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1. Optical biosensing of markers of mucosal inflammation

Author

Covarrubias-Zambrano, Obdulia, Motamedi, Massoud, Ameredes, Bill T., Tian, Bing, Calhoun, William J., Zhao, Yingxin, Brasier, Allan R., Kalubowilage, Madumali, Malalasekera, Aruni P., Yapa, Asanka S., Wang, Hongwang, Culbertson, Christopher T., Troyer, Deryl L., and Bossmann, Stefan H.

Published
2022
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3. Rationally designed peptide nanosponges for cell-based cancer therapy

Author

Wang, Hongwang, Yapa, Asanka S., Kariyawasam, Nilusha L., Shrestha, Tej B., Kalubowilage, Madumali, Wendel, Sebastian O., Yu, Jing, Pyle, Marla, Basel, Matthew T., Malalasekera, Aruni P., Toledo, Yubisela, Ortega, Raquel, Thapa, Prem S., Huang, Hongzhou, Sun, Susan X., Smith, Paul E., Troyer, Deryl L., and Bossmann, Stefan H.

Published
2017
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10. Stem cell-based photodynamic therapy

Author

Shrestha, Tej B., Seo, Gwi M., Basel, Matthew T., Kalita, Mausam, Wang, Hongwang, Villanueva, David, Pyle, Marla, Balivada, Sivasai, Rachakatla, Raja Shekar, Shinogle, Heather, Thapa, Prem S., Moore, David, Troyer, Deryl L., and Bossmann, Stefan H.

Published
2012
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12. Pyrazolyl Thioureas and Carbothioamides with an NNSN Motif against MSSA and MRSA

Author

Delpe-Acharige, Anjana, primary, Zhang, Man, additional, Eschliman, Kayla, additional, Dalecki, Alex, additional, Covarrubias-Zambrano, Obdulia, additional, Minjarez-Almeida, Azriel, additional, Shrestha, Tejaswi, additional, Lewis, Tanji, additional, Al-Ibrahim, Fatimah, additional, Leonard, Sophia, additional, Roberts, Riana, additional, Tebeje, Anteneh, additional, Malalasekera, Aruni P., additional, Wang, Hongwang, additional, Kalubowilage, Madumali, additional, Wolschendorf, Frank, additional, Kutsch, Olaf, additional, and Bossmann, Stefan H., additional

Published
2021
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15. A/C magnetic hyperthermia of melanoma mediated by iron(0)/iron oxide core/shell magnetic nanoparticles: a mouse study

Author

Koper Olga B, Leaym Xiaoxuan, Walker Brandon, Kroh Franklin O, Pyle Marla, Dani Raj, Samarakoon Thilani N, Wang Hongwang, Rachakatla Raja, Balivada Sivasai, Tamura Masaaki, Chikan Viktor, Bossmann Stefan H, and Troyer Deryl L

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background There is renewed interest in magnetic hyperthermia as a treatment modality for cancer, especially when it is combined with other more traditional therapeutic approaches, such as the co-delivery of anticancer drugs or photodynamic therapy. Methods The influence of bimagnetic nanoparticles (MNPs) combined with short external alternating magnetic field (AMF) exposure on the growth of subcutaneous mouse melanomas (B16-F10) was evaluated. Bimagnetic Fe/Fe3O4 core/shell nanoparticles were designed for cancer targeting after intratumoral or intravenous administration. Their inorganic center was protected against rapid biocorrosion by organic dopamine-oligoethylene glycol ligands. TCPP (4-tetracarboxyphenyl porphyrin) units were attached to the dopamine-oligoethylene glycol ligands. Results The magnetic hyperthermia results obtained after intratumoral injection indicated that micromolar concentrations of iron given within the modified core-shell Fe/Fe3O4 nanoparticles caused a significant anti-tumor effect on murine B16-F10 melanoma with three short 10-minute AMF exposures. We also observed a decrease in tumor size after intravenous administration of the MNPs followed by three consecutive days of AMF exposure 24 hrs after the MNPs injection. Conclusions These results indicate that intratumoral administration of surface modified MNPs can attenuate mouse melanoma after AMF exposure. Moreover, we have found that after intravenous administration of micromolar concentrations, these MNPs are capable of causing an anti-tumor effect in a mouse melanoma model after only a short AMF exposure time. This is a clear improvement to state of the art.

