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564 results on '"Wang, Mengge"'

2. Differentiated adaptative genetic architecture and language-related demographical history in South China inferred from 619 genomes from 56 populations

Author

Sun, Qiuxia, Wang, Mengge, Lu, Tao, Duan, Shuhan, Liu, Yan, Chen, Jing, Wang, Zhiyong, Sun, Yuntao, Li, Xiangping, Wang, Shaomei, Lu, Liuyi, Hu, Liping, Yun, Libing, Yang, Junbao, Yan, Jiangwei, Nie, Shengjie, Zhu, Yanfeng, Chen, Gang, Wang, Chuan-Chao, Liu, Chao, He, Guanglin, and Tang, Renkuan

Published
2024
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14. Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people

Author

Sun, Yuntao, Wang, Mengge, Sun, Qiuxia, Liu, Yan, Duan, Shuhan, Wang, Zhiyong, Zhou, Yunyu, Zhong, Jun, Huang, Yuguo, Huang, Xinyu, Yang, Qingxin, Li, Xiangping, Su, Haoran, Cai, Yan, Jiang, Xiucheng, Chen, Jing, Yan, Jiangwei, Nie, Shengjie, Hu, Liping, Yang, Junbao, Tang, Renkuan, Wang, Chuan-Chao, Liu, Chao, Deng, Xiaohui, Yun, Libing, and He, Guanglin

Published
2024
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22. Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing

Author

Yuan, Baolei, Zhou, Xuan, Suzuki, Keiichiro, Ramos-Mandujano, Gerardo, Wang, Mengge, Tehseen, Muhammad, Cortés-Medina, Lorena V, Moresco, James J, Dunn, Sarah, Hernandez-Benitez, Reyna, Hishida, Tomoaki, Kim, Na Young, Andijani, Manal M, Bi, Chongwei, Ku, Manching, Takahashi, Yuta, Xu, Jinna, Qiu, Jinsong, Huang, Ling, Benner, Christopher, Aizawa, Emi, Qu, Jing, Liu, Guang-Hui, Li, Zhongwei, Yi, Fei, Ghosheh, Yanal, Shao, Changwei, Shokhirev, Maxim, Comoli, Patrizia, Frassoni, Francesco, Yates, John R, Fu, Xiang-Dong, Esteban, Concepcion Rodriguez, Hamdan, Samir, Izpisua Belmonte, Juan Carlos, and Li, Mo

Subjects
Rare Diseases, Human Genome, Genetics, Generic health relevance, Alternative Splicing, Cell Nucleus, Humans, RNA Polymerase II, RNA Splicing Factors, RNA-Binding Proteins, Wiskott-Aldrich Syndrome, Wiskott-Aldrich Syndrome Protein
Abstract

The diverse functions of WASP, the deficiency of which causes Wiskott-Aldrich syndrome (WAS), remain poorly defined. We generated three isogenic WAS models using patient induced pluripotent stem cells and genome editing. These models recapitulated WAS phenotypes and revealed that WASP deficiency causes an upregulation of numerous RNA splicing factors and widespread altered splicing. Loss of WASP binding to splicing factor gene promoters frequently leads to aberrant epigenetic activation. WASP interacts with dozens of nuclear speckle constituents and constrains SRSF2 mobility. Using an optogenetic system, we showed that WASP forms phase-separated condensates that encompasses SRSF2, nascent RNA and active Pol II. The role of WASP in gene body condensates is corroborated by ChIPseq and RIPseq. Together our data reveal that WASP is a nexus regulator of RNA splicing that controls the transcription of splicing factors epigenetically and the dynamics of the splicing machinery through liquid-liquid phase separation.

Published
2022

29. Posttranslational ISGylation of NLRP3 by HERC enzymes facilitates inflammasome activation in models of inflammation

Author

Qin, Ying, Meng, Xintong, Wang, Mengge, Liang, Wenbo, Xu, Rong, Chen, Jingchunyu, Song, Hui, Fu, Yue, Li, Jingxin, Gao, Chengjiang, Jia, Mutian, Zhao, Chunyuan, and Zhao, Wei

Subjects
Inflammation -- Health aspects, Protein binding -- Health aspects, Ubiquitin -- Health aspects, Ethylenediaminetetraacetic acid -- Health aspects, Infection -- Health aspects, Ligases -- Health aspects, Virus diseases -- Health aspects, Health care industry
Abstract

The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is a crucial component of the innate immune system that initiates inflammatory responses. Posttranslational modifications (PTMs) of NLRP3, including ubiquitination and phosphorylation, control inflammasome activation and determine the intensity of inflammation. However, the role of other PTMs in controlling NLRP3 inflammasome activation remains unclear. This study found that TLR priming induced NLRP3 ISGylation (a type of PTM in which ISG15 covalently binds to the target protein) to stabilize the NLRP3 protein. Viral infection, represented by SARS-COV-2 infection, and type I IFNs induced expression of ISG15 and the predominant E3 ISGylation ligases HECT domain- and RCC1-like domain-containing proteins (HERCs; HERC5 in humans and HERC6 in mice). HERCs promoted NLRP3 ISGylation and inhibited K48-linked ubiquitination and proteasomal degradation, resulting in the enhancement of NLRP3 inflammasome activation. Concordantly, Herc6 deficiency ameliorated NLRP3-dependent inflammation as well as hyperinflammation caused by viral infection. The results illustrate the mechanism by which type I IFNs responses control inflammasome activation and viral infection-induced aberrant NLRP3 activation. This work identifies ISGylation as a PTM of NLRP3, revealing a priming target that modulates NLRP3-dependent immunopathology., Introduction The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is a vital component of the innate immune system that senses both pathogen-associated molecular patterns (PAMPs) from microbes and [...]

