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1. On the superconducting gap structure of the miassite Rh17S15: Nodal or nodeless?

Author

Nie, J. Y., Zhao, C. C., Xu, C. Q., Li, B., Tu, C. P., Zhang, X., Dai, D. Z., Wang, H. R., Xu, S., Jiao, Wenhe, Wang, B. M., Xu, Zhu'an, Xu, Xiaofeng, and Li, S. Y.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Materials Science, Condensed Matter - Strongly Correlated Electrons
Abstract

Recent penetration depth measurement claimed the observation of unconventional superconductivity in the miassite Rh$_{17}$S$_{15}$ single crystals, evidenced by the linear-in-temperature penetration depth at low temperatures, thereby arguing for the presence of the lines of node in its superconducting gap structure. Here we measure the thermal conductivity of Rh$_{17}$S$_{15}$ single crystals down to 110 mK and up to a field of 8 T ($\simeq 0.4H{\rm_{c2}}$). In marked contrast to the penetration depth measurement, we observe a negligible residual linear term $\kappa_0/T$ in zero field, in line with the nodeless gap structure. The field dependence of $\kappa_0(H)/T$ shows a profile that is more consistent with either a highly anisotropic gap structure or multiple nodeless gaps with significantly different magnitudes. Moreover, first-principles calculations give two electronic bands with complex shape of Fermi surfaces. These results suggest multigap nodeless superconductivity in this multiband Rh$_{17}$S$_{15}$ superconductor., Comment: 7 pages, 6 figures

Published
2024

2. $^{197}$Au($\gamma,\,xn;\,x\,=\,1\thicksim9$) Reaction Cross Section Measurements using Laser-Driven Ultra-Intense $\gamma$-Ray Source

Author

Wu, D., Lan, H. Y., Zhang, J. Y., Liu, J. X., Lu, H. G., Lv, J. F., Wu, X. Z., Zhang, H., Cai, J., Ma, Q. Y., Xia, Y. H., Wang, Z. N., Wang, M. Z., Yang, Z. Y., Xu, X. L., Geng, Y. X., Zhao, Y. Y., Lin, C., Ma, W. J., Yu, J. Q., Wang, H. R., Liu, F. L., He, C. Y., Guo, B., Zhu, P., Zhang, G. Q., Wang, N. Y., Ma, Y. G., and Yan, X. Q.

Subjects
Nuclear Experiment, Physics - Plasma Physics
Abstract

We present a new method for the measurements of photonuclear reaction flux-weighted average cross sections and isomeric ratios using a laser-driven bremsstrahlung $\gamma$-ray source. An ultra-bright ultra-fast 60$\,\thicksim\,$250 MeV bremsstrahlung $\gamma$-ray source was established using the 200 TW laser facility in the Compact Laser Plasma Accelerator Laboratory, Peking University, which could cover the energy range from knocking out neutrons to producing pions. Stable quasi-monoenergetic electron beams were generated via laser wakefield acceleration with a charge of 300$\,\thicksim\,$600 pC per shot. The averaged $\gamma$-ray intensities ($\geqslant$8 MeV) were higher than 10$^{8}$ per shot and the instantaneous intensities can reach above 10$^{19}$ s$^{-1}$ with a duration time about 6.7 ps. $^{65}$Cu($\gamma,\,n$)$^{64}$Cu and $^{27}$Al($\gamma,\,x$)$^{24}$Na reactions were used as $\gamma$-ray flux monitors in the experiments. The flux-weighted average cross sections and isomeric ratios of $^{197}$Au($\gamma,\,xn;\,x\,=\,1\thicksim9$) reactions were analyzed through activation measurements. The results showed good agreement with previous works and proved this method to be accurate. The $^{197}$Au($\gamma,\,xn;\,x\,=\,7\thicksim\,9$) reaction cross sections were first achieved with the highest threshold energy of 71.410 MeV. Theoretical cross sections of TALYS 1.9 were calculated to compare with experiment results. This method offered a unique way of gaining insight into photonuclear reaction research, especially for short-lived isomers which extremely lack experimental data.

