Search

Objectives. The purpose of this study was to explore the association of serum lipocalin-2 concentrations with psoriasis and psoriatic arthritis (PsA). Methods. A systematic search of studies on the association of serum lipocalin-2 concentrations with psoriasis/PsA was conducted in PubMed, Web of Science, Elsevier ScienceDirect, and Cochrane Library. Eventually, 8 eligible studies were included. The strength of association between serum lipocalin-2 concentrations and psoriasis/PsA was assessed by pooled standard mean difference (SMD) with its 95% confidence intervals (CIs). Results. A total of 8 case-control studies, consisting of 349 psoriasis/PsA patients and 258 controls, were included in the meta-analysis. This meta-analysis showed significant association between serum lipocalin-2 concentrations and psoriasis/PsA in overall population (SMD: 0.757, 95%CI=0.588‐0.926, and PH=0.114; PH is the P value for the heterogeneity test). Similar results were found in subgroup analysis by ethnicity. Conclusions. Serum lipocalin-2 concentrations are higher in psoriasis/PsA patients than controls. However, more large-scale studies are warranted to explore the association between serum lipocalin-2 and the pathogenetic mechanisms of psoriasis/PsA. [ABSTRACT FROM AUTHOR]

Objectives. The purpose of this study was to explore the association between rs2292239 polymorphism in ERBB3 gene and type 1 diabetes (T1D). Methods. A systematic search of studies on the association of rs2292239 polymorphism in ERBB3 gene with T1D susceptibility was conducted in PubMed, Web of science, Elsevier Science Direct, and Cochrane Library. Eventually, 9 published studies were included. The strength of association between rs2292239 polymorphism and T1D susceptibility was assessed by odds ratios (ORs) with its 95% confidence intervals (CIs). Results. A total of 9 case-control studies, consisting of 5369 T1D patients and 6920 controls, were included in the meta-analysis. This meta-analysis showed significant association between ERBB3 rs2292239 polymorphism and T1D susceptibility in overall population (A vs. C, OR: 1.292, 95% CI= 1.224-1.364, PH=0.450, PH is P value for the heterogeneity test). Similar results were found in subgroup analysis by ethnicity. Conclusions. ERBB3 rs2292239 polymorphism is associated with T1D susceptibility and rs2292239-A allele is a risk factor for T1D. However, more large-scale studies are warranted to replicate our findings. [ABSTRACT FROM AUTHOR]

Objectives. The purpose of this study was to explore the association of miRNA-146 and miRNA-499 polymorphisms with inflammatory arthritis. Methods. A systematic search of studies on the association of miRNA-146 and miRNA-499 polymorphisms with inflammatory arthritis susceptibility was conducted in PubMed, Web of science, Elsevier ScienceDirect, and Cochrane Library. Eventually, 18 published studies were included. The strength of association between miRNA-146/499 polymorphisms and inflammatory arthritis susceptibility was assessed by odds ratios (ORs) with its 95% confidence intervals (CIs). Results. A total of 18 case-control studies, consisting of 3385 inflammatory arthritis patients and 4584 controls, were included in the meta-analysis. This meta-analysis showed significant association between miRNA-499 rs3746444 polymorphism and inflammatory arthritis susceptibility in overall population (C vs T, OR: 1.422, 95% CI= 1.159-1.745, P=0.001). Similar results were found in subgroup analysis by region. But we did not find association between miRNA-146 rs2910164 polymorphism and inflammatory arthritis susceptibility in overall population (C vs T, OR: 1.061, 95% CI= 0.933-1.207, P=0.365). Conclusions. The present study indicates that miRNA-499 rs3746444 polymorphism is associated with inflammatory arthritis susceptibility. However, there is lack of association between miRNA-146 rs2910164 polymorphism and inflammatory arthritis susceptibility. But, we also find miRNA-146 rs2910164 and miRNA-499 rs3746444 polymorphism are associated with inflammatory arthritis in Middle East. Therefore, more large-scale studies are warranted to replicate our findings. [ABSTRACT FROM AUTHOR]

