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Acute respiratory distress syndrome (ARDS) is a common life-threatening clinical syndrome which accounts for 10% of intensive care unit admissions. Since the Berlin definition was developed, the clinical diagnosis and therapy have changed dramatically by adding a minimum positive end-expiratory pressure (PEEP) to the assessment of hypoxemia compared to the American-European Consensus Conference (AECC) definition in 1994. High-flow nasal cannulas (HFNC) have become widely used as an effective respiratory support for hypoxemia to the extent that their use was proposed in the expansion of the ARDS criteria. However, there would be problems if the diagnosis of a specific disease or clinical syndrome occurred, based on therapeutic strategies. [ABSTRACT FROM AUTHOR]

This review highlights the synthesis and applications of the carbon nitride (CN x) family with not only the different carbon/nitrogen ratios but also different basic units and linkages (triazine, triazole, and azo-linkage). Carbon nitride is a polymer semiconductor composed of carbon and nitrogen, with a basic sp2/sp3 unit of aromatic C–N rings. The most commonly synthesized form of graphitic carbon nitride (g-C 3 N 4) has a bandgap energy of 2.6–2.7 eV, making it suitable as a visible light-driven photocatalyst. Further, nitrogen atoms at the edges of 2D g-C 3 N 4 nanosheets have lone pair electrons, which can act as Lewis base sites in catalytic conversion reactions. The carbon/nitrogen ratio in carbon nitride and its structural features are affected by its precursors and the synthetic process. When the nitrogen content or carbon vacancy is increased in g-C 3 N 4 , the defects or unbonded nitrogen may act as recombination centers or introduce states within the forbidden gap, which affect the photocatalytic reaction. Contrastingly, the additional lone pair electrons provided by the unbonded nitrogen are advantageous to the catalytic reaction. However, excess nitrogen may result in the formation of unstable C–N–N bonds that weaken its structural stability. The correlation between different units, including triazine, triazole, tri-heptazine, and azo-linkage, in C 3 N x (x = 3–7) was studied to understand its structural features and their activity in photocatalytic and catalytic reactions. In this review, we summarize the latest synthetic approaches of CN x and discuss the outlooks of these materials for energy and environmental applications. [Display omitted] [ABSTRACT FROM AUTHOR]

The displacement ductility limit for seismic design of concrete piles is determined for the range of cohesionless soils expected in practice. The curvature ductility capacity associated with specified performance limit states, namely, the “serviceability” and “damage-control” limits, is determined based on the current provisions for confining steel. An analytical model is applied to assess the displacement ductility factor at the specified curvature ductility level. The investigated parameters include the soil stiffness, pile diameter, longitudinal reinforcement ratio, axial force level, and pile above-ground height. A set of design displacement ductility factors is recommended and verified to ensure the satisfactory seismic performance. [ABSTRACT FROM AUTHOR]

The technology of mathematical expression identification and recognition extracts mathematical expressions in document images, and it has been studied for over a decade. Based on previous works, we develop an automatic recognition tool, named EqnEye, which leverages the OpenCV library to perform image processing and Tesseract tool to recognize mathematical symbols. We also apply correction methods before the recognition stage to improve the recognition accuracy. To improve the efficiency for processing images of high resolution, the parallel implementation of thresholding method on GPU is integrated into this work. Experimental results exhibit the success of our correction methods to enhance the accuracy and the slight improvement to the performance. In addition, porting the recognition tool to handy devices can produce more value-added applications. [ABSTRACT FROM AUTHOR]

