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461 results on '"Wang, Jian-Dong"'

20. Downregulation of JAM3 occurs in cholangiocarcinoma by hypermethylation: A potential molecular marker for diagnosis and prognosis.

Author

Shi, Yi, Feng, Xiao, Zhang, Ying, Gao, Ji, Bao, Wei, Wang, Jian‐dong, and Bai, Jian‐feng

Subjects
CHOLANGIOCARCINOMA, MOLECULAR diagnosis, CELL-free DNA, DOWNREGULATION, PROGRESSION-free survival
Abstract

Junctional adhesion molecular 3 (JAM3) is downregulated by hypermethylation in cancers but is unclear in cholangiocarcinoma. The JAM3 expression level was checked in cholangiocarcinoma cell lines and tissues. Methylated JAM3 was detected in cell lines, tissues and plasma cell‐free DNAs (cfDNA). The roles of JAM3 in cholangiocarcinoma were studied by transfection of siRNA and pCMV3‐JAM3. The survival analysis was based on the Gene Set Cancer Analysis (GSCA) database. JAM3 was downregulated in HCCC‐9810 and HuCCT1 cell lines and tissues by hypermethylation. Methylated JAM3 was detected in cfDNAs with 53.3% sensitivity and 96.6% specificity. Transfection of pCMV3‐JAM3 into HCCC‐9810 and HuCCT1 induced apoptosis and suppressed cell proliferation, migration and invasion. The depletion of JAM3 in RBE cells using siRNA decreased apoptosis and increased cell proliferation, migration and invasion. Hypermethylation of JAM3 was associated with tumour differentiation, metastasis and TNM stage. Downregulation and hypermethylation of JAM3 were related to poor progression‐free survival. Junctional adhesion molecular 3 may function as a tumour suppressor in cholangiocarcinoma. Methylated JAM3 DNA may represent a non‐invasive molecular marker for the early detection of cholangiocarcinoma and prognosis. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Supplemental Table 1-9 and supplemental Figure 1-12 from Long Noncoding RNA GCASPC, a Target of miR-17-3p, Negatively Regulates Pyruvate Carboxylase–Dependent Cell Proliferation in Gallbladder Cancer

Author

Ma, Ming-zhe, primary, Zhang, Yan, primary, Weng, Ming-zhe, primary, Wang, Shou-hua, primary, Hu, Ye, primary, Hou, Zhao-yuan, primary, Qin, Yi-yu, primary, Gong, Wei, primary, Zhang, Yong-Jie, primary, Kong, Xiang, primary, Wang, Jian-dong, primary, and Quan, Zhi-wei, primary

Published
2023
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28. supplemental Figure legends from Long Noncoding RNA GCASPC, a Target of miR-17-3p, Negatively Regulates Pyruvate Carboxylase–Dependent Cell Proliferation in Gallbladder Cancer

Author

Ma, Ming-zhe, primary, Zhang, Yan, primary, Weng, Ming-zhe, primary, Wang, Shou-hua, primary, Hu, Ye, primary, Hou, Zhao-yuan, primary, Qin, Yi-yu, primary, Gong, Wei, primary, Zhang, Yong-Jie, primary, Kong, Xiang, primary, Wang, Jian-dong, primary, and Quan, Zhi-wei, primary

Published
2023
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29. Supplementary Methods from Long Noncoding RNA GCASPC, a Target of miR-17-3p, Negatively Regulates Pyruvate Carboxylase–Dependent Cell Proliferation in Gallbladder Cancer

Author

Ma, Ming-zhe, primary, Zhang, Yan, primary, Weng, Ming-zhe, primary, Wang, Shou-hua, primary, Hu, Ye, primary, Hou, Zhao-yuan, primary, Qin, Yi-yu, primary, Gong, Wei, primary, Zhang, Yong-Jie, primary, Kong, Xiang, primary, Wang, Jian-dong, primary, and Quan, Zhi-wei, primary

Published
2023
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41. Effect of dietary crude protein level on growth performance, serum biochemical indexes and reproductive performance of postpartum Angus cows.

Author

WANG Jian-dong, TANG Yu-lin, HOU Peng-xia, KANG Xiao-dong, YU Yang, SHI An, and LIANG Xiao-jun

Abstract

The experiment was conducted to investigate the effect of different dietary crude protein levels on growth performance, serum biochemical indexes and reproductive performance of postpartum Angus cows. A total of 24 healthy and similar postpartum Angus cows with an average body weight of (480±20) kg were selected and randomly divided into three groups, with eight replicates in each group and one cow in each replicate. The cows were fed with the diets with crude protein levels of 11.78% (group I), 13.51% (group II) and 15.43% (group III), respectively. The pre-trial period was 10 d, and the formal trial period was 60 d. The results showed that there was no significant difference in initial weight and final weight among the three groups (P>0.05), the average daily gain in group II was significantly higher than that in group I and group III (P<0.05), and the feed to gain ratio significantly higher than that in group I and group III (P<0.05). The content of TP and BUN in serum in group II and group III were significantly higher than those in group I (P<0.05). The IgG content in group III was significantly higher than that in group I and group II (P<0.05). The content of IGF-1 and GH in group II were extremely higher than those in group I (P<0.01). The survival rate of calves in group II was the highest. The experiment indicates that the 13.51% crude protein level in diet can improve the growth performance, some serum biochemical indexes and reproductive performance of postpartum Angus cows under the conditions of the experiment. [ABSTRACT FROM AUTHOR]

Published
2023
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