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23 results on '"Wang, Duocai"'

20. Experimental Study of the Shear Characteristics of Fault Filled with Different Types of Gouge in Underground Gas Storage.

Author

Ding, Guosheng, Liu, Hejuan, Xia, Debin, Wang, Duocai, Huang, Famu, Guo, Haitao, Xie, Lihuan, Guo, Yintong, Wu, Mingyang, and Mao, Haijun

Subjects
UNDERGROUND storage, GAS storage, NATURAL gas, FAULT gouge, NATURAL gas storage, GAS reservoirs
Abstract

In the current international situation, energy storage is an important means for countries to stabilize their energy supply, of which underground storage of natural gas is an important part. Depleted gas reservoir type underground gas storage (UGS) has become the key type of gas storage to be built by virtue of safety and environmental protection and low cost. The multi-cycle high injection and production rate of natural gas in the depleted gas reservoir type UGS will cause the in-situ stress disturbance. The slip risk of fault in the geological system increases greatly compared with that before the construction of the storage engineering, which becomes a great threat to the sealing of the gas storage. Reasonable injection and production strategy depend on the reliable assessment of the shear behavior of the fault belt, which can guarantee the sealing characteristics of the UGS geological system and the efficient operation of the UGS. Therefore, the shear behavior of the fault is studied by carrying out experiments, which can provide important parameters for the evaluation of fault stability. However, there is a large gap between the rock samples used in the previous experimental study and the natural faults, and it is difficult to reflect the shear failure characteristics of natural faults. In this paper, similar fault models based on high-precision three-dimensional scanners and engraving machines, filled with three types of fault gouge, are prepared for a batch of representative direct shear tests. The results show that the peak shear strength of the fault rocks with a shear surface is higher than that of the fault rocks with a tensile surface. Compared with the clay mineral content, the roughness of the fault surface is much more significant for the shear strength of the fault rock. For the fault rocks with similar fault surface morphology, the higher the clay content in the fault gouge, the greater the shear strength of the fault rocks. For the fault rocks with different fault surface morphology and the same fault gouge, the cohesion and internal friction angle of the tensile type is generally smaller than that of the shear type. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Double heterozygous pathogenic mutations in KIF3Cand ZNF513cause hereditary gingival fibromatosis

Author

Chen, Jianfan, Xu, Xueqing, Chen, Song, Lu, Ting, Zheng, Yingchun, Gan, Zhongzhi, Shen, Zongrui, Ma, Shunfei, Wang, Duocai, Su, Leyi, He, Fei, Shang, Xuan, Xu, Huiyong, Chen, Dong, Zhang, Leitao, and Xiong, Fu

Abstract

Hereditary gingival fibromatosis (HGF) is a rare inherited condition with fibromatoid hyperplasia of the gingival tissue that exhibits great genetic heterogeneity. Five distinct loci related to non-syndromic HGF have been identified; however, only two disease-causing genes, SOS1and REST, inducing HGF have been identified at two loci, GINGF1 and GINGF5, respectively. Here, based on a family pedigree with 26 members, including nine patients with HGF, we identified double heterozygous pathogenic mutations in the ZNF513(c.C748T, p.R250W) and KIF3C(c.G1229A, p.R410H) genes within the GINGF3 locus related to HGF. Functional studies demonstrated that the ZNF513p.R250W and KIF3Cp.R410H variants significantly increased the expression of ZNF513and KIF3Cin vitro and in vivo. ZNF513, a transcription factor, binds to KIF3Cexon 1 and participates in the positive regulation of KIF3Cexpression in gingival fibroblasts. Furthermore, a knock-in mouse model confirmed that heterozygous or homozygous mutations within Zfp513(p.R250W) or Kif3c(p.R412H) alone do not led to clear phenotypes with gingival fibromatosis, whereas the double mutations led to gingival hyperplasia phenotypes. In addition, we found that ZNF513 binds to the SOS1promoter and plays an important positive role in regulating the expression of SOS1. Moreover, the KIF3Cp.R410H mutation could activate the PI3K and KCNQ1 potassium channels. ZNF513 combined with KIF3C regulates gingival fibroblast proliferation, migration, and fibrosis response via the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK pathways. In summary, these results demonstrate ZNF513+ KIF3Cas an important genetic combination in HGF manifestation and suggest that ZNF513mutation may be a major risk factor for HGF.

Published
2023
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