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1. Clinical characteristics and risk stratification for late-onset herpes zoster following allogeneic hematopoietic stem cell transplantation

Author

Feng, Cheng-Jie, Zhao, Peng, Fu, Hai-Xia, Yan, Chen-Hua, Wang, Chen-Cong, Zhu, Xiao-Lu, He, Yun, Wang, Feng-Rong, Zhang, Yuan-Yuan, Mo, Xiao-Dong, Kong, Yuan, Han, Wei, Wang, Jing-Zhi, Wang, Yu, Chen, Huan, Chen, Yu-Hong, Zhao, Xiang-Yu, Chang, Ying-Jun, Xu, Lan-Ping, Liu, Kai-Yan, Huang, Xiao-Jun, and Zhang, Xiao-Hui

Published
2024
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4. A Prognostic Model Based on Clinical Biomarkers for Heart Failure in Adult Patients Following Allogeneic Hematopoietic Stem Cell Transplantation

Author

Zhang, Ao-Bei, Wang, Chen-Cong, Zhao, Peng, Tong, Ke-Ting, He, Yun, Zhu, Xiao-Lu, Fu, Hai-Xia, Wang, Feng-Rong, Mo, Xiao-Dong, Wang, Yu, Zhao, Xiang-Yu, Zhang, Yuan-Yuan, Han, Wei, Chen, Huan, Chen, Yao, Yan, Chen-Hua, Wang, Jing-Zhi, Han, Ting-Ting, Sun, Yu-Qian, Chen, Yu-Hong, Chang, Ying-Jun, Xu, Lan-Ping, Liu, Kai-Yan, Huang, Xiao-Jun, and Zhang, Xiao-Hui

Published
2023
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5. A predictive model of herpes zoster after allogeneic hematopoietic stem cell transplantation: VZV reactivation following antiviral prophylaxis discontinuation.

Author

Feng, Cheng‐Jie, Zhao, Peng, Fu, Hai‐Xia, Yan, Chen‐Hua, Wang, Chen‐Cong, Zhu, Xiao‐Lu, He, Yun, Wang, Feng‐Rong, Zhang, Yuan‐Yuan, Mo, Xiao‐Dong, Kong, Yuan, Han, Wei, Wang, Jing‐Zhi, Wang, Yu, Chen, Huan, Chen, Yu‐Hong, Zhao, Xiang‐Yu, Chang, Ying‐Jun, Xu, Lan‐Ping, and Liu, Kai‐Yan

Published
2024
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6. A predictive model of herpes zoster after allogeneic hematopoietic stem cell transplantation: VZV reactivation following antiviral prophylaxis discontinuation

Author

Feng, Cheng‐Jie, primary, Zhao, Peng, additional, Fu, Hai‐Xia, additional, Yan, Chen‐Hua, additional, Wang, Chen‐Cong, additional, Zhu, Xiao‐Lu, additional, He, Yun, additional, Wang, Feng‐Rong, additional, Zhang, Yuan‐Yuan, additional, Mo, Xiao‐Dong, additional, Kong, Yuan, additional, Han, Wei, additional, Wang, Jing‐Zhi, additional, Wang, Yu, additional, Chen, Huan, additional, Chen, Yu‐Hong, additional, Zhao, Xiang‐Yu, additional, Chang, Ying‐Jun, additional, Xu, Lan‐Ping, additional, Liu, Kai‐Yan, additional, Huang, Xiao‐Jun, additional, and Zhang, Xiao‐Hui, additional

Published
2023
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10. Tacrolimus prevents complement‐mediated Nod‐like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation and pyroptosis of mesenchymal stem cells from immune thrombocytopenia.

Author

Cai, Xuan, Wu, Jin, An, Zhuo‐Yu, Wang, Chen‐Cong, Zhu, Xiao‐Lu, He, Yun, Fu, Hai‐Xia, Huang, Xiao‐Jun, and Zhang, Xiao‐Hui

Subjects
MESENCHYMAL stem cells, IDIOPATHIC thrombocytopenic purpura, NLRP3 protein, PYRIN (Protein), INFLAMMASOMES
Abstract

