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7. Cancer germline predisposing variants and late mortality from subsequent malignant neoplasms among long-term childhood cancer survivors: a report from the St Jude Lifetime Cohort and the Childhood Cancer Survivor Study

Author

Chen, Cheng, Qin, Na, Wang, Mingjuan, Dong, Qian, Tithi, Saima Sultana, Hui, Yawei, Chen, Wenan, Wu, Gang, Kennetz, Dennis, Edmonson, Michael N, Rusch, Michael C, Thrasher, Andrew, Easton, John, Mulder, Heather L, Song, Nan, Plonski, Noel-Marie, Shelton, Kyla, Im, Cindy, Ehrhardt, Matthew J, Nichols, Kim E, Leisenring, Wendy M, Stratton, Kayla L, Howell, Rebecca, Yasui, Yutaka, Bhatia, Smita, Armstrong, Gregory T, Ness, Kirsten K, Hudson, Melissa M, Zhang, Jinghui, Wang, Hui, Srivastava, Deo Kumar, Robison, Leslie L, and Wang, Zhaoming

Published
2023
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11. Neurologic morbidity and functional independence in adult survivors of childhood cancer

Author

Vuotto, Stefanie C., primary, Wang, Mingjuan, additional, Okcu, M. Fatih, additional, Bowers, Daniel C., additional, Ullrich, Nicole J., additional, Ness, Kirsten K., additional, Li, Chenghong, additional, Srivastava, Deo Kumar, additional, Howell, Rebecca M., additional, Gibson, Todd M., additional, Leisenring, Wendy M., additional, Oeffinger, Kevin C., additional, Robison, Leslie L., additional, Armstrong, Gregory T., additional, Kull, Kevin R., additional, and Brinkman, Tara M., additional

Published
2023
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12. Deficit Accumulation Index and Biological Markers of Aging in Survivors of Childhood Cancer

Author

Williams, AnnaLynn M., primary, Mandelblatt, Jeanne S., additional, Wang, Mingjuan, additional, Dong, Qian, additional, Armstrong, Gregory T., additional, Bhakta, Nickhill, additional, Brinkman, Tara M., additional, Ehrhardt, Matthew J., additional, Mulrooney, Daniel A., additional, Gilmore, Nikesha, additional, Robison, Leslie L., additional, Yasui, Yutaka, additional, Small, Brent J., additional, Srivastava, Deokumar, additional, Hudson, Melissa M., additional, Ness, Kirsten K., additional, Krull, Kevin R., additional, and Wang, Zhaoming, additional

Published
2023
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17. Neurologic morbidity and functional independence in adult survivors of childhood cancer.

Author

Vuotto, Stefanie C., Wang, Mingjuan, Okcu, M. Fatih, Bowers, Daniel C., Ullrich, Nicole J., Ness, Kirsten K., Li, Chenghong, Srivastava, Deo Kumar, Howell, Rebecca M., Gibson, Todd M., Leisenring, Wendy M., Oeffinger, Kevin C., Robison, Leslie L., Armstrong, Gregory T., Krull, Kevin R., and Brinkman, Tara M.

Abstract

Objective: To examine associations between neurologic late effects and attainment of independence in adult survivors of childhood cancer treated with central nervous system (CNS)‐directed therapies. Methods: A total of 7881 survivors treated with cranial radiation therapy (n = 4051; CRT) and/or intrathecal methotrexate (n = 4193; IT MTX) ([CNS‐treated]; median age [range] = 25.5 years [18–48]; time since diagnosis = 17.7 years [6.8–30.2]) and 8039 without CNS‐directed therapy reported neurologic conditions including stroke, seizure, neurosensory deficits, focal neurologic dysfunction, and migraines/severe headaches. Functional independence was assessed using latent class analysis with multiple indicators (independent living, assistance with routine and personal care needs, ability to work/attend school, attainment of driver's license, marital/partner status). Multivariable regression models, adjusted for age, sex, race/ethnicity, and chronic health conditions, estimated odds ratios (OR) or relative risks (RR) for associations between neurologic morbidity, functional independence, and emotional distress. Results: Among CNS‐treated survivors, three classes of independence were identified: (1) moderately independent, never married, and non‐independent living (78.7%); (2) moderately independent, unable to drive (15.6%); and (3) non‐independent (5.7%). In contrast to 50% of non‐CNS‐treated survivors and 60% of siblings, a fourth fully independent class of CNS‐treated survivors was not identified. History of stroke (OR = 2.50, 95% CI: 1.70–3.68), seizure (OR = 9.70, 95% CI: 7.37–12.8), neurosensory deficits (OR = 2.67, 95% CI: 2.16–3.31), and focal neurologic dysfunction (OR = 3.05, 95% CI: 2.40–3.88) were associated with non‐independence among CNS‐treated survivors. Non‐independence was associated with emotional distress symptoms. Interpretation: CNS‐treated survivors do not attain full independence comparable to non‐CNS‐treated survivors or siblings. Interventions to promote independence may be beneficial for survivors with treatment‐related neurological sequalae. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Effects of Long Noncoding RNA AK093407 on the Biological Behavior of Colon Cancer Cells and the Underlying Mechanism

