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Objective·To detect the serum levels of high mobility group box 1 (HMGB1) and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in patients with multiple injuries at different time points, and to analyze their correlation with disease severity, complications and prognosis.Methods·Ninety-two patients with multiple injuries admitted to the Department of Emergency Medicine of the Suzhou Ninth People′s Hospital from December 2020 to December 2022 were selected. According to the injury severity scores of the patients at admission, the patients were divided into light injury group (n=24), grave injury group (n=58) and severe injury group (n=10). According to whether there was multiple organ dysfunction syndrome (MODS) after admission, the patients were divided into MODS group (n=20) and non-MODS group (n=72). According to the outcome within 28 d after trauma, the patients were divided into death group (n=13) and survival group (n=79). Inflammatory factor indicators in venous blood of patients after admission were detected. Enzyme linked immunosorbent assay (ELISA) was used to detect the serum HMGB1 and sTREM-1 levels at 24 h, 72 h and 7 d after trauma, and the differences of serum HMGB1 and sTREM-1 levels among different groups were analyzed. Multiple Logistic regression was used to analyze the influencing factors of adverse outcomes in patients with multiple injuries. The receiver operating characteristic (ROC) curve was used to evaluate the predictive value of HMGB1 and sTREM-1 for adverse outcomes.Results·The levels of HMGB1 and sTREM-1 in the grave injury and severe injury groups were significantly higher than those in the light injury group (P

To select the optimum tool material for the cutting of marine high-strength steels using a hole-opening equipment in the marine environment, this article conducted a comparative study on the corrosion property, tribological behavior and cutting performance of cermet, cemented carbide and coated tools. The results reveal that the coated tool materials have good corrosion resistance with coating protection, and poor wear resistance with adhesive and corrosive wear in artificial seawater, and present moderate cutting performance. In addition, the cemented carbide tool materials show poor corrosion resistance and good wear resistance due to the lubrication effect of corrosion products in artificial seawater, but have bad cutting performance with a high flank wear value. Moreover, the cermet tool materials present acceptable corrosion and wear resistance with adhesive and corrosive wear in artificial seawater and have the excellent cutting performance. Taking into account the corrosion resistance, wear resistance and cutting performance of tool materials and regarding cutting performance as an important indicator, the cermet tool materials with superior comprehensive performances are suitable for the cutting of marine high-strength steels in the marine environment. [ABSTRACT FROM AUTHOR]