Summary: The abnormal immunomodulatory functions of mesenchymal stem cells (MSCs) have been implicated in the development of immune thrombocytopenia (ITP). Recent studies have suggested important effects of complement on immune cell function. However, whether complement modulates bone marrow MSCs function in ITP is poorly defined. Tacrolimus has recently been applied to the treatment of autoimmune diseases. Here, we explored whether impaired ITP‐MSCs could be targeted by tacrolimus. Our results showed that the Nod‐like receptor family pyrin domain containing 3 (NLRP3) inflammasome was activated in ITP MSCs with complement deposition (MSCs‐C+) and initiated caspase‐1‐dependent pyroptosis. Transcriptome sequencing results showed abnormal fatty acid metabolism in MSCs‐C+. Enhanced fatty acid β‐oxidation and reactive oxygen species production activated the NLRP3 inflammasome. Adipocytes derived from MSCs‐C+ secreted less adiponectin. Adiponectin promoted the differentiation of megakaryocytes and inhibited the destruction of platelets. Tacrolimus inhibited NLRP3 inflammasome activation and MSCs‐C+ pyroptosis in vitro and in vivo. Tacrolimus plus danazol elicited a higher sustained response than danazol monotherapy in corticosteroid‐resistant patients with ITP. Our findings demonstrate that the activation of the NLRP3 inflammasome in ITP MSCs mediated by complement could be inhibited by tacrolimus, which might be a potential new therapy for ITP. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Machine-Learning Based Early Warning System for Prediction for Disseminated Intravascular Coagulation after Allogeneic Hematopoietic Stem Cell Transplantation: A Nationwide Multicenter Study

Author

An, Zhuo-Yu, primary, Wu, Ye-Jun, additional, He, Yun, additional, Zhu, Xiao-Lu, additional, Su, Yan, additional, Wang, Chen-Cong, additional, Han, Tian-Xiao, additional, Fu, Hai-Xia, additional, Wang, Feng-Rong, additional, Mo, Xiao-Dong, additional, Wang, Yu, additional, Zhao, Xiang-Yu, additional, Zhang, Yuan-Yuan, additional, Han, Wei, additional, Chen, Huan, additional, Chen, Yao, additional, Yan, Chen-Hua, additional, Wang, Jing-Zhi, additional, Han, Ting-Ting, additional, Chen, Yu-Hong, additional, Cheng, Yi-Fei, additional, Chang, Ying-Jun, additional, Xu, Lan-Ping, additional, Liu, Kai-Yan, additional, Huang, Xiao Jun, additional, and Zhang, Xiaohui, additional

Published
2021
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15. Tacrolimus Plus High-Dose Dexamethasone Versus High-Dose Dexamethasone Alone As First-Line Treatment for Adult Immune Thrombocytopenia: The Phase 2, Open Label, Randomized Trial (TARGET 020)

Author

An, Zhuo-Yu, primary, Wu, Ye-Jun, additional, He, Yun, additional, Zhu, Xiao-Lu, additional, Shi, Hong-Xia, additional, Wang, Chen-Cong, additional, Jiang, Hao, additional, Lu, Jin, additional, Jiang, Qian, additional, Huang, Qiu-Sha, additional, Fu, Hai-Xia, additional, Wang, Feng-Rong, additional, Mo, Xiao-Dong, additional, Wang, Yu, additional, Zhao, Xiang-Yu, additional, Zhang, Yuan-Yuan, additional, Han, Wei, additional, Chen, Huan, additional, Chen, Yao, additional, Yan, Chen-Hua, additional, Wang, Jing-Zhi, additional, Han, Ting-Ting, additional, Chen, Yu-Hong, additional, Cheng, Yi-Fei, additional, Chang, Ying-Jun, additional, Xu, Lan-Ping, additional, Liu, Kai-Yan, additional, Huang, Xiao-Jun, additional, and Zhang, Xiaohui, additional

Published
2021
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18. Baricitinib in Combination with High-Dose Dexamethasone As First-Line Treatment for Newly Diagnosed Immune Thrombocytopenia: A Prospective, Multicenter, Randomized Trial

Author

Zhao, Peng, An, Zhuoyu, Fu, Haixia, Liu, Daihong, Dou, Liping, Liu, Yi, Liu, Hui, Wang, Zhao, Dong, Yujun, Jing, Hongmei, Zhou, Hebing, Li, Zhen-Ling, Li, Lihong, Huang, Qiu-Sha, Wu, Jin, Wu, Yejun, Wang, Chen-Cong, Zhu, Xiaolu, Chen, Qi, He, Yun, Liu, Kaiyan, and Zhang, Xiaohui

Published
2023
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20. Dysregulated megakaryocyte distribution associated with nestin+ mesenchymal stem cells in immune thrombocytopenia

Author

Wang, Min, primary, Feng, Ru, additional, Zhang, Jia-min, additional, Xu, Lin-lin, additional, Feng, Fei-er, additional, Wang, Chen-cong, additional, Wang, Qian-ming, additional, Zhu, Xiao-lu, additional, He, Yun, additional, Xue, Jing, additional, Fu, Hai-xia, additional, Lv, Meng, additional, Kong, Yuan, additional, Chang, Ying-jun, additional, Xu, Lan-ping, additional, Liu, Kai-yan, additional, Huang, Xiao-jun, additional, and Zhang, Xiao-hui, additional