Many bridges located in seismic hazard regions suffer from serious foundation exposure caused by riverbed scour. Loss of surrounding soil significantly reduces the lateral strength of pile foundations. When the scour depth exceeds a critical level, the strength of the foundation is insufficient to withstand the imposed seismic demand, which induces the potential for unacceptable damage to the piles during an earthquake. This paper presents an analytical approach to assess the earthquake damage potential of bridges with foundation exposure and identify the critical scour depth that causes the seismic performance of a bridge to differ from the original design. The approach employs the well-accepted response spectrum analysis method to determine the maximum seismic response of a bridge. The damage potential of a bridge is assessed by comparing the imposed seismic demand with the strengths of the column and the foundation. The versatility of the analytical approach is illustrated with a numerical example and verified by the nonlinear finite element analysis. The analytical approach is also demonstrated to successfully determine the critical scour depth. Results highlight that relatively shallow scour depths can cause foundation damage during an earthquake, even for bridges designed to provide satisfactory seismic performance. [ABSTRACT FROM AUTHOR]

Superpixel can capture redundancy of the image and reduce the complexity of subsequent processing tasks. These advantages make it receive more and more attentions from researchers at home and abroad. This paper first analyzed the development of the superpixel segmentation, and summarized the state-of-the-art superpixel segmentation algorithms in the view of graph-based and gradient-ascent-based methods. Then, it compared several superpixel segmentation algorithms by experiments, and illustrated their strengths and weaknesses respectively. At last, it introduced the latest applications of superpixel segmentation techniques with prospects. [ABSTRACT FROM AUTHOR]

Recently, single-electron transistors (SETs) have been attracting substantial attention and are considered candidate devices for future integrated circuits due to their ultralow power consumption. To realize SETs, a binary decision diagram-based SET array is proposed as a suitable candidate for implementing Boolean circuits. Then, some works started developing computer-aided design techniques for this new architecture. However, most of them focused on the development of mapping techniques. How to verify the mapping results is still an open problem. Thus, in this paper, we address this problem and develop a satisfiability (SAT)-based verification method. We propose a transformation approach to model the functionality of a mapped SET array as a conjunctive normal form formula. Then, the problem that whether the SET array is functionally equivalent to its specification circuit can be solved with a SAT solver. The experimental results show that the proposed method can successfully verify correct and incorrect SET array implementations with reasonable verification time. [ABSTRACT FROM PUBLISHER]

This paper presents a logic restructuring technique named node addition and removal (NAR). It works by adding a node into a circuit to replace an existing node and then removing the replaced node. Previous node-merging techniques focus on replacing one node with an existing node in a circuit, but fail to replace a node that has no substitute node. To enhance the node-merging techniques on logic restructuring and optimization, we propose an NAR approach in this paper. We first present two sufficient conditions that state the requirements of added nodes for safely replacing a target node. Then, an NAR approach is proposed to quickly detect the added nodes by performing logic implications based on these conditions. We apply the NAR approach to circuit minimization together with two techniques: redundancy removal and mandatory assignment reuse. We also apply it to satisfiability (SAT)-based bounded sequential equivalence checking (BSEC) to reduce the computation complexity of SAT solving. The experimental results show that our approach can enhance our prior automatic test pattern generation-based node-merging approach. Additionally, our approach has a competitive capability of circuit minimization with 44 times speedup compared to a SAT-based node-merging approach. For BSEC, our approach can work together with other optimization technique to save a total of approximately 39-h verification time for all the benchmarks. [ABSTRACT FROM AUTHOR]

Node merging is a popular and effective logic restructuring technique that has recently been applied to minimize logic circuits. However, in the previous satisfiability (SAT)-based methods, the search for node mergers required trial-and-error validity checking of a potentially large set of candidate mergers. Here, we propose a new method, which directly identifies node mergers using logic implications without any SAT solving calls. Although the efficiency benefits of the method come at the expense of quality, we further engage the redundancy removal and the wire replacement techniques to enhance its quality. The experimental results show that the proposed optimization method achieves approximately 46 times the speedup while possessing a competitive capability of circuit minimization compared to the state-of-the-art method. [ABSTRACT FROM PUBLISHER]