Author

Zhao, Xuerong, Sun, Ao, Wang, Jianping, Zheng, Xin, Tian, Duoduo, Wang, Mingjuan, Xiao, Lijun, Zhao, Enhong, and Zheng-Guo, Cui

Subjects
Organic Chemistry, Drug Discovery, General Medicine, Computer Science Applications
Abstract

Introduction: The incidence of colorectal cancer is steadily increasing, and the detection of related molecular targets is critical for its diagnosis and treatment. Long noncoding RNA (lncRNA) can play a regulatory role before and after genome transcription, and epigenetic regulation is involved in the process of tumorigenesis and tumor development. Method: In this study, qRT-PCR was performed to evaluate the expression of AK093407 in colon cancer and colon para-carcinoma tissues and HCT-15 and HCT-116 cells. SiRNA was transfected into HCT-15 and HCT-116 cells to knock down lncRNA-AK093407. Then, MTT assay was used to test cell proliferation, and flow cytometry was used to test apoptosis and cell cycle. The protein expression of caspase-3, caspase-8, caspase-9, bax, bcl-2, cyclin-A1, cyclin-B1, cyclin-D1, cyclin- E1, p21, p27, and p-Stat3 was determined by Western blot. Results: The results showed that the expression of AK093407 in human colon cancer tissue was higher than in para-carcinoma tissue. The amount of AK093407 in HCT-15 and HCT-116 cells was higher than that in normal colorectal epithelial NM460 cells. When AK093407 was silenced, the proliferation of HCT-15 and HCT-116 cells decreased, the apoptosis rate increased, the cell cycle was arrested in the G1/S phase, the expression of caspase-3, caspase-8, caspase-9, bax, cyclin-A1, cyclin- B1, p21, p27 increased, and the expression of bcl-2, cyclin-D1, cyclin-E1, p-Stat3 decreased. Conclusion: These results showed that knockdown of AK093407 could inhibit colon cancer cell proliferation, induce apoptosis and cell cycle arrest, influence the expression of vital factors in mitochondrial apoptosis pathway and cell cycle regulatory pathway, and may negatively regulate JAK/STAT3 through down-regulating p-Stat3.

Published
2023

21. Emotional, behavioral, and physical health consequences of loneliness in young adult survivors of childhood cancer: Results from the Childhood Cancer Survivor Study

Author

Papini, Chiara, primary, Fayad, Ameera A., additional, Wang, Mingjuan, additional, Schulte, Fiona S. M., additional, Huang, I‐Chan, additional, Chang, Yu‐Ping, additional, Howell, Rebecca M., additional, Srivastava, Deokumar, additional, Leisenring, Wendy M., additional, Armstrong, Gregory T., additional, Gibson, Todd M., additional, Robison, Leslie L., additional, Oeffinger, Kevin C., additional, Krull, Kevin R., additional, and Brinkman, Tara M., additional

Published
2023
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22. Premature aging as an accumulation of deficits in young adult survivors of pediatric cancer

Author

Williams, AnnaLynn M, primary, Mandelblatt, Jeanne, additional, Wang, Mingjuan, additional, Armstrong, Gregory T, additional, Bhakta, Nickhill, additional, Brinkman, Tara M, additional, Chemaitilly, Wassim, additional, Ehrhardt, Matthew J, additional, Mulrooney, Daniel A, additional, Small, Brent J, additional, Wang, Zhaoming, additional, Srivastava, Deokumar, additional, Robison, Leslie L, additional, Hudson, Melissa M, additional, Ness, Kirsten K, additional, and Krull, Kevin R, additional

Published
2022
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26. One case report and literature review of arrhythmia caused by pituitrin.