Red-bed mudstone is widely distributed throughout the Three Gorges Reservoir Area, China. This geological material easily disintegrates into fragments during engineering activities. The potential factors that influence the disintegration (grain composition, slake durability index, grain roundness, fractal dimension, and surface energy) and shear strength (cohesion and friction angle) of red-bed mudstone fragments are investigated via cyclic wetting and drying tests and direct shear tests. The results show that the disintegration process includes three stages and that the grains gradually become well graded. The roundness exhibits a linear relationship with the number of cycles. However, the variations in the slake durability index, fractal dimension (mass-size distribution based), surface energy, cohesion, and friction angle show three distinct stages. In addition, the fractal dimension (quantity-size distribution based) and friction angle are significantly affected by the assumption that the specimens are isotropic, and the grain behaviors involve compaction, rotation, and separation. The cohesion and friction angle display linear relationships with the slake durability index, roundness, fractal dimension (mass-size distribution based), and surface energy, indicating the potential to assess the shear strength of mudstone fragments from the aspect of disintegration. [ABSTRACT FROM AUTHOR]

Fluctuant marine and reservoir water levels are the main failure-inducing factors for embankment slopes. The soft embankment rocks, e.g., red-bed mudstone, eroded by the reservoir water level in the Three Gorges Reservoir area greatly influence the stability of the embankment slopes. In this study, unified strength theory was innovatively applied for damage evaluation and combined with the Weibull distribution to obtain the strength statistics of micro units. Additionally, one damage constitutive model and one damage evolution model considering the initial damage, strain softening and damage weakening were proposed. Then, a series of tests, e.g., modified cyclic wetting and drying test, triaxial compression test and modified numerical simulation test for reservoir embankment red-bed mudstone, were conducted to verify the feasibility of the proposed models. In addition, grey system theory was originally used to evaluate the effects of the Weibull distribution parameters (m and w) and the confining stress on the peak stress. Finally, the proposed model was tentatively applied to the modification of the limit failure height model of the bedded rock slopes. The verification implies that the proposed model results are consistent with the testing results, especially in the simulation of compaction, elastic deformation and strain softening and in the prediction of peak strength. The results from grey system theory analysis indicate that the micro unit strength parameter (w) has the most obvious effect on the strength. Moreover, the modified method based on the damage evolution model for calculating the limit failure height of the bedded rock slopes is conservative. [ABSTRACT FROM AUTHOR]

The slake durability; grain quantity, size, roundness, and slake degree of red-bed mudstones are experimentally investigated using the slake durability test and the cyclic wetting and drying test. Results indicate that the complete slaking process exhibits three distinct stages. During the process, the slake durability index decreases linearly with increasing cycle number. Slight variation in grain quantity is observed. Smaller grain size fractions tend to have higher slaking degree indexes in earlier cycles. Grain roundness fluctuates. Two parameters, namely, fractal dimension and surface energy, are revealed to have the ability to represent the degree of slaking of red-bed mudstones. [ABSTRACT FROM AUTHOR]

In recent years, numerous landslide catastrophes have occurred, generating considerable financial losses and other tolls. The deformational and mechanical properties of sliding zone soil would be in primary significance to landslide research, as the sliding zone basically controls the initiation and mobility of the landslide. An in situ triaxial test was carried out on a sample from the sliding zone of the Huangtupo 1# landslide, a subdivision of the Huangtupo landslide in the Three Gorges area of China. The test results indicate that (a) the sliding zone exhibits low compressibility due to the high rock content (54.3%) and long-time consolidation by the overlying soil mass; (b) only decaying creep occurs without abrupt failure, and a constitutive equation with both linear and nonlinear viscoplastic terms is deduced to accurately fit the test data; (c) the surface with an orientation of 35° presents anisotropic traits in terms of displacement, possibly due to cracks that formed at similar orientations within the sample cube; and (d) the creep behavior of the landslide may be closely related to the properties of the sliding zone soil. When a similar stress magnitude to that of the in situ stress environment is applied to the sample, the sliding zone soil behavior matches the landslide deformative behavior. The test results indicate that the Huangtupo 1# landslide will continue to creep, as interpreted from the deformation traits and structural properties of the sample. However, unavoidable limitations of the test and extreme external factors, namely unexpected rainfall and water fluctuation, cannot be ignored. [ABSTRACT FROM AUTHOR]