Abstract: The influence of process condition on the resistivity of the arsenic-doped polysilicon electrode for the cell capacitors in trench DRAM was investigated. Rather than the arsine flow, it is found that the thickness of the undoped amorphous silicon plays a vital role in determining the overall resistivity. When the total polysilicon thickness is kept unchanged, moderately increasing the thickness of the lower two undoped amorphous silicon would engender a reduced resistivity while moving the arsenic peak location away from the polysilicon/storage dielectric interface, which is critical in leakage current suppression. With these improved properties, less bit line coupling (BLC) loss from the characterization on DRAM product is observed. The result of this study is quite important for trench DRAM manufacturer to enhance product yield before the technology of metal electrode is mature. [Copyright &y& Elsevier]

• We have successfully fabricated the Cu-Zn alloy micropillars by microanode-guided electroplating (MAGE) process. • The effect of bath composition on the micropillar composition and mechanical property was of concern. • Surface morphology, composition, crystal phase, microstructure and property of the micropillars are significantly dominated by the ratio of [Zn2+/[Cu2+ in the bath. • The micropillar was composed of 40.51 at.% Zn, present in nanocrystals by a mixed phases of α and β, displays the most remarkable mechanical property (i.e., hardness at 5.30 GPa; young's modulus at 113.64 GPa). Cu–Zn alloy micropillars were fabricated using microanode-guided electroplating (MAGE) at a constant voltage of 4.6 V under an initial inter-electrode gap of 30 µm in pyrophosphate baths. Energy-dispersive spectroscopy and X-ray diffractometry analysis revealed that the micropillar alloys exhibit an increase in the Zn content from 8.05 at.% (in α phase) to 54.60 at.% (in β, and β' phases) with an increase in the ratio of [Zn2+/[Cu2+ in the bath from 8/1 to 128/1. Transmission electron microscopy revealed that the Cu–Zn alloy micropillars were composed of nano-grains with different sizes depending on the bath employed. Nano-indentation test indicated that the micropillar containing 40.51 at.% Zn (in presence of β-phase) exhibits the maximum hardness (at 5.30 GPa) and highest Young's modulus (at 113.64 GPa). Simulation of the electric field using the commercial software COMSOL 5.2 revealed that the highest field strength centralized at the cylindrical top displayed only a slight increase (from 152.2 to 152.5 kV/m) with an increase in the ratio of [Zn2+/ [Cu2+ in the bath. Potentiodynamic cathodic polarization is useful for understanding the mechanism of microanode-guided electroplating. Electrochemical impedance spectroscopy performed at characteristic potentials confirms the mechanism extremely well. [Display omitted] [ABSTRACT FROM AUTHOR]

Introduction: The impact of immunosuppression on prognosis of carbapenem-resistant organism (CRO) bloodstream infection (BSI) remains unclear. The aim of this study was to clarify the relationship between immunosuppression and mortality of CRO-BSI and to identify the risk factors associated with mortality in immunosuppressed patients. Methods: This retrospective study included 279 patients with CRO-BSI from January 2018 to March 2023. Clinical characteristics and outcomes were compared between the immunosuppressed and immunocompetent patients. The relationship between immunosuppression and 30-day mortality after BSI onset was assessed through logistic-regression analysis, propensity score matching (PSM) and inverse probability of treatment weighting (IPTW). Factors associated with mortality in immunosuppressed patients were analyzed using multivariable logistic regression analysis. Results: A total of 88 immunocompetent and 191 immunosuppressed patients were included, with 30-day all-cause mortality of 58.8%. Although the 30-day mortality in immunosuppressed patients was significantly higher than in immunocompetent patients (46.6% vs. 64.4%, P = 0.007), immunosuppression was not an independent risk factor for mortality in multivariate logistic regression analysis (odds ratio [OR] 3.53, 95% confidence interval [CI] 0.74–18.89; P = 0.123), PSM (OR 1.38, 95% CI 0.60–3.18; P = 0.449,) or IPTW (OR 1.40, 95% CI 0.58–3.36; P = 0.447). For patients with CRO-BSI, regardless of immune status, appropriate antibiotic therapy was associated with decreased 30-day mortality, while Charlson comorbidity index (CCI), intensive care unit (ICU)-acquired infection and thrombocytopenia at CRO-BSI onset were associated with increased mortality. Conclusion: Despite the high mortality rate of CRO-BSI, immunosuppression did not affect the mortality. Appropriate antibiotic therapy is crucial for improving the prognosis of CRO-BSI, regardless of the immune status. [ABSTRACT FROM AUTHOR]