Published
2022

3. Construction and commissioning of the collinear laser spectroscopy system at BRIF

Author

Wang, S. J., Yang, X. F., Bai, S. W., Liu, Y. C., Zhang, P., Liu, Y. S., Hu, H. R., Li, H. W., Tang, B., Cui, B. Q., He, C. Y., Ma, X., Li, Q. T., Chen, J. H., Ma, K., Yang, L. S., Hu, Z. Y., Pu, W. L., Chen, Y., Guo, Y. F., Du, Z. Y., Yan, Z., Liu, F. L., Wang, H. R., Yang, G. Q., Ye, Y. L., and Guo, B.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

We have constructed a collinear laser spectroscopy (CLS) system installed at the Beijing Radioactive Ion-beam Facility (BRIF), aiming to investigate the nuclear properties of unstable nuclei. The first on-line commissioning experiment of this system was performed using the continuous stable ($^{39}$K) and unstable ($^{38}$K) ion beams produced by impinging a 100-MeV proton beam on a CaO target. Hyperfine structure spectra of these two isotopes are reasonably reproduced, and the extracted magnetic dipole hyperfine parameters and isotope shift agree with the literature values. The on-line experiment demonstrates the overall functioning of this CLS system, opening new opportunities for laser spectroscopy measurement of unstable isotopes at BRIF and other radioactive ion beam facilities in China.

Published
2022
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4. Signatures of a topological phase transition in a planar Josephson junction

Author

Banerjee, A., Lesser, O., Rahman, M. A., Wang, H. -R., Li, M. -R., Kringhøj, A., Whiticar, A. M., Drachmann, A. C. C., Thomas, C., Wang, T., Manfra, M. J., Berg, E., Oreg, Y., Stern, Ady, and Marcus, C. M.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Superconductivity
Abstract

A growing body of work suggests that planar Josephson junctions fabricated using superconducting hybrid materials provide a highly controllable route toward one-dimensional topological superconductivity. Among the experimental controls are in-plane magnetic field, phase difference across the junction, and carrier density set by electrostatic gate voltages. Here, we investigate planar Josephson junctions with an improved design based on an epitaxial InAs/Al heterostructure, embedded in a superconducting loop, probed with integrated quantum point contacts (QPCs) at both ends of the junction. For particular ranges of in-plane field and gate voltages, a closing and reopening of the superconducting gap is observed, along with a zero-bias conductance peak (ZBCP) that appears upon reopening of the gap. Consistency with a simple theoretical model supports the interpretation of a topological phase transition. While gap closings and reopenings generally occurred together at the two ends of the junction, the height, shape, and even presence of ZBCPs typically differed between the ends, presumably due to disorder and variation of couplings to local probes.

Published
2022
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5. Reaction dynamics of proton drip-line nuclei at energies around the Coulomb barrier.

Author

Chang, C., Yang, L., Lin, C. J., Yamaguchi, H., Ma, N. R., Hayakawa, S., Wen, P. W., Jia, H. M., Luo, T. P., Yin, C., Huang, Z. J., Duan, H. R., Zhu, S. X., Wang, H. R., Fan, Z. R., Li, H. Y., and Fu, L. Y.

Subjects
NUCLEAR reactions, NUCLEAR energy, COULOMB barriers (Nuclear fusion), KINEMATICS, ELASTIC scattering
Abstract

This work briefly introduces our recent studies on reactions induced by proton drip-line nuclei, 8B and 17F, at energies around the Coulomb barrier. Using detector arrays with large solid-angle coverage, the complete kinematics measurements were performed for systems of 8B+120Sn and 17F+58Ni. For the 8B+120Sn, the coincident measurement of the breakup fragments was achieved for the first time for a proton-halo nuclear system. The correlations between the breakup fragments reveal that the prompt breakup occurring on the outgoing trajectory dominates the breakup dynamics of 8B. For 17F+58Ni, the complete reaction channel information, such as quasi-elastic scattering, breakup and total fusion, was derived for the first time. An enhancement of the fusion cross section of 17F+58Ni was observed at the energy below the Coulomb barrier. Theoretical calculations indicate that this phenomenon is mainly due to the couplings to the continuum states. Moreover, different direct reaction dynamics were found in 8B and 17F systems, suggesting the influence of proton-halo structure on the reaction dynamics. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Density functional theory (DFT) study on the reaction mechanism of in-situ no reduction in hydrogen rich blast furnace

