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2. Observing Context Improves Disparity Estimation when Race is Unobserved

Author

Kwegyir-Aggrey, Kweku, Durvasula, Naveen, Wang, Jennifer, and Venkatasubramanian, Suresh

Subjects
Computer Science - Computers and Society
Abstract

In many domains, it is difficult to obtain the race data that is required to estimate racial disparity. To address this problem, practitioners have adopted the use of proxy methods which predict race using non-protected covariates. However, these proxies often yield biased estimates, especially for minority groups, limiting their real-world utility. In this paper, we introduce two new contextual proxy models that advance existing methods by incorporating contextual features in order to improve race estimates. We show that these algorithms demonstrate significant performance improvements in estimating disparities on real-world home loan and voter data. We establish that achieving unbiased disparity estimates with contextual proxies relies on mean-consistency, a calibration-like condition.

Published
2024

4. Interferometric Purcell suppression of spontaneous emission in a superconducting qubit

Author

Yen, Alec, Ye, Yufeng, Peng, Kaidong, Wang, Jennifer, Cunningham, Gregory, Gingras, Michael, Niedzielski, Bethany M., Stickler, Hannah, Serniak, Kyle, Schwartz, Mollie E., and O'Brien, Kevin P.

Subjects
Quantum Physics
Abstract

In superconducting qubits, suppression of spontaneous emission is essential to achieve fast dispersive measurement and reset without sacrificing qubit lifetime. We show that resonator-mediated decay of the qubit mode to the feedline can be suppressed using destructive interference, where the readout resonator is coupled to the feedline at two points. This "interferometric Purcell filter" does not require dedicated filter components or impedance mismatch in the feedline, making it suitable for applications such as all-pass readout. We design and fabricate a device with the proposed scheme and demonstrate suppression of resonator-mediated decay that exceeds 2 orders of magnitude over a bandwidth of 400 MHz., Comment: 10 pages, 10 figures

Published
2024

5. Directional emission of a readout resonator for qubit measurement

Author

Yen, Alec, Ye, Yufeng, Peng, Kaidong, Wang, Jennifer, Cunningham, Gregory, Gingras, Michael, Niedzielski, Bethany M., Stickler, Hannah, Serniak, Kyle, Schwartz, Mollie E., and O'Brien, Kevin P.

Subjects
Quantum Physics
Abstract

We propose and demonstrate transmission-based dispersive readout of a superconducting qubit using an all-pass resonator, which preferentially emits readout photons toward the output. This is in contrast to typical readout schemes, which intentionally mismatch the feedline at one end so that the readout signal preferentially decays toward the output. We show that this intentional mismatch creates scaling challenges, including larger spread of effective resonator linewidths due to non-ideal impedance environments and added infrastructure for impedance matching. A future architecture using multiplexed all-pass readout resonators would avoid the need for intentional mismatch and potentially improve the scaling prospects of quantum computers. As a proof-of-concept demonstration of "all-pass readout," we design and fabricate an all-pass readout resonator that demonstrates insertion loss below 1.17 dB at the readout frequency and a maximum insertion loss of 1.53 dB across its full bandwidth for the lowest three states of a transmon qubit. We demonstrate qubit readout with an average single-shot fidelity of 98.1% in 600 ns; to assess the effect of larger dispersive shift, we implement a shelving protocol and achieve a fidelity of 99.0% in 300 ns., Comment: 16 pages, 15 figures

Published
2024

6. Improving patient retention of medical information: lessons from the contact dermatitis clinic

Author

Li-Wang, Jennifer and Katta, Rajani

Subjects
communication, counseling, dermatitis, retention
Abstract

Medical communication skills are widely recognized as important, especially for situations in which providers must present complex and detailed information. Although much research focuses on how providers can improve their delivery of medical information, an equally important part of communication is supporting patient retention of the information. We present several methods to improve patient retention of medical information that we have found successful in an allergic contact dermatitis clinic. Some recommendations address information transfer (follow effective structure, teach to different learning styles, provide written instructions, employ the teach-back method). Other methods are effective, focusing on the patient's emotional, social, and relational needs (include storytelling, metaphor, and analogy, allay negative emotions, listen deeply/know your patient). This list is not exhaustive, but we have found these methods effective when counseling patients with allergic contact dermatitis. Patient retention of medical information is an important part of effective health care, benefits both the provider and the patient, and is applicable to every medical practice.

