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Abstract: Taspine solid lipid nanoparticles (Ta-SLN) and taspine solid lipid nanoparticles modified by galactoside (Ta-G2SLN) were prepared by the film evaporation-extrusion method. The nanoparticles were spherical or near-spherical particles with smooth surface, small size and high encapsulation efficiency. Ta-G2SLN and Ta-SLN showed significant inhibition on 7721 cell growth. Intravenous injection of either Ta-SLN or Ta-G2SLN resulted in a higher plasma and liver concentration and a longer retention time in mice compared with the administration of Ta. These results suggested that SLN tended to be preferentially delivered to the liver and Ta-G2SLN may further enhance liver targeting. [Copyright &y& Elsevier]

The article discusses the findings of a study to determine the separability of two types of exocytosis. It notes the function of Ca2+-regulated exocytosis the somata of dorsal root ganglions (DRG) in neurotransmitter and hormone release. The experiment cites the use of electrical stimulation to confirm the presence of distinct exocytosis and vesicle pools within DRG neurons without any effect on Ca2+ -independent but voltage-dependent secretion (CVIDS) exocytosis.