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15. Study on Site Quality Assessment of Afforestation Land Based on GA-RBF Neural Network

Author

Chen Yuling, Wang Chengde, Wu Baoguo and Liu Jiancheng

Subjects
Environmental effects of industries and plants, TD194-195, Science (General), Q1-390
Abstract

The assessment of forest site quality at early stages of stand development is very essential for scientific afforestation and forest management. In order to enhance the accuracy of the existing models, a new site quality assessment model based on Genetic Algorithm-Radial Basis Function (GA-RBF) was proposed to predict site index (stand dominant height). Data used in this study came from 980 permanent sample plots for Chinese fir (Cunninghamia lanceolata) plantations in Fujian Province, China, which were randomly divided into the training dataset (786 plots) and the testing dataset (194 plots) with a ratio of 8:2. In this paper, the GA-RBF was compared with the radial basis function (RBF) and the traditional Quantitative Theory I (QT-I) method. The results indicated that the predicted accuracy was significantly increased by using the GA-RBF model. Furthermore, we used the existing site-specific site index table of Chinese fir to test the results of the GA-RBF and the agreement was 73.2%. Therefore, we recommend the GA-RBF for assessing site quality of afforestation land.

Published
2019

37. β-Catenin induces transcriptional expression of PD-L1 to promote glioblastoma immune evasion

Author

Du, Linyong, primary, Lee, Jong-Ho, additional, Jiang, Hongfei, additional, Wang, Chengde, additional, Wang, Silu, additional, Zheng, Zhihong, additional, Shao, Fei, additional, Xu, Daqian, additional, Xia, Yan, additional, Li, Jing, additional, Zheng, Yanhua, additional, Qian, Xu, additional, Li, Xinjian, additional, Kim, Hyung-Ryong, additional, Xing, Dongming, additional, Liu, Pengyuan, additional, Lu, Zhimin, additional, and Lyu, Jianxin, additional

Published
2020
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42. Temozolomide promotes immune escape of GBM cells via upregulating PD-L1

Author

Wang, Silu, Yao, Fuli, Lu, Xianghe, Li, Qun, Su, Zhipeng, Lee, Jong-Ho, Wang, Chengde, and Du, Linyong

Subjects
Original Article
Abstract

Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor with poor prognosis, and currently effective therapeutic strategies are still limited. Although temozolomide (TMZ) is commonly used for GBM therapy and its mechanism was well characterized, while its side effects were required comprehensive investigation. In the present study, we revealed that TMZ-challenged GBM cells strongly suppressed pro-inflammatory cytokines expression in activated periphery blood mononuclear cells (PBMC), which depended on enhanced transcription of CD274 (encoding PD-L1), but not other immune checkpoints, such as CD276, HVEM and galectin-9. Moreover, abundance of membranous PD-L1 was also increased in TMZ-treated GBM cells. When PD-L1 expression was knocked down by short hairpin RNA (shRNA), inhibitory effect of TMZ-treated GBM cells on PBMC became weakened, suggesting that PD-L1 was crucial for immune inhibition capacity of TMZ-treated GBM cells. Additionally, actinomycin D reduced PD-L1 expression in GBM cells after TMZ challenge, indicating that PD-L1 induction occurred at transcriptional level. The immunoblotting results demonstrated that STAT3 signaling was involved in TMZ-mediated PD-L1 induction, and attenuated expression of PD-L1 was observed using STAT3 inhibitor VI or STAT3 shRNA. Finally, the animal study showed that combination of TMZ and PD-1 antibody therapy strongly inhibited tumor growth and achieved the improved survival rate of GBM mice. Accordingly, this study revealed the classical chemotherapy drug TMZ promoted GBM cells immune escape, even TMZ combine with PD-1 antibody treatment not further improve survival ratio of recurrent GBM patients compared with traditional therapy methods, while our animal study provided evidence that combination of TMZ and PD-1 antibody was a promising way to treat GBM, these contradictory results indicate improving the PD-1 antibody delivery efficiency can exert strong combinational therapy outcomes.

Published
2019

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