Background: Tissue oxygen saturation (StO2) decrease could appear earlier than lactate alteration. However, the correlation between StO2 and lactate clearance was unknown. Methods: This was a prospective observational study. All consecutive patients with circulatory shock and lactate over 3 mmol/L were included. Based on the rule of nines, a BSA (body surface area) weighted StO2 was calculated from four sites of StO2 (masseter, deltoid, thenar and knee). The formulation was as follows: masseter StO2 × 9% + (deltoid StO2 + thenar StO2) × (18% + 27%)/ 2 + knee StO2 × 46%. Vital signs, blood lactate, arterial and central venous blood gas were measured simultaneously within 48 h of ICU admission. The predictive value of BSA-weighted StO2 on 6-hour lactate clearance > 10% since StO2 initially monitored was assessed. Results: A total of 34 patients were included, of whom 19 (55.9%) had a lactate clearance higher than 10%. The mean SOFA score was lower in cLac ≥ 10% group compared with cLac < 10% group (11 ± 3 vs. 15 ± 4, p = 0.007). Other baseline characteristics were comparable between groups. Compared to non-clearance group, StO2 in deltoid, thenar and knee were significantly higher in clearance group. The area under the receiver operating curves (AUROC) of BSA-weighted StO2 for prediction of lactate clearance (0.92, 95% CI [Confidence Interval] 0.82-1.00) was significantly higher than StO2 of masseter (0.65, 95% CI 0.45–0.84; p < 0.01), deltoid (0.77, 95% CI 0.60–0.94; p = 0.04), thenar (0.72, 95% CI 0.55–0.90; p = 0.01), and similar to knee (0.87, 0.73-1.00; p = 0.40), mean StO2 (0.85, 0.73–0.98; p = 0.09). Additionally, BSA-weighted StO2 model had continuous net reclassification improvement (NRI) over the knee StO2 and mean StO2 model (continuous NRI 48.1% and 90.2%, respectively). The AUROC of BSA-weighted StO2 was 0.91(95% CI 0.75-1.0) adjusted by mean arterial pressure and norepinephrine dose. Conclusions: Our results suggested that BSA-weighted StO2 was a strong predictor of 6-hour lactate clearance in patients with shock. [ABSTRACT FROM AUTHOR]

Reducing the number of AND gates in logic networks benefits the applications in cryptography, security, and quantum computing. This work proposes a don’t-care-based (DC-based) approach to reduce the number of AND gates further in the well-optimized network. Furthermore, this work also proposes an enhanced synthesis flow by integrating our approach with the state-of-the-art. The experimental results show that our approach can further reduce up to 25% of the number of AND gates in the network. For the experiments about the enhanced synthesis flow, we achieve a speedup of almost $10\times $ on average for the cryptography benchmarks while having competitive results as compared to the flow in the state-of-the-art. [ABSTRACT FROM AUTHOR]

