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1. Topical Versus Intravenous Tranexamic Acid in Patients Undergoing Cardiac Surgery: The DEPOSITION Randomized Controlled Trial

Author

Lamy, André, Sirota, Dmitry A., Jacques, Frederic, Poostizadeh, Ahmad, Noiseux, Nicolas, Efremov, Sergey, Demers, Philippe, Akselrod, Boris, Wang, Chew Yin, Arora, Rakesh C., Branny, Piotr, McGuinness, Shay P., Brown, Craig D., Jeanmart, Hugues, Zhao, Qiang, Zhang, Haibo, Belley-Côté, Emilie P., Whitlock, Richard P., Browne, Austin, Copland, Ingrid, Vincent, Jessica, Khatun, Rutaba, Balasubramanian, Kumar, Bangdiwala, Shrikant I., McGillion, Michael H., Fox-Robichaud, Alison E., Spence, Jessica, Yusuf, Salim, and Devereaux, P.J.

Published
2024
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2. The relative merits of using a high-sensitivity cardiac Troponin T assay compared to a nonhigh-sensitivity troponin T assay after noncardiac surgery

Author

Borges, Flavia K., Sessler, Daniel I., Tiboni, Maria, Patel, Ameen, LeManach, Yannick, Heels-Ansdell, Diane, Srinathan, Sadeesh, Wang, Chew Yin, Chow, Clara, Duceppe, Emmanuelle, Kavsak, Peter, Ofori, Sandra N., Pettit, Shirley, Berwanger, Otavio, Kurz, Andrea, Turan, Alparslan, Tonelli, Ana Claudia, and Devereaux, PJ

Published
2024
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3. A sub-study of the POISE-3 randomized trial examined effects of a perioperative hypotension-avoidance strategy versus a hypertension-avoidance strategy on the risk of acute kidney injury

Author

Garg, Amit X., Marcucci, Maura, Cuerden, Meaghan S., Sontrop, Jessica M., Painter, Thomas W., Lomivorotov, Vladimir, Sessler, Daniel I., Chan, Matthew T.V., Borges, Flavia K., Leslie, Kate, Duceppe, Emmanuelle, Parikh, Chirag R., Roshanov, Pavel, Martínez-Zapata, María José, Wang, Chew Yin, Xavier, Denis, Efremov, Sergey, Landoni, Giovanni, Kleinlugtenbelt, Ydo V., Szczeklik, Wojciech, Schmartz, Denis, Meyhoff, Christian S., Short, Timothy G., Amir, Mohammed, Torres, David, Wittmann, Maria, Patel, Ameen, Ruetzler, Kurt, Parlow, Joel L., Jayaram, Raja, Polanczyk, Carisi A., Fleischmann, Edith, Tandon, Vikas, Astrakov, Sergey V., Conen, David, Kei Wu, William Ka, Cheong, Chao Chia, Ayad, Sabry, Kirov, Mikhail, de Nadal, Miriam, Likhvantsev, Valery V., Paniagua, Pilar, Aguado, Hector J., Ofori, Sandra N., Vincent, Jessica, Copland, Ingrid, Balasubramanian, Kumar, Biccard, Bruce M., Srinathan, Sadeesh, Ismoilov, Samandar, Wang, Michael Ke, Kurz, Andrea, Belley-Cote, Emilie P., Bhatt, Keyur, Eikelboom, John, Gross, Peter, Lamy, Andre, McGillion, Michael, McIntyre, William, Richards, Toby, Spence, Jessica, Van Helder, Thomas, Whitlock, Richard, and Devereaux, P.J.

Published
2024
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4. Effect of colchicine on perioperative atrial fibrillation and myocardial injury after non-cardiac surgery in patients undergoing major thoracic surgery (COP-AF): an international randomised trial

Author

Conen, David, Devereaux, PJ, Vincent, Jessica, Wang, Michael Ke, Wells, Jennifer R., Healey, Jeff S., Landoni, Giovanni, McIntyre, William F., Popova, Ekaterine, Sessler, Daniel I., Srinathan, Sadeesh K., Amir, Mohammed, Bangdiwala, Shrikant I., Bossard, Matthias, Chan, Matthew TV, Eikelboom, John W., Fleischmann, Edith, Jolly, Sanjit, Montes, Felix Ramón, Reimer, Cara, Schmartz, Denis, Wang, Chew Yin, Ofori, Sandra N., Blum, Steffen, Alvarez-Garcia, Jesus, Lo Bianco, Giuliana, Traquair, Hugh, Guerrero-Pinedo, Fernando Andres, Oleynick, Christopher, Meyre, Pascal B., Méndez-Zurita, Francisco, Chiarella-Redfern, Helene, Marcucci, Maura, Donati, Francesco, Gonzalez-Osuna, Aranzazu, Minervini, Fabrizio, Moreno Weidmann, Zoraida, Guerra-Ramos, Jose M., Dion, Gabriel, Ramos-Pachón, Anna, Borges, Flavia K., de Sa Boasquevisque, Danielle, Mosconi, Maria Giulia, Amarenco, Pierre, Mitchell, L. Brent, Wyse, George, Cheng, Davy, McAlister, Finlay A., Wells, George A., Baskaran, Geethan, Burns, Andrew T., Gennaccaro, Julia, Howe, Rosemary, Mastrangelo, Louise, Pettit, Shirley, Popovic, Michelle, Shahbaz, Subana, Tosh, Makayla, Zucchetto, Simona J., Heenan, Laura, Lee, Shun Fu, Li, Zhuoru, Xu, Lizhen, Kabon, Barbara, Hoetzenecker, Konrad, Schweiger, Thomas, Reiterer, Christian, Zotti, Oliver, Bsuchner, Paul, Hochreiter, Beatrix, Taschner, Alexander, Adamowitsch, Nikolas, Horvath, Katharina, Hantáková, Nicole, Bidgoli, Javad, Huybrechts, Isabelle, Cappeliez, Serge, Neary, John D., Shargall, Yaron, Tandon, Vikas, Finley, Christian, Agzarian, John, Hanna, Waël, Abdulrahman, Muammar, Lawrence, Kelly, Gregus, Krysten, Quraishi, Faraaz, Wikkerink, Spencer, Wallace, Christine, Prine, Merissa, Gregus, Emily, Hare, Jacqueline, Lombardo, Kristen, Fezia, Behashta, Columbus, Teresa, Rushton, Jacob, DuMerton, Deborah, Reid, Ken, Parlow, Joel, Chung, Wiley, Karizhenskaia, Maria, Malik, Aftab, Tanzola, Rob, Giles, Andrew, McLean, Sean R., McGuire, Anna, Lohser, Jens, Lim, Shirley, Grey, Rebecca, Yee, John, Grant, Kyle, Lee, Alex L., Choi, James J., Dewar, Leith R., Durkin, Christopher, Schisler, Travis, Hecht, Patrick, Hughes, Bevan, Kidane, Biniam, Liu, Richard, Tan, Lawrence, Gowing, Stephen, Buduhan, Gordon, Enns, Stephanie, Poole, Emma, Graham, Kristin, Dubik, Niina, Chin, Alex, Maziak, Donna E., Seely, Andrew JE, Gilbert, Sebastien, Villeneuve, P. James, Sundaresan, Sudhir, Gingrich, Molly, Fazekas, Anna, Bucciero, Kirby, Malthaner, Richard A., Lewis, Deb, Fortin, Dalilah, Qiabi, Mehdi, Nayak, Rahul, Plourde, Madelaine Marie, Haider, Tehmina, Murphy, Rowan, Sellers, Daniel, Donahoe, Laura, Lefebvre, Marco, Lanthier, Luc, Ko, Michael Augustine, Parente, David, Cheung, Victoria, Schieman, Colin, Bessissow, Amal, Wong, Randolph HL, Joynt, Gavin M., Lam, Carmen KM, Lau, Rainbow WH, Wan, Innes YP, Underwood, Malcolm J., Wu, William KK, Wong, Wai Tat, Choi, Gordon YS, Lee, Eva, Hui, Ka Yan, Fung, Beaker, Chan, Chee Sam, Ng, Fung Kei, Thung, Kin Hoi, Gutiérrez-Soriano, Laura, Castañeda, Laura Carmenza, Téllez, Luis Jaime, Ortiz-Ramirez, Lina Marcela, Baiardo-Redaelli, Martina, Belletti, Alessandro, Dieci, Elisa, Monaco, Fabrizio, Muriana, Piergiorgio, Nakhnoukh, Cristina, Novellis, Pierluigi, Turi, Stefano, Viscardi, Stefano, Veronesi, Giulia, Voltolini, Luca, Bongiolatti, Stefano, Salvicchi, Alberto, Gatteschi, Lavinia, Indino, Rossella, Tombelli, Simone, Ravasin, Alice, Salimbene, Ottavia, Rosboch, Giulio Luca, Balzani, Eleonora, Ceraolo, Edoardo, Neitzert, Luca, Brazzi, Luca, Londero, Francesco, Grossi, William, Massullo, Domenico, Fiorelli, Silvia, Margaritora, Stefano, Hashim, Shahrul Amry, Krishnasamy, Sivakumar, See, Woan Shiang, Nawaz, Mohammed Asghar, Bilal, Haris, Trujillo Reyes, Juan Carlos, Martínez-Téllez, Elisabeth, Belda Sanchis, Josep, Planas Canovas, Georgina, Libreros Niño, Alejandra, Parera Ruiz, Ana, Cladellas Gutierrez, Esther, Guarino, Mauro, Urrutia Cuchi, Gerard, Argilaga Nogues, Marta, Rovira Juan, Anna, Medina-Aedo, Melixa, Turró Castillejo, Mª Asunción, Gil Sanchez, Josep Mª, Araúz-Sarmiento, Ibell, Herranz Perez, Gracia, Chavarria Murillo, Stephania, Garcia-Osuna, Alvaro, Rodriguez-Arias, Ainhoa, Berga Garrote, Nuria, Martín Grande, Ascension, Parise Roux, Diego, Gajate Martín, Luis, De Pablo Pajares, Angélica, Candela Toha, Angel Manuel, Moreno Mata, Nicolás, Muñoz Molina, Gema, Caballero Silva, Usue, Cabañero, Alberto, Fra Fernandez, Sara, Cavestany García-Matres, Cristina, Simón, Luisa, Montenegro, Cristina, Pozo, Sergio, Gonzàlez-Tallada, Anna, González Suarez, Susana, Ribas Ball, Montserrat, De Nadal Clanchet, Miriam, Pérez Vélez, Javier, Cruz, Patrícia, Sánchez-Pedrosa, Guillermo, Duque, Patricia, González, Guillermo, Huerta, Luis, Rodríguez, Laura, Garutti, Ignacio, Ruiz-Villa, Laura, Martí-Ejarque, Maria del Mar, Gili-Bueno, Mireia, Maddio Vieyra, Ricardo Matias, Fibla, Juan J., Durán, Núria, de Temple Pla, Marina, Rodríguez-Fuster, Alberto, Bermejo-Martínez, Silvia, Carramiñana, Albert, Opitz, Isabelle, Etienne, Harry, Cata, Juan P., Guerra-Londono, Juan Jose, Rajaram, Ravi, Corrales, German, Vaporciyan, Ara, Mehran, Reza, Sepesi, Boris, Walsh, Garrett, Rice, David, Cukierman, Daniel S., Swisher, Stephen, Marchant, Bryan E., Harris, Lynne C., Cusson, Bruce D., Miller, Scott A., Ayad, Sabry, Araujo, Jorge, Marquez-Roa, Leonardo, Hofstra, Richard L., Wudel, Jr., Leonard J., Minear, Steven C., Teixeira, Camila, Pimentel, Mario, Popoff, Andrew M., Marsack, Kelly, Meehan, Sarah, Chen, Tzonghuei H., Essandoh, Michael, Poppers, Jeremy S., Ke Wang, Michael, Chan, Matthew T V, Cata, Juan P, McLean, Sean R, Srinathan, Sadeesh K, Reyes, Juan Carlos Trujillo, Grande, Ascension Martín, Tallada, Anna Gonzalez, Sessler, Daniel I, Maziak, Donna E, McIntyre, William F, Wong, Randolph H L, McGuire, Anna L, Roux, Diego Parise, Wells, Jennifer R, Ofori, Sandra N, Eikelboom, John W, Jolly, Sanjit S, Healey, Jeff S, and Devereaux, P J