Author

Huang, J. K., Li, X., Hong, S. X., Gu, T. J., Huang, Y. B., Wang, H. R., Huang, J. K., Li, X., Hong, S. X., Gu, T. J., Huang, Y. B., and Wang, H. R.

Abstract

Based on density functional theory and classical transition state theory, the reaction mechanism of NO reduction by H2 catalyzed by coke in hydrogen rich blast furnace was investigated. The results showed that the presence of active sites on the coke surface promoted the NO reduction reaction. Reactive oxygen species remaining on the coke edge inhibited the NO reaction after NO reduction. Both coke and H2 can release edge sites by reducing reactive oxygen species, but reactive oxygen species reduction by H2 requires a high barrier value of 634,3 kJ/mol, which is higher than that by coke.

Published
2024

7. Signatures of a topological phase transition in a planar Josephson junction

Author

Banerjee, A., primary, Lesser, O., additional, Rahman, M. A., additional, Wang, H.-R., additional, Li, M.-R., additional, Kringhøj, A., additional, Whiticar, A. M., additional, Drachmann, A. C. C., additional, Thomas, C., additional, Wang, T., additional, Manfra, M. J., additional, Berg, E., additional, Oreg, Y., additional, Stern, Ady, additional, and Marcus, C. M., additional

Published
2023
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8. New measurements of 92Mo(γ, n) and (γ, 3n) reactions using laser-driven bremsstrahlung γ-ray

Author

Wu, D., primary, Lan, H. Y., additional, Zhang, J. Y., additional, Liu, J. X., additional, Lu, H. G., additional, Lv, J. F., additional, Wu, X. Z., additional, Zhang, H., additional, Cai, J., additional, Xu, X. L., additional, Geng, Y. X., additional, Ma, W. J., additional, Lin, C., additional, Zhao, Y. Y., additional, Wang, H. R., additional, Liu, F. L., additional, He, C. Y., additional, Yu, J. Q., additional, Guo, B., additional, Wang, N. Y., additional, and Yan, X. Q., additional

Published
2023
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9. Signatures of a topological phase transition in a planar Josephson junction

Author

Banerjee, A., Lesser, O., Rahman, M. A., Wang, H.-r., Li, M.-r., Kringhøj, A., Whiticar, A. M., Drachmann, A. C. C., Thomas, C., Wang, T., Manfra, M. J., Berg, E., Oreg, Y., Stern, Ady, Marcus, C. M., Banerjee, A., Lesser, O., Rahman, M. A., Wang, H.-r., Li, M.-r., Kringhøj, A., Whiticar, A. M., Drachmann, A. C. C., Thomas, C., Wang, T., Manfra, M. J., Berg, E., Oreg, Y., Stern, Ady, and Marcus, C. M.

Published
2023

11. $^{197}$Au($\gamma,\,xn;\,x\,=\,1\thicksim7$) Reaction Measurements using Laser-Driven Ultra-Bright Ultra-Fast Bremsstrahlung $\gamma$-Ray

Author

Wu, D., Zhang, J. Y., Lan, H. Y., Liu, J. X., Lv, J. F., Lu, H. G., Wu, X. Z., Zhang, H., Geng, Y. X., Zhao, Y. Y., Xu, J. Y., Cai, J., Yu, J. Q., Lin, C., Ma, W. J., Wang, H. R., Liu, F. L., He, C. Y., Guo, B., Zhang, G. Q., Wang, N. Y., Ma, Y. G., and Yan, X. Q.