Growth-regulating factor (GRF) is a transcription factor unique to plants that plays a crucial role in the growth, development and stress adaptation of plants. However, information on the GRFs related to salt stress in Populus davidiana × P. bolleana is lacking. In this study, we characterized the activity of PdbGRF1 in transgenic Populus davidiana × P. bolleana under salt stress. qRT PCR analyses showed that PdbGRF1 was highly expressed in young leaves and that the pattern of PdbGRF1 expression was significantly changed at most time points under salt stress, which suggests that PdbGRF1 expression may be related to the salt stress response. Moreover, PdbGRF1 overexpression enhanced tolerance to salt stress. A physiological parameter analysis showed that the overexpression of PdbGRF1 significantly decreased the contents of hydrogen peroxide (H 2 O 2) and malondialdehyde (MDA) and increased the activities of antioxidant enzymes (SOD and POD) and the proline content. A molecular analysis showed that PdbGRF1 regulated the expression of PdbPOD17 and PdbAKT1 by binding to the DRE ('A/GCCGAC') in their respective promoters. Together, our results demonstrate that the binding of PdbGRF1 to DRE regulates genes related to stress tolerance and activates the associated physiological pathways, and these effects increase the ROS scavenging ability, reduce the degree of damage to the plasma membrane and ultimately enhance the salt stress response in Populus davidiana × P. bolleana. • PdbGRF1 acts as a transcriptional activator to enhance salt stress tolerance by regulating PdbPOD17 and PdbAKT1. [ABSTRACT FROM AUTHOR]

For modal testing, active vibration control, or structural health monitoring, determination of sensing locations becomes a crucial issue once the interesting mode has nodal lines on which the sensors are bonded. Theoretically, only nodal points but not nodal lines would exist along free edges of the structures. Thus, measurements of vibrations along free edges of structures would maximize the number of detecting (i.e., for monitoring application) or observing (i.e., for active control application) modes. However, conventional sensors such as strain gauges or accelerometers can only be bonded on flat or smooth surfaces. In this work, fiber Bragg gratings, which possess linear geometric shape, are employed to investigate the feasibility of detecting more vibration modes along free edges of structures. A traction-free aluminum solid with symmetric geometry subjected to various impact loadings is considered. To verify the capability of the free-edge bonded FBG sensors for detecting vibration modes from impact-induced responses, relationships between sensing locations, impact locations, and intensities of modes, are discussed with the aid of mode shapes obtained by the finite element me\thod. Within frequencies up to 30 kHz, 14 out-of-plane dominated and 25 in-plane dominated modes in frequency domain are examined. Multiple modes, that is, repeated roots, two or more modes with identical frequencies due to symmetric geometry, are also analyzed. Our experimental results show that placing the FBGs along free edges of structures to acquire and analyze more vibration modes is feasible. Copyright © 2016 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

In this work, the feasibility of liquid level detection based on structural vibration modes is investigated. We specifically consider impact-induced vibration modes of an aluminum solid partially immersed in a water tank. A free-edge bonded fiber Bragg grating (FBG) sensor and a corresponding high-speed FBG filter-based demodulation system are employed to measure the transient impact responses. To perform more accurate in vacuo finite element analysis (i.e., for the mode shapes, resonant frequencies, and the impact responses), elastic constants of the aluminum solid and impact loading history of a steel ball are obtained beforehand respectively according to the elastic wave theory and with a polyvinylidene fluoride (PVDF)-based technique. Our experimental results show good correspondences of intensities and shifts of the impact-induced resonant modes with liquid levels. The modes of the same type (e.g., double modes in out-of-plane or in-plane dominated modes) are shown to possess similar behaviors in relationships between shifts of the resonant modes and the liquid level. This work also provides related experimental evidence for future researchers interesting in simulation of complicated fluid-structure interaction (FSI) problems for three-dimensional structures. [ABSTRACT FROM AUTHOR]

Threshold logic has been attracting great attention from researchers due to the rapid development in nanotechnology-based devices. In the state-of-the-art approach to the threshold logic network (TLN) synthesis using don’t cares, we observed that not all the computed don’t cares contribute to the cost minimization of threshold logic gate (TLG). Therefore, in this work, we focus on computing the don’t cares that effectively provide the opportunities for cost minimization. Furthermore, De Morgan’s law for TLGs is applied such that global TLN optimization considering the cost and the number of inverters can be achieved. The experimental results show that the proposed approach is capable of obtaining efficiently a smaller cost and fewer inverters for a set of TLN benchmarks. [ABSTRACT FROM AUTHOR]

