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17 results on '"Wang, Chiyi"'

4. Re-usable electrochemical glucose sensors integrated into a smartphone platform

Author

Bandodkar, Amay J, Imani, Somayeh, Nuñez-Flores, Rogelio, Kumar, Rajan, Wang, Chiyi, Mohan, AM Vinu, Wang, Joseph, and Mercier, Patrick P

Subjects
Analytical Chemistry, Chemical Sciences, Engineering, Biomedical Engineering, Nanotechnology, Bioengineering, Biosensing Techniques, Blood Glucose, Electrochemical Techniques, Electrodes, Equipment Design, Humans, Point-of-Care Systems, Reproducibility of Results, Smartphone, Electrochemical biosensors, Glucose, Glucometer, Bioinformatics, Analytical chemistry, Biomedical engineering
Abstract

This article demonstrates a new smartphone-based reusable glucose meter. The glucose meter includes a custom-built smartphone case that houses a permanent bare sensor strip, a stylus that is loaded with enzyme-carbon composite pellets, and sensor instrumentation circuits. A custom-designed Android-based software application was developed to enable easy and clear display of measured glucose concentration. A typical test involves the user loading the software, using the stylus to dispense an enzymatic pellet on top of the bare sensor strip affixed to the case, and then introducing the sample. The electronic module then acquires and wirelessly transmits the data to the application software to be displayed on the screen. The deployed pellet is then discarded to regain the fresh bare sensor surface. Such a unique working principle allows the system to overcome challenges faced by previously reported reusable sensors, such as enzyme degradation, leaching, and hysteresis effects. Studies reveal that the enzyme loaded in the pellets are stable for up to 8 months at ambient conditions, and generate reproducible sensor signals. The work illustrates the significance of the pellet-based sensing system towards realizing a reusable, point-of-care sensor that snugly fits around a smartphone and which does not face issues usually common to reusable sensors. The versatility of this system allows it to be easily modified to detect other analytes for application in a wide range of healthcare, environmental and defense domains.

Published
2018

13. QX-OH/Levobupivacaine: A Structurally Novel, Potent Local Anesthetic Produces Fast-Onset and Long-Lasting Regional Anesthesia in Rats

Author

Yang,Yang, Wang,Chiyi, Liu,Jin, Liao,Daqing, Zhang,Wensheng, Zhou,Cheng, Yang,Yang, Wang,Chiyi, Liu,Jin, Liao,Daqing, Zhang,Wensheng, and Zhou,Cheng

Abstract

Yang Yang,1,2 Chiyi Wang,1,2 Jin Liu,1,2 Daqing Liao,2 Wensheng Zhang,1,2 Cheng Zhou2 1Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 2Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People’s Republic of ChinaCorrespondence: Cheng ZhouLaboratory of Anaesthesia & Critical Care Medicine, Translational Neuroscience Center, The Research Units of West China (2018RU012), Chinese Academy of Medical Sciences, West China Hospital of Sichuan University, Chengdu, 610041, People’s Republic of China, Tel +81-28-85164145, Fax +81-28-85164039, Email zhouc@163.com; Wensheng ZhangDepartment of Anaesthesiology and Laboratory of Anaesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, People’s Republic of China, Tel/Fax +81-28-85164144, Email zhang_ws@scu.edu.cnPurpose: Local anesthetics (LAs) are an important alternative for postoperative analgesia; however, the short duration of LAs limits their use. Thus, we previously developed LL-1, a mixture of QX-OH and levobupivacaine (LB) that produces regional anesthesia for more than 10 h in rats. The aim of this study is to investigate the long-acting mechanism of LL-1 in vivo and in vitro.Methods: Regional anesthetic effects and local toxicity of the LL-1, QX-OH and LB treatment groups were investigated in a sciatic nerve block rat model. Whole-cell patch-clamping recordings were used to measure the inhibition Nav currents (INa) in ND7/23 cells.Results: The onset of LL-1 (35mM QX-OH+10mM LB) and 10 mM LB was 10 min, which was much faster than 35 mM QX-OH (27 [18, 60] min, t[12] = − 4.535, p = 0.001). The duration of LL-1 (35mM QX-OH+10 mM LB) was significantly longer than 35 mM QX-OH or 10 mM LB alone (F[3

Published
2022

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