Subjects
Nuclear Experiment
Abstract

We present a new method for the measurements of photonuclear reaction flux-weighted average cross sections and isomeric yield ratios using laser-driven ultra-bright ultra-fast bremsstrahlung $\gamma$-ray, especially for photonuclear reactions with short half-life times. A 200 TW laser was used to generate stable near-monoenergetic electron beams via laser wakefield acceleration. The flux-weighted average cross sections and isomeric ratios of $^{197}$Au($\gamma,\,xn;\,x\,=\,1\thicksim7$) reactions were analyzed through activation measurements. The results showed good agreements with previous works and were compared with TALYS 1.9 calculations. The $^{197}$Au($\gamma$,\,7n)$^{190}$Au reaction cross sections were first achieved. This method offered a unique way of gaining insight into photonuclear reaction researches with short half-life times, which extremely lack experimental data.

Published
2022

12. A Thermoelectric Energy Generator With High-Density Stacked Thermocouples by Standard BiCMOS Process

Author

Yang, S. M. and Wang, H. R.

Abstract

A thermoelectric energy generator (TEG) with high area density, high Seebeck coefficient, and high-temperature gradient of thermocouples is developed by standard bipolar complementary metal–oxide–semiconductor (BiCMOS) process. The TEG has the stacked thermocouple design for high area density, the polysilicon germanium (poly-SiGe) thermocouple for better thermoelectric conversion efficiency, and the double cavity design for sufficient thermal gradient. It is shown that a $5\times $ 5 mm2 TEG chip with stacked thermocouples in optimal size $65\times 2\,\,\mu \text{m}$ at $2 \mu \text{m}$ width spacing, or about 3512 thermocouple/mm2, can achieve 0.131- $\mu \text{W}$ /cm $^{{2}}\text{K}^{{2}}$ power factor and 37.01-V/cm $^{{2}}\text{K}$ voltage factor in analysis, and $0.105 \mu \text{W}$ /cm $^{{2}}\text{K}^{{2}}$ and 33.91 V/cm $^{{2}}\text{K}$ in measurement. The thermocouple area density can be increased further by reducing the width spacing to $1.067 \mu \text{m}$ , or about 4802 thermocouple/mm2, to achieve $0.103 \mu \text{W}$ /cm $^{{2}}\text{K}^{{2}}$ and 36.19 V/cm $^{{2}}\text{K}$ in measurement. The optimal thermocouple size is $78\times 2\,\,\mu \text{m}$ to achieve $0.131 \mu \text{W}$ /cm $^{{2}}\text{K}^{{2}}$ and 44.95 V/cm $^{{2}}\text{K}$ in analysis. The performance increase is shown to be superior to all the other semiconductor TEGs.

Published
2023
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14. Signatures of a topological phase transition in a planar Josephson junction

Author

Banerjee, Abhishek, Lesser, Omri, Rahman, Wang, H. R., Li, M. R., Kringhøj, Anders, Whiticar, Alexander, Drachmann, Asbjørn, Thomas, Candice, Wang, T., Manfra, Michael, Berg, Erez, Oreg, Yuval, Stern, Ady, and Marcus, Charles

Subjects
Superconductivity (cond-mat.supr-con), Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter::Superconductivity, Condensed Matter - Superconductivity, Mesoscale and Nanoscale Physics (cond-mat.mes-hall), FOS: Physical sciences, Condensed Matter::Mesoscopic Systems and Quantum Hall Effect
Abstract

A growing body of work suggests that planar Josephson junctions fabricated using superconducting hybrid materials provide a highly controllable route toward one-dimensional topological superconductivity. Among the experimental controls are in-plane magnetic field, phase difference across the junction, and carrier density set by electrostatic gate voltages. Here, we investigate planar Josephson junctions with an improved design based on an epitaxial InAs/Al heterostructure, embedded in a superconducting loop, probed with integrated quantum point contacts (QPCs) at both ends of the junction. For particular ranges of in-plane field and gate voltages, a closing and reopening of the superconducting gap is observed, along with a zero-bias conductance peak (ZBCP) that appears upon reopening of the gap. Consistency with a simple theoretical model supports the interpretation of a topological phase transition. While gap closings and reopenings generally occurred together at the two ends of the junction, the height, shape, and even presence of ZBCPs typically differed between the ends, presumably due to disorder and variation of couplings to local probes.