Published
2023
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5. Rationale and design of the colchicine for the prevention of perioperative atrial fibrillation in patients undergoing major noncardiac thoracic surgery (COP-AF) trial

Author

Devereaux, Vincent, Jessica, Wang, Michael Ke, Wells, Jennifer R., Conen, David, Devereaux, PJ, Healey, Jeff S., Landoni, Giovanni, McIntyre, William F., Popova, Ekaterine, Sessler, Daniel I., Srinathan, Sadeesh K., Amir, Mohammed, Bangdiwala, Shrikant I., Bossard, Matthias, Chan, Matthew T.V., Eikelboom, John W., Fleischmann, Edith, Jolly, Sanjit S., Montes, Felix Ramón, Reimer, Cara, Schmartz, Denis, Wang, Chew Yin, Alvarez-Garcia, Jesus, Bianco, Giuliana Lo, Blum, Steffen, Boasquevisque, Danielle de Sa, Borges, Flavia K., Chiarella-Redfern, Helene, Gonzalez-Osuna, Aranzazu, Guerra-Ramos, Jose M., Marcucci, Maura, Meyre, Pascal B., Ofori, Sandra N., Oleynick, Christopher, Ramos-Pachón, Anna, Traquair, Hugh, Mitchell, L. Brent, Wyse, George, Cheng, Davy, McAlister, Finlay A., Wells, George A., Baskaran, Geethan, Gennaccaro, Julia, Howe, Rosemary, Mastrangelo, Louise, Pettit, Shirley, Shahbaz, Subana, Tosh, Makayla, Zucchetto, Simona J., Heenan, Laura, Lee, Shun Fu, Li, Zhuoru, Xu, Lizhen, Kabon, Barbara, Reiterer, Christian, Taschner, Alexander, Horvath, Katharina, Adamowitsch, Nikolas, Zotti, Oliver, Hantáková, Nicole, Hochreiter, Beatrix, Huybrechts, Isabelle, Cappeliez, Serge, Neary, John D., Shargall, Yaron, Tandon, Vikas, Finley, Christian, Agzarian, John, Hanna, Waël, Abdulrahman, Muammar, Lawrence, Kelly, Gregus, Krysten, Quraishi, Faraaz, Wikkerink, Spencer, Wallace, Christine, Prine, Merissa, Gregus, Emily, Hare, Jacqueline, Lombardo, Kristen, Fezia, Behashta, Columbus, Teresa, DuMerton, Deborah, Reid, Ken, Parlow, Joel, Chung, Wiley, Karizhenskaia, Maria, Malik, Aftab, Kidane, Biniam, Liu, Richard, Tan, Lawrence, Gowing, Stephen, Buduhan, Gordon, Enns, Stephanie, Poole, Emma, Graham, Kristin, McLean, Sean R., McGuire, Anna, Lohser, Jens, Lim, Shirley, Grey, Rebecca, Grant, Kyle, Lee, Alex L., Choi, James J., Dewar, Leith R., Yee, John, Maziak, Donna E., Seely, Andrew J.E., Gilbert, Sebastien, Villeneuve, P. James, Sundaresan, Sudhir, Moffatt-Bruce, Susan D., Gingrich, Molly, Fazekas, Anna, Bucciero, Kirby, Malthaner, Richard A., Lewis, Deb, Fortin, Dalilah, Qiabi, Mehdi, Nayak, Rahul, Plourde, Madelaine Marie, Sellers, Daniel, Donahoe, Laura, Lefebvre, Marco, Lanthier, Luc, Schieman, Colin, Bessissow, Amal, Joynt, Gavin M., Wong, Randolph H.L., Lau, Rainbow W.H., Wong, Wai Tat, Choi, Gordon Y.S., Lee, Eva, Hui, Ka Yan, Fung, Beaker, Chan, Chee Sam, Gutiérrez-Soriano, Laura, Castañeda, Laura Carmenza, Téllez, Luis Jaime, Ortiz-Ramirez, Lina Marcela, De Santis, Simona, Favaro, Giovanni, Muriana, Piergiorgio, Nakhnoukh, Cristina, Novellis, Pierluigi, Turi, Stefano, Veronesi, Giulia, Angelini, Matteo, Voltolini, Luca, Bongiolatti, Stefano, Salvicchi, Alberto, Gatteschi, Lavinia, Indino, Rossella, Tombelli, Simone, Ravasin, Alice, Salimbene, Ottavia, Rosboch, Giulio Luca, Balzani, Eleonora, Massullo, Domenico, Fiorelli, Silvia, Londero, Francesco, Grossi, William, Ng, Tyng Yan, See, Woan Shiang, Nawaz, Mohammed Asghar, Reyes, Juan Carlos Trujillo, Tellez, Elisabeth Martinez, Sanchis, Josep Belda, Cánovas, Georgina Planas, Ruiz, Ana Parera, Gutierrez, Esther Cladellas, Guarino, Mauro, Cuchi, Gerard Urrutia, Nogues, Marta Argilaga, Juan, Anna Rovira, Medina-Aedo, Melixa, Grande, Ascensión Martín, Roux, Diego Parise, Martín, Luis Gajate, Pajares, Angélica De Pablo, Toha, Angel Manuel Candela, Mata, Nicolás Moreno, Molina, Gema Muñoz, Silva, Usue Caballero, Cabañero, Alberto, Fernandez, Sara Fra, Tallada, Anna Gonzàlez, Suarez, Susana González, Ball, Montserrat Ribas, Clanchet, Miriam De Nadal, Ruiz-Villa, Laura, Martí-Ejarque, M.M., Gili-Bueno, Mireia, Ferrández, Jorge Hernández, Llobet, Neus Pons, Cruz, Patricia, Sánchez-Pedrosa, Guillermo, Duque, Patricia, Azcárate, Leire, Martín-Albo, Lorena, Rodríguez-Fuster, Alberto, Bermejo-Martínez, Silvia, Carramiñana, Albert, Minervini, Fabrizio, Cata, Juan P., Rajaram, Ravi, Corrales, German, Guerra-Londono, Juan Jose, Mehran, Reza, Sepesi, Boris, Walsh, Garrett, Cukierman, Daniel S., Marchant, Bryan E., Harris, Lynne C., Cusson, Bruce D., Miller, Scott A., Minear, Steven C., Teixeira, Camila, Pimentel, Mario, Popoff, Andrew M., Cheung, Wing Lee, Marsack, Kelly, Ayad, Sabry, Araujo, Jorge, Chen, Tzonghuei H., Essandoh, Michael, Poppers, Jeremy S., Trujillo Reyes, Juan Carlos, Gonzalez Tallada, Anna, and Garg, Amit X.

Published
2023
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6. The relative merits of using a high-sensitivity cardiac Troponin T assay compared to a non-high-sensitivity Troponin T assay after noncardiac surgery

Author

Borges, Flavia K., primary, Sessler, Daniel I., additional, Tiboni, Maria, additional, Patel, Ameen, additional, LeManach, Yannick, additional, Heels-Ansdell, Diane, additional, Srinathan, Sadeesh, additional, Wang, Chew Yin, additional, Chow, Clara, additional, Duceppe, Emmanuelle, additional, Kavsak, Peter, additional, Ofori, Sandra N., additional, Pettit, Shirley, additional, Berwanger, Otavio, additional, Kurz, Andrea, additional, Turan, Alparslan, additional, Tonelli, Ana Claudia, additional, and Devereaux, PJ, additional

Published
2024
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8. Effect of Volatile Anesthetics on Myocardial Infarction After Coronary Artery Surgery: A Post Hoc Analysis of a Randomized Trial

Author

Zangrillo, Alberto, Lomivorotov, Vladimir V., Pasyuga, Vadim V., Belletti, Alessandro, Gazivoda, Gordana, Monaco, Fabrizio, Nigro Neto, Caetano, Likhvantsev, Valery V., Bradic, Nikola, Lozovskiy, Andrey, Lei, Chong, Bukamal, Nazar A.R., Silva, Fernanda Santos, Bautin, Andrey E., Ma, Jun, Yong, Chow Yen, Carollo, Cristiana, Kunstyr, Jan, Wang, Chew Yin, Grigoryev, Evgeny V., Riha, Hynek, Wang, Chengbin, El-Tahan, Mohamed R., Scandroglio, Anna Mara, Mansor, Marzida, Lembo, Rosalba, Ponomarev, Dmitry N., Bezerra, Francisco José Lucena, Ruggeri, Laura, Chernyavskiy, Alexander M., Xu, Junmei, Tarasov, Dmitry G., Navalesi, Paolo, Yavorovskiy, Andrey, Bove, Tiziana, Kuzovlev, Artem, Hajjar, Ludhmila A., and Landoni, Giovanni

