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1,358 results on '"Wang, Lingyan"'

1. Universal Sign Language Recognition System Using Gesture Description Generation and Large Language Model

Author

Podder, Kanchon Kanti, Zhang, Jian, Wang, Lingyan, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Cai, Zhipeng, editor, Takabi, Daniel, editor, Guo, Shaoyong, editor, and Zou, Yifei, editor

Published
2025
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4. Mn-inlaid antiphase boundaries in perovskite structure

Author

Li, Chao, Wang, Lingyan, Xu, Liqiang, Ren, Xuerong, Yao, Fangzhou, Lu, Jiangbo, Wang, Dong, Liang, Zhongshuai, Huang, Ping, Wu, Shengqiang, Jing, Hongmei, Zhang, Yijun, Dong, Guohua, Liu, Haixia, Ma, Chuansheng, Lyu, Yinong, Wei, Xiaoyong, Ren, Wei, Wang, Ke, Ye, Zuo-Guang, and Chen, Feng

Published
2024
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18. Computational investigations on target-site searching and recognition mechanisms by thymine DNA glycosylase during DNA repair process

Author

Wang, Lingyan, Song, Kaiyuan, Yu, Jin, and Da, Lin-Tai

Subjects
Biochemistry and Cell Biology, Biological Sciences, Genetics, 1.1 Normal biological development and functioning, Generic health relevance, DNA, DNA Repair, Nucleotides, Sugars, Thymine DNA Glycosylase, DNA repair, DNA glycosylase, Markov state model, molecular dynamics simulation, Biochemistry & Molecular Biology, Biochemistry and cell biology
Abstract

DNA glycosylase, as one member of DNA repair machineries, plays an essential role in correcting mismatched/damaged DNA nucleotides by cleaving the N-glycosidic bond between the sugar and target nucleobase through the base excision repair (BER) pathways. Efficient corrections of these DNA lesions are critical for maintaining genome integrity and preventing premature aging and cancers. The target-site searching/recognition mechanisms and the subsequent conformational dynamics of DNA glycosylase, however, remain challenging to be characterized using experimental techniques. In this review, we summarize our recent studies of sequential structural changes of thymine DNA glycosylase (TDG) during the DNA repair process, achieved mostly by molecular dynamics (MD) simulations. Computational simulations allow us to reveal atomic-level structural dynamics of TDG as it approaches the target-site, and pinpoint the key structural elements responsible for regulating the translocation of TDG along DNA. Subsequently, upon locating the lesions, TDG adopts a base-flipping mechanism to extrude the mispaired nucleobase into the enzyme active-site. The constructed kinetic network model elucidates six metastable states during the base-extrusion process and suggests an active role of TDG in flipping the intrahelical nucleobase. Finally, the molecular mechanism of product release dynamics after catalysis is also summarized. Taken together, we highlight to what extent the computational simulations advance our knowledge and understanding of the molecular mechanism underlying the conformational dynamics of TDG, as well as the limitations of current theoretical work.

Published
2022

19. Effect of lncRNA H19 on Rats with Chronic Heart Failure Based on TGF-β1/Smad3 Signaling Pathway

Author

WANG Lingyan, CAO Guojun, MEI Yang, ZHANG Bin, and ZHOU Shijing

Subjects
heart failure, long non-coding RNA H19, microRNA-200a, TGF-β1/Smad3 signaling pathway, heart function, myocardial fibrosis, Medicine
Abstract

ObjectiveTo explore the effect of long non-coding RNA H19 (lncRNA H19) and microRNA (miRNA)-200a on cardiac function and myocardial fibrosis in rats with chronic heart failure based on transforming growth factor-β1 (TGF-β1)/Smad homolog 3 (Smad3) signaling pathway.MethodsA total of 60 clean grade adult healthy male SD rats were randomly divided into sham surgery group and model group. The model group were selected to construct rats model of chronic heart failure by ligation. After successful modeling, the model rats were randomly divided into heart failure group, lncRNA H19 negative control group (negative control group), lncRNA H19 overexpression group (overexpression group) and lncRNA H19 overexpression+miRNA-200a overexpression group (combined overexpression group), with 12 rats in each group. At the 1st, 4th, 7th, 10th, 13th and 16th day, the negative control group, the overexpression group and the combined overexpression group were injected intravenously with lncRNA H19 negative control plasmid at 5 mL/(kg·d), lncRNA H19 plasmid at 5 mL/(kg·d), lncRNA H19 plasmid at 5 mL/(kg·d) and miRNA-200a plasmid at 2 mL/(kg·d) in the tails respectively; the heart failure group and the sham surgery group were only injected with equal dose of normal saline, once a day. Two days after the last injection, color Doppler ultrasound was used to detect cardiac function indexes [left ventricular ejection fraction (LVEF), left ventricular fractional shortening (LVFS), left ventricular end-systolic dimension (LVESD), left ventricular end-diastolic dimension (LVEDD)]; Masson staining was used to detect myocardial fibrosis and collagen volume fraction (CVF); real-time fluorescence quantitative PCR was used to detect the transcription level of lncRNA H19 and miRNA-200a in myocardial tissue of rats; Western blot method was used to detect the protein expression level of TGF-β1 and Smad3 in myocardial tissue of rats.ResultsCompared with sham surgery group, the protein expression level of LVEDD, LVESD, TGF-β1, Smad3 and transcription level of miRNA-200a in the other four groups significantly increased, while the protein expression level of LVFS, LVEF and transcription level of lncRNA H19 significantly decreased (PPPP>0.05). In the sham surgery group, only a small amount of collagen was distributed in the myocardium, and the tissue cells were closely arranged without obvious gaps; compared with sham surgery group, there was a large amount of collagen hyperplasia in the myocardial tissue of rats in the heart failure group, the cell arrangement was not uniform, and CVF increased significantly (PPP

Published
2023
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33. A pref-1-controlled non-inflammatory mechanism of insulin resistance

Author

Huang, Yiheng, Cui, Donghong, Chen, Liujun, Tong, Haibin, Wu, Hong, Muller, Grace K., Qi, Yadan, Wang, Shuxia, Xu, Jinjie, Gao, Xiang, Fifield, Kathleen E., Wang, Lingyan, Xia, Zhengyuan, Vanderluit, Jacqueline L., Liu, Suixin, Leng, Lin, Sun, Guang, McGuire, John, Young, Lawrence H., Bucala, Richard, and Qi, Dake

Published
2023
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38. Natural Wetland Evolution in China: A Review

Author

Wang, Lingyan, Ma, Liang, Sheng, Lianxi, Zang, Shuying, Wang, Hanxi, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, He, Bao-Jie, editor, Prasad, Deo, editor, and Jupesta, Joni, editor

Published
2022
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39. Research on a Space Anti-irradiation Magnetic Feedback DCDC Conversion Technology

Author

Li, Chunyu, Wang, Lingyan, Hu, Cong, Li, Xuyang, Yue, Changlu, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Jia, Yingmin, editor, Zhang, Weicun, editor, Fu, Yongling, editor, Yu, Zhiyuan, editor, and Zheng, Song, editor

Published
2022
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40. Research on Anti-saturation Control Strategy of High-Power and High-Dynamic Servo Power Supply

Author

Wang, Lingyan, Li, Xuyang, Yang, Lei, Hu, Cong, Yue, Changlu, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Jia, Yingmin, editor, Zhang, Weicun, editor, Fu, Yongling, editor, Yu, Zhiyuan, editor, and Zheng, Song, editor

Published
2022
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