Published
2010
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16. Peptide nanosponges designed for rapid uptake by leukocytes and neural stem cells

Author

Yapa, Asanka S., Wang, Hongwang, Wendel, Sebastian O., Shrestha, Tej. B., Kariyawasam, Nilusha L., Kalubowilage, Madumali, Perera, Ayomi S., Pyle, Marla, Basel, Matthew T., Malalasekera, Aruni P., Manawadu, Harshi, Yu, Jing, Toledo, Yubisela, Ortega, Raquel, Thapa, Prem S., Smith, Paul E., Troyer, Deryl L., and Bossmann, Stefan H.

Subjects
chemistry
Abstract

The structure of novel binary nanosponges consisting of (cholesterol-(K/D)ₙDEVDGC)₃-trimaleimide units possessing a trigonal maleimide linker, to which either lysine (K)₂₀ or aspartic acid (D)₂₀ are tethered, has been elucidated by means of TEM. A high degree of agreement between these findings and structure predictions through explicit solvent and then coarse-grained molecular dynamics (MD) simulations has been found. Based on the nanosponges' structure and dynamics, caspase-6 mediated release of the model drug 5(6)-carboxyfluorescein has been demonstrated. Furthermore, the binary (DK20) nanosponges have been found to be virtually non-toxic in cultures of neural progenitor cells. It is of a special importance for the future development of cell-based therapies that DK20 nanosponges were taken up efficiently by leucocytes (WBC) in peripheral blood within 3 h of exposure. The percentage of live cells among the WBC was not significantly decreased by the DK20 nanosponges. In contrast to stem cell or leucocyte cell cultures, which have to be matched to the patient, autologous cells are optimal for cell-mediated therapy. Therefore, the nanosponges hold great promise for effective cell-based tumor targeting.

Published
2018

17. Peptide Nanosponges Designed for the Delivery of Perillyl Alcohol to Glioma Cells

Author

Yapa, Asanka S., primary, Shrestha, Tej B., additional, Wendel, Sebastian O., additional, Kalubowilage, Madumali, additional, Yu, Jing, additional, Wang, Hongwang, additional, Pyle, Marla, additional, Basel, Matthew T., additional, Toledo, Yubisela, additional, Ortega, Raquel, additional, Malalasekera, Aruni P., additional, Thapa, Prem S., additional, Troyer, Deryl L., additional, and Bossmann, Stefan H., additional

Published
2018
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18. Early detection of pancreatic cancers in liquid biopsies by ultrasensitive fluorescence nanobiosensors

Author

Kalubowilage, Madumali, primary, Covarrubias-Zambrano, Obdulia, additional, Malalasekera, Aruni P., additional, Wendel, Sebastian O., additional, Wang, Hongwang, additional, Yapa, Asanka S., additional, Chlebanowski, Lauren, additional, Toledo, Yubisela, additional, Ortega, Raquel, additional, Janik, Katharine E., additional, Shrestha, Tej B., additional, Culbertson, Christopher T., additional, Kasi, Anup, additional, Williamson, Stephen, additional, Troyer, Deryl L., additional, and Bossmann, Stefan H., additional

Published
2018
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19. Faraday rotation enhancement of gold coated Fe2O3 nanoparticles: Comparison of experiment and theory.