Published
2022
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13. Mortality and major postoperative complications within one year after vascular surgery: a prospective cohort study

Author

Polok, Kamil, primary, Biccard, Bruce M., additional, Chan, Matthew T.V., additional, Archbold, R. Andrew, additional, Wang, Chew Yin, additional, Sigamani, Alben, additional, Urrútia, Gerard, additional, Cruz, Patricia, additional, Srinathan, Sadeesh K., additional, Szalay, David, additional, Harlock, John, additional, Tittley, Jacques G., additional, Elias, Fadi, additional, Jacka, Michael J., additional, Malaga, German, additional, Berwanger, Otavio, additional, Studzińska, Dorota, additional, Górka, Jacek, additional, Montes, Félix R., additional, Chow, Clara K., additional, Ackland, Gareth L., additional, Dubois, Luc, additional, Sapsford, Robert J., additional, Williams, Colin, additional, Cortés, Olga L., additional, Devereaux, P.J., additional, and Szczeklik, Wojciech, additional

Published
2024
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15. A Systematic Review and International Web-Based Survey of Randomized Controlled Trials in the Perioperative and Critical Care Setting: Interventions Increasing Mortality

Author

Sartini, Chiara, Lomivorotov, Vladimir, Pisano, Antonio, Riha, Hynek, Baiardo Redaelli, Martina, Lopez-Delgado, Juan Carlos, Pieri, Marina, Hajjar, Ludhmila, Fominskiy, Evgeny, Likhvantsev, Valery, Cabrini, Luca, Bradic, Nikola, Avancini, Daniele, Wang, Chew Yin, Lembo, Rosalba, Novikov, Maxim, Paternoster, Gianluca, Gazivoda, Gordana, Alvaro, Gabriele, Roasio, Agostino, Wang, Chengbin, Severi, Luca, Pasin, Laura, Mura, Paolo, Musu, Mario, Silvetti, Simona, Votta, Carmine Domenico, Belletti, Alessandro, Corradi, Francesco, Brusasco, Claudia, Tamà, Simona, Ruggeri, Laura, Yong, Chow-Yen, Pasero, Daniela, Mancino, Giuseppe, Spadaro, Savino, Conte, Massimiliano, Lobreglio, Rosetta, Di Fraja, Diana, Saporito, Emanuela, D'Amico, Alessandro, Sardo, Salvatore, Ortalda, Alessandro, Yavorovskiy, Andrey, Riefolo, Claudio, Monaco, Fabrizio, Bellomo, Rinaldo, Zangrillo, Alberto, and Landoni, Giovanni

Published
2019
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16. A Systematic Review and International Web-Based Survey of Randomized Controlled Trials in the Perioperative and Critical Care Setting: Interventions Reducing Mortality

Author

Sartini, Chiara, Lomivorotov, Vladimir, Pieri, Marina, Lopez-Delgado, Juan Carlos, Baiardo Redaelli, Martina, Hajjar, Ludhmila, Pisano, Antonio, Likhvantsev, Valery, Fominskiy, Evgeny, Bradic, Nikola, Cabrini, Luca, Novikov, Maxim, Avancini, Daniele, Riha, Hynek, Lembo, Rosalba, Gazivoda, Gordana, Paternoster, Gianluca, Wang, Chengbin, Tamà, Simona, Alvaro, Gabriele, Wang, Chew Yin, Roasio, Agostino, Ruggeri, Laura, Yong, Chow-Yen, Pasero, Daniela, Severi, Luca, Pasin, Laura, Mancino, Giuseppe, Mura, Paolo, Musu, Mario, Spadaro, Savino, Conte, Massimiliano, Lobreglio, Rosetta, Silvetti, Simona, Votta, Carmine Domenico, Belletti, Alessandro, Di Fraja, Diana, Corradi, Francesco, Brusasco, Claudia, Saporito, Emanuela, D'Amico, Alessandro, Sardo, Salvatore, Ortalda, Alessandro, Riefolo, Claudio, Fabrizio, Monaco, Zangrillo, Alberto, Bellomo, Rinaldo, and Landoni, Giovanni

Published
2019
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18. Troponin T monitoring to detect myocardial injury after noncardiac surgery: a cost--consequence analysis

Author

Buse, Giovanna Lurati, Manns, Braden, Lamy, Andre, Guyatt, Gordon, Polanczyk, Carisi A., Chan, Matthew T.V., Wang, Chew Yin, Villar, Juan Carlos, Sigamani, Alben, Sessler, Daniel I., Berwanger, Otavio, Biccard, Bruce M., Pearse, Rupert, Urrútia, Gerard, Szczeklik, R. Wojciech, Garutti, Ignacio, Srinathan, Sadeesh, Malaga, German, Abraham, Valsa, Chow, Clara K., Jacka, Michael J., Tiboni, Maria, Ackland, Gareth, Macneil, Danielle, Sapsford, Robert, Leuwer, Martin, Manach, Yannick Le, and Devereaux, Philip J.

Subjects
Myocardial diseases -- Risk factors -- Diagnosis, Physiologic monitoring -- Methods -- Economic aspects, Troponin -- Health aspects -- Physiological aspects, Postoperative complications -- Diagnosis, Postoperative care -- Methods -- Economic aspects, Health, Health care industry
Abstract

Background: Myocardial injury after noncardiac surgery (MINS) is a mostly asymptomatic condition that is strongly associated with 30-day mortality; however, it remains mostly undetected without systematic troponin T monitoring. We evaluated the cost and consequences of postoperative troponin T monitoring to detect MINS. Methods: We conducted a model-based cost--consequence analysis to compare the impact of routine troponin T monitoring versus standard care (troponin T measurement triggered by ischemic symptoms) on the incidence of MINS detection. Model inputs were based on Canadian patients enrolled in the Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION) study, which enrolled patients aged 45 years or older undergoing inpatient noncardiac surgery. We conducted probability analyses with 10 000 iterations and extensive sensitivity analyses. Results: The data were based on 6021 patients (48% men, mean age 65 [standard deviation 12] yr). The 30-day mortality rate for MINS was 9.6%. We determined the incremental cost to avoid missing a MINS event as $1632 (2015 Canadian dollars). The cost-effectiveness of troponin monitoring was higher in patient subgroups at higher risk for MINS, e.g., those aged 65 years or more, or with a history of atherosclerosis or diabetes ($1309). Conclusion: The costs associated with a troponin T monitoring program to detect MINS were moderate. Based on the estimated incremental cost per health gain, implementation of postoperative troponin T monitoring seems appealing, particularly in patients at high risk for MINS. Contexte: Les lésions myocardiques après chirurgie non cardiaque (CNC) sont majoritairement asymptomatiques et fortement associées au risque de mortalité dans les 30 jours; toutefois, dans la plupart des cas, elles ne sont pas détectées en l'absence d'une surveillance systématique de la troponine T. Nous avons évalué les coûts et les conséquences d'une telle surveillance pour détecter les lésions myocardiques après CNC. Méthodes: Nous avons mené une analyse coût--conséquence modélisée pour comparer la surveillance systématique de la troponine T aux soins habituels seuls (mesure de la troponine T seulement s'il y a présence de symptômes d'ischémie) sur la fréquence de détection de lésions myocardiques après CNC. Les données ayant servi à l'analyse provenaient des patients canadiens ayant participé à l'étude de cohorte VISION, qui visait à évaluer les complications vasculaires chez les patients de 45 ans et plus ayant subi une CNC. Nous avons mené des analyses de probabilité avec 10 000 itérations et des analyses de sensibilité approfondies. Résultats: Les données portaient sur 6021 patients (48% du sexe masculin; âge moyen de 65 ans [écart-type de 12 ans]). Le taux de mortalité dans les 30 jours associé à une lésion myocardique après CNC était de 9,6%. Nous avons déterminé que le coût marginal de la détection de la présence d'une lésion par surveillance de la troponine T était de 1632 $ (dollars canadiens en 2015). Le rapport coût--efficacité était plus bas pour les sous-groupes de patients à risque élevé de lésion myocardique après CNC, comme les patients de 65 ans et plus ou ceux ayant des antécédents d'athérosclérose ou de diabète (1309 $), que pour leurs pairs. Conclusion: Les coûts associés à un programme de surveillance de la troponine T pour détecter les lésions myocardiques après CNC étaient modérés. Le coût marginal estimé par gain de santé indique que la mise en oeuvre de ce type de programme pourrait être une option intéressante, surtout pour les patients à risque élevé de lésion myocardique après CNC., About 500 000 noncardiac surgical procedures take place in Canada annually. (1) In the Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION) study, myocardial injury after noncardiac surgery (MINS) [...]

Published
2018
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19. Hypotension-Avoidance Versus Hypertension-Avoidance Strategies in Noncardiac Surgery :An International Randomized Controlled Trial.

