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1,294 results on '"Wang, Lingyan"'

5. Mn-inlaid antiphase boundaries in perovskite structure

Author

Li, Chao, Wang, Lingyan, Xu, Liqiang, Ren, Xuerong, Yao, Fangzhou, Lu, Jiangbo, Wang, Dong, Liang, Zhongshuai, Huang, Ping, Wu, Shengqiang, Jing, Hongmei, Zhang, Yijun, Dong, Guohua, Liu, Haixia, Ma, Chuansheng, Lyu, Yinong, Wei, Xiaoyong, Ren, Wei, Wang, Ke, Ye, Zuo-Guang, and Chen, Feng

Published
2024
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10. Computational investigations on target-site searching and recognition mechanisms by thymine DNA glycosylase during DNA repair process

Author

Wang, Lingyan, Song, Kaiyuan, Yu, Jin, and Da, Lin-Tai

Subjects
Biochemistry and Cell Biology, Biological Sciences, Genetics, 1.1 Normal biological development and functioning, Generic health relevance, DNA, DNA Repair, Nucleotides, Sugars, Thymine DNA Glycosylase, DNA repair, DNA glycosylase, Markov state model, molecular dynamics simulation, Biochemistry & Molecular Biology, Biochemistry and cell biology
Abstract

DNA glycosylase, as one member of DNA repair machineries, plays an essential role in correcting mismatched/damaged DNA nucleotides by cleaving the N-glycosidic bond between the sugar and target nucleobase through the base excision repair (BER) pathways. Efficient corrections of these DNA lesions are critical for maintaining genome integrity and preventing premature aging and cancers. The target-site searching/recognition mechanisms and the subsequent conformational dynamics of DNA glycosylase, however, remain challenging to be characterized using experimental techniques. In this review, we summarize our recent studies of sequential structural changes of thymine DNA glycosylase (TDG) during the DNA repair process, achieved mostly by molecular dynamics (MD) simulations. Computational simulations allow us to reveal atomic-level structural dynamics of TDG as it approaches the target-site, and pinpoint the key structural elements responsible for regulating the translocation of TDG along DNA. Subsequently, upon locating the lesions, TDG adopts a base-flipping mechanism to extrude the mispaired nucleobase into the enzyme active-site. The constructed kinetic network model elucidates six metastable states during the base-extrusion process and suggests an active role of TDG in flipping the intrahelical nucleobase. Finally, the molecular mechanism of product release dynamics after catalysis is also summarized. Taken together, we highlight to what extent the computational simulations advance our knowledge and understanding of the molecular mechanism underlying the conformational dynamics of TDG, as well as the limitations of current theoretical work.

Published
2022

27. A pref-1-controlled non-inflammatory mechanism of insulin resistance

Author

Huang, Yiheng, Cui, Donghong, Chen, Liujun, Tong, Haibin, Wu, Hong, Muller, Grace K., Qi, Yadan, Wang, Shuxia, Xu, Jinjie, Gao, Xiang, Fifield, Kathleen E., Wang, Lingyan, Xia, Zhengyuan, Vanderluit, Jacqueline L., Liu, Suixin, Leng, Lin, Sun, Guang, McGuire, John, Young, Lawrence H., Bucala, Richard, and Qi, Dake

Published
2023
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30. Natural Wetland Evolution in China: A Review

Author

Wang, Lingyan, Ma, Liang, Sheng, Lianxi, Zang, Shuying, Wang, Hanxi, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, He, Bao-Jie, editor, Prasad, Deo, editor, and Jupesta, Joni, editor

Published
2022
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31. Research on a Space Anti-irradiation Magnetic Feedback DCDC Conversion Technology

Author

Li, Chunyu, Wang, Lingyan, Hu, Cong, Li, Xuyang, Yue, Changlu, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Jia, Yingmin, editor, Zhang, Weicun, editor, Fu, Yongling, editor, Yu, Zhiyuan, editor, and Zheng, Song, editor

Published
2022
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32. Research on Anti-saturation Control Strategy of High-Power and High-Dynamic Servo Power Supply

Author

Wang, Lingyan, Li, Xuyang, Yang, Lei, Hu, Cong, Yue, Changlu, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Jia, Yingmin, editor, Zhang, Weicun, editor, Fu, Yongling, editor, Yu, Zhiyuan, editor, and Zheng, Song, editor

Published
2022
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41. Samarium modified lead-free potassium sodium niobate-based grain orientation-controlled ceramics and its ultrasonic transducer applications.