Published
2024

12. Assessment of antibody levels to SARS-CoV-2 in patients with idiopathic inflammatory myopathies receiving treatment with intravenous immunoglobulin.

Author

Charles-Schoeman, Christina, Faure-Kumar, Emmanuelle, Ferbas, Kathie, Wang, Jennifer, Shahbazian, Ani, Truong, Linh, McMahon, Maureen, Yang, Howard, FitzGerald, John, and Bae, Sangmee

Subjects
Anti-SARS-CoV2 antibodies, Dermatomyositis, Idiopathic inflammatory myopathies, Intravenous immunoglobulin, Polymyositis, Humans, Immunoglobulins, Intravenous, SARS-CoV-2, COVID-19, Antibodies, Viral, Myositis, Vaccination
Abstract

Antibodies to Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) have been reported in pooled healthy donor plasma and intravenous immunoglobulin products (IVIG). It is not known whether administration of IVIG increases circulating anti-SARS-CoV-2 antibodies (COVID ab) in IVIG recipients. COVID ab against the receptor binding domain of the spike protein were analyzed using a chemiluminescent microparticle immunoassay in patients with idiopathic inflammatory myopathies (IIM) both receiving and not receiving IVIG (IVIG and non-IVIG group, respectively). No significant differences in COVID ab levels were noted between IVIG and non-IVIG groups (417 [67-1342] AU/mL in IVIG vs 5086 [43-40,442] AU/mL in non-IVIG, p = 0.11). In linear regression models including all post-vaccination patient samples, higher number of vaccine doses was strongly associated with higher COVID ab levels (2.85 [1.21, 4.48] log AU/mL, regression coefficient [Formula: see text] [95% CI], p = 0.001), while use of RTX was associated with lower ab levels (2.73 [- 4.53, - 0.93] log AU/mL, [Formula: see text][95%CI], p = 0.004). In the IVIG group, higher total monthly doses of IVIG were associated with slightly higher COVID ab levels (0.02 [0.002-0.05] log AU/mL, p = 0.04). While patients on IVIG did not have higher COVID ab levels compared to the non-IVIG group, higher monthly doses of IVIG were associated with higher circulating levels of COVID ab in patients receiving IVIG, particularly in patients concomitantly receiving RTX. Our findings suggest that IIM patients, especially those at increased risk of COVID infection and worse COVID outcomes due to RTX therapy may have protective benefits when on concurrent IVIG treatment.

Published
2023

13. Author Correction: Distinct molecular and immune hallmarks of inflammatory arthritis induced by immune checkpoint inhibitors for cancer therapy

Author

Kim, Sang T., Chu, Yanshuo, Misoi, Mercy, Suarez-Almazor, Maria E., Tayar, Jean H., Lu, Huifang, Buni, Maryam, Kramer, Jordan, Rodriguez, Emma, Hussain, Zulekha, Neelapu, Sattva S., Wang, Jennifer, Shah, Amishi Y., Tannir, Nizar M., Campbell, Matthew T., Gibbons, Don L., Cascone, Tina, Lu, Charles, Blumenschein, George R., Altan, Mehmet, Lim, Bora, Valero, Vincente, Loghin, Monica E., Tu, Janet, Westin, Shannon N., Naing, Aung, Garcia-Manero, Guillermo, Abdel-Wahab, Noha, Tawbi, Hussein A., Hwu, Patrick, Oliva, Isabella C. Glitza, Davies, Michael A., Patel, Sapna P., Zou, Jun, Futreal, Andrew, Diab, Adi, Wang, Linghua, and Nurieva, Roza

Published
2024
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17. Designerly Understanding: Information Needs for Model Transparency to Support Design Ideation for AI-Powered User Experience

Author

Liao, Q. Vera, Subramonyam, Hariharan, Wang, Jennifer, and Vaughan, Jennifer Wortman

Subjects
Computer Science - Human-Computer Interaction, Computer Science - Artificial Intelligence
Abstract