Author

Dani, Raj Kumar, Wang, Hongwang, Bossmann, Stefan H., Wysin, Gary, and Chikan, Viktor

Subjects
*ROTATIONAL motion, *COLLOIDAL gold, *METAL coating, *MAGNETIC materials, *COMPARATIVE studies, *THICKNESS measurement, *FARADAY effect
Abstract

Understanding plasmonic enhancement of nanoscale magnetic materials is important to evaluate their potential for application. In this study, the Faraday rotation (FR) enhancement of gold coated Fe2O3 nanoparticles (NP) is investigated experimentally and theoretically. The experiment shows that the Faraday rotation of a Fe2O3 NP solution changes from approximately 3 rad/Tm to 10 rad/Tm as 5 nm gold shell is coated on a 9.7 nm Fe2O3 core at 632 nm. The results also show how the volume fraction normalized Faraday rotation varies with the gold shell thickness. From the comparison of experiment and calculated Faraday rotation based on the Maxwell-Garnett theory, it is concluded that the enhancement and shell dependence of Faraday rotation of Fe2O3 NPs is a result of the shifting plasmon resonance of the composite NP. In addition, the clustering of the NPs induces a different phase lag on the Faraday signal, which suggests that the collective response of the magnetic NP aggregates needs to be considered even in solution. From the Faraday phase lag, the estimated time of the full alignment of the magnetic spins of bare (cluster size 160 nm) and gold coated NPs (cluster size 90 nm) are found to be 0.65 and 0.17 μs. The calculation includes a simple theoretical approach based on the Bruggeman theory to account for the aggregation and its effect on the Faraday rotation. The Bruggeman model provides a qualitatively better agreement with the experimentally observed Faraday rotation and points out the importance of making a connection between component properties and the average 'effective' optical behavior of the Faraday medium containing magnetic nanoparticles. [ABSTRACT FROM AUTHOR]

Published
2011
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20. Peptide nanosponges designed for rapid uptake by leukocytes and neural stem cells

Author

Yapa, Asanka S., primary, Wang, Hongwang, additional, Wendel, Sebastian O., additional, Shrestha, Tej. B., additional, Kariyawasam, Nilusha L., additional, Kalubowilage, Madumali, additional, Perera, Ayomi S., additional, Pyle, Marla, additional, Basel, Matthew T., additional, Malalasekera, Aruni P., additional, Manawadu, Harshi, additional, Yu, Jing, additional, Toledo, Yubisela, additional, Ortega, Raquel, additional, Thapa, Prem S., additional, Smith, Paul E., additional, Troyer, Deryl L., additional, and Bossmann, Stefan H., additional

Published
2018
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21. Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses

Author

Maroto, Rosario, primary, Zhao, Yingxin, additional, Jamaluddin, Mohammad, additional, Popov, Vsevolod L., additional, Wang, Hongwang, additional, Kalubowilage, Madumali, additional, Zhang, Yueqing, additional, Luisi, Jonathan, additional, Sun, Hong, additional, Culbertson, Christopher T., additional, Bossmann, Stefan H., additional, Motamedi, Massoud, additional, and Brasier, Allan R., additional

Published
2017
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26. Early breast cancer screening using iron/iron oxide-based nanoplatforms with sub-femtomolar limits of detection

Author

Udukala, Dinusha N, primary, Wang, Hongwang, additional, Wendel, Sebastian O, additional, Malalasekera, Aruni P, additional, Samarakoon, Thilani N, additional, Yapa, Asanka S, additional, Abayaweera, Gayani, additional, Basel, Matthew T, additional, Maynez, Pamela, additional, Ortega, Raquel, additional, Toledo, Yubisela, additional, Bossmann, Leonie, additional, Robinson, Colette, additional, Janik, Katharine E, additional, Koper, Olga B, additional, Li, Ping, additional, Motamedi, Massoud, additional, Higgins, Daniel A, additional, Gadbury, Gary, additional, Zhu, Gaohong, additional, Troyer, Deryl L, additional, and Bossmann, Stefan H, additional

Published
2016
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33. Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model

Author

Basel,Matthew T, Balivada,Sivasai, Wang,Hongwang, Shrestha,Tej B, Seo,Gwi Moon, Pyle,Marla, Ayabaweera,Gayani, Dani,Raj, Koper,Olga B, Tamura,Masaaki, Chikan,Viktor, Bossmann,Stefan H, Troyer,Deryl L, Basel,Matthew T, Balivada,Sivasai, Wang,Hongwang, Shrestha,Tej B, Seo,Gwi Moon, Pyle,Marla, Ayabaweera,Gayani, Dani,Raj, Koper,Olga B, Tamura,Masaaki, Chikan,Viktor, Bossmann,Stefan H, and Troyer,Deryl L