Author

Marcucci, Maura, Painter, Thomas TW, Conen, David, Lomivorotov, Vladimir, Sessler, Daniel I, Chan, Matthew T V, Borges, Flavia K, Leslie, Kate, Duceppe, Emmanuelle, Martínez-Zapata, María José, Wang, Chew Yin, Xavier, Denis, Ofori, Sandra N, Wang, Michael Ke, Efremov, Sergey, Landoni, Giovanni, Kleinlugtenbelt, Ydo YV, Szczeklik, Wojciech, Schmartz, Denis, Garg, Amit X, Short, Timothy TG, Wittmann, Maria, Meyhoff, Christian Sylvest, Amir, Mohammed, Torres, David, Patel, Ameen, Ruetzler, Kurt, Parlow, Joel JL, Tandon, Vikas, Fleischmann, Edith, Polanczyk, Carísi Anne, Lamy, Andre, Jayaram, Raja, Astrakov, Sergey SV, Wu, William Ka Kei, Cheong, Chao Chia, Ayad, Sabry, Kirov, Mikhail M.Y., de Nadal, Miriam, Likhvantsev, Valery VV, Paniagua, Pilar, Aguado, Hector HJ, Maheshwari, Kamal, Whitlock, Richard RP, McGillion, Michael MH, Vincent, Jessica, Copland, Ingrid, Balasubramanian, Kumar, Biccard, Bruce BM, Srinathan, Sadeesh, Ismoilov, Samandar, Pettit, Shirley, Stillo, David, Kurz, Andrea, Belley-Côté, Emilie EP, Spence, Jessica, McIntyre, William WF, Bangdiwala, Shrikant SI, Guyatt, Gordon, Yusuf, Salim, Devereaux, P J, POISE-3 Trial Investigators and Study Groups, Marcucci, Maura, Painter, Thomas TW, Conen, David, Lomivorotov, Vladimir, Sessler, Daniel I, Chan, Matthew T V, Borges, Flavia K, Leslie, Kate, Duceppe, Emmanuelle, Martínez-Zapata, María José, Wang, Chew Yin, Xavier, Denis, Ofori, Sandra N, Wang, Michael Ke, Efremov, Sergey, Landoni, Giovanni, Kleinlugtenbelt, Ydo YV, Szczeklik, Wojciech, Schmartz, Denis, Garg, Amit X, Short, Timothy TG, Wittmann, Maria, Meyhoff, Christian Sylvest, Amir, Mohammed, Torres, David, Patel, Ameen, Ruetzler, Kurt, Parlow, Joel JL, Tandon, Vikas, Fleischmann, Edith, Polanczyk, Carísi Anne, Lamy, Andre, Jayaram, Raja, Astrakov, Sergey SV, Wu, William Ka Kei, Cheong, Chao Chia, Ayad, Sabry, Kirov, Mikhail M.Y., de Nadal, Miriam, Likhvantsev, Valery VV, Paniagua, Pilar, Aguado, Hector HJ, Maheshwari, Kamal, Whitlock, Richard RP, McGillion, Michael MH, Vincent, Jessica, Copland, Ingrid, Balasubramanian, Kumar, Biccard, Bruce BM, Srinathan, Sadeesh, Ismoilov, Samandar, Pettit, Shirley, Stillo, David, Kurz, Andrea, Belley-Côté, Emilie EP, Spence, Jessica, McIntyre, William WF, Bangdiwala, Shrikant SI, Guyatt, Gordon, Yusuf, Salim, Devereaux, P J, and POISE-3 Trial Investigators and Study Groups

Abstract

Among patients having noncardiac surgery, perioperative hemodynamic abnormalities are associated with vascular complications. Uncertainty remains about what intraoperative blood pressure to target and how to manage long-term antihypertensive medications perioperatively., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2023

21. Myocardial Injury After Noncardiac Surgery (MINS) in Vascular Surgical Patients: A Prospective Observational Cohort Study

Author

Biccard, Bruce M., Scott, David Julian Ashbridge, Chan, Matthew T. V., Archbold, Andrew, Wang, Chew-Yin, Sigamani, Alben, Urrútia, Gerard, Cruz, Patricia, Srinathan, Sadeesh K., Szalay, David, Harlock, John, Tittley, Jacques G., Rapanos, Theodore, Elias, Fadi, Jacka, Michael J., Malaga, German, Abraham, Valsa, Berwanger, Otavio, Montes, Félix R., Heels-Ansdell, Diane M., Hutcherson, Matthew T., Chow, Clara K., Polanczyk, Carisi A., Szczeklik, Wojciech, Ackland, Gareth L., Dubois, Luc, Sapsford, Robert J., Williams, Colin, Cortés, Olga L., Le Mananch, Yannick, and Devereaux, P. J.

Published
2018
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23. Tranexamic Acid in Patients Undergoing Noncardiac Surgery

Author

UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, Devereaux, P.J., Marcucci, Maura, Painter, Thomas W., Conen, David, Lomivorotov, Vladimir, Sessler, Daniel I., Chan, Matthew T.V., Borges, Flavia K., Martínez-Zapata, María J., Wang, Chew Yin, Xavier, Denis, Ofori, Sandra N., Wang, Michael K., Efremov, Sergey, Landoni, Giovanni, Kleinlugtenbelt, Ydo V., Szczeklik, Wojciech, Schmartz, Denis, Garg, Amit X., Short, Timothy G., Wittmann, Maria, Meyhoff, Christian S., Amir, Mohammed, Torres, David, Patel, Ameen, Duceppe, Emmanuelle, Ruetzler, Kurt, Parlow, Joel L., Tandon, Vikas, Fleischmann, Edith, Polanczyk, Carisi A., Lamy, Andre, Astrakov, Sergey V., Rao, Mangala, Wu, William K.K., Bhatt, Keyur, de Nadal, Miriam, Likhvantsev, Valery V., Paniagua, Pilar, Aguado, Hector J., Whitlock, Richard P., McGillion, Michael H., Prystajecky, Michael, Vincent, Jessica, Eikelboom, John, Copland, Ingrid, Balasubramanian, Kumar, Turan, Alparslan, Bangdiwala, Shrikant I., Stillo, David, Gross, Peter L., Cafaro, Teresa, Alfonsi, Pascal, Roshanov, Pavel S., Belley-Côté, Emilie P., Spence, Jessica, Richards, Toby, VanHelder, Tomas, McIntyre, William, Guyatt, Gordon, Yusuf, Salim, Leslie, Kate, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, Devereaux, P.J., Marcucci, Maura, Painter, Thomas W., Conen, David, Lomivorotov, Vladimir, Sessler, Daniel I., Chan, Matthew T.V., Borges, Flavia K., Martínez-Zapata, María J., Wang, Chew Yin, Xavier, Denis, Ofori, Sandra N., Wang, Michael K., Efremov, Sergey, Landoni, Giovanni, Kleinlugtenbelt, Ydo V., Szczeklik, Wojciech, Schmartz, Denis, Garg, Amit X., Short, Timothy G., Wittmann, Maria, Meyhoff, Christian S., Amir, Mohammed, Torres, David, Patel, Ameen, Duceppe, Emmanuelle, Ruetzler, Kurt, Parlow, Joel L., Tandon, Vikas, Fleischmann, Edith, Polanczyk, Carisi A., Lamy, Andre, Astrakov, Sergey V., Rao, Mangala, Wu, William K.K., Bhatt, Keyur, de Nadal, Miriam, Likhvantsev, Valery V., Paniagua, Pilar, Aguado, Hector J., Whitlock, Richard P., McGillion, Michael H., Prystajecky, Michael, Vincent, Jessica, Eikelboom, John, Copland, Ingrid, Balasubramanian, Kumar, Turan, Alparslan, Bangdiwala, Shrikant I., Stillo, David, Gross, Peter L., Cafaro, Teresa, Alfonsi, Pascal, Roshanov, Pavel S., Belley-Côté, Emilie P., Spence, Jessica, Richards, Toby, VanHelder, Tomas, McIntyre, William, Guyatt, Gordon, Yusuf, Salim, and Leslie, Kate

Abstract

BACKGROUND Perioperative bleeding is common in patients undergoing noncardiac surgery. Tranexamic acid is an antifibrinolytic drug that may safely decrease such bleeding. METHODS We conducted a trial involving patients undergoing noncardiac surgery. Patients were randomly assigned to receive tranexamic acid (1-g intravenous bolus) or placebo at the start and end of surgery (reported here) and, with the use of a partial factorial design, a hypotension-avoidance or hypertension-avoidance strategy (not reported here). The primary efficacy outcome was life-threatening bleeding, major bleeding, or bleeding into a critical organ (composite bleeding outcome) at 30 days. The pri- mary safety outcome was myocardial injury after noncardiac surgery, nonhemor- rhagic stroke, peripheral arterial thrombosis, or symptomatic proximal venous thromboembolism (composite cardiovascular outcome) at 30 days. To establish the noninferiority of tranexamic acid to placebo for the composite cardiovascular out- come, the upper boundary of the one-sided 97.5% confidence interval for the hazard ratio had to be below 1.125, and the one-sided P value had to be less than 0.025. RESULTS A total of 9535 patients underwent randomization. A composite bleeding outcome event occurred in 433 of 4757 patients (9.1%) in the tranexamic acid group and in 561 of 4778 patients (11.7%) in the placebo group (hazard ratio, 0.76; 95% confi- dence interval [CI], 0.67 to 0.87; absolute difference, −2.6 percentage points; 95% CI, −3.8 to −1.4; two-sided P<0.001 for superiority). A composite cardiovascular outcome event occurred in 649 of 4581 patients (14.2%) in the tranexamic acid group and in 639 of 4601 patients (13.9%) in the placebo group (hazard ratio, 1.02; 95% CI, 0.92 to 1.14; upper boundary of the one-sided 97.5% CI, 1.14; absolute difference, 0.3 per- centage points; 95% CI, −1.1 to 1.7; one-sided P=0.04 for noninferiority). CONCLUSIONS Among patients undergoing noncardiac surgery, the incidence of the com

Published
2022

24. Accelerated Surgery Versus Standard Care in Hip Fracture (HIP ATTACK-1): A Kidney Substudy of a Randomized Clinical Trial.

Author

UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, UCL - SSS/IREC/NMSK - Neuro-musculo-skeletal Lab, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service d'anesthésiologie, UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur, UCL - (SLuc) Service de médecine interne générale, Borges, Flavia K, Devereaux, P J, Cuerden, Meaghan, Sontrop, Jessica M, Bhandari, Mohit, Guerra-Farfán, Ernesto, Patel, Ameen, Sigamani, Alben, Umer, Masood, Neary, John, Tiboni, Maria, Tandon, Vikas, Ramokgopa, Mmampapatla Thomas, Sancheti, Parag, Lawendy, Abdel-Rahman, Balaguer-Castro, Mariano, Jenkinson, Richard, Ślęczka, Paweł, Nur, Aamer Nabi, Wood, Gavin C A, Feibel, Robert J, McMahon, John Stephen, Biccard, Bruce M, Ortalda, Alessandro, Szczeklik, Wojciech, Wang, Chew Yin, Tomás-Hernández, Jordi, Vincent, Jessica, Harvey, Valerie, Pettit, Shirley, Balasubramanian, Kumar, Slobogean, Gerard, Garg, Amit X, HIP ATTACK-1 Investigators, Veevaete, Laurent, Le Polain de Waroux, Bernard, Lavand'homme, Patricia, Cornu, Olivier, Tribak, Karim, Yombi, Jean Cyr, Touil, Nassim, UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, UCL - SSS/IREC/NMSK - Neuro-musculo-skeletal Lab, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service d'anesthésiologie, UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur, UCL - (SLuc) Service de médecine interne générale, Borges, Flavia K, Devereaux, P J, Cuerden, Meaghan, Sontrop, Jessica M, Bhandari, Mohit, Guerra-Farfán, Ernesto, Patel, Ameen, Sigamani, Alben, Umer, Masood, Neary, John, Tiboni, Maria, Tandon, Vikas, Ramokgopa, Mmampapatla Thomas, Sancheti, Parag, Lawendy, Abdel-Rahman, Balaguer-Castro, Mariano, Jenkinson, Richard, Ślęczka, Paweł, Nur, Aamer Nabi, Wood, Gavin C A, Feibel, Robert J, McMahon, John Stephen, Biccard, Bruce M, Ortalda, Alessandro, Szczeklik, Wojciech, Wang, Chew Yin, Tomás-Hernández, Jordi, Vincent, Jessica, Harvey, Valerie, Pettit, Shirley, Balasubramanian, Kumar, Slobogean, Gerard, Garg, Amit X, HIP ATTACK-1 Investigators, Veevaete, Laurent, Le Polain de Waroux, Bernard, Lavand'homme, Patricia, Cornu, Olivier, Tribak, Karim, Yombi, Jean Cyr, and Touil, Nassim

Abstract

To the Editor: Acute kidney injury (AKI) is a lesser-known complication of hip fracture that may come about owing to decreased kidney perfusion and heightened inflammation from trauma, pain, bleeding, and fasting. Approximately 15%-20% of patients undergoing surgery for a hip fracture develop AKI, with 0.5%-1.8% receiving dialysis. [...]