Despite the widespread use of artificial intelligence (AI), designing user experiences (UX) for AI-powered systems remains challenging. UX designers face hurdles understanding AI technologies, such as pre-trained language models, as design materials. This limits their ability to ideate and make decisions about whether, where, and how to use AI. To address this problem, we bridge the literature on AI design and AI transparency to explore whether and how frameworks for transparent model reporting can support design ideation with pre-trained models. By interviewing 23 UX practitioners, we find that practitioners frequently work with pre-trained models, but lack support for UX-led ideation. Through a scenario-based design task, we identify common goals that designers seek model understanding for and pinpoint their model transparency information needs. Our study highlights the pivotal role that UX designers can play in Responsible AI and calls for supporting their understanding of AI limitations through model transparency and interrogation., Comment: Accepted at ACM CHI Conference on Human Factors in Computing Systems (CHI 2023)

Published
2023

21. Duloxetine for Postoperative Pain Control Following Knee or Hip Replacement: A Systematic Review and Meta-Analysis

Author

Jones, Ian A, Talehakimi, Arad, Murphy, Linda S, Wang, Jennifer C, Piple, Amit S, Christ, Alexander B, and Heckmann, Nathanael D

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Clinical Sciences, Clinical Trials and Supportive Activities, Arthritis, Pain Research, Neurodegenerative, Chronic Pain, Neurosciences, Drug Abuse (NIDA only), Clinical Research, Substance Misuse, Musculoskeletal, Arthroplasty, Duloxetine, Pain catastrophizing, THA, TKA
Abstract

BackgroundDuloxetine is a Food and Drug Administration-approved selective norepinephrine reuptake inhibitor for treating depression, anxiety, fibromyalgia, and neuropathic and chronic musculoskeletal pain. This meta-analysis aims to evaluate the efficacy of duloxetine in reducing pain and postoperative opioid use following lower extremity total joint arthroplasty.MethodsA literature search was performed, identifying randomized controlled trials investigating duloxetine for pain management after total hip and total knee arthroplasty. Data from the visual analog scale (VAS) for pain during movement and at rest were extracted for postoperative days (PODs) 1, 3, 7, and 14, as well as postoperative week 6 and postoperative month 3. Opioid use data were obtained at 24, 48 and 72 hours. All data were analyzed using inverse variance with random effects and presented as weighted mean difference.ResultsEight unique studies were identified and included, 7 of which were analyzed quantitatively. Duloxetine decreased postoperative opioid consumption at 48 and 72 hours. For VAS for pain at rest, significantly reduced pain was reported by duloxetine-treated patients at POD 3, POD 7, and postoperative week 6. For VAS for pain at movement, significantly reduced pain was reported by duloxetine-treated patients at POD1, POD 3, POD 7, POD 14, postoperative week 6, and postoperative month 3.ConclusionsDuloxetine appears to decrease postoperative pain and opioid consumption following total joint arthroplasty. However, definitive conclusions are limited by small sample size and study heterogeneity. While there is a need for follow-up studies to determine the optimal dose, duration, and patient population, strong preliminary data provide robust support for future large-scale efficacy studies.

Published
2023

23. RLang: A Declarative Language for Describing Partial World Knowledge to Reinforcement Learning Agents

Author

Rodriguez-Sanchez, Rafael, Spiegel, Benjamin A., Wang, Jennifer, Patel, Roma, Tellex, Stefanie, and Konidaris, George

Subjects
Computer Science - Artificial Intelligence, Computer Science - Machine Learning
Abstract

We introduce RLang, a domain-specific language (DSL) for communicating domain knowledge to an RL agent. Unlike existing RL DSLs that ground to \textit{single} elements of a decision-making formalism (e.g., the reward function or policy), RLang can specify information about every element of a Markov decision process. We define precise syntax and grounding semantics for RLang, and provide a parser that grounds RLang programs to an algorithm-agnostic \textit{partial} world model and policy that can be exploited by an RL agent. We provide a series of example RLang programs demonstrating how different RL methods can exploit the resulting knowledge, encompassing model-free and model-based tabular algorithms, policy gradient and value-based methods, hierarchical approaches, and deep methods.