Published
2019
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21. ADAM28 promotes tumor growth and dissemination of acute myeloid leukemia through IGFBP-3 degradation and IGF-I-induced cell proliferation

Author

Zhang, Jia-Min, primary, Wang, Chen-Cong, additional, Zhang, Gao-Chao, additional, Jiang, Qian, additional, Yang, Shen-Miao, additional, Fu, Hai-Xia, additional, Wang, Qian-Ming, additional, Zhu, Xiao-Lu, additional, Zhu, Hong-Hu, additional, Jiang, Hao, additional, Wang, Yu, additional, Lv, Meng, additional, Lu, Jin, additional, Chen, Huan, additional, Han, Wei, additional, Chang, Ying-Jun, additional, Kong, Yuan, additional, Xu, Lan-Ping, additional, Liu, Kai-Yan, additional, Huang, Xiao-Jun, additional, and Zhang, Xiao-Hui, additional

Published
2019
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22. Berberine May Correct Corticosteroid Resistance Induced By Gut Microbiota Dysbiosis in Immune Thrombocytopenia

Author

Wang, Ya-Nan, primary, Liu, Xiao, additional, He, Yun, additional, Wang, Qian-Ming, additional, Zhu, Xiao-Lu, additional, Wang, Chen-Cong, additional, Fu, Hai-Xia, additional, Lv, Meng, additional, Chang, Ying-Jun, additional, Zhao, Xiao-Su, additional, Zhao, Xiang-Yu, additional, Xu, Lan-Ping, additional, Liu, Kai-Yan, additional, Huang, Xiao-Jun, additional, and Zhang, Xiaohui, additional

Published
2018
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23. Arsenic Trioxide Encapsulated in MSC-Derived Extracellular Vesicles: A Novel Therapy for aGVHD in Mice

Author

Liu, Xiao, primary, Wang, Ya-Nan, additional, Zhang, Gao-chao, additional, Su, Yan, additional, Huang, Qiu-sha, additional, Wang, Chen-Cong, additional, Fu, Hai-Xia, additional, He, Yun, additional, Wang, Qian-Ming, additional, Zhao, Xiang-Yu, additional, Zhao, Xiao-Su, additional, Lv, Meng, additional, Chang, Ying-Jun, additional, Xu, Lan-Ping, additional, Liu, Kai-Yan, additional, Huang, Xiao-Jun, additional, and Zhang, Xiaohui, additional

Published
2018
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24. Impaired Function of Bone Marrow Mesenchymal Stem Cells from Immune Thrombocytopenia Patients in Inducing Regulatory Dendritic Cell Differentiation Through the Notch-1/Jagged-1 Signaling Pathway

Author

Xu, Lin-lin, primary, Fu, Hai-xia, additional, Zhang, Jia-min, additional, Feng, Fei-er, additional, Wang, Qian-ming, additional, Zhu, Xiao-lu, additional, Xue, Jing, additional, Wang, Chen-cong, additional, Chen, Qi, additional, Liu, Xiao, additional, Wang, Ya-zhe, additional, Qin, Ya-zhen, additional, Kong, Yuan, additional, Chang, Ying-Jun, additional, Xu, Lan-ping, additional, Liu, Kai-yan, additional, Huang, Xiao-jun, additional, and Zhang, Xiao-hui, additional

Published
2017
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25. ADAM28 Enhanced the Growth and Dissemination of AML and Identified a Subgroup of AML Patients with a High Risk of Relapse in a Prospective Clinical Study

Author

Zhang, Jia-Min, primary, Wang, Chen-Cong, additional, Wang, Qian-Ming, additional, Zhu, Xiao-Lu, additional, Jiang, Hao, additional, Jiang, Qian, additional, Wang, Yu, additional, Lv, Meng, additional, Wang, Feng-Rong, additional, Lu, Jin, additional, Chen, Huan, additional, Han, Wei, additional, Xu, Lan-Ping, additional, Liu, Kai-Yan, additional, Huang, Xiao-Jun, additional, and Zhang, Xiao-Hui, additional

Published
2016
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26. Dysregulated megakaryocyte distribution associated with nestin+mesenchymal stem cells in immune thrombocytopenia

