E., additional, French, Amy J., additional, Haile, Robert W., additional, Potter, John D., additional, Slager, Susan L., additional, Smyrk, Thomas C., additional, Thibodeau, Stephen N., additional, Cerhan, James R., additional, and Limburg, Paul J., additional

Published
2013
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