Published
2022

29. Immune correlates analysis of the ENSEMBLE single Ad26.COV2.S dose vaccine efficacy clinical trial.

Author

Fong, Youyi, McDermott, Adrian, Benkeser, David, Roels, Sanne, Stieh, Daniel, Vandebosch, An, Le Gars, Mathieu, Van Roey, Griet, Houchens, Christopher, Martins, Karen, Jayashankar, Lakshmi, Castellino, Flora, Amoa-Awua, Obrimpong, Basappa, Manjula, Flach, Britta, Lin, Bob, Moore, Christopher, Naisan, Mursal, Naqvi, Muhammed, Narpala, Sandeep, OConnell, Sarah, Mueller, Allen, Serebryannyy, Leo, Castro, Mike, Wang, Jennifer, Petropoulos, Christos, Luedtke, Alex, Hyrien, Ollivier, Lu, Yiwen, Yu, Chenchen, Borate, Bhavesh, van der Laan, Lars, Hejazi, Nima, Kenny, Avi, Carone, Marco, Wolfe, Daniel, Sadoff, Jerald, Gray, Glenda, Grinsztejn, Beatriz, Goepfert, Paul, Little, Susan, Paiva de Sousa, Leonardo, Maboa, Rebone, Randhawa, April, Andrasik, Michele, Hendriks, Jenny, Truyers, Carla, Struyf, Frank, Schuitemaker, Hanneke, Douoguih, Macaya, Kublin, James, Corey, Lawrence, Neuzil, Kathleen, Carpp, Lindsay, Follmann, Dean, Gilbert, Peter, Koup, Richard, and Donis, Ruben

Subjects
Humans, Ad26COVS1, COVID-19, ChAdOx1 nCoV-19, 2019-nCoV Vaccine mRNA-1273, Vaccine Efficacy, Antibodies, Neutralizing
Abstract

Measuring immune correlates of disease acquisition and protection in the context of a clinical trial is a prerequisite for improved vaccine design. We analysed binding and neutralizing antibody measurements 4 weeks post vaccination as correlates of risk of moderate to severe-critical COVID-19 through 83 d post vaccination in the phase 3, double-blind placebo-controlled phase of ENSEMBLE, an international randomized efficacy trial of a single dose of Ad26.COV2.S. We also evaluated correlates of protection in the trial cohort. Of the three antibody immune markers we measured, we found most support for 50% inhibitory dilution (ID50) neutralizing antibody titre as a correlate of risk and of protection. The outcome hazard ratio was 0.49 (95% confidence interval 0.29, 0.81; P = 0.006) per 10-fold increase in ID50; vaccine efficacy was 60% (43%, 72%) at non-quantifiable ID50 (

Published
2022

30. Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression

Author

Cao, Shaolong, Wang, Jennifer R, Ji, Shuangxi, Yang, Peng, Dai, Yaoyi, Guo, Shuai, Montierth, Matthew D, Shen, John Paul, Zhao, Xiao, Chen, Jingxiao, Lee, Jaewon James, Guerrero, Paola A, Spetsieris, Nicholas, Engedal, Nikolai, Taavitsainen, Sinja, Yu, Kaixian, Livingstone, Julie, Bhandari, Vinayak, Hubert, Shawna M, Daw, Najat C, Futreal, P Andrew, Efstathiou, Eleni, Lim, Bora, Viale, Andrea, Zhang, Jianjun, Nykter, Matti, Czerniak, Bogdan A, Brown, Powel H, Swanton, Charles, Msaouel, Pavlos, Maitra, Anirban, Kopetz, Scott, Campbell, Peter, Speed, Terence P, Boutros, Paul C, Zhu, Hongtu, Urbanucci, Alfonso, Demeulemeester, Jonas, Van Loo, Peter, and Wang, Wenyi

Subjects
Human Genome, Genetics, Cancer, 2.1 Biological and endogenous factors, Aetiology, Humans, Neoplasms, Genetic Heterogeneity, Genomics, RNA, Messenger, Disease Progression
Abstract

Single-cell RNA sequencing studies have suggested that total mRNA content correlates with tumor phenotypes. Technical and analytical challenges, however, have so far impeded at-scale pan-cancer examination of total mRNA content. Here we present a method to quantify tumor-specific total mRNA expression (TmS) from bulk sequencing data, taking into account tumor transcript proportion, purity and ploidy, which are estimated through transcriptomic/genomic deconvolution. We estimate and validate TmS in 6,590 patient tumors across 15 cancer types, identifying significant inter-tumor variability. Across cancers, high TmS is associated with increased risk of disease progression and death. TmS is influenced by cancer-specific patterns of gene alteration and intra-tumor genetic heterogeneity as well as by pan-cancer trends in metabolic dysregulation. Taken together, our results indicate that measuring cell-type-specific total mRNA expression in tumor cells predicts tumor phenotypes and clinical outcomes.