Author

Wang, Min, Feng, Ru, Zhang, Jia-min, Xu, Lin-lin, Feng, Fei-er, Wang, Chen-cong, Wang, Qian-ming, Zhu, Xiao-lu, He, Yun, Xue, Jing, Fu, Hai-xia, Lv, Meng, Kong, Yuan, Chang, Ying-jun, Xu, Lan-ping, Liu, Kai-yan, Huang, Xiao-jun, and Zhang, Xiao-hui

Abstract

Impaired megakaryocyte (MK) maturation and reduced platelet production are important causes of immune thrombocytopenia (ITP). However, MK distribution and bone marrow (BM) niche alteration in ITP are unclear. To investigate the maturation and distribution of MKs in the BM niche and examine the components of BM niche regulation of MK migration, BM and peripheral blood were obtained from 30 ITP patients and 28 healthy donors. Nestin+mesenchymal stem cells (MSCs) and CD41+MKs were sorted by fluorescence-activated cell sorting. The components of the BM niche and related signaling were analyzed via immunofluorescence, flow cytometry, enzyme-linked immunosorbent assay, reverse transcription polymerase chain reaction, and western blot analysis. The number of MKs in the BM vascular niche was reduced in ITP. Moreover, the concentrations of CXCL12 and CXCR4+MKs in the BM were decreased in ITP. Further investigation demonstrated that nestin+MSCs and CXCL12 messenger RNA (mRNA) in nestin+MSCs were both reduced whereas the apoptosis of nestin+MSCs was significantly increased in ITP. Sympathetic nerves, Schwann cells, the proportion of β3-adrenoreceptor (β3-AR)+nestin+MSCs, and β3-AR mRNA in nestin+MSCs were all markedly reduced in ITP. Moreover, matrix metalloproteinase 9, vascular endothelial growth factor (VEGF), and VEGF receptor 1 were significantly reduced in ITP. Our data show that impaired MK distribution mediated by an abnormal CXCL12/CXCR4 axis is partially involved in reduced platelet production in ITP. Moreover, sympathetic neuropathy and nestin+MSC apoptosis may have an effect on the alterations of BM CXCL12 in ITP.

Published
2019
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33. Integrated mRNA and miRNA Profiling Revealed Deregulation of the Cellular Stress Response in Bone Marrow Mesenchymal Stem Cells Derived from Patients with Immune Thrombocytopenia

Author

Zhang, Jia-Min, Zhu, Xiao-Lu, Xue, Jing, Liu, Xiao, Chen, Qi, Wang, Ya-Nan, Wang, Chen-Cong, He, Yun, Wang, Qian-Ming, Kong, Yuan, Fu, Hai-Xia, Chang, Ying-Jun, Liu, Kai-Yan, Huang, Xiao-Jun, and Zhang, Xiaohui

Abstract

Introduction:Immune thrombocytopenia (ITP) is an autoimmune disease characterized by accelerated platelet destruction and decreased platelet production. Our understanding of its pathogenesis remains limited due to the complexity of the immune system and the heterogeneity of the disease (Rivière et al. Br J Haematol. 2015, 170). Recently, we found that the bone marrow mesenchymal stem cells (MSCs) derived from ITP patients (MSC-ITP) exhibited growth defects and functional abnormalities, which may be implicated in the breakdown of self-tolerance in ITP (Zhang et al. Stem Cells Transl Med.2016, 5). The underlying mechanism of these defects remains unclear. In this study, by utilizing microarray technique and bioinformatics analysis, we aimed to profile both the mRNA and microRNA expression and decipher the underlying mechanism involved in the impairment of MSC-ITP.

Published
2017
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34. Dysregulated megakaryocyte distribution associated with nestin + mesenchymal stem cells in immune thrombocytopenia.

Author

Wang M, Feng R, Zhang JM, Xu LL, Feng FE, Wang CC, Wang QM, Zhu XL, He Y, Xue J, Fu HX, Lv M, Kong Y, Chang YJ, Xu LP, Liu KY, Huang XJ, and Zhang XH

Subjects
Adult, Bone Marrow metabolism, Bone Marrow pathology, Case-Control Studies, Chemokine CXCL12 metabolism, Female, Humans, Male, Matrix Metalloproteinase 9 metabolism, Megakaryocytes metabolism, Mesenchymal Stem Cells cytology, Middle Aged, Receptors, Adrenergic, beta-3 genetics, Receptors, Adrenergic, beta-3 metabolism, Receptors, CXCR4 metabolism, Signal Transduction, Vascular Endothelial Growth Factor A metabolism, Vascular Endothelial Growth Factor Receptor-1 metabolism, Megakaryocytes cytology, Mesenchymal Stem Cells metabolism, Nestin metabolism, Purpura, Thrombocytopenic, Idiopathic pathology
Abstract