Author

Cao, Xiaohong, Shi, Xiuzhi, Wang, Mingjuan, Su, Zhiying, He, Xiaoyan, Zheng, Liqin, and Bu, Lixia

Abstract

Arrhythmias are perceived as a complication of pituitrin. However, injecting a standard dose of pituitrin via vein causes different arrhythmias. In our case, a 35‐year‐old female patient was admitted to the hospital due to a productive cough with sputum for 5 days and two occasions of massive hemoptysis. After 1 day of treatment using 500 ml normal saline with 10u pituitrin, the sputum was filled with small amounts of kermesinus bloodstains. When pituitrin was stopped without any other treatment, all presenting symptoms gradually subsided after half an hour, and the ECG returned to normal. Therefore, when treating massive hemoptysis by administering pituitrin intravenously, it is necessary to exercise great precaution and therapeutic measures. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Premature Aging as an Accumulation of Deficits in Young Adult Survivors of Pediatric Cancer.

Author

Williams, AnnaLynn M, Mandelblatt, Jeanne, Wang, Mingjuan, Armstrong, Gregory T, Bhakta, Nickhill, Brinkman, Tara M, Chemaitilly, Wassim, Ehrhardt, Matthew J, Mulrooney, Daniel A, Small, Brent J, Wang, Zhaoming, Srivastava, Deokumar, Robison, Leslie L, Hudson, Melissa M, Ness, Kirsten K, and Krull, Kevin R

Subjects
PREMATURE aging (Medicine), CHILDHOOD cancer, YOUNG adults, CANCER survivors, RACE, CANCER fatigue
Abstract

Background: We aimed to characterize premature aging as an accumulation of deficits in survivors of pediatric cancer compared to community controls and examine associations with host/treatment factors, neurocognition, and mortality.Methods: Pediatric cancer survivors (N = 4,000, median age 28.6 [IQR 23-35], 20 [15-27] years post-diagnosis) and community controls (N = 638, median age 32 [25-40]) completed clinical assessments, questionnaires, and were followed for mortality through April 30th, 2020 (mean [SD] follow-up 7.0 [3.4] years). A deficit accumulation index (DAI) score was calculated from 44 aging-related items including: self-reported daily function, psychosocial symptoms, and health conditions. Items were weighted from 0 (absent) to 1 (present/most severe), summed and divided by the total yielding a ratio (higher=more deficits). Scores <0.20 are robust and 0.06 is a clinically meaningful difference. Linear regression compared the DAI in survivors and controls with an age*survivor/control interaction. Logistic regression and Cox-proportional hazards estimated the risk of neurocognitive impairment and death. Models were minimally adjusted for age, sex, and race andethnicity.Results: The adjusted mean DAI among survivors at age 30 years was 0.16 corresponding to age 63 in controls (33 years premature aging; β = 0.07 95%CI 0.06-0.08; p<.001). Cranial/abdominal radiation, alkylators, platinum, and neurosurgery were associated with worse DAI (p's≤.001). Higher scores were associated with increased risk of neurocognitive impairment in all domains (p's<.001) and increased risk of death (DAI 0.20-0.35 HR = 2.80, 95%CI 1.97-3.98; DAI ≥0.35 HR = 5.08, 95%CI 3.52-7.34).Conclusion:  Pediatric cancer survivors experience significant premature aging. The DAI may be used to identify survivors at greatest risk of poor health outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Patient-reported neurocognitive function in adult survivors of childhood and adolescent osteosarcoma and Ewing sarcoma

Author

Kadan-Lottick, Nina S., primary, Zheng, Daniel J., additional, Wang, Mingjuan, additional, Bishop, Michael W., additional, Srivastava, Deo Kumar, additional, Ross, Wilhelmenia L., additional, Rodwin, Rozalyn L., additional, Ness, Kirsten K., additional, Gibson, Todd M., additional, Spunt, Sheri L., additional, Okcu, Mehmet Fatih, additional, Leisenring, Wendy M., additional, Robison, Leslie L., additional, Armstrong, Gregory T., additional, and Krull, Kevin R., additional

Published
2022
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32. Accelerated aging and mortality in long-term survivors of childhood cancer: A report from the St. Jude Lifetime Cohort (SJLIFE).