Published
2022

35. Abnormal paraoxonase-1 (PON1) enzyme activity in idiopathic inflammatory myopathies

Author

Bae, Sangmee Sharon, Shahbazian, Ani, Wang, Jennifer, Golub, Ilana, Oganesian, Buzand, Dowd, Tyler, Vayngortin, Beata, Wang, Ryan, Elashoff, David, Reddy, Srinivasa T, and Charles-Schoeman, Christina

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Genetics, Rare Diseases, 2.1 Biological and endogenous factors, Aetiology, Good Health and Well Being, Aryldialkylphosphatase, Genotype, Humans, Lung Diseases, Interstitial, Myositis, Polymorphism, Single Nucleotide, idiopathic inflammatory myopathy, dermatomyositis, polymyositis, inclusion body myositis, paraoxonase1, PON1, paraoxonase, arylesterase, lactonase, Immunology, Public Health and Health Services, Arthritis & Rheumatology, Clinical sciences
Abstract

ObjectivesPatients with idiopathic inflammatory myopathies (IIM) have severe vascular involvement, which contributes to disease morbidity and mortality. Paraoxonase-1 (PON1) is a high-density lipoprotein (HDL) associated protein that protects the vascular endothelium from oxidative injury and damage. The current work assessed the functional and genetic determinants of PON1 activity in IIM patients.MethodsA total of 184 IIM patients and 112 healthy controls (HC) were included. PON1 enzyme activity was assessed by paraoxonase, arylesterase and lactonase assays, and the Q192R PON1 single nucleotide polymorphism (SNP) was analysed. Multivariate regression models examined associations of PON1 activity with IIM diagnosis and myositis disease outcomes.ResultsThe arylesterase and lactonase activities of PON1 were significantly lower in IIM patients compared with HC. Higher myositis disease activity, the presence of severe IIM-associated interstitial lung disease (ILD), and the presence of MDA5 or anti-synthetase antibodies were significantly associated with lower PON1 activity. The PON1 Q192R polymorphism was strongly linked to the paraoxonase activity of PON1 in IIM, and patients with the PON1 QQ genotype had better IIM disease outcomes compared with patients with the QR or RR genotypes.ConclusionsThe arylesterase and lactonase activities of PON1 are significantly impaired in IIM patients compared with HC, and inversely associate with IIM disease activity and the presence of severe ILD. The PON1 QQ genotype associates with more favourable disease outcomes in IIM patients. Large prospective studies are needed to further evaluate the role of PON1 and PON1 genetic polymorphisms in the development and propagation of IIM and IIM-ILD.

Published
2022

41. Red Light Phototherapy Using Light-Emitting Diodes Inhibits Melanoma Proliferation and Alters Tumor Microenvironments

Author

Austin, Evan, Huang, Alisen, Wang, Jennifer Y, Cohen, Marc, Heilman, Edward, Maverakis, Emanual, Michl, Josef, and Jagdeo, Jared

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Prevention, Cancer, melanoma, phototherapy, low level light therapy, photobiomodulation therapy, reactive oxygen species, tumor micro environment, Clinical sciences, Oncology and carcinogenesis
Abstract

BackgroundTotal annual cancer rates have decreased due to improved treatment and prevention. However, the incidence of melanoma is rising, and not all patients respond to immune and targeted approaches. Therefore, we sought to determine the efficacy of red light (RL) phototherapy in preclinical models of melanoma.MethodsMelanoma cells (A375, B16F10, MNT-1) were irradiated with RL. Melanoma proliferation, apoptosis, oxidative stress, and p53 phosphorylation were measured in vitro. In C57BL/6 mice, phototherapy safety, B16F10 tumor growth, and immunocyte infiltration were assessed following RL.ResultsIn vitro, 640 J/cm2 RL decreased cellular proliferation without increasing apoptosis, while 1280 J/cm2 increased apoptosis. RL increased intracellular reactive oxygen species generation and p53 phosphorylation. In animal models, 2560 J/cm2 RL significantly prevented melanoma growth and increased the expression of CD103+ dendritic cells. 1280 and 1920 J/cm2 RL decreased tumor volume, but not significantly. RL did not cause skin inflammation or erythema in normal skin.ConclusionRL represents a potentially safe and effective melanoma therapeutic. RL prevented tumor growth and increased the expression of immune markers, such as CD103, that are associated with favorable melanoma outcomes. Further research is needed to determine the optimal clinical treatment regimen for melanoma using RL.