Published
2022

32. A tale of two genera: Exotic Eucalyptus and Acacia species in China. 2. Plantation resource development.

Author

ARNOLD, R. J., XIE, Y. J., LUO, J. Z., WANG, H. R., and MIDGLEY, S. J.

Subjects
EUCALYPTUS, PLANTATIONS, ACACIA, SPECIES, GERMPLASM
Abstract

Copyright of International Forestry Review is the property of Commonwealth Forestry Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020
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33. A tale of two genera: exotic Eucalyptus and Acacia species in China. 1. Domestication and research.

Author

ARNOLD, R. J., XIE, Y. J., LUO, J. Z., WANG, H. R., and MIDGLEY, S. J.

Subjects
EUCALYPTUS, ACACIA, SPECIES, GERMPLASM, RESEARCH & development projects, INDUSTRIAL capacity
Abstract

Copyright of International Forestry Review is the property of Commonwealth Forestry Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020
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34. Total cholesterol affects the outcome of patients with anterior cerebral artery-occluded acute ischemic stroke treated with thrombolysis.

Author

NIU, L., JIANG, S.-W., WANG, Y., PENG, Y., FEI, A.-H., WANG, H.-R., LI, Y., ZHANG, J.-C., MEANEY, C., GAO, C.-J., and PAN, S.-M.

Abstract

OBJECTIVE: In this study, we investigated whether certain types of lipid profiles are major contributors of acute ischemic stroke (AIS). PATIENTS AND METHODS: We screened 13,285 hospitalized patients in two stroke medical centers treated with thrombolysis, thrombectomy, or conventional care for anterior cerebral artery-occluded AIS, and found 266 patients. We examined their plasma lipid profiles using the cutoff values from a receiver operating characteristic (ROC) curve. We applied a multivariate logistic regression or Fisher's exact test to compare their outcomes and risk factors. We used the modified Rankin scale (mRS) score to assess the major clinical outcome of the patients 3 months after disease onset. Mortality and symptomatic intracranial hemorrhage (sICH) were both evaluated as risk factors. We analyzed symptoms' improvements at discharge as a disease outcome measure. RESULTS: In the patients with anterior cerebral artery-occluded AIS (NIHSS = 10) treated by intravenous (IV) thrombolysis, a total cholesterol (TC) level greater than 5.07 mmol/L predicted a poor outcome (OR 3.55, 95% CI 1.21,10.46, p=0.021). CONCLUSIONS: In patients with anterior cerebral artery-occluded AIS, the TC level is a promising prognosis marker for the IV thrombolysis outcome. [ABSTRACT FROM AUTHOR]

Published
2020

35. Effects of rumen-protected betaine supplementation on meat quality and the composition of fatty and amino acids in growing lambs.

Author

Dong, L., Zhong, Z. X., Cui, H. H., Wang, S. N., Luo, Y., Yu, L. H., Loor, J. J., and Wang, H. R.