Quantum-dot cellular automata (QCA) is considered as a promising emerging technology due to its low power dissipation and high device density. Since the majority function is the main operation in QCA circuits, minimizing the number of majority gates in QCA circuits is crucial to the corresponding QCA circuit minimization. A previous work used the node-merging technique to replace one target node with an existing substitute node in majority circuits for optimization. However, this technique may fail when no substitute nodes exist for a target node. In this article, we propose an enhanced optimization technique for majority circuits by adding a new node into the circuits and removing the target node and its fanin nodes. The experimental results show that this technique improves the results of the node-merging technique on a set of EPFL logic synthesis benchmarks. Additionally, this enhanced technique can work together with other optimization techniques. The circuit size reduction in the integrated approach reaches 1.26 times as compared to the results using the node-merging technique. [ABSTRACT FROM AUTHOR]

LOOPLock is the state-of-the-art cyclic logic locking method in hardware security. LOOPLock is able to invalidate SAT Attack, Removal Attack, and CycSAT simultaneously by introducing two types of cycle pairs in a circuit. In this work, we analyze LOOPLock’s locking mechanism and propose an attacking approach based on locking structure analysis. Furthermore, to defend the new attack, we propose LOOPLock 2.0, which strengthens the original cyclic logic locking method—LOOPLock. Experimental results show the efficiency and effectiveness of the proposed attacking approach to LOOPLock and the high defense capability of LOOPLock 2.0. [ABSTRACT FROM AUTHOR]

Abstract: As the first step of DRAM manufacture, preanneal process plays an important role in determining the threshold voltage variation. It is found that the higher trans-1,2-dichloroethene flow in pad oxide growth and the higher nitrogen flow in high-temperature annealing step would respectively engender a lower boron segregation coefficient and higher nitridation of the oxide, both modify the boron distribution in the substrate and consequently the behavior of the threshold voltage. As the feature size of DRAM devices enter nanometer regime, besides gate oxidation, ion implantation and related thermal processes, the impact of preanneal process condition should be prudentially taken into consideration for rigorous control of the threshold voltage in the advanced DRAM production. [Copyright &y& Elsevier]

This article proposes a new necessary condition and the corresponding speedup strategies to the threshold function (TF) identification problem. The state-of-the-art to this identification problem could be very time-consuming when the function-under-identification is a non-TF with the unateness property. The proposed new necessary condition can be seamlessly integrated into this identification algorithm. As compared with the state-of-the-art, the improved identification algorithm with the proposed necessary condition can more effectively and efficiently detect non-TFs. Furthermore, according to the experimental results, the ratio of CPU time overhead in the process of checking the proposed necessary condition for identifying all the 8-input TF is only 0.1%. [ABSTRACT FROM AUTHOR]

Objective: The etiologies of acute respiratory failure in patients with systemic rheumatic diseases (SRDs) requiring intensive care remain unknown. This study was undertaken to investigate the etiologies and outcomes. Methods: A medical records review study was performed of 259 adult SRDs patients with respiratory failure admitted to medical ICU across a 5-year period. The etiologies were classified as infection, SRD exacerbation, and undetermined. The factors associated with ICU mortality were identified with multivariate logistic regression analysis. Results: The etiologies of respiratory failure included infection (n = 209, 80.7%), SRD exacerbation (n = 71, 27.4%), and undetermined (n = 21, 8.1%). The most common pathogen was Pneumocystis jirovecii (39.8%), followed by Aspergillus spp. (33.2%), and cytomegalovirus (23.2%). The ICU mortality rate was 59.8%. A high acute physiology and chronic health evaluation II score (OR 1.118, 95% CI 1.054 to 1.186, p < 0.001), a PaO2/FiO2 ratio < 100 mmHg (OR 3.918, 95% CI 2.199 to 6.892, p < 0.001), and a diagnosis of dermatomyositis/polymyositis (OR 4.898, 95% CI 1.949 to 12.309, p = 0.001), vasculitis (OR 3.007, 95% CI 1.237 to 7.309, p = 0.015), and Pneumocystis pneumonia (OR 2.345, 95% CI 1.168 to 4.705, p = 0.016) were associated with increased mortality. Conclusions: Opportunistic infections and SRD exacerbation were the most common etiologies of acute respiratory failure in patients with SRDs requiring ICU admission, with high ICU mortality. Development of a standard protocol for differential diagnosis in this population might help initiate definitive therapy and improve clinical outcome. Key Points • Infections, especially with opportunistic infections, were the leading cause of acute respiratory failure in critically ill rheumatology patients, with high mortality. • Severity of illness, certain types of rheumatic diseases, and opportunistic fungal infections were associated with increased mortality. • Using a comprehensive diagnostic workup might help to confirm the infective etiology and improve outcome. [ABSTRACT FROM AUTHOR]