Published
2022

42. Floquet-Mode Traveling-Wave Parametric Amplifiers

Author

Peng, Kaidong, Naghiloo, Mahdi, Wang, Jennifer, Cunningham, Gregory D, Ye, Yufeng, and O'Brien, Kevin P

Subjects
Quantum Physics, Condensed Matter - Superconductivity, Physics - Applied Physics
Abstract

Simultaneous ideal quantum measurements of multiple single-photon-level signals would advance applications in quantum information processing, metrology, and astronomy, but require the first amplifier to be simultaneously broadband, quantum limited, and directional. However, conventional traveling-wave parametric amplifiers support broadband amplification at the cost of increased added noise and are not genuinely directional due to non-negligible nonlinear backward wave generation. In this work, we introduce a new class of amplifiers which encode the information in the Floquet modes of the system. Such Floquet mode amplifiers prevent information leakage and overcome the trade-off between quantum efficiency (QE) and bandwidth. Crucially, Floquet mode amplifiers strongly suppress the nonlinear forward-backward wave coupling and are therefore genuinely directional and readily integrable with qubits, clearing another major obstacle towards broadband ideal quantum measurements. Furthermore, Floquet mode amplifiers are insensitive to out-of-band impedance mismatch, which otherwise may lead to gain ripples, parametric oscillations, and instability in conventional traveling-wave parametric amplifiers. Finally, we show that a Floquet mode Josephson traveling-wave parametric amplifier implementation can simultaneously achieve $>\!20\,$dB gain and a QE of $\eta/\eta_{\mathrm{ideal}}\!> 99.9\%$ of the quantum limit over more than an octave of bandwidth. The proposed Floquet scheme is also widely applicable to other platforms, such as kinetic inductance traveling-wave amplifiers and optical parametric amplifiers., Comment: 20 pages, 12 figures, appendices

Published
2021
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43. ZMYND8 protects breast cancer stem cells against oxidative stress and ferroptosis through activation of NRF2

Author

Luo, Maowu, Bao, Lei, Xue, Yuanyuan, Zhu, Ming, Kumar, Ashwani, Xing, Chao, Wang, Jennifer E., Wang, Yingfei, and Luo, Weibo

Subjects
Thermo Fisher Scientific Inc., STEMCELL Technologies Inc., Scientific equipment and supplies industry, Stem cells, Antioxidants, Diagnostic reagents industry, Oxidative stress, Genetic transcription, Breast cancer, Health care industry
Abstract

Breast cancer stem cells (BCSCs) mitigate oxidative stress to maintain their viability and plasticity. However, the regulatory mechanism of oxidative stress in BCSCs remains unclear. We recently found that the histone reader ZMYND8 was upregulated in BCSCs. Here, we showed that ZMYND8 reduced ROS and iron to inhibit ferroptosis in aldehyde dehydrogenase-high ([ALDH.sup.hi]) BCSCs, leading to BCSC expansion and tumor initiation in mice. The underlying mechanism involved a two-fold posttranslational regulation of nuclear factor erythroid 2-related factor 2 (NRF2). ZMYND8 increased stability of NRF2 protein through KEAP1 silencing. On the other hand, ZMYND8 interacted with and recruited NRF2 to the promoters of antioxidant genes to enhance gene transcription in mammospheres. NRF2 phenocopied ZMYND8 to enhance BCSC stemness and tumor initiation by inhibiting ROS and ferroptosis. Loss of NRF2 counteracted ZMYND8's effects on antioxidant genes and ROS in mammospheres. Interestingly, ZMYND8 expression was directly controlled by NRF2 in mammospheres. Collectively, these findings uncover a positive feedback loop that amplifies the antioxidant defense mechanism sustaining BCSC survival and stemness., Introduction Breast cancer stem cells (BCSCs) are defined as a subpopulation of tumor cells with capability of self renewal and long-term maintenance of breast tumors and are responsible for breast [...]