Author

Quan, Yi, Sun, Yajun, Zheng, Kun, Fei, Chunlong, Wang, Yecheng, Wang, Zhe, Zhao, Tianlong, Zhuang, Jian, Wang, Lingyan, Zhang, Junshan, Ren, Wei, and Yang, Yintang

Subjects
ULTRASONIC transducers, CERAMICS, POTASSIUM, PIEZOELECTRIC materials, ACOUSTIC impedance, SAMARIUM, GRAIN
Abstract

Environment-friendly lead-free potassium sodium niobate-based piezoelectric materials have been widely used in acoustic device applications because of its high piezoelectric response, high Curie temperature, and low acoustic impedance. In our previous works, samarium modified 0.915(K0.45Na0.5Li0.05)NbO3–0.075BaZrO3–0.01(Bi0.5Na0.5)TiO3 (Sm–KNLN–BZ–BNT) ceramics have achieved high piezoelectric properties with good thermal stability. To further improve its properties and thermal stability, grain orientation-controlled methods have been introduced to Sm–KNLN–BZ–BNT ceramics. In this work, textured Sm–KNLN–BZ–BNT ceramics with a 93% ⟨001⟩c-oriented textured degree have been prepared. The samples have achieved a d33* value with 532 pm/V and better thermal stability between room temperature to 150 °C than the non-textured samples. Moreover, ultrasonic transducers with a 25 MHz center frequency have been designed and fabricated by the textured Sm–KNLN–BZ–BNT ceramics. The peak-to-peak of the transducers has reached a 1.78 V high level, which demonstrated the textured Sm–KNLN–BZ–BNT ceramics are a good candidate for acoustic applications. [ABSTRACT FROM AUTHOR]

Published
2023
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47. Mendelian randomization analysis of psoriasis and psoriatic arthritis associated with risks of ulcerative colitis.

Author

Pan, Jing, Lv, Yanwei, Wang, Lingyan, Chang, Xiaodan, Zhao, Kaiping, and Liu, Xiao

Subjects
PSORIATIC arthritis, ULCERATIVE colitis, PSORIASIS, GENOME-wide association studies, INFLAMMATORY bowel diseases, SINGLE nucleotide polymorphisms
Abstract

Objective: This study is designed to explore the potential causal relationship between psoriasis and psoriatic arthritis (PsA) while investigating the genetic basis shared by these inflammatory diseases. Methods: Significant single nucleotide polymorphisms (SNPs) associated with UC, psoriasis, and PsA were selected as genetic instrumental variables using Genome‐Wide Association Study (GWAS) datasets. Additionally, Mendelian randomization (MR) methods, including inverse‐variance weighting (IVW), MR‐Egger regression, and Weighted Median (WME), were utilized to evaluate the causal relationships between these diseases. Moreover, sensitivity analysis and heterogeneity testing were conducted to validate the stability of the results. Results: A total of 123 significant SNPs associated with psoriasis, PsA, and UC were identified as genetic instrumental variables based on GWAS datasets. The analysis revealed a 36% increased risk of UC with psoriasis (odds ratio [OR] = 1.350, 95% confidence interval [CI] = 1.065‐1.729, P = 0.012) and a 32.9% increased risk of UC with PsA (OR = 1.329, 95% CI = 1.176‐1.592, P < 0.001). Further analysis showed a 43.5% increased risk of psoriasis with UC (OR = 1.435, 95% CI = 1.274‐1.831, P < 0.001) and a 45.8% increased risk of PsA with UC (OR = 1.458, 95% CI = 1.166‐1.822, P = 0.0013). In addition, sensitivity analysis and heterogeneity testing demonstrated the high stability of these results. Particularly, neither MR‐Egger regression analysis nor leave‐one‐out analysis revealed significant heterogeneity or pleiotropy bias, indicating the reliability of these causal estimates. Moreover, the use of the MR‐PRESSO further confirmed the positive correlation between psoriasis and UC, and the corrected estimates remained consistent with IVW analysis results after excluding potential outlier SNPs, enhancing the credibility of the analysis. Conclusions: This study strengthens the understanding of the genetic and causal relationships among UC, psoriasis, and PsA through GWAS and MR methods, revealing the genetic basis they may share. These findings not only provide a novel perspective on the comorbidity mechanisms of these diseases but also offer a valuable reference for the development of future treatment strategies and intervention measures. [ABSTRACT FROM AUTHOR]

Published
2024
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