Published
2023
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37. Author Correction: Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing

Author

Yuan, Baolei, Zhou, Xuan, Suzuki, Keiichiro, Ramos-Mandujano, Gerardo, Wang, Mengge, Tehseen, Muhammad, Cortés-Medina, Lorena V., Moresco, James J., Dunn, Sarah, Hernandez-Benitez, Reyna, Hishida, Tomoaki, Kim, Na Young, Andijani, Manal M., Bi, Chongwei, Ku, Manching, Takahashi, Yuta, Xu, Jinna, Qiu, Jinsong, Huang, Ling, Benner, Christopher, Aizawa, Emi, Qu, Jing, Liu, Guang-Hui, Li, Zhongwei, Yi, Fei, Ghosheh, Yanal, Shao, Changwei, Shokhirev, Maxim, Comoli, Patrizia, Frassoni, Francesco, Yates, III, John R., Fu, Xiang-Dong, Esteban, Concepcion Rodriguez, Hamdan, Samir, Izpisua Belmonte, Juan Carlos, and Li, Mo

Published
2022
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40. Investigating the Hierarchical Relationship Between Clause and Phrase Using the Menzerath-Altmann Law: Evidence from Academic Research Articles.

Author

Wang, Mengge and Jiang, Jingyang

Subjects
*UNIVERSITY research, *TERMS & phrases, *CURVE fitting, *CLUSTER analysis (Statistics), *ENGLISH language
Abstract

The study justifies phrases (instead of words) as the direct constituents of clauses using English academic research articles (RAs) by fitting the Menzerath-Altmann Law (MAL) to the correlations between sentence length (in clause numbers) and clause length (in phrase numbers), and between clause length and phrase length (in word numbers). The study was conducted under the framework of dependency grammar, with a self-built corpus of 104,499 tokens. The results indicate that 1) both correlations abide by the MAL, or abide when excluding the second MAL regime, regardless of part-genres, suggesting that phrases are the appropriate direct constituents of clauses. 2) The increasing MAL fitting curve is found in Abstract, which has the shortest mean dependency distance. 3) Clustering analysis on the MAL parameters in dependency structure can effectively differentiate the size-restricted Abstract from the other part-genres at the lower level, i.e., clause-phrase-word level. Furthermore, our findings have important implications: 1) The second regime may be closely related to text characteristics or linguistic unit levels. 2) The dependency distance minimization effect is possibly a counteractive force against the Menzerathian shortening effect. 3) The competing relationship between clausal and phrasal complexity in RAs is driven by the self-regulating and self-adapting language system. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Multiple Human Population Movements and Cultural Dispersal Events Shaped the Landscape of Chinese Paternal Heritage.

Author

Wang, Mengge, Huang, Yuguo, Liu, Kaijun, Wang, Zhiyong, Zhang, Menghan, Yuan, Haibing, Duan, Shuhan, Wei, Lanhai, Yao, Hongbing, Sun, Qiuxia, Zhong, Jie, Tang, Renkuan, Chen, Jing, Sun, Yuntao, Li, Xiangping, Su, Haoran, Yang, Qingxin, Hu, Liping, Yun, Libing, and Yang, Junbao

Subjects
CHINESE people, TECHNOLOGICAL innovations, CULTURAL movements, EAST Asians, FOSSIL DNA
Abstract

Large-scale genomic projects and ancient DNA innovations have ushered in a new paradigm for exploring human evolutionary history. However, the genetic legacy of spatiotemporally diverse ancient Eurasians within Chinese paternal lineages remains unresolved. Here, we report an integrated Y-chromosome genomic database encompassing 15,563 individuals from both modern and ancient Eurasians, including 919 newly reported individuals, to investigate the Chinese paternal genomic diversity. The high-resolution, time-stamped phylogeny reveals multiple diversification events and extensive expansions in the early and middle Neolithic. We identify four major ancient population movements, each associated with technological innovations that have shaped the Chinese paternal landscape. First, the expansion of early East Asians and millet farmers from the Yellow River Basin predominantly carrying O2/D subclades significantly influenced the formation of the Sino-Tibetan people and facilitated the permanent settlement of the Tibetan Plateau. Second, the dispersal of rice farmers from the Yangtze River Valley carrying O1 and certain O2 sublineages reshapes the genetic makeup of southern Han Chinese, as well as the Tai-Kadai, Austronesian, Hmong-Mien, and Austroasiatic people. Third, the Neolithic Siberian Q/C paternal lineages originated and proliferated among hunter-gatherers on the Mongolian Plateau and the Amur River Basin, leaving a significant imprint on the gene pools of northern China. Fourth, the J/G/R paternal lineages derived from western Eurasia, which were initially spread by Yamnaya-related steppe pastoralists, maintain their presence primarily in northwestern China. Overall, our research provides comprehensive genetic evidence elucidating the significant impact of interactions with culturally distinct ancient Eurasians on the patterns of paternal diversity in modern Chinese populations. [ABSTRACT FROM AUTHOR]

Published
2024
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