Abstract

Matthew T Basel1, Sivasai Balivada1, Hongwang Wang2, Tej B Shrestha1, Gwi Moon Seo1, Marla Pyle1, Gayani Abayaweera2, Raj Dani2, Olga B Koper2, Masaaki Tamura1, Viktor Chikan2, Stefan H Bossmann2, Deryl L Troyer11Department of Anatomy and Physiology, College of Veterinary Medicine, 2Department of Chemistry, Kansas State University, Manhattan, KS, USAAbstract: Using magnetic nanoparticles to absorb alternating magnetic field energy as a method of generating localized hyperthermia has been shown to be a potential cancer treatment. This report demonstrates a system that uses tumor homing cells to actively carry iron/iron oxide nanoparticles into tumor tissue for alternating magnetic field treatment. Paramagnetic iron/iron oxide nanoparticles were synthesized and loaded into RAW264.7 cells (mouse monocyte/macrophage-like cells), which have been shown to be tumor homing cells. A murine model of disseminated peritoneal pancreatic cancer was then generated by intraperitoneal injection of Pan02 cells. After tumor development, monocyte/macrophage-like cells loaded with iron/iron oxide nanoparticles were injected intraperitoneally and allowed to migrate into the tumor. Three days after injection, mice were exposed to an alternating magnetic field for 20 minutes to cause the cell-delivered nanoparticles to generate heat. This treatment regimen was repeated three times. A survival study demonstrated that this system can significantly increase survival in a murine pancreatic cancer model, with an average post-tumor insertion life expectancy increase of 31%. This system has the potential to become a useful method for specifically and actively delivering nanoparticles for local hyperthermia treatment of cancer.Keywords: cytotherapy, pancreatic cancer, disseminated peritoneal carcinomatosis, targeted magnetic hyperthermia, nanoparticles

Published
2012

34. Meeting the challenges : carbon-hydrogen bond activation and cancer treatment

Author

Wang, Hongwang. and Wang, Hongwang.

Abstract

My thesis is divided into two parts. The first part is focused on studies of N-heterocyclic carbene (NHC) palladium(IV) intermediates, which are involved in oxidative addition mediated C-C, and C-O bond formation processes as well as in C-Cl bond forming reactions via a reductive elimination process. Bis-NHC-Pd(II) complexes have been reported as effective catalysts to mediate direct conversion of methane into methanol. However, a H-D exchange study revealed that the bis-NHC-Pd(II) complexes are not the active species responsible for the C-H bond activation reaction. This unexpected result implies that the high oxidation state bis- NHC-Pd(IV) species may be the real catalyst! The oxidative addition of methyl iodide to the bis- NHC-Pd(II)-Me2 complex led to the successful observation of the formation of a transient trimethyl bis-NHC-Pd(IV) intermediate by both 1H-NMR and 13C-NMR spectroscopy. Different oxidants such as O2, PhI(OAc)2, PhI(OTFA)2 and Cl2 reacted with the bis-NHC-Pd(II)-Me2 complex, and competitive C-C and C-O bond formations, as well as C-C and C-Cl bond formations were observed. Dioxygen triggered C-C bond formation under dry condition and both C-C and C-O bond formation in the presence of H2O gave strong indications that the bis-NHCPd(II)-Me2 complex can be oxidized to a bis-NHC-Pd(IV) intermediate by dioxygen. The reaction between the hypervalent iodine regents PhI(OAc)2 and PhI(OTFA)2 and the bis-NHCPd(II)-Me2 complex gave only reductive elimination products. Therefore, this system can act as a model system, which is able to providing valuable information of the product forming (functionalization) step of the C-H bond activation system. The reaction between chlorine and the bis-NHC-Pd(II)-Me2 complex resulted in a relatively stable bis-NHC-Pd(IV)-Cl4 complex, which was characterized by 1H-NMR spectroscopy and mass spectroscopy. The structure of bis- NHC-Pd(IV)-Cl4 was unambiguously established by X-ray crystallography. The second part of this thesis describes the synthesis of functionalized bimagnetic core/shell iron/iron oxide nanoparticles for the treatment of cancer. Biocompatible dopamineoligoethylene glycol functionalized bimagnetic core/shell Fe/Fe3O4 nanoparticles were prepared via ligand exchange, and purified by repeated dispersion/magneto-precipitation cycles. A porphyrin (TCPP) has been tethered to the stealth nanoparticles to enhance their uptake by tumor cells and (neural) stem cells. The stealth nanoparticles have been delivered in a mouse model to tumor sites intravenously by using the EPR (enhanced permeation and retention) effect. Magnetic hyperthermia proved to be very effective against B16-F10 mouse melanomas in Charles River black mice. After hyperthermia, the nanoparticles have shown a significant effect on the growth of tumor (up to 78% growth inhibition).