Published
2022

25. Intraoperative Inspiratory Oxygen Fraction and Myocardial Injury After Noncardiac Surgery:Results From an International Observational Study in Relation to Recent Controlled Trials

Author

Pedersen, Sofie S., Holse, Cecilie, Mathar, Clara E., Chan, Matthew T.V., Sessler, Daniel I., Liu, Yingzhi, Zhang, Lin, Kurz, Andrea, Jacka, Mike, Torborg, Alexandra, Biyase, Thuli, Montes, Felix R., Wang, Chew Yin, Pettit, Shirley, Devereaux, P. J., Meyhoff, Christian S., Pedersen, Sofie S., Holse, Cecilie, Mathar, Clara E., Chan, Matthew T.V., Sessler, Daniel I., Liu, Yingzhi, Zhang, Lin, Kurz, Andrea, Jacka, Mike, Torborg, Alexandra, Biyase, Thuli, Montes, Felix R., Wang, Chew Yin, Pettit, Shirley, Devereaux, P. J., and Meyhoff, Christian S.

Abstract

BACKGROUND: Two trials reported that a high inspiratory oxygen fraction (F io2 ) does not promote myocardial infarction or death. Observational studies can provide larger statistical strength, but associations can be due to unobserved confounding. Therefore, we evaluated the association between intraoperative F io2 and cardiovascular complications in a large international cohort study to see if spurious associations were observed. METHODS: We included patients from the Vascular events In noncardiac Surgery patIents cOhort evaluatioN (VISION) study, who were ≥45 years of age, scheduled for overnight hospital admission, and had intraoperative F io2 recorded. The primary outcome was myocardial injury after noncardiac surgery (MINS), and secondary outcomes included mortality and pneumonia, all within 30 postoperative days. Data were analyzed with logistic regression, adjusted for many baseline cardiovascular risk factors, and illustrated in relation to findings from 2 recent controlled trials. RESULTS: We included 6588 patients with mean age of 62 years of whom 49% had hypertension. The median intraoperative F io2 was 0.46 (5%-95% range, 0.32-0.94). There were 808 patients (12%) with MINS. Each 0.10 increase in median F io2 was associated with a confounder-adjusted increase in odds for MINS: odds ratio (OR), 1.17 (95% confidence interval [CI], 1.12-1.23; P < .0001). MINS occurred in contrast with similar frequencies and no significant difference in controlled trials (2240 patients, 194 events), in which patients were given 80% vs 30% oxygen. Mortality was 2.4% and was not significantly associated with a median F io2 (OR, 1.07; 95% CI, 0.97-1.19 per 0.10 increase; P = .18), and 2.9% of patients had pneumonia (OR, 1.05; 95% CI, 0.95-1.15 per 0.10 increase; P = .34). CONCLUSIONS: We observed an association between intraoperative F io2 and risk of myocardial injury within 30 days after noncardiac surgery, which contrasts with recent controlled clinical trials. F io2 w

Published
2022

26. Tranexamic Acid in Patients Undergoing Noncardiac Surgery

Author

Devereaux, P.J., primary, Marcucci, Maura, additional, Painter, Thomas W., additional, Conen, David, additional, Lomivorotov, Vladimir, additional, Sessler, Daniel I., additional, Chan, Matthew T.V., additional, Borges, Flavia K., additional, Martínez-Zapata, María J., additional, Wang, Chew Yin, additional, Xavier, Denis, additional, Ofori, Sandra N., additional, Wang, Michael K., additional, Efremov, Sergey, additional, Landoni, Giovanni, additional, Kleinlugtenbelt, Ydo V., additional, Szczeklik, Wojciech, additional, Schmartz, Denis, additional, Garg, Amit X., additional, Short, Timothy G., additional, Wittmann, Maria, additional, Meyhoff, Christian S., additional, Amir, Mohammed, additional, Torres, David, additional, Patel, Ameen, additional, Duceppe, Emmanuelle, additional, Ruetzler, Kurt, additional, Parlow, Joel L., additional, Tandon, Vikas, additional, Fleischmann, Edith, additional, Polanczyk, Carisi A., additional, Lamy, Andre, additional, Astrakov, Sergey V., additional, Rao, Mangala, additional, Wu, William K.K., additional, Bhatt, Keyur, additional, de Nadal, Miriam, additional, Likhvantsev, Valery V., additional, Paniagua, Pilar, additional, Aguado, Hector J., additional, Whitlock, Richard P., additional, McGillion, Michael H., additional, Prystajecky, Michael, additional, Vincent, Jessica, additional, Eikelboom, John, additional, Copland, Ingrid, additional, Balasubramanian, Kumar, additional, Turan, Alparslan, additional, Bangdiwala, Shrikant I., additional, Stillo, David, additional, Gross, Peter L., additional, Cafaro, Teresa, additional, Alfonsi, Pascal, additional, Roshanov, Pavel S., additional, Belley-Côté, Emilie P., additional, Spence, Jessica, additional, Richards, Toby, additional, VanHelder, Tomas, additional, McIntyre, William, additional, Guyatt, Gordon, additional, Yusuf, Salim, additional, and Leslie, Kate, additional

Published
2022
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27. Intraoperative Inspiratory Oxygen Fraction and Myocardial Injury After Noncardiac Surgery: Results From an International Observational Study in Relation to Recent Controlled Trials

Author

Pedersen, Sofie S., primary, Holse, Cecilie, additional, Mathar, Clara E., additional, Chan, Matthew T. V., additional, Sessler, Daniel I., additional, Liu, Yingzhi, additional, Zhang, Lin, additional, Kurz, Andrea, additional, Jacka, Mike, additional, Torborg, Alexandra, additional, Biyase, Thuli, additional, Montes, Felix R., additional, Wang, Chew Yin, additional, Pettit, Shirley, additional, Devereaux, P. J., additional, and Meyhoff, Christian S., additional

Published
2022
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28. High-Sensitivity Troponin I after Cardiac Surgery and 30-Day Mortality

Author

Devereaux, P.J., primary, Lamy, Andre, additional, Chan, Matthew T.V., additional, Allard, René V., additional, Lomivorotov, Vladimir V., additional, Landoni, Giovanni, additional, Zheng, Hong, additional, Paparella, Domenico, additional, McGillion, Michael H., additional, Belley-Côté, Emilie P., additional, Parlow, Joel L., additional, Underwood, Malcolm J., additional, Wang, Chew Yin, additional, Dvirnik, Nazari, additional, Abubakirov, Marat, additional, Fominskiy, Evgeny, additional, Choi, Stephen, additional, Fremes, Stephen, additional, Monaco, Fabrizio, additional, Urrútia, Gerard, additional, Maestre, Marialuz, additional, Hajjar, Ludhmila A., additional, Hillis, Graham S., additional, Mills, Nicholas L., additional, Margari, Vito, additional, Mills, Joseph D., additional, Billing, J. Stephen, additional, Methangkool, Emily, additional, Polanczyk, Carisi A., additional, Sant’Anna, Roberto, additional, Shukevich, Dmitry, additional, Conen, David, additional, Kavsak, Peter A., additional, McQueen, Matthew J., additional, Brady, Katheryn, additional, Spence, Jessica, additional, Le Manach, Yannick, additional, Mian, Rajibul, additional, Lee, Shun Fu, additional, Bangdiwala, Shrikant I., additional, Hussain, Sara, additional, Borges, Flavia K., additional, Pettit, Shirley, additional, Vincent, Jessica, additional, Guyatt, Gordon H., additional, Yusuf, Salim, additional, Alpert, Joseph S., additional, White, Harvey D., additional, and Whitlock, Richard P., additional

Published
2022
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32. Association of Obstructive Sleep Apnea With Difficult Intubation: Prospective Multicenter Observational Cohort Study

Author

Seet, Edwin, primary, Chung, Frances, additional, Wang, Chew Yin, additional, Tam, Stanley, additional, Kumar, Chandra M., additional, Ubeynarayana, Chalani U., additional, Yim, Carolyn C., additional, Chew, Eleanor F. F., additional, Lam, Carmen K. M., additional, Cheng, Benny C. P., additional, and Chan, Matthew T. V., additional

Published
2021
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34. Obstructive sleep apnoea and open heart surgery: a review of its incidence and impact to patients

Author

Wang Chew Yin, Shahrul Amry Hashim, Sivakumar Krishnasamy, Raja Amin Raja Mokhtar, Sukcharanjit Singh, Frances Chung, and Saidah Mohd Sahid

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Work productivity, business.industry, Incidence (epidemiology), 030204 cardiovascular system & hematology, medicine.disease, Cardiac surgery, Surgery, respiratory tract diseases, Obstructive sleep apnea, 03 medical and health sciences, 0302 clinical medicine, Waistline, 030202 anesthesiology, medicine, Breathing, Original Article, Sleep study, Sleep (system call), business
Abstract

Background: Obstructive sleep apnea (OSA) is a serious health disorder which contributes to cardiovascular complications, decreased work productivity, automobile accidents, and death. This condition is characterized by a temporary cessation of breathing resulting due to upper airway closure during a person’s sleep. Strain to the heart caused by this repetitive hypoxic insult can lead to postoperative complications for patients undergoing heart surgery. Recognizing cardiac surgical patients with OSA is important. Early recognition and intervention such as use of BiPAP device can reduce the postoperative complications due to OSA. Methods: The aim of this study is to identify the incidence of unrecognized OSA in cardiac surgical patients. This is a retrospective analysis of a prospective data of the study which was done between July 2012 and July 2013 in University Malaya Medical Center. All patients undergoing elective cardiac surgery were recruited and the demographic data, questionnaire and the portable sleep study results were obtained. Patients were followed up till 30 days to record any complications. Data were entered in SPSS version 17 and analysis was done. Results: The incidence of OSA was 61.4% and 43.5% were moderate to severe OSA. There was male predominance of OSA (79%) with a mean age of 60 years. OSA subjects had shorter inter-incisor distance (4.18±0.6 cm) and larger waistline (94.1±12.1 cm). The STOP-Bang questionnaire has a sensitivity of 75.8% in predicting apnoa-hypopnea index (AHI) ≥5/hour. Conclusions: OSA can be diagnosed with a simple screening questionnaire and a bedside portable sleep study. Cardiac patients diagnosed with OSA can be pre-emptively given extra attention in managing their postoperative care.

