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Slab rollback is one of the primary processes in shaping tectonic framework. However, in the Tibet–Himalaya orogen, the timing of the Neo-Tethyan slab rollback remains controversial. In this contribution, we investigated an early Paleocene (ca. 62 Ma) A1-type granitic intrusion (South Gongshan) from the Gaoligong–Tengliang–Yingjiang (GTY) area, SE Tibet. It is mainly characterized by high 10,000*Ga/Al ratios (4.0–9.1) and extremely high HFSEs contents (Zr + Nb + Ce + Y = 669–3146 ppm), with relatively low Y/Nb ratios (0.8–1.1). The samples collected from the intrusion exhibit high zircon εHf(t) (+1.1 to +5.7) and whole-rock εNd(t) values (− 0.8 to − 3.1). Geochemical data indicated that it was probably produced by extreme FC of asthenospheric mantle-derived basaltic magmas. Together with results from convergence rate between India and Asia, the emplacement of the South Gongshan intrusion was likely to be associated with a transition from flat to steep subduction triggered by the Neo-Tethyan slab rollback. We proposed that the Neo-Tethyan slab rollback beneath the GTY area might have occurred at ca. 62 Ma. [ABSTRACT FROM AUTHOR]

Background/aims: To describe survival rates and prognostic factors for colorectal cancer (CRC) operated in a district general hospital setting with a special focus on the number of lymph nodes examined., Methodology: Between December 2004 and December 2006, a total of 277 CRC patients who underwent surgical treatment in QHSU were included. All patients were followed up intensively from discharge until death or the end of the follow-up (December 31, 2010)., Results: The median follow-up period was 53 months (range, 1-72 months). Overall 3-year survival was 72.9%. In only 11.5% of the specimens were 12 or more lymph nodes retrieved, but this did not affect survival. A multivariate analysis identified that the significant prognostic factors were TNM stage III [adjusted hazard ratio (HR): 5.49; 95%CI: 1.64-18.41], TNM stage IV (adjusted HR: 7.55; 95%CI: 2.12-26.84), tumor histology (adjusted HR: 1.88; 95%CI: 1.16-3.04), hospital stay (adjusted HR: 1.03; 95%CI: 1.00-1.06) and lymph node ratio (LNR) (adjusted HR: 3.92; 95%CI: 1.79-8.55) for stage III., Conclusions: TNM stage, tumor histology and the length of hospital stay could prominently affect outcome overall. The lymph node count did not have a significant impact on survival, whereas the LNR proved significant for stage III. Nevertheless, a protocol using overall lymph node yield as a surrogate measure for more radical surgery seems warranted to improve the lymph node resected.

Objective: To assess the association between single nucleotide polymorphisms (SNPs) of mannose-binding lectin 2 gene (MBL2) (rs1800450, rs1800451 and rs11003125) and protein kinase C-beta 1 gene (PRKC beta 1) (rs3700106, rs2575390) with diabetic macroangiopathy in northern Chinese Han population., Methods: The samples have included 318 type 2 diabetes mellitus (T2DM) patients and 448 normoglycemic controls. The five SNPs were determined by a Multiplex SnaPshot method. Biochemical indices such as fasting plasma-glucose, triglyceride and total cholesterol were also measured. Linkage disequilibrium and haplotype analysis were carried out for all samples using Haploview 4.2. Additive model was applied to assess the effect of interaction between SNPs and environment factors on macrovascular complications., Results: Genotypic frequencies of rs11003125 have differed significantly between the controls and patients with coronary heart disease and peripheral vascular disease (P=0.024 and 0.004, respectively). The allele frequency of rs11003125 was also statistically significant between the two groups (P=0.014 and 0.001, respectively). Compared with patients without macrovascular complications, the allele frequency of rs11003125 was significantly different in patients with peripheral vascular disease (P=0.031). No significant differences were found between the distribution of the genotype frequency and allele frequencies of other variants. Haplotype analysis indicated that, compared with controls and patients without macrovascular complications, individuals with G allele of rs1800450 and C allele of rs11003125 had a higher risk for macrovascular complications., Conclusion: The rs11003125 polymorphism located in the promoter region of MBL2 gene is associated with macrovascular complications of T2DM in northern Chinese Han population. G allele of rs1800450 and C allele of rs11003125 may be risk factors for macrovascular complications. There were additive interactive effects for rs11003125 polymorphism (GC+CC) and hypertension, diabetic nephropathy, diabetic neuropathy and diabetic retinopathy on macrovascular complications.