Published
2024
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45. Immunomodulators for immunocompromised patients hospitalized for COVID-19: a meta-analysis of randomized controlled trials

Author

Hermine, Olivier, Mariette, Xavier, Ravaud, Philippe, Bureau, Serge, Dougados, Maxime, Resche-Rigon, Matthieu, Tharaux, Pierre-Louis, Tibi, Annick, Azoulay, Elie, Cadranel, Jacques, Emmerich, Joseph, Fartoukh, Muriel, Guidet, Bertrand, Humbert, Marc, Lacombe, Karine, Mahevas, Matthieu, Pene, Frédéric, Porcher, Raphaël, Pourchet-Martinez, Valerie, Schlemmer, Frédéric, Yazdanpanah, Yazdan, Baron, Gabriel, Perrodeau, Elodie, Vanhoye, Damien, Kedzia, Cécile, Demerville, Lauren, Gysembergh-Houal, Anne, Bourgoin, Alexandre, Raked, Nabil, Mameri, Lakhdar, Montlahuc, Claire, Biard, Lucie, Alary, St.phanie, Hamiria, Samir, Bariz, Thinhinane, Semri, Hala, Hai, Dhiaa Meriem, Benafla, Moustafa, Belloul, Mohamed, Vauboin, Pernelle, Flamand, Saskia, Pacheco, Claire, Walter-Petrich, Anouk, Stan, Emilia, Benarab, Souad, Nyanou, Corine, Charreteur, Robin, Dupre, Céline, Cardet, Kévin, Lehmann, Blandine, Baghli, Kamyl, Madelaine, Claire, D'Ortenzio, Eric, Puéchal, Oriane, Semaille, Caroline, Savale, Laurent, Harrois, Anatole, Figueiredo, Samy, Duranteau, Jacques, Anguel, Nadia, Pavot, Arthur, Monnet, Xavier, Richard, Christian, Teboul, Jean-Louis, Durand, Philippe, Tissieres, Pierre, Jevnikar, Mitja, Montani, David, Pavy, Stephan, Nocturne, Gaétane, Bitoun, Samuel, Noel, Nicolas, Lambotte, Olivier, Escaut, Lelia, Jauréguiberry, Stephane, Baudry, Elodie, Verny, Christiane, Lefevre, Edouard, Zaidan, Mohamad, Molinari, Domitille, Leprun, Gaël, Fourreau, Alain, Cylly, Laurent, Grimaldi, Lamiae, Virlouvet, Myriam, Meftali, Ramdane, Fabre, Soléne, Licois, Marion, Mamoune, Asmaa, Boudali, Yacine, Le Tiec, Clotilde, Verstuyft, Céline, Roques, Anne-Marie, Georgin-Lavialle, Sophie, Senet, Patricia, Pialoux, Gilles, Soria, Angele, Parrot, Antoine, François, Helene, Rozensztajn, Nathalie, Blin, Emmanuelle, Choinier, Pascaline, Camuset, Juliette, Rech, Jean-Simon, Canellas, Antony, Rolland-Debord, Camille, Lemarié, Nadege, Belaube, Nicolas, Nadal, Marine, Siguier, Martin, Petit-Hoang, Camille, Chas, Julie, Drouet, Elodie, Lemoine, Matthieu, Phibel, Audrey, Aunay, Lucie, Bertrand, Eliane, Ravato, Sylviane, Vayssettes, Marie, Adda, Anne, Wilpotte, Celine, Thibaut, Pélagie, Fillon, Julie, Debrix, Isabelle, Fellahi, Soraya, Bastard, Jean-Philippe, Lefévre, Guillaume, Gottenberg, Jacques-Eric, Hansmann, Yves, Blanc, Frédéric, Ohlmann-Caillard, Sophie, Castelain, Vincent, Chatelus, Emmanuel, Chatron, Eva, Collange, Olivier, Danion, François, De Blay, Frédéric, Diemunsch, Pierre, Diemunsch, Sophie, Felten, Renaud, Goichot, Bernard, Greigert, Valentin, Guffroy, Aurelien, Heger, Bob, Kaeuffer, Charlotte, Kassegne, Loic, Korganow, Anne Sophie, Le