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507 results on '"Wang, Leiming"'

1. Blood–brain-barrier-crossing lipid nanoparticles for mRNA delivery to the central nervous system

Author

Wang, Chang, Xue, Yonger, Markovic, Tamara, Li, Haoyuan, Wang, Siyu, Zhong, Yichen, Du, Shi, Zhang, Yuebao, Hou, Xucheng, Yu, Yang, Liu, Zhengwei, Tian, Meng, Kang, Diana D., Wang, Leiming, Guo, Kaiyuan, Cao, Dinglingge, Yan, Jingyue, Deng, Binbin, McComb, David W., Parsons, Ramon E., Minier-Toribio, Angelica M., Holt, Leanne M., Pan, Jiayi, Hashemi, Alice, Kopell, Brian H., Charney, Alexander W., Nestler, Eric J., Peng, Paul C., and Dong, Yizhou

Published
2025
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21. The absence of regional international law in the world order crisis : -Thoughts based on the supply side of international law

Author

Wang, Leiming, Striełkowski, Wadim, Editor-in-Chief, Black, Jessica M., Series Editor, Butterfield, Stephen A., Series Editor, Chang, Chi-Cheng, Series Editor, Cheng, Jiuqing, Series Editor, Dumanig, Francisco Perlas, Series Editor, Al-Mabuk, Radhi, Series Editor, Scheper-Hughes, Nancy, Series Editor, Urban, Mathias, Series Editor, Webb, Stephen, Series Editor, Kassim, Hafizoah, editor, Malik, Nadeem, editor, Rajagopal, Premkumar, editor, and Singh, Manjet Kaur Mehar, editor

Published
2023
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26. Genetic Algorithm-Based Assessment of the Legal Compliance of Regional Arbitration Pathways in Cross-Border Dispute Resolution

Author

Wang Leiming

Subjects
lda topic model, if-idf, word co-occurrence model, ga-bp, legal compliance assessment, 65y20, Mathematics, QA1-939
Abstract

This paper uses the IF-IDF and word co-occurrence model to extract and process high-frequency words from the legal compliance text of cross-border dispute arbitration. The LDA theme model then combines with it to extract the theme of legal text compliance, which is then used to construct a cross-border dispute arbitration legal compliance evaluation index system. After that, the genetic algorithm is employed to optimize the BP neural network, construct the GA-BP legal compliance evaluation model, and conduct training simulation. The results show that the word frequency of regional, arbitration, cross-border, fair, consultation, maintenance, reasonable, system, perfect, and conformity is up to more than 3,000 times, which is a high-frequency keyword in the legal text of cross-border dispute arbitration. The output values of the three legal sample cases based on GA-BP are very compliant, compliant, and non-compliant, indicating that the regional arbitration path’s legal compliance in cross-border dispute resolution needs to be improved.

Published
2024
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41. Clinical, genomic, and histopathologic diversity in cerebral cavernous malformations.

Author

Ren, Jian, Wang, Daochao, Wang, Leiming, Jiang, Chendan, Tian, An, Cui, Ziwei, Ren, Yeqing, Bian, Lisong, Zeng, Gao, Meng, Guolu, Shan, Yongzhi, Liang, Jiantao, Xiao, Xinru, Tang, Jie, Wei, Yukui, He, Chuan, Sun, Liyong, Ma, Yongjie, Yu, Jiaxing, and Li, Guilin

Subjects
HEMORRHAGIC diseases, BLOOD cells, IMMUNOHISTOCHEMISTRY, SYMPTOMS, GENOTYPES
Abstract

Cerebral cavernous malformations (CCMs) are hemorrhagic vascular disorders with varied clinical and radiological presentations, occurring sporadically due to MAP3K3 or PIK3CA mutations or through inherited germline mutations of CCM genes. This study aimed to clarify the clinical, genetic, and pathological features of CCMs using a multicenter cohort across three Chinese centers. We analyzed 290 surgical specimens from symptomatic CCM patients, utilizing whole-exome sequencing, droplet digital PCR, and targeted panel sequencing, alongside immunohistology to examine genotypic and phenotypic differences. Among 290 cases, 201 had somatic MAP3K3, PIK3CA, or germline CCM mutations, each associated with distinct clinical parameters: hemorrhage risk (P < 0.001), lesion size (P = 0.019), non-hemorrhagic epilepsy (P < 0.001), Zabramski classifications (P < 0.001), developmental venous anomaly presence (P < 0.001), and MRI-detected edema (P < 0.001). PIK3CA mutations showed a higher hemorrhage risk than MAP3K3 and combined MAP3K3 & PIK3CA mutations (P < 0.001). Within PIK3CA mutations, the p.H1047R variant correlated with higher bleeding risk than p.E545K (P = 0.007). For non-hemorrhagic epilepsy, patients with single MAP3K3 mutations or combined MAP3K3 & PIK3CA mutations were at greater risk than those with PIK3CA mutations alone. Histopathologically, lesions with PIK3CA mutations displayed cyst walls, pS6-positive dilated capillaries, and fresh blood cells, while MAP3K3 and double mutation lesions exhibited classic CCM pathology with SMA-positive and KLF4-positive vessels, collagen, and calcification. PIK3CA lesions had fewer KLF4-positive cells than double mutations lesions (P < 0.001), and EndMT (SMA-positive) cells compared to double mutation lesions (P < 0.05) and MAP3K3 mutations (P < 0.001), with more pS6 compared to MAP3K3 mutations (P < 0.05). This study underscores the diverse clinical, genomic, and histopathological characteristics in CCMs, suggesting potential predictive markers based on mutation subtypes and MRI features. [ABSTRACT FROM AUTHOR]

Published
2025
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