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115 results on '"Wang, Juxiang"'

7. Effects of Blood Hemoadsorption Therapy with HA-380 in Total Arch Replacement for Acute Type A Aortic Dissection: A Retrospective Observational Study.

Author

Wang, Juxiang, Chen, Bin, Xie, Junhao, Chen, Huilong, Li, Lihua, Zhang, Weiqun, and Lu, Lin

Subjects
*CARDIOPULMONARY bypass, *AORTIC dissection, *SURGICAL complications, *ADULT respiratory distress syndrome, *LOGISTIC regression analysis, *INTENSIVE care units
Abstract

Introduction: This study aimed to evaluate whether the addition of a hemoadsorption (HA) cartridge, HA-380, in the cardiopulmonary bypass (CPB) circuit in acute type A aortic dissection (ATAAD) surgery reduced inflammatory cytokine levels and decreased postoperative complications. Methods: A retrospective observational cohort study was conducted between March 1, 2021, and February 28, 2022. Patients with ATAAD undergoing emergent total arch replacement surgery were divided into the control (CON) and HA groups on the basis of the addition of the HA-380 cartridge in the CPB circuit. Results: Overall, 121 patients met the eligibility criteria; 2 patients in each group who died within the first postoperative week were excluded. Further, 57 and 60 patients in the CON and HA groups, respectively, were included in the pooled analysis. The major perioperative data, baseline values of interleukin-6 (IL-6) and C-reactive protein, and therapeutic interventions were similar in the two groups (all, p > 0.05). The serum IL-6 levels increased more rapidly in the CON group than those in the HA group postoperatively (205.73 ± 174.72 vs. 146.13 ± 64.15 pg/mL, p = 0.020). The HA group had a lower incidence of postoperative acute kidney injury (AKI) and severe acute respiratory distress syndrome than the CON group (25.4 vs. 44.6%, p = 0.032 and 18.3 vs. 35.1%, p = 0.040, respectively). Logistic regression analyses showed that HA may be a protective factor against postoperative AKI. The incidence of bleeding, delirium, and stroke as well as the lengths of intensive care unit and hospital stay in both groups were similar (all, p > 0.05). Conclusions: The use of HA-380 in the CPB circuit may attenuate inflammatory response and reduce major complications following ATAAD surgery. HA may be associated with lower rate of postoperative AKI. [ABSTRACT FROM AUTHOR]

Published
2024
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11. An Extended TODIM Method and Applications for Multi-Attribute Group Decision-Making Based on Bonferroni Mean Operators under Probabilistic Linguistic Term Sets.

Author

Wang, Juxiang, Zhou, Xiangyu, Li, Si, and Hu, Jianwei

Subjects
*GROUP decision making, *AGGREGATION operators, *PUBLIC opinion, *ONLINE comments, *PROBLEM solving, *SCIENTIFIC method, *SOCIAL media, *CELL phone systems
Abstract

Due to the complexity and uncertainty of decision-making, probabilistic linguistic term sets (PLTSs) are currently important tools for qualitative evaluation of decision-makers. The asymmetry of evaluation information can easily lead to the loss of subjective preference information for decision-makers, and the existing operation of decision-maker evaluation information fusion operators is difficult to solve this problem. To solve such problems, this paper proposes some new operational methods for PLTSs based on Dombi T-conorm and T-norm. Considering the interrelationships between the input independent variables of PLTSs, the probabilistic linguistic weighted Dombi Bonferroni mean Power average (PLWDBMPA) operators are extended and the properties of these aggregation operators are proposed. Secondly, the PLWDBMPA operator is used to fuse the evaluation information of decision-makers, avoiding the loss of decision information as much as possible. This paper uses social media platforms and web crawler technology to obtain online comments from users on decision-making to obtain the public's attitude towards decision events. TF-IDF and Word2Vec are used to calculate the weight of alternatives on each attribute. Under traditional group decision-making methods and integrating the wisdom of the public, a novel multi-attribute group decision-making method based on TODIM method is proposed. Finally, the case study of Turkey earthquake shelter selection proves this method is scientific and effective. Meanwhile, the superiority of this method was further verified through comparisons with the PL-TOPSIS, PLWA, SPOTIS and PROMETHEE method. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Decitabine Combined with Minimally Myelosuppressive Therapy for Induction of Remission of Pediatric High-Risk Acute Myeloid Leukemia with Chromosome 5q Deletion. a Report of Three Cases

Author

Cheng, Shengqin, primary, Xiao, Peifang, additional, Wang, Juxiang, additional, Gao, Li, additional, Zheng, Jiajia, additional, Hu, Yixin, additional, Ding, Xin, additional, Ling, Jing, additional, Lu, Qin, additional, Pan, Jian, additional, Li, Bohan, additional, Lu, Jun, additional, Wang, Yi, additional, Ribeiro, Raul C, additional, and Hu, Shaoyan, additional

Published
2021
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19. Pharmacokinetics and Bioequivalence of Rasagiline Tablets in Chinese Healthy Subjects Under Fasting and Fed Conditions: An Open, Randomized, Single-Dose, Double-Cycle, Two-Sequence, Crossover Trial

Author

Lu Qi, Haihong Bai, Ying Liu, Qi Qi, Sun Yongqiang, Rongxia Fan, Zhou Da, Wang Juxiang, Xinghe Wang, Yinjuan Li, Tu Yongrui, and Feng Xiaohui

