Search

Your search keyword '"Wang, Hong‐juan"' showing total 298 results
Start Over Author "Wang, Hong‐juan"
298 results on '"Wang, Hong‐juan"'

10. Kaempferol alleviates oxidative stress injury of human keratinocytes

Author

ZOU Xue-lian, HU Wen, LEI Zi-xian, WANG Hong-juan, XU Chen, Halina HAIRUOLA, KANG Xiao-jing

Subjects
vernonia anthelmintica (l.) willd., kaempferol, vitiligo, oxidative stress, keratinocytes, Medicine
Abstract

Objective To explore the antioxidant effect and mechanism of kaempferol(KP), a component of Vernonia anthelmintica (L.) Willd., in human immortalized keratinocytes (HaCaT). Methods Using selective reaction/multiple response monitoring technique for quantitative analysis of the flavonoids in the seeds of Vernonia anthelmintica (L.) Willd.. HaCaT cells were divided into control group, model group(HaCaT cells were treated with AAPH to establish the oxidative stress model), low-, middle- and high-dose KP intervention groups.CCK-8 assay for proliferation, RT-qPCR was used for checking the expression of Nrf2, HO-1, NQO1, GCLC and GCLM mRNA, Western blot was used for checking the expression of Nrf2 protein. Results 1)The content of total flavonoids of Vernonia anthelmintica (L.) Willd.. was 0.97 g/100 g, and a total of 36 flavonoid compounds were quantified, the content of KP was 62.96 ng/100 g. 2)The optimum concentration of AAPH for constructing oxidative stress model was 25 mmol/L, and when the concentration of KP was 0-40 μmol/L, no obvious cytotoxicity was found. 3)Low-dose KP increased the expression of Nrf2, HO-1 and GCLC mRNA. Among them, the expression of HO-1 changed most significantly. 4)KP increased the expression of Nrf2 protein in a concentration-dependent manner. Conclusions A component of Vernonia anthelmintica (L.) Willd., reduces the oxidative stress injury of human keratinocytes, the mechanism might be related to the up-regulation of Nrf2 expression.

Published
2021

13. Evolution of the Coronal Magnetic Configurations Including a Current-Carrying Flux Rope in Response to the Change in the Background Field

Author

Wang, Hong-Juan, Liu, Si-Qing, Gong, Jian-Cun, and Lin, Jun

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

We investigate equilibrium height of the flux rope, and its internal equilibrium in a realistic plasma environment by carrying out numerical simulations of the evolution of systems including a current-carrying flux rope. We find that the equilibrium height of the flux rope is approximately a power-law function of the relative strength of the background field. Our simulations indicate that the flux rope can escape more easily from a weaker background field. This further confirms the catastrophe in the magnetic configuration of interest can be triggered by decrease of strength of the background field. Our results show that it takes some time to reach internal equilibrium depending on the initial state of the flux rope. The plasma flow inside the flux rope due to the adjustment for the internal equilibrium of the flux rope remains small and does not last very long when the initial state of the flux rope commences from the stable branch of the theoretical equilibrium curve. This work also confirms the influence of the initial radius of flux rope on its evolution, the results indicate that the flux rope with larger initial radius erupts more easily. In addition, by using the realistic plasma environment and much higher resolution in our simulations, we notice some different characters compared to previous studies in Forbes (1990)., Comment: accepted for publication in the Research in Astronomy and Astrophysics

Published
2014

38. Two mixed-ligand transition metal coordination polymers: crystal structures and prevention effect on chronic obstructive pulmonary disease.

Author

Chen, Xiao-Jun, Wang, Hong-Juan, and Shan, Wei

Subjects
*CHRONIC obstructive pulmonary disease, *CRYSTALLINE polymers, *TRANSITION metals, *POLYMER structure, *ORGANIC conductors, *COORDINATION polymers, *CHEMICAL formulas
Abstract

In the current study, via applying the mixed ligand approach, two new transition metal coordination polymers (CPs) with the chemical formulae of [Zn(OBPB)(tfbdc)]n (1) and {[Cd(OBPB)(tfbdc)(H2O)]·DMF}n (2), were hydrothermally synthesized using the self-assembly of the "V-shape" OBPB ligand (1,1'-(oxybis(4,1-phenylene))bis(1H-imidazole)) and the H2tfbdc ligand (2,3,5,6-tetrafluorobenzene-1,4-dicarboxylic acid) with Zn/Cd metal salts. Furthermore, the treatment activity of compounds 1 and 2 against chronic obstructive pulmonary disease (COPD) was evaluated and the related mechanism was explored at the same time. Firstly, the content of the INF-γ released from the respiratory tract was evaluated with ELISA detection kit. Besides, the real time RT-PCR was performed in this study to measure the expression levels of the ampk and stat-1 in the respiratory tract endothelial cells. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results