Borgne, Pierrick, Lefebvre, Nicolas, Mertes, Paul-Michel, Noll, Eric, Oberlin, Mathieu, Poindron, Vincent, Pottecher, Julien, Ruch, Yvon, Weill, François, Meyer, Nicolas, Andres, Emmanuel, Demonsant, Eric, Tayebi, Hakim, Nisand, Gabriel, Brin, Stéphane, Sublon, Cédric, Becker, Guillaume, Hutt, Anne, Martin, Tristan, Bayer, Sophie, Metzger, Catherine, Mekinian, Arsene, Abisror, Noémie, Adedjouma, Amir, Bollens, Diane, Bonneton, Marion, Bourcicaux, Nathalie, Bourrier, Anne, Thibault Chiarabiani, Maria Chauchard, Chopin, Doroth.e, Cohen, Jonathan, Devred, Ines, Donadille, Bruno, Fain, Olivier, Hariri, Geoffrey, Jachiet, Vincent, Ingliz, Patrick, Garnier, Marc, Gatfosse, Marc, Ghrenassia, Etienne, Gobert, Delphine, Krause le Garrec, Jessica, Landman, Cecilia, Lavillegrand, Jean Remy, Lefebvre, Benedicte, Mahevas, Thibault, Mazerand, Sandie, Meynard, Jean Luc, Morgand, Marjolaine, Ouaz.ne, Zineb, Pacanowski, Jerome, Riviere, S.bastien, Seksik, Philippe, Sokol, Harry, Soliman, Heithem, Valin, Nadia, Urbina, Thomas, McAvoy, Chloé, Miranda, Maria Pereira, Aratus, Gladys, Berard, Laurence, Simon, Tabassome, Nguyen, Anne Daguenel, Girault, Elise, Mayala-Kanda, Cl.mentine, Antignac, Marie, Leplay, Céline, Arlet, Jean-Benoit, Diehl, Jean-Luc, Bellenfant, Florence, Blanchard, Anne, Buffet, Alexandre, Cholley, Bernard, Fayol, Antoine, Flamarion, Edouard, Godier, Anne, Gorget, Thomas, Hamada, Sophie-Rym, Hauw-Berlemont, Caroline, Hulot, Jean-Sébastien, Lebeaux, David, Livrozet, Marine, Michon, Adrien, Neuschwander, Arthur, Pennet, Marie-Aude, Planquette, Benjamin, Ranque, Brigitte, Sanchez, Olivier, Volle, Geoffroy, Briois, Sandrine, Cornic, Mathias, Elisee, Virginie, Denis, Jesuthasan, Djadi-Prat, Juliette, Jouany, Pauline, Junquera, Ramon, Henriques, Mickael, Kebir, Amina, Lehir, Isabelle, Meunier, Jeanne, Patin, Florence, Paquet, Val.rie, Tréhan, Anne, Vigna, Véronique, Sabatier, Brigitte, Bergerot, Damien, Jouve, Charléne, Knosp, Camille, Lenoir, Olivia, Mahtal, Nassim, Resmini, Léa, Lescure, Xavier, Ghosn, Jade, Bachelard, Antoine, Rachline, Anne, Isernia, Valentina, Bao-chau, Phung, Vallois, Dorothée, Sautereau, Aurelie, Neukrich, Catherine, Dossier, Antoine, Borie, Raphaël, Crestani, Bruno, Ducrocq, Gregory, Steg, Philippe Gabriel, Dieude, Philippe, Papo, Thomas, Marcault, Estelle, Chaudhry, Marhaba, Da 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2024
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48. Long trimer-immunization interval and appropriate adjuvant reduce immune responses to the soluble HIV-1-envelope trimer base

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Duan, Hongying, Corrigan, Angela R., Cheng, Cheng, Biju, Andrea, Gonelli, Christopher A., Olia, Adam S., Teng, I-Ting, Xu, Kai, O’Dell, Sijy, Narpala, Sandeep, Castro, Mike, Serebryannyy, Leonid, Wang, Jennifer, Parchment, Danealle K., Sarfo, Edward K., van Schooten, Jelle, Todd, John-Paul, Wang, Shuishu, Harris, Darcy R., Geng, Hui, Jafari, Alexander J., Woodward, Ruth A., Doria-Rose, Nicole A., Foulds, Kathryn E., McDermott, Adrian B., van Gils, Marit J., Koup, Richard A., Pierson, Theodore C., Kwong, Peter D., and Mascola, John R.

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2024
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