Subjects
medicine.medical_specialty, Cmax, Bioequivalence, 030226 pharmacology & pharmacy, Gastroenterology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Pharmacokinetics, Internal medicine, food effect, Medicine, Pharmacology (medical), pharmacokinetic, Pharmacology, Rasagiline, bioequivalence, rasagiline, business.industry, lcsh:RM1-950, Clinical Trial, Crossover study, Confidence interval, Postprandial, lcsh:Therapeutics. Pharmacology, chemistry, Tolerability, business, 030217 neurology & neurosurgery, highly variable drug
Abstract

Objective: This study evaluated the pharmacokinetics, safety, and bioequivalence (BE) of two formulations of rasagiline tablets in healthy Chinese subjects under fasting and fed conditions.Methods: An open, randomized, single-dose, double-cycle, two-sequence, self-crossover pharmacokinetic study in healthy Chinese subjects under fasting and high-fat postprandial conditions was performed. A total of 108 healthy subjects (36 in the fasting group and 72 in the postprandial group) were recruited. In each cycle of the study under both conditions, subjects received a single oral dose of 1 mg of a test or reference preparation of rasagiline tablets (1 mg each). A washout period of 3 days was observed. Blood samples were obtained up to 10 h post-intake. Primary endpoints were the BE of major pharmacokinetic parameters (AUC0–t and AUC0–∞) and the maximum observed serum concentration (Cmax). Secondary endpoints were safety parameters.Results: The 90% confidence interval (CI) of the geometric mean ratio (GMR) of the test drug vs. the reference drug for rasagiline was 94.16–105.35% for the AUC0–t under fasting conditions and 99.88–107.07% under postprandial conditions. The 90% CIs for the AUC0–∞ were 93.55–105.01% and 99.59–107.05% under fasting and postprandial conditions, respectively. The 90% CIs for the Cmax were 88.26–108.46% and 89.54–118.23% under fasting and postprandial conditions, respectively. The 90% CIs for the test/reference AUC ratio and Cmax ratio were within the acceptable range (0.80–1.25) for BE. In this BE study, there were no serious adverse events (AEs).Conclusion: BE between the test and the reference products was established in both fasting and postprandial conditions. The two formulations of rasagiline showed good tolerability and a similar safety profile.Clinical Trial Registration:chinaDrugtrials.org.cn, identifier CTR20181466.

Published
2020

22. Pharmacokinetics and Bioequivalence of Rasagiline Tablets in Chinese Healthy Subjects Under Fasting and Fed Conditions: An Open, Randomized, Single-Dose, Double-Cycle, Two-Sequence, Crossover Trial

Author

Li, Yinjuan, primary, Qi, Lu, additional, Bai, Haihong, additional, Liu, Ying, additional, Fan, Rongxia, additional, Tu, Yongrui, additional, Sun, Yongqiang, additional, Wang, Juxiang, additional, Qi, Qi, additional, Feng, Xiaohui, additional, Zhou, Da, additional, and Wang, Xinghe, additional

Published
2020
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44. Solar-blind SnO2nanowire photo-synapses for associative learning and coincidence detection

Author

Chen, Yang, Qiu, Weijie, Wang, Xiaowu, Liu, Wanrong, Wang, Juxiang, Dai, Guozhang, Yuan, Yongbo, Gao, Yongli, and Sun, Jia

Abstract

With the rapid development of artificial intelligence, memristive devices capable of detecting, processing, and memorizing deep-ultraviolet (DUV) signals are very promising for encoding, recognizing, and performing solar-blind sensitive tasks. Here, we propose a DUV-triggered SnO2nanowire synaptic transistor in which the programmable persistent photoconductivity (PPC) effect is used to mimic essential bio-synaptic behaviors. The bio-synapse-like behaviors, such as excitatory postsynaptic current (EPSC), paired pulse facilitation (PPF), and spike-timing dependence plasticity (STDP) (named the first law of synaptic plasticity) were investigated and imitated using various gate voltages. Larger gate bias permits a more significant transition from short-term (STP) to long-term plasticity (LTP). A detailed theoretical model is presented herein based on results from a systematic analysis of optoelectronic synaptic performances. Importantly, Pavlov's learning (classical conditioning) was conceptually demonstrated through DUV photoinduction. We also observed a novel situation where the memory effect was slightly inhibited when the devices were simultaneously stimulated by optical and electric pulses, allowing detection of temporally close, spatially distributed DUV incident signals. This approach opens up a new application domain for ultrafast, robust, and adaptive processing in future optoelectronic neural systems.

Published
2019
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45. Robust non-fragile observer design for non-linear uncertain time-delay systems

Author

Wang Juxiang and Li Yingchun

Subjects
Lyapunov function, symbols.namesake, Mathematical optimization, Observer (quantum physics), Robustness (computer science), Control theory, symbols, Linear matrix inequality, Symmetric matrix, Robust control, Separation principle, Mathematics
Abstract

This paper focuses on the designing of the robust non-fragile controller based on observer for a class of non-linear uncertain time-delay systems. The uncertainties exist in the controller. Under the assumption that the uncertainty is time-varying and norm-bounded, based on linear matrix inequality, by constructing Lyapunov functions and selecting proper observer, we bring forward an approach for designing robust non-fragile controller based on observer. This approach is proved to be able to make the closed-loop systems asymptotically stable. The non-fragile controller can be obtained by solving the corresponding linear matrix inequality. At last, a numerical example is presented to illustrate the validity and feasibility of this approach.

Published
2009

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