Published
2020

41. Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial

Author

Borges, Flavia K, primary, Bhandari, Mohit, additional, Guerra-Farfan, Ernesto, additional, Patel, Ameen, additional, Sigamani, Alben, additional, Umer, Masood, additional, Tiboni, Maria E, additional, Villar-Casares, Maria del Mar, additional, Tandon, Vikas, additional, Tomas-Hernandez, Jordi, additional, Teixidor-Serra, Jordi, additional, Avram, Victoria RA, additional, Winemaker, Mitchell, additional, Ramokgopa, Mmampapatla T, additional, Szczeklik, Wojciech, additional, Landoni, Giovanni, additional, Wang, Chew Yin, additional, Begum, Dilshad, additional, Neary, John D, additional, Adili, Anthony, additional, Sancheti, Parag K, additional, Lawendy, Abdel-Rahman, additional, Balaguer-Castro, Mariano, additional, Ślęczka, Paweł, additional, Jenkinson, Richard J, additional, Nur, Aamer Nabi, additional, Wood, Gavin CA, additional, Feibel, Robert J, additional, McMahon, Stephen J, additional, Sigamani, Alen, additional, Popova, Ekaterine, additional, Biccard, Bruce M, additional, Moppett, Iain K, additional, Forget, Patrice, additional, Landais, Paul, additional, McGillion, Michael H, additional, Vincent, Jessica, additional, Balasubramanian, Kumar, additional, Harvey, Valerie, additional, Garcia-Sanchez, Yaiza, additional, Pettit, Shirley M, additional, Gauthier, Leslie P, additional, Guyatt, Gordon H, additional, Conen, David, additional, Garg, Amit X, additional, Bangdiwala, Shrikant I, additional, Belley-Cote, Emilie P, additional, Marcucci, Maura, additional, Lamy, Andre, additional, Whitlock, Richard, additional, Le Manach, Yannick, additional, Fergusson, Dean A, additional, Yusuf, Salim, additional, Devereaux, PJ, additional, Veevaete, Laurent, additional, le Polain de Waroux, Bernard, additional, Lavand'homme, Patricia, additional, Cornu, Olivier, additional, Tribak, Karim, additional, Yombi, Jean Cyr, additional, Touil, Nassim, additional, Reul, Maike, additional, Bhutia, Jigme Tshering, additional, Clinckaert, Carol, additional, De Clippeleir, Dirk, additional, de Beer, Justin, additional, Simpson, Diane L, additional, Worster, Andrew, additional, Alvarado, Kim A, additional, Gregus, Krysten K, additional, Lawrence, Kelly H, additional, Leong, Darryl P, additional, Joseph, Philip G, additional, Magloire, Patrick, additional, Deheshi, Benjamin, additional, Bisland, Stuart, additional, Wood, Thomas J, additional, Tushinski, Daniel M, additional, Wilson, David AJ, additional, Kearon, Clive, additional, Cowan, David D, additional, Khanna, Vickas, additional, Zaki, Amna, additional, Farrell, Janet C, additional, MacDonald, Anne Marie, additional, Wong, Steven CW, additional, Karbassi, Arsha, additional, Wright, Douglas Steven, additional, Shanthanna, Harsha, additional, Coughlin, Ryan, additional, Khan, Moin, additional, Wikkerink, Spencer, additional, Quraishi, Faraaz A, additional, Kishta, Waleed, additional, Schemitsch, Emil, additional, Carey, Timothy, additional, Macleod, Mark D, additional, Sanders, David W, additional, Vasarhelyi, Edward, additional, Bartley, Debra, additional, Dresser, George K, additional, Tieszer, Christina, additional, Shadowitz, Steven, additional, Lee, Jacques S, additional, Choi, Stephen, additional, Kreder, Hans J, additional, Nousiainen, Markku, additional, Kunz, Monica R, additional, Tuazon, Ravianne, additional, Shrikumar, Mopina, additional, Ravi, Bheeshma, additional, Wasserstein, David, additional, Stephen, David JG, additional, Nam, Diane, additional, Henry, Patrick DG, additional, Mann, Stephen M, additional, Jaeger, Melanie T, additional, Sivilotti, Marco LA, additional, Smith, Christopher A, additional, Frank, Christopher C, additional, Grant, Heather, additional, Ploeg, Leone, additional, Yach, Jeff D, additional, Harrison, Mark M, additional, Campbell, Aaron R, additional, Bicknell, Ryan T, additional, Bardana, Davide D, additional, McIlquham, Katie, additional, Gallant, Catherine, additional, Halman, Samantha, additional, Thiruganasambandamoorth, Venkatesh, additional, Ruggiero, Sara, additional, Hadden, William J, additional, Chen, Brian P-J, additional, Coupal, Stephanie A, additional, McLean, Lisa M, additional, Shirali, Hemant R, additional, Haider, Syed Y, additional, Smith, Crystal A, additional, Watts, Evan, additional, Santone, David J, additional, Koo, Kevin, additional, Yee, Allan J, additional, Oyenubi, Ademilola N, additional, Nauth, Aaron, additional, Schemitsch, Emil H, additional, Daniels, Timothy R, additional, Ward, Sarah E, additional, Hall, Jeremy A, additional, Ahn, Henry, additional, Whelan, Daniel B, additional, Atrey, Amit, additional, Khoshbin, Amir, additional, Puskas, David, additional, Droll, Kurt, additional, Cullinan, Claude, additional, Payendeh, Jubin, additional, Lefrancois, Tina, additional, Mozzon, Lise, additional, Marion, Travis, additional, Jacka, Michael J, additional, Greene, James, additional, Menon, Matthew, additional, Stiegelmahr, Robert, additional, Dillane, Derek, additional, Irwin, Marleen, additional, Beaupre, Lauren, additional, Coles, Chad P, additional, Trask, Kelly, additional, MacDonald, Shelley, additional, Trenholm, J Andrew I, additional, Oxner, William, additional, Richardson, C Glen, additional, Dehghan, Niloofar, additional, Sadoughi, Mehdi, additional, Sharma, Achal, additional, White, Neil J, additional, Olivieri, Loretta, additional, Hunt, Stephen B, additional, Turgeon, Thomas R, additional, Bohm, Eric R, additional, Tran, Sarah, additional, Giilck, Stephen M, additional, Hupel, Tom, additional, Guy, Pierre, additional, O'Brien, Peter J, additional, Duncan, Andrew W, additional, Crawford, Gordon A, additional, Zhou, Junlin, additional, Zhao, Yanrui, additional, Liu, Yang, additional, Shan, Lei, additional, Wu, Anshi, additional, Muñoz, Juan Manuel, additional, Chaudier, Philippe, additional, Douplat, Marion, additional, Fessy, Michel Henri, additional, Piriou, Vincent, additional, Louboutin, Lucie, additional, David, Jean Stephane, additional, Friggeri, Arnaud, additional, Beroud, Sebastien, additional, Fayet, Jean Marie, additional, Leung, Frankie Ka Li, additional, Fang, Christian Xinshuo, additional, Yee, Dennis King Hang, additional, Sancheti, Parag Kantilal, additional, Pradhan, Chetan Vijay, additional, Patil, Atul Ashok, additional, Puram, Chetan Prabhakar, additional, Borate, Madhav Pandurang, additional, Kudrimoti, Kiran Bhalchandra, additional, Adhye, Bharati Anil, additional, Dongre, Himanshu Vijaykumar, additional, John, Bobby, additional, Abraham, Valsamma, additional, Pandey, Ritesh Arvind, additional, Rajkumar, Arti, additional, George, Preetha Elizabeth, additional, Stephen, Manesh, additional, Chandran, Nitheesh, additional, Ashraf, Mohammed, additional, Georgekutty, AM, additional, Sulthan, Ahamad Shaheel, additional, Adinarayanan, S, additional, Sharma, Deep, additional, Barnawal, Satish Prasad, additional, Swaminathan, Srinivasan, additional, Bidkar, Prasanna Udupi, additional, Mishra, Sandeep Kumar, additional, Menon, Jagdish, additional, M, Niranjan, additional, K, Varghese Zachariah, additional, Hiremath, Santosh Angad, additional, NC, Madhusudhan, additional, Jawali, Abhijit, additional, Gnanadurai, Kingsly Robert, additional, George, Carolin Elizabeth, additional, Maddipati, Tatarao, additional, KP, Mary KP, additional, Sharma, Vijay, additional, Farooque, Kamran, additional, Malhotra, Rajesh, additional, Mittal, Samarth, additional, Sawhney, Chavi, additional, Gupta, Babita, additional, Mathur, Purva, additional, Gamangati, Shivanand, additional, Tripathy, Vijaylaxmi, additional, Menon, Prem Haridas, additional, Dhillon, Mandeep S, additional, Chouhan, Devendra K, additional, Patil, Sharanu, additional, Narayan, Ravi, additional, Lal, Purushotham, additional, Bilchod, Prashanth Nabhirajappa, additional, Singh, Surya Udai, additional, Gattu, Uttam Vaidya, additional, Dashputra, Ravi Prabhakar, additional, Rahate, Prashant Vitthal, additional, Turiel, Maurizio, additional, De Blasio, Giuseppe, additional, Accetta, Riccardo, additional, Perazzo, Paolo, additional, Stella, Daniele, additional, Bonadies, Marika, additional, Colombo, Chiara, additional, Fozzato, Stefania, additional, Pino, Fabio, additional, Morelli, Ilaria, additional, Colnaghi, Eleonora, additional, Salini, Vincenzo, additional, Denaro, Giuseppe, additional, Beretta, Luigi, additional, Placella, Giacomo, additional, Giardina, Giuseppe, additional, Binda, Mirko, additional, Marcato, Anna, additional, Guzzetti, Luca, additional, Piccirillo, Fabio, additional, Cecconi, Maurizio, additional, Khor, HM, additional, Lai, Hou Yee, additional, Kumar, CS, additional, Chee, KH, additional, Loh, PS, additional, Tan, Kit Mun, additional, Singh, Simmrat, additional, Foo, Li Lian, additional, Prakasam, Komella, additional, Chaw, Sook Hui, additional, Lee, Meng-Li, additional, Ngim, Joanne HL, additional, Boon, Huck Wee, additional, Chin, Im Im, additional, Kleinlugtenbelt, Ydo V, additional, Landman, Ellie BM, additional, Flikweert, Elvira R, additional, Roerdink, Herbert W, additional, Brokelman, Roy B.G., additional, Elskamp-Meijerman, Hannie F, additional, Horst, Maarten R, additional, Cobben, Jan-Hein MG, additional, Anjum, Anila, additional, Hashmi, Pervaiz Mehmood, additional, Ahmed, Tashfeen, additional, Rashid, Haroon Ur, additional, Khattak, Mujahid Jamil, additional, Rashid, Rizwan Haroon, additional, Lakdawala, Riaz Hussain, additional, Noordin, Shahryar, additional, Juman, Naveed Muhammed, additional, Khan, Robyna Irshad, additional, Riaz, Muhammad Mehmood, additional, Bokhari, Syedah Saira, additional, Almas, Ayesha, additional, Wahab, Hussain, additional, Ali, Arif, additional, Khan, Hammad Naqi, additional, Khan, Eraj Khurshid, additional, Janjua, Kholood Abid, additional, Orakzai, Sajjad Hassan, additional, Khan, Abdus Salam, additional, Mustafa, Khawaja Junaid, additional, Sohail, Mian Amjad, additional, Umar, Muhammad, additional, Khan, Siddra Ahmed, additional, Ashraf, Muhammad, additional, Khan, Muhammad Kashif, additional, Shiraz, Muhammad, additional, Furgan, Ahmad, additional, Dąbek, Piotr, additional, Kumoń, Adam, additional, Satora, Wojciech, additional, Ambroży, Wojciech, additional, Święch, Mariusz, additional, Rycombel, Jacek, additional, Grzelak, Adrian, additional, Gucwa, Jaroslaw, additional, Machala, Waldemar, additional, Ramokgopa, Mmampapatla Thomas, additional, Firth, Gregory Bodley, additional, Karera, Mwalimu, additional, Fourtounas, Maria, additional, Singh, Virsen, additional, Biscardi, Anna, additional, Iqbal, Muhammad Nasir, additional, Campbell, Ryan Jonathan, additional, Maluleke, Matimba Lenny, additional, Moller, Carien, additional, Nhlapo, Lerato, additional, Maqungo, Sithombo, additional, Flint, Margot, additional, Nejthardt, Marcin B, additional, Chetty, Sean, additional, Naidoo, Rubendren, additional, Garrido Clua, Miriam, additional, Molero-Garcia, Vicente, additional, Minguell-Monyart, Joan, additional, Selga Marsa, Jordi, additional, Porcel-Vazquez, Juan A, additional, Andres-Peiro, Jose-Vicente, additional, Aguilar, Marc, additional, Mestre-Torres, Jaume, additional, Colomina, Maria J, additional, Guilabert, Patricia, additional, Paños Gozalo, M Luisa, additional, Abarca, Luis, additional, Martin, Nuria, additional, Usua, Gemma, additional, Martinez-Ripol, Pedro, additional, Gonzalez Posada, MA, additional, Lalueza-Broto, Pilar, additional, Sanchez-Raya, Judith, additional, Nuñez Camarena, Jorge, additional, Fraguas-Castany, Antoni, additional, Torner, Pere, additional, Jornet-Gibert, Monsant, additional, Serrano-Sanz, Jorge, additional, Cámara-Cabrera, Jaume, additional, Salomó-Domènech, Mònica, additional, Yela-Verdú, Christian, additional, Peig-Font, Anna, additional, Ricol, Laura, additional, Carreras-Castañer, Anna, additional, Martínez-Sañudo, Luis, additional, Herranz, Susana, additional, Feijoo-Massó, Carlos, additional, Sianes-Gallén, Mònica, additional, Castillón, Pablo, additional, Bernaus, Martí, additional, Quintas, Saioa, additional, Gómez, Olga, additional, Salvador, Jordi, additional, Abarca, Javiera, additional, Estrada, Cristina, additional, Novellas, Marga, additional, Torra, Mercè, additional, Dealbert, Alfred, additional, Macho, Oscar, additional, Ivanov, Alexia, additional, Valldosera, Esther, additional, Arroyo, Marta, additional, Pey, Borja, additional, Yuste, Antoni, additional, Mateo, Llorenç, additional, De Caso, Julio, additional, Anaya, Rafael, additional, Higa-Sansone, JL, additional, Millan, Angelica, additional, Baños, Victoria, additional, Herrera-Mateo, Sergio, additional, Aguado, Hector J, additional, Martinez-Municio, Gonzalo, additional, León, Ricardo, additional, Santiago-Maniega, Silvia, additional, Zabalza, Ana, additional, Labrador, Gregorio, additional, Guerado, Enrique, additional, Cruz, Encarnacion, additional, Cano, Juan Ramon, additional, Bogallo, Jose Manuel, additional, Sa-ngasoongsong, Paphon, additional, Kulachote, Noratep, additional, Sirisreetreerux, Norachart, additional, Pengrung, Nachapan, additional, Chalacheewa, Theerawat, additional, Arnuntasupakul, Vanlapa, additional, Yingchoncharoen, Teerapat, additional, Naratreekoon, Bundit, additional, Kadry, Miriam Adel, additional, Thayaparan, Surendini, additional, Abdlaziz, Ihab, additional, Aframian, Arash, additional, Imbuldeniya, Arjuna, additional, Bentoumi, Souad, additional, Omran, Sherif, additional, Vizcaychipi, Marcela Paola, additional, Correia, Patricia, additional, Patil, Shashank, additional, Haire, Kevin, additional, Mayor, Amy SE, additional, Dillingham, Sally, additional, Nicholson, Laura, additional, Elnaggar, Mohamed, additional, John, Joby, additional, Nanjayan, Shashi Kumar, additional, Parker, Martyn J, additional, O'Sullivan, Susan, additional, Marmor, Meir T, additional, Matityahu, Amir, additional, McClellan, Robert Trigg, additional, Comstock, Curt, additional, Ding, Anthony, additional, Toogood, Paul, additional, Slobogean, Gerard, additional, Joseph, Katherine, additional, O'Toole, Robert, additional, Sciadini, Marcus, additional, Ryan, Scott P, additional, Clark, Molly E, additional, Cassidy, Charles, additional, Balonov, Konstantin, additional, Bergese, Sergio D, additional, Phieffer, Laura S, additional, Gonzalez Zacarias, Alicia A, additional, Marcantonio, Andrew J, additional, Borges, Flavia K, additional, Dragic-Taylor, Sanela, additional, Maxwell, Chelsea, additional, Molnar, Sarah, additional, Wells, Jennifer R, additional, Ofori, Sandra N, additional, Yang, Stephen S, additional, Wang, Michael K, additional, Duceppe, Emmanuelle, additional, Spence, Jessica, additional, Vasquez, Javiera P, additional, Marcano-Fernández, Francesc, additional, Ham, Hyungjoo, additional, Prada, Carlos, additional, Yung, Terence CH, additional, Sanz Pérez, Isidro, additional, Bosch, Michael J, additional, Prystajecky, Michael R, additional, Chowdhury, Chinmoy, additional, Khan, James S, additional, Stella, Steffan F, additional, Heidary, Behrouz, additional, Tran, Allen, additional, Wawrzycka-Adamczyk, Katarzyna, additional, Chen, Yu Chiao Peter, additional, González-Osuna, Aránzazu, additional, Biedroń, Grzegorz, additional, Wludarczyk, Anna, additional, Lefebvre, Marco, additional, Ernst, Jaclyn A, additional, Staffhorst, Bas, additional, Woodfine, Jason D, additional, Alwafi, Emad M, additional, Mrkobrada, Marko, additional, Parlow, Simon, additional, Roberts, Robin, additional, McAlister, Finlay, additional, Sackett, David, additional, and Wright, James, additional