Impaired megakaryocyte (MK) maturation and reduced platelet production are important causes of immune thrombocytopenia (ITP). However, MK distribution and bone marrow (BM) niche alteration in ITP are unclear. To investigate the maturation and distribution of MKs in the BM niche and examine the components of BM niche regulation of MK migration, BM and peripheral blood were obtained from 30 ITP patients and 28 healthy donors. Nestin + mesenchymal stem cells (MSCs) and CD41 + MKs were sorted by fluorescence-activated cell sorting. The components of the BM niche and related signaling were analyzed via immunofluorescence, flow cytometry, enzyme-linked immunosorbent assay, reverse transcription polymerase chain reaction, and western blot analysis. The number of MKs in the BM vascular niche was reduced in ITP. Moreover, the concentrations of CXCL12 and CXCR4 + MKs in the BM were decreased in ITP. Further investigation demonstrated that nestin + MSCs and CXCL12 messenger RNA (mRNA) in nestin + MSCs were both reduced whereas the apoptosis of nestin + MSCs was significantly increased in ITP. Sympathetic nerves, Schwann cells, the proportion of β3-adrenoreceptor (β3-AR) + nestin + MSCs, and β3-AR mRNA in nestin + MSCs were all markedly reduced in ITP. Moreover, matrix metalloproteinase 9, vascular endothelial growth factor (VEGF), and VEGF receptor 1 were significantly reduced in ITP. Our data show that impaired MK distribution mediated by an abnormal CXCL12/CXCR4 axis is partially involved in reduced platelet production in ITP. Moreover, sympathetic neuropathy and nestin + MSC apoptosis may have an effect on the alterations of BM CXCL12 in ITP., (© 2019 by The American Society of Hematology.)

Published
2019
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35. [Pathogenesis and Prevention of Transfusion-Associated Graft-versus-Host Disease].

Author

Feng FE, Wang QM, Zhu XL, Wang CC, and Zhang XH

Subjects
Bone Marrow, Gastrointestinal Tract, Humans, Liver, T-Lymphocytes, Tissue Donors, Blood Transfusion, Graft vs Host Disease
Abstract

Transfusion-associated graft-versus-host disease (TA-GVHD) is a rare complication of blood transfusion. The disease is fulminant and fatal in most patients. TA-GVHD is caused by transfused alloreactive donor T lymphocytes that attack host tissue, including skin, liver, gastrointestinal tract and bone marrow. Most patients are immunocompromised, but immunocompetent patients can also be involved. Irradiation of blood components is generally recommended to prevent the onset of TA-GVHD for susceptible recipients. This review focus on pathogenesis and prevention of TA-GVHD.

Published
2015
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36. [Construction of Lentivirus Vector Carrying HGF and Exploration of Transfection Condition of Rat Adipocyte-derived Mesenchymal Stem Cells].

Author

Zhang JM, Feng FE, Wang QM, Zhu XL, Wang CC, Pei BY, and Zhang XH

Subjects
Adipocytes, Animals, Cell Line, Gene Expression, Genetic Vectors, Hepatocyte Growth Factor, Humans, Lentivirus, Plasmids, Rats, Transfection, Mesenchymal Stem Cells
Abstract

Objective: This study was to construct the lentivirus vector carrying hepatocyte growth factor (HGF) gene and to explore the condition for transfecting the adipocyte-derived mesenchymal stem cells (ADSC) by HGF lentivirus., Methods: The target gene was obtained from plasmid carrying HGF gene by PCR and was cloned into GV287 vector. The recombinant GV287-HGF vector plasmid and lentivirus-packing plasmid were co-transfected into 293 T cells to generate HGF lentivirus, and the virus titer was assayed, then the ADSC were transfected by using recombinant HGF lentivirus, and the optimal multplicity of infection (MOI) was detected., Results: The PCR product of HGF gene was consistent with expectant sizes, suggesting that the electrophoretic result of recombinant GV287-HGF plasmid PCR product was correct. The sequencing analysis of cleaved product showed consistance of obtained results with the sequences of target gene, suggesting correct construction of recombinant lentivirus carrying HGF gene. The ELISA showed that the virus tilter was 5×10(8) TU/ml. The optimal MOI for transfecting ADSC with recombinant lentivirus carrying HGF gene was 50., Conclusion: The lentivirus vector expressing human HGF gene has been constructed, and transfected the ADSC succesfully. This study lays a foundation for further stadying the ADSC over-expressioning HGF, treating the radiation damage of bone marrow and impartant internal organs.

Published
2015
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