Abstract

Rumen-protected betaine (RPB) can enhance betaine absorption in the small intestine of ruminants, while betaine can alter fat distribution and has the potential to affect the meat quality of livestock. Hence, we hypothesized that RPB might also affect the meat quality of lambs. Sixty male Hu sheep of similar weight (30.47 ± 2.04 kg) were selected and randomly subjected to five different treatments. The sheep were fed a control diet (control treatment, CTL); 1.1 g/day unprotected-betaine supplemented diet (UPB); or doses of 1.1 g/day (low RPB treatment; L-PB), 2.2 g/day (middle RPB treatment; M-PB) or 3.3 g/day (high RPB treatment; H-PB) RPB-supplemented diet for 70 days. Slaughter performance, meat quality, fatty acid and amino acid content in the longissimus dorsi (LD) muscle, shoulder muscle (SM) and gluteus muscle (GM) were measured. Compared with CTL, betaine (including UPB and RPB) supplementation increased the average daily weight gain (ADG) (P < 0.05) and average daily feed intake (P < 0.01) of lambs. Rumen-protected betaine increased ADG (P < 0.05) compared with UPB. With increasing RPB doses, the eye muscle area of the lambs linearly increased (P < 0.05). Compared with CTL, betaine supplementation decreased water loss (P < 0.05) in SM and increased pH24 in the SM (P < 0.05) and GM (P < 0.05). Compared with UPB, RPB decreased water loss in the GM (P < 0.01), decreased shear force (P < 0.05) in the LD and SM and increased the pH of the meat 24 h after slaughter (pH 24 ). With increasing RPB doses, the shear force and b* value in the LD linearly decreased (P < 0.05), and the pH24 of the meat quadratically increased (P < 0.05). Compared with CTL, betaine supplementation increased the polyunsaturated fatty acid in the GM (P < 0.05). Compared with UPB, RPB supplementation decreased the saturated fatty acid (SFA) content in the LD (P < 0.05) and increased the unsaturated fatty acids (UFA), mono-unsaturated fatty acids and UFA/SFA ratio in the LD (P < 0.05). Compared with CTL, the content of histidine in the LD increased with betaine supplementation. Compared with UPB, RPB supplementation increased the content of total free amino acids and flavor amino acids in the LD of lambs (P < 0.05). With increasing RPB, the isoleucine and phenylalanine contents in the LD linearly increased (P < 0.05). Overall, the data collected indicated that the meat quality of lambs (especially in the LD) improved as a result of betaine supplementation, and RPB showed better effects than those of UPB. [ABSTRACT FROM AUTHOR]

Published
2020
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36. Rubber seed oil and flaxseed oil supplementation alter digestion, ruminal fermentation and rumen fatty acid profile of dairy cows.

Author

Pi, Y., Ma, L., Pierce, K. M., Wang, H. R., Xu, J. C., and Bu, D. P.

Abstract

Rubber seed oil (RO) that is rich in polyunsaturated fatty acids (FA) can improve milk production and milk FA profiles of dairy cows; however, the responses of digestion and ruminal fermentation to RO supplementation in vivo are still unknown. This experiment was conducted to investigate the effect of RO and flaxseed oil (FO) supplementation on nutrients digestibility, rumen fermentation parameters and rumen FA profile of dairy cows. Forty-eight mid-lactation Holstein dairy cows were randomly assigned to one of four treatments for 8 weeks, including basal diet (CON) or the basal dietary supplemented with 4% RO, 4% FO or 2% RO plus 2% FO on a DM basis. Compared with CON, dietary oil supplementation improved the total tract apparent digestibility of DM, neutral detergent fibre and ether extracts (P < 0.05). Oil treatment groups had no effects on ruminal digesta pH value, ammonia N and microbial crude protein (P > 0.05), whereas oil groups significantly changed the volatile fatty acid (VFA) profile by increasing the proportion of propionate whilst decreasing total VFA concentration, the proportion of acetate and the ratio of acetate to propionate (P < 0.05). However, there were no differences in VFA proportions between the three oil groups (P > 0.05). In addition, dietary oil supplementation increased the total unsaturated FA proportion in the rumen by enhancing the proportion of trans -11 C18:1 vaccenic acid (VA), cis -9, trans -11 conjugated linoleic acid (CLA) and α-linolenic acid (ALA) (P < 0.05). These results indicate that dietary supplementation with RO and FO could improve nutrients digestibility, ruminal fermentation and ruminal FA profile by enhancing the VA, cis -9, trans -11 CLA and ALA composition of lactating dairy cows. These findings provide a theoretical basis for the application of RO in livestock production. [ABSTRACT FROM AUTHOR]

Published
2019
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42. MiRNA-485-5p suppresses the proliferation of acute myeloid leukemia via targeting SALL4.