Published
2020
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42. Preoperative N-Terminal Pro–B-Type Natriuretic Peptide and Cardiovascular Events After Noncardiac Surgery

Author

Duceppe, Emmanuelle, primary, Patel, Ameen, additional, Chan, Matthew T.V., additional, Berwanger, Otavio, additional, Ackland, Gareth, additional, Kavsak, Peter A., additional, Rodseth, Reitze, additional, Biccard, Bruce, additional, Chow, Clara K., additional, Borges, Flavia K., additional, Guyatt, Gordon, additional, Pearse, Rupert, additional, Sessler, Daniel I., additional, Heels-Ansdell, Diane, additional, Kurz, Andrea, additional, Wang, Chew Yin, additional, Szczeklik, Wojciech, additional, Srinathan, Sadeesh, additional, Garg, Amit X., additional, Pettit, Shirley, additional, Sloan, Erin N., additional, Januzzi Jr., James L., additional, McQueen, Matthew, additional, Buse, Giovanna Lurati, additional, Mills, Nicholas L., additional, Zhang, Lin, additional, Sapsford, Robert, additional, Paré, Guillaume, additional, Walsh, Michael, additional, Whitlock, Richard, additional, Lamy, Andre, additional, Hill, Stephen, additional, Thabane, Lehana, additional, Yusuf, Salim, additional, and Devereaux, P.J., additional

Published
2019
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44. Risk of stroke and other adverse outcomes in patients with perioperative atrial fibrillation 1 year after non-cardiac surgery

Author

Conen, David, Alonso-Coello, Pablo, Douketis, James, Chan, Matthew T. V., Kurz, Andrea, Sigamani, Alben, Parlow, Joel L., Wang, Chew Yin, Villar, Juan C., Srinathan, Sadeesh K., Tiboni, Maria, Málaga Rodríguez, Germán Javier, Guyatt, Gordon, Sivakumaran, Soori, Rodriguez Funes, Maria-Virginia, Cruz, Patricia, Yang, Homer, Dresser, George K., Alvarez-Garcia, Jesus, Schricker, Thomas, Jones, Philip M., Drummond, Leanne W., Balasubramanian, Kumar, Yusuf, Salim, and Devereaux, P. J.

