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146 results on '"Wang, Fu‐Yu"'

6. Early identification of delayed wound healing in complex diabetic foot ulcers treated with a dermal regeneration template: A novel clinical target and its risk factors

Author

Tai, Ting-Yu, primary, Lin, Kuan-Jie, additional, Chang, Hao-Yun, additional, Wu, Yi-Chun, additional, Huang, Ching-Uen, additional, Lin, Xin-Yi, additional, Tsai, Feng-Chou, additional, Tsai, Ching-Sung, additional, Chen, Yu-Han, additional, Wang, Fu-Yu, additional, and Chang, Shun-Cheng, additional

Published
2023
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7. Short-term and long-term effectiveness of acupuncture and Tuina on knee osteoarthritis: study protocol for a randomized controlled trial

Author

Zhao, Rui-li, primary, Ma, Pei-hong, additional, Liu, Bao-yan, additional, Yu, Chang-he, additional, Zhang, Hao-ran, additional, Lv, Qian, additional, Yang, Da-wei, additional, Yang, Yu-ping, additional, Liu, Hong-yan, additional, Wang, Fu-yu, additional, Yin, Chun-sheng, additional, Su, Shao-guang, additional, Wang, Hong-chi, additional, Wang, Xi-you, additional, and Yan, Shi-yan, additional

Published
2023
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8. Eicosapentaenoic acid induces neovasculogenesis in human endothelial progenitor cells by modulating c-kit protein and PI3-K/Akt/eNOS signaling pathways

Author

Chiu, Shao-Chih, Chiang, En-Pei Isabel, Tsai, Shu-Yao, Wang, Fu-Yu, Pai, Man-Hui, Syu, Jia-Ning, Cheng, Ching-Chang, Rodriguez, Raymond L, and Tang, Feng-Yao

Subjects
Nutrition, Stem Cell Research - Nonembryonic - Non-Human, Stem Cell Research, Prevention, Prevention of disease and conditions, and promotion of well-being, 3.3 Nutrition and chemoprevention, Cardiovascular, Animals, Cells, Cultured, Eicosapentaenoic Acid, Endothelial Progenitor Cells, Humans, Mice, Mice, Nude, Neovascularization, Physiologic, Nitric Oxide Synthase Type III, Phosphatidylinositol 3-Kinases, Phosphorylation, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins c-kit, Real-Time Polymerase Chain Reaction, Signal Transduction, Akt, c-kit, Eicosapentaenoic acid, eNOS, Human endothelial progenitor cells, microRNA 221, Neovasculogenesis, Biochemistry and Cell Biology, Food Sciences, Nutrition and Dietetics, Nutrition & Dietetics
Abstract

Human endothelial progenitor cells (hEPCs) derived from bone marrow play a crucial in the prevention of ischemic injuries in the course of postnatal neovasculogenesis. Frequent fish oil (FO) consumption is reportedly associated with a significantly lower incidence of cardiovascular disease. However, the molecular mechanisms of eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) are not well elucidated, and the beneficial effect of FO consumption on neovasculogenesis has not been demonstrated yet. In the current study, we investigated the effects of EPA/DHA and FO consumption on neovasculogenesis by using vascular tube formation assay, Western blotting, real-time polymerase chain reaction, immunohistochemical staining and Doppler imaging in both in vitro and in vivo models. The results demonstrate that EPA and DHA dose-dependently enhance the neovasculogenesis and cell migration of hEPCs in vitro. The mechanisms of action included up-regulation of the c-kit protein as well as the phosphorylation of the ERK1/2, Akt and endothelial nitric oxide synthase signaling molecules in hEPCs. Furthermore, EPA significantly suppressed the expression of microRNA 221 in vitro. In experimental animal models, FO consumption significantly induced the formation of new blood vessels (neovasculogenesis) and prevented ischemia. Taken together, it is suggested that FO consumption enhances neovasculogenesis mainly through the effects of EPA in hEPCs, thereby exerting a preventive effect against ischemic injury. © 2014 Elsevier Inc. All rights reserved.

Published
2014

11. Use of consecutive transcutaneous oxygen measurement when assessing the need for revascularization and association with the outcomes of ischemic diabetic ulcers.