Author

-L- WANG, W., WANG, H.-R., JI, W.-G., GUO, S.-L., LI, H.-X., and XU, X.-Y.

Abstract

OBJECTIVE: To examine the expression level of microRNA-485-5p (miRNA-485-5p) in acute myeloid leukemia (AML) and its biological function in regulating the proliferative ability of AML through targeting SALL4. PATIENTS AND METHODS: Serum level of miRNA-485-5p in AML patients and healthy controls was determined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). MiRNA-485-5p level in AML cell lines was detected by qRT-PCR as well. Proliferative and apoptotic changes in AML5 and U937 cells overexpressing miRNA-485-5p were assessed. Subsequently, the regulatory effect of miRNA-485-5p on SALL4 level was evaluated. Rescue experiments were conducted to uncover the role of miRNA-485-5p/SALL4 regulatory loop in regulating cellular behaviors of AML. RESULTS: Compared with healthy controls, serum level of miRNA-485-5p was lower in AML patients. MiRNA-485-5p was similarly downregulated in AML cell lines. Overexpression of miRNA-485-5p stimulated proliferation and alleviated apoptosis in AML. SALL4 level was downregulated by transfection of miRNA-485-5p mimics in AML5 and U937 cells. Overexpression of SALL4 could reverse the regulatory effect of miRNA-485-5p on proliferative and apoptotic abilities of AML. CONCLUSIONS: MiRNA-485-5p is downregulated in AML. Overexpression of miRNA-485-5p alleviates the malignant progression of AML through downregulating SALL4. [ABSTRACT FROM AUTHOR]

Published
2019

43. Feeding corn grain steeped in citric acid modulates rumen fermentation and inflammatory responses in dairy goats.

Author

Shen, Y. Z., Ding, L. Y., Chen, L. M., Xu, J. H., Zhao, R., Yang, W. Z., Wang, H. R., and Wang, M. Z.

Abstract

Cereal grains treated with organic acids were proved to increase ruminal resistant starch and can relieve the risk of ruminal acidosis. However, previous study mainly focussed on acid-treated barley, the effects of organic acid-treated corn is still unknown. The objectives of this study were to evaluate whether feeding ground corn steeped in citric acid (CA) would affect ruminal pH and fermentation patterns, milk production and innate immunity responses in dairy goats. Eight ruminally cannulated Saanen dairy goats were used in a crossover designed experiment. Each experimental period was 21 day long including 14 days for adaption to new diet and 7 days for sampling and data collection. The goats were fed high-grain diet contained 30% hay and 70% corn-based concentrate. The corn was steeped either in water (control) or in 0.5% (wt/vol) CA solution for 48 h. Goats fed CA diet showed improved ruminal pH status with greater mean and minimum ruminal pH, and shorter (P< 0.05) duration of ruminal pH<5.6 and less area of ruminal pH<5.6, 5.8 and 6.0. Concentration of total volatile fatty acid and molar proportion of propionate were less but the molar proportion of acetate was greater (P< 0.05) in goats fed the CA diet than the control diet. Concentration of ruminal lipopolysaccharide (LPS) was lower (P< 0.05) and that of lactic acid also tended (P< 0.10) to be lower in goats fed CA than the control. Although dry matter intake, actual milk yield, yield and content of milk protein and lactose were not affected, the milk fat content and 4% fat-corrected milk tended (P< 0.10) to be greater in goats fed CA diet. For the inflammatory responses, peripheral LPS did not differ, whereas the concentration of LPS binding protein and serum amyloid A tended (P< 0.10) to be less in goats fed CA diet. Similarly, goats fed CA diet had less (P< 0.05) concentration of haptoglobin and tumour necrosis factor. These results indicated that feeding ground corn treated with CA effectively improved ruminal pH status, thus alleviated the risk of ruminal acidosis, reduced inflammatory response, and tend to improve milk yield and milk fat test. [ABSTRACT FROM AUTHOR]

Published
2019
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49. Protective effect of simvastatin on arterial plaque instability induced by p-cresyl sulfate.