Published
2009

37. Channel Blocking of MspA Revisited

Author

Perera, Ayomi S., primary, Wang, Hongwang, additional, Basel, Matthew T., additional, Pokhrel, Megh Raj, additional, Gamage, Pubudu Siyambalagoda, additional, Kalita, Mausam, additional, Wendel, Sebastian, additional, Sears, Bryan, additional, Welideniya, Dhanushi, additional, Liu, Yao, additional, Turro, Claudia, additional, Troyer, Deryl L., additional, and Bossmann, Stefan H., additional

Published
2012
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38. Magnetic-Fe/Fe3O4-nanoparticle-bound SN38 as carboxylesterase-cleavable prodrug for the delivery to tumors within monocytes/macrophages

Author

Wang, Hongwang, primary, Shrestha, Tej B, additional, Basel, Matthew T, additional, Dani, Raj Kumar, additional, Seo, Gwi-Moon, additional, Balivada, Sivasai, additional, Pyle, Marla M, additional, Prock, Heidy, additional, Koper, Olga B, additional, Thapa, Prem S, additional, Moore, David, additional, Li, Ping, additional, Chikan, Viktor, additional, Troyer, Deryl L, additional, and Bossmann, Stefan H, additional

Published
2012
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41. Abstract LB-205: Using cell-delivered nanoparticles to cause local hyperthermia increases survival in a murine metastatic pancreatic cancer model

Author

Basel, Matthew T., primary, Balivada, Sivasai, additional, Wang, Hongwang, additional, Shrestha, Tej B., additional, Seo, Gwi Moon, additional, Pyle, Marla M., additional, Abayaweera, Gayani, additional, Dani, Raj, additional, Chikan, Viktor, additional, Bossmann, Stefan, additional, and Troyer, Deryl, additional

Published
2011
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43. Attenuation of Mouse Melanoma by A/C Magnetic Field after Delivery of Bi-Magnetic Nanoparticles by Neural Progenitor Cells

Author

Rachakatla, Raja Shekar, primary, Balivada, Sivasai, additional, Seo, Gwi-Moon, additional, Myers, Carl B., additional, Wang, Hongwang, additional, Samarakoon, Thilani N., additional, Dani, Raj, additional, Pyle, Marla, additional, Kroh, Franklin O., additional, Walker, Brandon, additional, Leaym, Xiaoxuan, additional, Koper, Olga B., additional, Chikan, Viktor, additional, Bossmann, Stefan H., additional, Tamura, Masaaki, additional, and Troyer, Deryl L., additional

Published
2010
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44. A/C magnetic hyperthermia of melanoma mediated by iron(0)/iron oxide core/shell magnetic nanoparticles: a mouse study

Author

Balivada, Sivasai, primary, Rachakatla, Raja Shekar, additional, Wang, Hongwang, additional, Samarakoon, Thilani N, additional, Dani, Raj Kumar, additional, Pyle, Marla, additional, Kroh, Franklin O, additional, Walker, Brandon, additional, Leaym, Xiaoxuan, additional, Koper, Olga B, additional, Tamura, Masaaki, additional, Chikan, Viktor, additional, Bossmann, Stefan H, additional, and Troyer, Deryl L, additional

Published
2010
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48. Channel Blocking of MspARevisited.