Author

Sun, Hao‐Yi, Wu, Yi‐Chun, Sung, Li‐Chin, Lin, Xin‐Yi, Tsai, Feng‐Chou, Lin, Yen‐Kuang, Tam, Ka‐Wai, Wang, Fu‐Yu, and Chang, Shun‐Cheng

Subjects
PERIPHERAL vascular disease diagnosis, ISCHEMIA, TRAUMATOLOGY diagnosis, CHRONIC kidney failure, GLOMERULAR filtration rate, STATISTICS, ANKLE brachial index, BLOOD vessels, CONFIDENCE intervals, REVASCULARIZATION (Surgery), PERIPHERAL vascular diseases, DIABETIC foot, HEALTH outcome assessment, MANN Whitney U Test, COMPARATIVE studies, URBAN hospitals, T-test (Statistics), RESEARCH funding, LIMB salvage, CHI-squared test, DESCRIPTIVE statistics, RECEIVER operating characteristic curves, PREDICTIVE validity, LOGISTIC regression analysis, COMPUTED tomography, AMPUTATION, DATA analysis, DATA analysis software, ODDS ratio, TRANSCUTANEOUS blood gas monitoring, MEDICAL needs assessment, LONGITUDINAL method, WOUND care, DISEASE risk factors
Abstract

This study compared the ankle‐brachial index (ABI) with transcutaneous oxygen pressure (TcPO2) in assessing peripheral vascular disease (PVD) prevalence in 100 diabetic foot ulcer (DFU) patients. Patients were categorized into vascular or nonvascular reconstruction groups and underwent both ABI and TcPO2 measurements four times over 6 months. Predictive validity for PVD diagnosis was analysed using the area under the receiver‐operating characteristic curve (AUC). The study found TcPO2 to be a superior predictor of PVD than ABI. Among the DFU patients, 51 with abnormal TcPO2 values underwent vascular reconstruction. Only TcPO2 values showed significant pretreatment differences between the groups and increased post‐reconstruction. These values declined over a 6‐month follow‐up, whereas ABI values rose. For those with end‐stage renal disease (ESRD), TcPO2 values saw a sharp decrease within 3 months. Pre‐reconstruction TcPO2 was notably lower in amputation patients versus limb salvage surgery patients. In conclusion, TcPO2 is more effective than ABI for evaluating ischemic limb perfusion and revascularization necessity. It should be prioritized as the primary follow‐up tool, especially for ESRD patients. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Meta‐analysis of association between migraine and risk of dementia.

Author

Wang, Long, Wu, Jun‐Cang, Wang, Fu‐Yu, Chen, Xin, and Wang, Yu

Subjects
DISEASE risk factors, MIGRAINE, VASCULAR dementia, ALZHEIMER'S disease, DEMENTIA
Abstract

Objectives: The association between migraine and dementia has rarely been investigated, and available results are conflicting. Thus, the aim of this meta‐analysis was to evaluate whether an association exists between migraine and dementia. Materials & Methods: We searched for cohort studies from databases including PubMed, EBSCO, Web of Science, and EMBASE database from inception to April 1, 2021, using subject and free words. RevMan 5.1 software was used to calculate the risk ratio (RR) of dementia in patients with migraine. Subgroup and sensitivity analyses were conducted to assess the source of heterogeneity. A random‐effects model was used when heterogeneity was present. The Funnel plot and Egger's test were used to evaluate publication bias. Results: Five published cohort studies covering a total of 249,303 individuals were identified. Pooled analysis showed that migraine was associated with increased risk of all‐cause dementia (RR: 1.34, 95% CI: 1.13–1.59) and Alzheimer's disease (AD) (RR: 2.49, 95% CI: 1.16–5.32). However, we did not found any association between migraine and risk of vascular dementia (VaD) (RR: 1.51, 95% CI: 0.77–2.96). Conclusions: Our results revealed that migraine was a potential risk indicator for AD and all‐cause dementia. [ABSTRACT FROM AUTHOR]

Published
2022
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29. An Opt-electronic Method for Inspecting Foreign Particles in Injections

Author

管相宇 Guan Xiang-yu, 孙小小 Sun Xiao-xiao, 王馥宇 Wang Fu-yu, 汪洋 Wang Yang, 曾涛 Zeng Tao, and 黄梅珍 Huang Mei-zhen

Subjects
stomatognathic diseases, Computer science, Order (business), education, Inspection method, Track (rail transport), humanities, Atomic and Molecular Physics, and Optics, Simulation
Abstract

In the production process of the injection,foreign particles are probably interfused into the injections,so the injections must be inspected before leaving the factory.An opt-electronic method is proposed based on light-blocking theory for foreign particles detected in injections,and the principle of this inspecting method is introduced.Compared with the conventional manual inspection method,the preliminary experimental results show that the new method has a satisfied conformance rate of 96.30% in the case of static offline detection.In order to improve the inspection effect,a method of dual-light-path is also proposed to avoid the foreign particles miss inspection in case of the track testing time is too short or the testing area is too small.