Author

LI, H. Y., WANG, H. R., LIU, F., and GAO, C.

Abstract

OBJECTIVE: To study the protective effect of simvastatin on arterial plaque instability induced by p-cresyl sulfate (PCS). MATERIALS AND METHODS: Apolipoprotein E (ApoE)-/- mice were selected as objects of this study. All mice were randomly divided into three groups: 1) the control group, 2) the PCS group and 3) the PCS + simvastatin group. After successful modeling, the levels of plasma cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein, interleukin-1 (IL-1), interleukin- 6 (IL-6) and tumor necrosis factor-β (TNF-β) were detected. The gross specimen of coronary artery was stained. Meanwhile, oil red O staining and Sirius red staining were performed for coronary arterial sections to observe the lipid and collagen components. The expression levels of smooth muscle cells and macrophages were observed by immunohistochemistry. In addition, the expression levels of matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs) and monocyte chemoattractant protein-1 (MCP-1) in tissues were detected by Western blotting. RESULTS: Simvastatin could improve atherosclerotic plaque growth and atherosclerotic plaque instability induced by PCS. Moreover, simvastatin could also improve the changes of MMPs and TIMPs caused by PCS as well as the inflammatory status in mice. CONCLUSIONS: Simvastatin can improve the inflammatory status in mice, eventually improving the arterial plaque instability caused by PCS. [ABSTRACT FROM AUTHOR]

Published
2018

50. Correlation between Nurr1 expression and drug resistance in the brain of rats with epileps.

Author

LI, H.-Y., LIU, F., and WANG, H.-R.

Abstract

OBJECTIVE: To investigate the correlation between nuclear receptor related 1 (Nurr1) expression and drug resistance in the brain of rats with epilepsy. MATERIALS AND METHODS: A total of 60 adult male Sprague-Dawley rats were selected, and the animal model of epilepsy was established by electrical stimulation. These rats were randomly divided into the control group and the drug-resistant group. The model of drug-resistant epilepsy was screened with phenytoin (PHT) and phenobarbital (PB); the hippocampus and temporal lobe cortex tissues were isolated from rats; the messenger ribonucleic acid (mRNA) and protein levels of Nurr1 in the hippocampus and cortex tissues of the two groups of rats were detected by reverse transcription polymerase chain reaction (RT-PCR), Western blotting and immunohistochemistry, respectively. The budding tissue marker growth-associated protein-43 (GAP43) in hippocampus tissues were labeled by immunofluorescence staining; the mRNA and protein levels of indicators related to drug-resistant epilepsy, including leukemia-associated phenotype (LAP), multi-drug resistance protein (MRP), P-glycoprotein (P-gp) and monocyte chemoattractant protein-1 (MCP-1), were further detected. Pearson correlation analysis was used to analyze the correlations of the protein level of Nurr1 with drug-resistant indicators. RESULTS: The mRNA and protein levels of Nurr1 in hippocampus tissues of the drug-resistant group were significantly increased compared with those of the control group (p < 0.05). In temporal lobe cortex tissues, there was no significant difference in the mRNA level of Nurr1 between the control group and the drug-resistant group (p > 0.05). The immunohistochemistry results showed that the fluorescence intensity of GAP3 in hippocampus tissues of the drug-resistant group was significantly higher than that of the control group. The mRNA and protein levels of epilepsy-related indicators, LAP, MRP, P-gp and MCP-1 in hippocampus tissues of drug-resistant group were significantly up-regulated compared with those of the control group (p < 0.05). Pearson correlation analysis indicated that the protein level of Nurr1 in hippocampus tissues was positively correlated with those of LAP, MRP, P-gp and MCP-1 in the corresponding regions (p < 0.05). CONCLUSIONS: Nurr1 enhances the drug resistance of epilepsy in rats by up-regulating the expression of proteins related to drug resistance. [ABSTRACT FROM AUTHOR]

Published
2018

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