Subjects
cardiovascular risk, adverse outcome, conservative treatment, mortality rate, Cardiovascular, postoperative period, Article, male, follow up, atrial fibrillation, controlled study, purl.org/pe-repo/ocde/ford#3.02.04 [https], Perioperative, human, Mortality, clonidine, risk reduction, drug effect, high risk population, acetylsalicylic acid, cohort analysis, major clinical study, metoprolol, Stroke, peroperative complication, aged, female, priority journal, risk factor, randomized controlled trial, incidence, placebo, mortality risk, cerebrovascular accident
Abstract

AIMS: To determine the 1-year risk of stroke and other adverse outcomes in patients with a new diagnosis of perioperative atrial fibrillation (POAF) after non-cardiac surgery. METHODS AND RESULTS: The PeriOperative ISchemic Evaluation (POISE)-1 trial evaluated the effects of metoprolol vs. placebo in 8351 patients, and POISE-2 compared the effect of aspirin vs. placebo, and clonidine vs. placebo in 10 010 patients. These trials included patients with, or at risk of, cardiovascular disease who were undergoing non-cardiac surgery. For the purpose of this study, we combined the POISE datasets, excluding 244 patients who were in atrial fibrillation (AF) at the time of randomization. Perioperative atrial fibrillation was defined as new AF that occurred within 30 days after surgery. Our primary outcome was the incidence of stroke at 1 year of follow-up; secondary outcomes were mortality and myocardial infarction (MI). We compared outcomes among patients with and without POAF using multivariable adjusted Cox proportional hazards models. Among 18 117 patients (mean age 69 years, 57.4% male), 404 had POAF (2.2%). The stroke incidence 1 year after surgery was 5.58 vs. 1.54 per 100 patient-years in patients with and without POAF, adjusted hazard ratio (aHR) 3.43, 95% confidence interval (CI) 2.00-5.90; P < 0.001. Patients with POAF also had an increased risk of death (incidence 31.37 vs. 9.34; aHR 2.51, 95% CI 2.01-3.14; P < 0.001) and MI (incidence 26.20 vs. 8.23; aHR 5.10, 95% CI 3.91-6.64; P < 0.001). CONCLUSION: Patients with POAF have a significantly increased risk of stroke, MI, and death at 1 year. Intervention studies are needed to evaluate risk reduction strategies in this high-risk population.

Published
2019

46. Perioperative covert stroke in patients undergoing non-cardiac surgery (NeuroVISION): a prospective cohort study

Author

Mrkobrada, Marko, primary, Chan, Matthew T.V., additional, Cowan, David, additional, Campbell, Douglas, additional, Wang, Chew Yin, additional, Torres, David, additional, Malaga, German, additional, Sanders, Robert D., additional, Sharma, Manas, additional, Brown, Carl, additional, Sigamani, Alben, additional, Szczeklik, Wojciech, additional, Sharma, Mukul, additional, Guyatt, Gordon, additional, Smith, Eric E., additional, Agid, Ronit, additional, Dmytriw, Adam A., additional, Spence, Jessica, additional, Adunuri, Nikesh R., additional, Borges, Flavia K., additional, Short, Timothy G., additional, Hill, Michael D., additional, Saad, Feryal, additional, Copland, Ingrid, additional, Pettit, Shirley, additional, Ibrahim, Quazi, additional, Bangdiwala, Shrikant I., additional, Yusuf, Salim, additional, Tsai, Scott, additional, Sahlas, Demetrios J, additional, Mensinkai, Arun, additional, Sposato, Luciano A, additional, Hussain, Sara, additional, Yang, Steven, additional, Siegal, Deborah, additional, Khaw, Alexander, additional, Mandzia, Jennifer, additional, Simpson, Sara, additional, Raval, Manoj, additional, Karimuddin, Ahmer, additional, Phang, PT, additional, Mok, Vincent CT, additional, Wu, William KK, additional, Yu, Simon CH, additional, Gin, Tony, additional, Loh, Pui San, additional, Liew, Mun Thing, additional, Ramli, Norlisah, additional, Siow, Yee Lein, additional, Fuentes, Maite, additional, Ortiz-Soriano, Victor, additional, Waymouth, Ellen, additional, Kumar, Jonathan, additional, Sadana, Divya, additional, Thomas, Lenimol, additional, Kaczmarek, Bogusz, additional, Lindroth, Heidi, additional, Sessler, Daniel, additional, Apolcer, Sarah, additional, Trombetta, Amelia, additional, Handsor, Stephanie, additional, Dasgupta, Monidipa, additional, Murkin, John M, additional, Lee, Shun Fu, additional, and Devereaux, P.J., additional

Published
2019
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47. Effects of accelerated versus standard care surgery on the risk of acute kidney injury in patients with a hip fracture: a substudy protocol of the hip fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) international randomised controlled trial

Author

Borges, Flavia K, primary, Devereaux, P J, additional, Cuerden, Meaghan, additional, Bhandari, Mohit, additional, Guerra-Farfán, Ernesto, additional, Patel, Ameen, additional, Sigamani, Alben, additional, Umer, Masood, additional, Neary, John, additional, Tiboni, Maria, additional, Tandon, Vikas, additional, Ramokgopa, Mmampapatla Thomas, additional, Sancheti, Parag, additional, John, Bobby, additional, Lawendy, AbdelRahman, additional, Balaguer-Castro, Mariano, additional, Jenkinson, Richard, additional, Ślęczka, Paweł, additional, Nabi Nur, Aamer, additional, Wood, Gavin C A, additional, Feibel, Robert, additional, McMahon, John Stephen, additional, Sigamani, Alen, additional, Biccard, Bruce M, additional, Landoni, Giovanni, additional, Szczeklik, Wojciech, additional, Wang, Chew Yin, additional, Tomas-Hernandez, Jordi, additional, Abraham, Valsa, additional, Vincent, Jessica, additional, Harvey, Valerie, additional, Pettit, Shirley, additional, Sontrop, Jessica, additional, and Garg, Amit X, additional

Published
2019
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48. Risk of stroke and other adverse outcomes in patients with perioperative atrial fibrillation 1 year after non-cardiac surgery

Author

Conen, David, primary, Alonso-Coello, Pablo, additional, Douketis, James, additional, Chan, Matthew T V, additional, Kurz, Andrea, additional, Sigamani, Alben, additional, Parlow, Joel L, additional, Wang, Chew Yin, additional, Villar, Juan C, additional, Srinathan, Sadeesh K, additional, Tiboni, Maria, additional, Malaga, German, additional, Guyatt, Gordon, additional, Sivakumaran, Soori, additional, Rodriguez Funes, Maria-Virginia, additional, Cruz, Patricia, additional, Yang, Homer, additional, Dresser, George K, additional, Alvarez-Garcia, Jesus, additional, Schricker, Thomas, additional, Jones, Philip M, additional, Drummond, Leanne W, additional, Balasubramanian, Kumar, additional, Yusuf, Salim, additional, and Devereaux, P J, additional

Published
2019
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49. Rationale and design of the HIP fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) Trial: a protocol for an international randomised controlled trial evaluating early surgery for hip fracture patients

Author

Borges, Flavia K, primary, Bhandari, Mohit, additional, Patel, Ameen, additional, Avram, Victoria, additional, Guerra-Farfán, Ernesto, additional, Sigamani, Alben, additional, Umer, Masood, additional, Tiboni, Maria, additional, Adili, Anthony, additional, Neary, John, additional, Tandon, Vikas, additional, Sancheti, Parag K, additional, Lawendy, AbdelRahman, additional, Jenkinson, Richard, additional, Ramokgopa, Mmampapatla, additional, Biccard, Bruce M, additional, Szczeklik, Wojciech, additional, Wang, Chew Yin, additional, Landoni, Giovanni, additional, Forget, Patrice, additional, Popova, Ekaterine, additional, Wood, Gavin, additional, Nabi Nur, Aamer, additional, John, Bobby, additional, Ślęczka, Paweł, additional, Feibel, Robert J, additional, Balaguer-Castro, Mariano, additional, Deheshi, Benjamin, additional, Winemaker, Mitchell, additional, de Beer, Justin, additional, Kolesar, Richard, additional, Teixidor-Serra, Jordi, additional, Tomas-Hernandez, Jordi, additional, McGillion, Michael, additional, Shanthanna, Harsha, additional, Moppett, Iain, additional, Vincent, Jessica, additional, Pettit, Shirley, additional, Harvey, Valerie, additional, Gauthier, Leslie, additional, Alvarado, Kim, additional, and Devereaux, P J, additional

Published
2019
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50. Volatile Anesthetics versus Total Intravenous Anesthesia for Cardiac Surgery

Author

Landoni, Giovanni, primary, Lomivorotov, Vladimir V., additional, Nigro Neto, Caetano, additional, Monaco, Fabrizio, additional, Pasyuga, Vadim V., additional, Bradic, Nikola, additional, Lembo, Rosalba, additional, Gazivoda, Gordana, additional, Likhvantsev, Valery V., additional, Lei, Chong, additional, Lozovskiy, Andrey, additional, Di Tomasso, Nora, additional, Bukamal, Nazar A.R., additional, Silva, Fernanda S., additional, Bautin, Andrey E., additional, Ma, Jun, additional, Crivellari, Martina, additional, Farag, Ahmed M.G.A., additional, Uvaliev, Nikolay S., additional, Carollo, Cristiana, additional, Pieri, Marina, additional, Kunstýř, Jan, additional, Wang, Chew Yin, additional, Belletti, Alessandro, additional, Hajjar, Ludhmila A., additional, Grigoryev, Evgeny V., additional, Agrò, Felice E., additional, Riha, Hynek, additional, El-Tahan, Mohamed R., additional, Scandroglio, A. Mara, additional, Elnakera, Abeer M., additional, Baiocchi, Massimo, additional, Navalesi, Paolo, additional, Shmyrev, Vladimir A., additional, Severi, Luca, additional, Hegazy, Mohammed A., additional, Crescenzi, Giuseppe, additional, Ponomarev, Dmitry N., additional, Brazzi, Luca, additional, Arnoni, Renato, additional, Tarasov, Dmitry G., additional, Jovic, Miomir, additional, Calabrò, Maria G., additional, Bove, Tiziana, additional, Bellomo, Rinaldo, additional, and Zangrillo, Alberto, additional

Published
2019
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