Published
2012

30. Hemodynamics model of fluid–solid interaction in internal carotid artery aneurysms

Author

Ju Hai-Yue, Bai-nan Xu, Liu Lei, Wang Fu-yu, and Zhang Xiaojun

Subjects
medicine.medical_specialty, Models, Neurological, Clinical Neurology, Image processing, Blood Pressure, Aneurysm, Ruptured, DICOM, Motion, Software, medicine, Image Processing, Computer-Assisted, Pressure, Humans, ComputingMethodologies_COMPUTERGRAPHICS, Fluid–solid interaction (FSI), Models, Statistical, medicine.diagnostic_test, business.industry, Computational fluid dynamic (CFD), Hemodynamics, Angiography, Digital Subtraction, Intracranial Aneurysm, General Medicine, Digital subtraction angiography, Biomechanical Phenomena, Cerebral Angiography, Angiography, Workbench, Surgery, Original Article, Neurology (clinical), Radiology, business, Aneurysms, Displacement (fluid), Algorithms, Cerebral angiography, Biomedical engineering
Abstract

The objective of this study is to present a relatively simple method to reconstruct cerebral aneurysms as 3D numerical grids. The method accurately duplicates the geometry to provide computer simulations of the blood flow. Initial images were obtained by using CT angiography and 3D digital subtraction angiography in DICOM format. The image was processed by using MIMICS software, and the 3D fluid model (blood flow) and 3D solid model (wall) were generated. The subsequent output was exported to the ANSYS workbench software to generate the volumetric mesh for further hemodynamic study. The fluid model was defined and simulated in CFX software while the solid model was calculated in ANSYS software. The force data calculated firstly in the CFX software were transferred to the ANSYS software, and after receiving the force data, total mesh displacement data were calculated in the ANSYS software. Then, the mesh displacement data were transferred back to the CFX software. The data exchange was processed in workbench software. The results of simulation could be visualized in CFX-post. Two examples of grid reconstruction and blood flow simulation for patients with internal carotid artery aneurysms were presented. The wall shear stress, wall total pressure, and von Mises stress could be visualized. This method seems to be relatively simple and suitable for direct use by neurosurgeons or neuroradiologists, and maybe a practical tool for planning treatment and follow-up of patients after neurosurgical or endovascular interventions with 3D angiography.

Published
2010

32. Role and mechanism of Sophoridine on proliferation inhibition in human glioma U87MG cell line

Author

Wang, Wen-Xin, Sun, Zheng-Hui, Chen, Han-Men, Xu, Bai-Nan, and Wang, Fu-Yu

Subjects
Original Article
Abstract

Sophoridine, a natural product obtained from medicinal plants, which has a variety of pharmacological effects, including anti-cancer effects, and selectively induces apoptotic cell death in a variety of human cancer cells in vitro and in vivo; however, its mechanism of action needs to be further elaborated. In this study, we investigated the effects of Sophoridine on the induction of apoptosis in human Glioma U87MG cells. Here, we found that Sophoridine can significantly inhibited cell proliferation, G2/M phase arrest, induced cell apoptosis and caused reactive oxygen species (ROS) generation and GSH content reduction. Sophoridine also triggered significant down-regulated the expression of p27, CDK2, Survivin, Livin, Bcl-2, E2F1 and the transcriptional activity of FoxM1, NF-κb and AP-1, meanwhile, up-regulated the expression of caspase-3/8, p53, Smac, c-JNK and p38-MAPK. Moreover, we found that Sophoridine significantly inhibited ubiquitin-proteasome in tumor cells. In conclusion, Sophoridine shows obvious anti-cancer activity on glioma cells by inducing cell apoptosis, inducing ROS accumulation, and activating mitochondrial signal pathways. Eventually, we believe Sophoridine could be used as a new drug for the treatment of glioma.

Published
2015

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