SAT Attack, CycSAT, and Removal Attack have demonstrated their abilities to break most existing logic locking methods. In this article, we propose a new cyclic logic locking method to invalidate these attacks simultaneously. Our main intention is to create noncombinational cycles to lock a circuit. Specifically, the noncombinational behavior in the noncombinational cycles that is unobservable at the primary outputs (POs) needs to be preserved when the correct key-vector is fed to resist CycSAT, and the noncombinational behavior in the noncombinational cycles affecting POs needs to be preserved when the incorrect key-vector is fed to invalidate SAT Attack. Furthermore, some nodes will be removed when applying our locking method, which is able to defend Removal Attack. The experimental results show the effectiveness and low area overhead of the proposed method. [ABSTRACT FROM AUTHOR]

The identification of threshold function (TF), which determines whether a Boolean function can be represented by an linear threshold logic gate (LTG) or not, is a fundamental but important task in the theories of threshold logic. In this paper, we propose a more efficient and effective algorithm of TF identification by constructing the system of irredundant inequalities and adjusting the weight assignment comprehensively. This is the first non-ILP-based approach that is able to identify all the eight-input TFs. The experimental results demonstrated that the proposed approach is more effective than all the existing non-ILP-based approaches and the LTGs obtained by the proposed approach are optimal for near 100% cases. For TFs with 9–15 inputs, the proposed approach can identify 100 000 randomly generated TFs as well in a reasonable CPU time. [ABSTRACT FROM AUTHOR]

Purpose: A population-level description and analysis of sepsis-related mortality in China is key to the planning and assessment of interventional strategies.Methods: Retrospective analysis of multiple cause of death (MCOD) recorded in the population-based national mortality surveillance system (NMSS) of China. All sepsis-related deaths occurring in 605 disease surveillance points (DSPs) covering 323.8 million population across China were included in our study. Age-standardized mortality and national estimate of sepsis-related deaths were estimated using the census population in 2010 and 2015, respectively.Results: In 2015, a total of 1,937,299 deaths occurring in any of the 605 DSPs and standardized sepsis-related mortality rate was 66.7 (95% confidence interval [CI] 66.4-67.0) deaths per 100,000 population. This produced a national estimate of 1,025,997 sepsis-related deaths. Sepsis-related mortality rates exhibited significant geographic variation. In multilevel analysis, male sex (rate ratio [RR] 1.582, 95% CI 1.570-1.595), increasing age (RR 1.914 for 5-year group, 95% CI 1.910-1.917), and presence of comorbidity (RR 2.316, 95% CI 2.298-2.335) were independently associated with increased sepsis-related mortality. Higher disposable income (RR 0.717 for the fourth interquartile range vs. the first interquartile range, 95% CI 0.515-0.978) and mean years of education (RR 0.808 for the fourth interquartile range vs. the first interquartile range, 95% CI 0.684-0.955) were negatively associated with sepsis-related mortality. However, population-based hospital doctors were not significantly associated with sepsis-related mortality.Conclusions: The standardized sepsis-related mortality rate in China was high and varied according to socioeconomic indices, even though some uncertainty remained. [ABSTRACT FROM AUTHOR]

