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412 results on '"Wang, Fajun"'

20. Role of Cerebellum in Gaze-Holding Disorders

Author

Fotedar, Neel, Wang, Fajun, Shaikh, Aasef G., Schmahmann, Jeremy D., Section editor, Manto, Mario U., Section editor, Manto, Mario U., editor, Gruol, Donna L., editor, Schmahmann, Jeremy D., editor, Koibuchi, Noriyuki, editor, and Sillitoe, Roy V., editor

Published
2022
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35. Phenobarbital as Anticonvulsant Prophylaxis in Patients With Traumatic Brain Injury at Risk for Alcohol Withdrawal Syndrome.

Author

McGinnis, Cory B., Wang, Fajun, Chiappelli, Abby L., Okonkwo, David O., and Darby, Joseph M.

Subjects
*RISK assessment, *DRUG overdose, *PHARMACEUTICAL arithmetic, *DRUG side effects, *PHENOBARBITAL, *DESCRIPTIVE statistics, *PRE-exposure prophylaxis, *TRACHEA intubation, *INTRAVENOUS therapy, *ALCOHOL withdrawal syndrome, *TRAUMATIC epilepsy, *DRUG efficacy, *BRAIN injuries, *ANTICONVULSANTS, *ANESTHESIA, *EVALUATION, *PHARMACODYNAMICS, *DISEASE risk factors, *DISEASE complications
Abstract

Background: Anticonvulsant prophylaxis (ACP) for early post-traumatic seizures (PTS) is recommended in patients with traumatic brain injury (TBI). Phenobarbital (PB) may be used to prevent alcohol withdrawal syndrome (AWS) in at-risk patients. The dual-purpose use of PB in the TBI population would allow for consolidation of pharmacotherapy. Objective: The primary objective of this study was to determine the frequency of early PTS in TBI patients at risk of AWS treated with PB as ACP. Secondary objectives included determining rates of over sedation and endotracheal intubation. Methods: Patients received an intravenous (IV) loading dose of PB at 15-20 mg/kg followed by 1 mg/kg every 12 hours for 7 days with a goal level of 15-20 mcg/mL. Medication data, seizure frequency, and episodes of over sedation and endotracheal intubation were collected. Results: Eighty patients were treated with PB over a 1-year period. Thirty-nine patients were analyzed. Median loading dose was 19.9 (Interquartile Range 19.1-20.0) mg/kg with a median post load level of 21.7 mcg/mL (IQR 18.3-25.8) mcg/mL. One patient (2.6%) had electrographic evidence for early PTS. PB was discontinued in 4 (10.3%) patients out of concern for over sedation. One patient required endotracheal intubation after rapid PB loading. Conclusion: The frequency of early PTS was low when PB was used as primary ACP in patients with TBI at risk for AWS. Over sedation is a potential adverse effect that should be considered in the choice of ACP. No conclusions can be drawn as to the effectiveness of PB in preventing AWS. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Durable Self-Cleaning Radiative Cooling Coatings for Building Energy Efficiency

Author

Ju, Huiquan, Long, Haibin, Yang, Shasha, Wang, Fajun, Fang, Xinzuo, Fan, Wangxi, Li, Changquan, Ou, Junfei, and Li, Wen

Abstract

Passive daytime radiative cooling (PDRC) is an energy-saving technology without an additional energy supply or environmental pollution. At present, most PDRC coatings for buildings are only aiming at high solar reflectivity (RS) and high mid-infrared emissivity (EMIR) while ignoring practicalities such as adhesion strength, scalability, and durability. In this work, modified calcined kaolin/(ethylene trifluorochloroethylene copolymer-polydimethylsiloxane) (MK/(FEVE–PDMS)) coating with super practicability is prepared by using MK as a filler, FEVE as an adhesive, and PDMS as a hydrophobic modifier. The RSand EMIRof the coating are 92.5 and 94.6%, respectively. The MK/(FEVE–PDMS) coating exhibits superhydrophobicity, with an advancing contact angle (ACA) of 160.2° and a hysteresis contact angle of 7.3°. At an average solar irradiance of 742.78 W m–2, the coating achieved a temperature drop of 13.12 °C (shielded with PE film) and 3.09 °C (without shielding), respectively, relative to the environment. The coating adheres firmly to the substrate with an adhesion strength of class 2. The superhydrophobicity of the coating provides excellent durability and ease of repair, which can resist UV aging and mechanical damage. The durable superhydrophobicity gives the coating long-term stability in PDRC performance. Additionally, the cheap raw materials and the preparation process, consistent with the production of existing paints, show excellent scalability. Moreover, the energy consumption simulation results show that the energy saving ratio of the coating is more than 10% in the densely populated Yangtze River Delta and Pearl River Delta. The durable self-cleaning radiative coating developed in this work has potential application prospects in areas where the demand for cooling in summer is large and the demand for heating in winter is small.

Published
2024
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