Author

Perera, Ayomi S., Wang, Hongwang, Basel, Matthew T., Pokhrel, Megh Raj, Gamage, Pubudu Siyambalagoda, Kalita, Mausam, Wendel, Sebastian, Sears, Bryan, Welideniya, Dhanushi, Liu, Yao, Turro, Claudia, Troyer, Deryl L., and Bossmann, Stefan H.

Subjects
*MYCOBACTERIUM smegmatis, *ELECTROLYTES, *CELL membranes, *TUBERCULOSIS treatment, *RUTHENIUM compounds, *HIGH performance liquid chromatography
Abstract

Porin A from Mycobacterium smegmatis(MspA) is a highly stable, octameric channel protein, which actsas the main transporter of electrolytes across the cell membrane.MspA features a narrow, negatively charged constriction zone, allowingstable binding of various analytes thereby blocking the channel. Investigationof channel blocking of mycobacterial porins is of significance indeveloping alternate treatment methods for tuberculosis. The conceptthat ruthenium(II)quaterpyridinium complexes have the capability toact as efficient channel blockers for MspA and related porins, emergedafter very high binding constants were measured by high-performanceliquid chromatography and steady-state luminescence studies. Consequently,the interactions between the ruthenium(II) complex RuC2 moleculesand MspA, leading to RuC2@MspA assemblies, have been studied utilizingtime-resolved absorption/emission, atomic force microscopy, dynamiclight scattering, ζ potential measurements, and isothermal titrationcalorimetry. The results obtained provide evidence for the formationof clusters/large aggregates of RuC2 and MspA. The results are ofinterest with respect to utilizing prospective channel blockers inporins. The combination of results from conceptually different techniquesshed some light onto the chemical nature of MspA–channel blockerinteractions thus contributing to the development of a paradigm forchannel blocking. [ABSTRACT FROM AUTHOR]

Published
2013
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50. Early detection of pancreatic cancers in liquid biopsies by ultrasensitive fluorescence nanobiosensors.

Author

Kalubowilage M, Covarrubias-Zambrano O, Malalasekera AP, Wendel SO, Wang H, Yapa AS, Chlebanowski L, Toledo Y, Ortega R, Janik KE, Shrestha TB, Culbertson CT, Kasi A, Williamson S, Troyer DL, and Bossmann SH

Subjects
Case-Control Studies, Female, Humans, Liquid Biopsy, Male, Biosensing Techniques, Carcinoma, Pancreatic Ductal diagnosis, Early Detection of Cancer methods, Fluorescent Dyes chemistry, Nanoparticles chemistry, Pancreatic Neoplasms diagnosis
Abstract

Numerous proteases, such as matrix metalloproteinases (MMPs), cathepsins (CTS), and urokinase plasminogen activator (UpA), are dysfunctional (that is, over- or under-expressed) in solid tumors, when compared to healthy human subjects. This offers the opportunity to detect early tumors by liquid biopsies. This approach is of particular advantage for the early detection of pancreatic cancer, which is a "silent killer". We have developed fluorescence nanobiosensors for ultrasensitive (sub-femtomolar) arginase and protease detection, consisting of water-dispersible Fe/Fe 3 O 4 core/shell nanoparticles and two tethered fluorescent dyes: TCPP (Tetrakis(4-carboxyphenyl)porphyrin) and cyanine 5.5. Upon posttranslational modification or enzymatic cleavage, the fluorescence of TCPP increases, which enables the detection of proteases at sub-femtomolar activities utilizing conventional plate readers. We have identified an enzymatic signature for the detection of pancreatic adenocarcinomas in serum, consisting of arginase, matrix metalloproteinase-1, -3, and - 9, cathepsin-B and -E, urokinase plasminogen activator, and neutrophil elastase, which is a potential game-changer., (Copyright © 2018 Elsevier Inc. All rights reserved.)

Published
2018
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