Background: Serum procalcitonin (PCT) concentration is used to guide antibiotic decisions in choice, timing, and duration of anti-infection therapy to avoid antibiotic overuse. Thus, we performed a systematic review and meta-analysis to seek evidence of different PCT-guided antimicrobial strategies for critically ill patients in terms of predefined clinical outcomes. Methods: We searched for relevant studies in PubMed, Embase, Web of Knowledge, and the Cochrane Library up to 25 February 2017. Randomized controlled trials (RCTs) were included if they reported data on any of the predefined outcomes in adult ICU patients managed with a PCT-guided algorithm or according to standard care. Results were expressed as risk ratio (RR) or mean difference (MD) with accompanying 95% confidence interval (CI). Data synthesis: We included 13 trials enrolling 5136 patients. These studies used PCT in three clinical strategies: initiation, discontinuation, or combination of antibiotic initiation and discontinuation strategies. Pooled analysis showed a PCT-guided antibiotic discontinuation strategy had fewer total days with antibiotics (MD − 1.66 days; 95% CI − 2.36 to − 0.96 days), longer antibiotic-free days (MD 2.26 days; 95% CI 1.40-3.12 days), and lower short-term mortality (RR 0.87; 95% CI 0.76-0.98), without adversely affecting other outcomes. Only few studies reported data on other PCT-guided strategies for antibiotic therapies, and the pooled results showed no benefit in the predefined outcomes. Conclusions: Our meta-analysis produced evidence that among all the PCT-based strategies, only using PCT for antibiotic discontinuation can reduce both antibiotic exposure and short-term mortality in a critical care setting. [ABSTRACT FROM AUTHOR]

Traditionally, we expect that circuit designs can be executed without errors. However, for error resilient applications such as image processing, 100% correctness is not necessary. By pursuing less than 100% correctness, power consumption can be significantly reduced. Recently, probabilistic CMOS and probabilistic Boolean circuits (PBCs) have been proposed to deal with power consumption issue. However, to the best of our knowledge, no correctness analysis and power optimization algorithms have been proposed for PBCs. Thus, in this paper, we first propose a statistical approach for evaluating the correctness of PBCs. Then, we propose strategies for power optimization of PBCs. Finally, we integrate these strategies with the correctness analysis as a power optimization algorithm for PBCs. The experimental results show that the proposed correctness analysis method is highly efficient and accurate, and that the power optimization algorithm saves 36% of total power-delay-product on average under a correctness constraint of 90% on a set of International Workshop on Logic and Synthesis (IWLS) 2005 benchmarks. [ABSTRACT FROM PUBLISHER]

Background: Pneumocystis jiroveci pneumonia (PJP) in non-HIV patients is still a challenge for intensivists. The aim of our study was to evaluate mortality predictors of PJP patients requiring Intensive care unit (ICU) admission.Methods: Retrospectively review medical records of patients with diagnosis of PJP admitted to four ICUs of two academic medical centers from October 2012 to October 2015.Results: Eighty-two patients were enrolled in the study. Overall hospital mortality was 75.6 %. Compared with survivors, the non-survivors had older age (55 ± 16 vs. 45 ± 17, p = 0.014), higher APACHE II score (20 ± 5 vs. 17 ± 5, p = 0.01), lower white blood cell count (7.68 ± 3.44 vs. 10.48 ± 4.62, p = 0.005), less fever (80.6%vs. 100 %, p = 0.033), more hypotension (58.1 % vs. 20 %, p = 0.003), more pneumomediastinum (29 % vs. 5 %, p = 0.027). Logistic regression analysis demonstrated that age [odds ratio (OR)1.051; 95 % CI 1.007-1.097; p = 0.022], white blood cell count [OR 0.802; 95 % CI 0.670-0.960; p = 0.016], and pneumomediastinum [OR 16.514; 95 % CI 1.330-205.027; p = 0.029] were independently associated with hospital mortality.Conclusions: Mortality rate for non-HIV PJP patients requiring ICU admission was still high. Poor prognostic factors included age, white blood cell count and pneumomediastinum. [ABSTRACT FROM AUTHOR]