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Simple Summary: Mycoplasma capricolum subsp. capricolum (Mcc) is an important pathogen associated with diseases in goats, hindering the development of the livestock industry. We previously isolated the HN-B strain of Mcc from goats on Hainan Island, China. The genomic and biological characteristics of this strain were investigated. In this study, we infected mice and RAW264.7 cells with Mcc HN-B to explore its pathogenic mechanism in the host. Differentially expressed genes related to immune terms and pathways were identified using bioinformatic analyses. The expression of two inflammatory proteins, S100A8 and S100A9, was up-regulated in mouse lungs post Mcc HN-B infection. This study preliminarily elucidates the pathogenesis of Mcc in mice and paves the way for further research in goats. Mycoplasma capricolum subsp. capricolum (Mcc), a member of the Mycoplasma mycoides cluster, has a negative impact on the goat-breeding industry. However, little is known about the pathogenic mechanism of Mcc. This study infected mice using a previously isolated strain, Mcc HN-B. Hematoxylin and eosin staining, RNA sequencing, bioinformatic analyses, RT-qPCR, and immunohistochemistry were performed on mouse lung tissues. The results showed that 235 differentially expressed genes (DEGs) were identified. GO and KEGG enrichment analyses suggested that the DEGs were mainly associated with immune response, defensive response to bacteria, NF-kappa B signaling pathway, natural killer cell-mediated cytotoxicity, and T cell receptor signaling pathway. RT-qPCR verified the expression of Ccl5, Cd4, Cd28, Il2rb, Lck, Lat, Ptgs2, S100a8, S100a9, and Il-33. The up-regulation of S100A8 and S100A9 at the protein level was confirmed by immunohistochemistry. Moreover, RT-qPCR assays on Mcc HN-B-infected RAW264.7 cells also showed that the expression of S100a8 and S100a9 was elevated. S100A8 and S100A9 not only have diagnostic value in Mcc infection but also hold great significance in clarifying the pathogenic mechanism of Mcc. This study preliminarily elucidates the mechanism of Mcc HN-B-induced lung injury and provides a theoretical basis for further research on Mcc–host interactions. [ABSTRACT FROM AUTHOR]

With the development of digital technology and the continuous expansion of digital economy, digital industry is playing an important role in the development of traditional manufacturing industry. As an important field of modern industry, especially light industry, chemical fiber manufacturing industry has made a great contribution to the economic growth of people’s livelihood in China. Through in-depth research and analysis of the innovation path of digital technology to promote the development of chemical fiber industry, this paper found that: The 1% growth of digital technology will drive the growth of chemical fiber industry by 0.58%, this driving effect promotes the efficiency of process innovation, product innovation, marketing efficiency and management efficiency of the chemical industry, digital technology will enable the chemical fiber industry to break through the limitations of the traditional development mode in all links of the industrial chain and form a strong driving force for its sustainable development. Therefore, accelerating the in-depth integration of digital technology and chemical fiber industry is the key path for China’s chemical fiber industry to resolve the current challenges in terms of price and supply chain relations and to achieve high-quality development.

In the context of the current technological revolution and unprecedented major changes, countries are facing the situation of accelerating the development of key core technologies, which is caused by the transformation from the dispute over trade to the dispute over ecology and scientific and technological strength. Competitive situation analysis is an important link of key core technology innovation. The construction of a universal model of international competitive situation analysis of key core technology can provide scientific support for decision makers of science and technology innovation to solve technical difficulties. This study takes the new generation of information technology industry as an example, identifies key core technologies of the industry and evaluates the competitive situation of the major world countries. Studies indicate that in the field of new generation information technology, the US and Japan is in the leading position globally. In addition, China has active innovation activities in all fields, but overall there remains a considerable gap with the world-leading level, and its R&D quality needs to be further improved. [ABSTRACT FROM AUTHOR]

The immune-excluded tumors (IETs) show limited response to current immunotherapy due to intrinsic and adaptive immune resistance. In this study, it is identified that inhibition of transforming growth factor-β (TGF-β) receptor 1 can relieve tumor fibrosis, thus facilitating the recruitment of tumor-infiltrating T lymphocytes. Subsequently, a nanovesicle is constructed for tumor-specific co-delivery of a TGF-β inhibitor (LY2157299, LY) and the photosensitizer pyropheophorbide a (PPa). The LY-loaded nanovesicles suppress tumor fibrosis to promote intratumoral infiltration of T lymphocytes. Furthermore, PPa chelated with gadolinium ion is capable of fluorescence, photoacoustic and magnetic resonance triple-modal imaging-guided photodynamic therapy, to induce immunogenic death of tumor cells and elicit antitumor immunity in preclinical cancer models in female mice. These nanovesicles are further armored with a lipophilic prodrug of the bromodomain-containing protein 4 inhibitor (i.e., JQ1) to abolish programmed death ligand 1 expression of tumor cells and overcome adaptive immune resistance. This study may pave the way for nanomedicine-based immunotherapy of the IETs. Targeting the TGF-β signaling pathway has been exploited to relieve immunosuppression in the tumor microenvironment. Here the authors describe the design of a nanoplatform integrating the TGF-β receptor 1 inhibitor LY2157299 and the ROS-responsive JQ1 pro-drug, promoting anti-tumor immune responses in preclinical cancer models. [ABSTRACT FROM AUTHOR]