Author

Williams, AnnaLynn M., primary, Mandelblatt, Jeanne S., additional, Wang, Mingjuan, additional, Ness, Kirsten K., additional, Armstrong, Gregory T., additional, Bhakta, Nickhill, additional, Brinkman, Tara M., additional, Chemaitilly, Wassim, additional, Ehrhardt, Matthew J., additional, Mulrooney, Daniel A., additional, Small, Brent, additional, Wang, Zhaoming, additional, Yasui, Yutaka, additional, Srivastava, Deokumar, additional, Hudson, Melissa M., additional, Robison, Leslie L., additional, and Krull, Kevin R., additional

Published
2021
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34. Prevalence and predictors of cancer‐related worry and associations with health behaviors in adult survivors of childhood cancer

Author

McDonnell, Glynnis A., primary, Brinkman, Tara M., additional, Wang, Mingjuan, additional, Gibson, Todd M., additional, Heathcote, Lauren C., additional, Ehrhardt, Matthew J., additional, Srivastava, Deo Kumar, additional, Robison, Leslie L., additional, Hudson, Melissa M., additional, and Alberts, Nicole M., additional

Published
2021
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36. Kidney Function after Treatment for Childhood Cancer: A Report from the St. Jude Lifetime Cohort Study

Author

Green, Daniel M., primary, Wang, Mingjuan, additional, Krasin, Matthew, additional, Srivastava, DeoKumar, additional, Onder, Songul, additional, Jay, Dennis W., additional, Ness, Kirsten K., additional, Greene, William, additional, Lanctot, Jennifer Q., additional, Shelton, Kyla C., additional, Zhu, Liang, additional, Mulrooney, Daniel A., additional, Ehrhardt, Matthew J., additional, Davidoff, Andrew M., additional, Robison, Leslie L., additional, and Hudson, Melissa M., additional

Published
2021
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37. The Contribution of Stress and Distress to Cardiovascular Health in Adult Survivors of Childhood Cancer

Author

Lubas, Margaret M., primary, Wang, Mingjuan, additional, Jefferies, John L., additional, Ness, Kirsten K., additional, Ehrhardt, Matthew J., additional, Krull, Kevin R., additional, Mulrooney, Daniel A., additional, Srivastava, Deo Kumar, additional, Howell, Rebecca M., additional, Robison, Leslie L., additional, Hudson, Melissa M., additional, Armstrong, Gregory T., additional, and Brinkman, Tara M., additional

Published
2021
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39. Psychological, educational, and social late effects in adolescent survivors of Wilms tumor: A report from the Childhood Cancer Survivor Study

Author

Foster, Rebecca H., primary, Hayashi, Robert J., additional, Wang, Mingjuan, additional, Liu, Wei, additional, Mohrmann, Caroline, additional, Howell, Rebecca M., additional, Smith, Susan A., additional, Gibson, Todd M., additional, Srivastava, DeoKumar, additional, Green, Daniel M., additional, Oeffinger, Kevin C., additional, Leisenring, Wendy M., additional, Robison, Leslie L., additional, Armstrong, Gregory T., additional, Krull, Kevin R., additional, and Hardy, Kristina K., additional

Published
2020
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42. Long‐term renal function after treatment for unilateral, nonsyndromic Wilms tumor. A report from the St. Jude Lifetime Cohort Study

Author

Green, Daniel M., primary, Wang, Mingjuan, additional, Krasin, Matthew J., additional, Davidoff, Andrew M., additional, Srivastava, DeoKumar, additional, Jay, Dennis W., additional, Ness, Kirsten K., additional, Shulkin, Barry L., additional, Spunt, Sheri L., additional, Jones, Deborah P., additional, Lanctot, Jennifer Q., additional, Shelton, Kyla C., additional, Brennan, Rachel C., additional, Mulrooney, Daniel A., additional, Ehrhardt, Matthew J., additional, Gibson, Todd M., additional, Kurt, Beth A., additional, Robison, Leslie L., additional, and Hudson, Melissa M., additional

Published
2020
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43. Emotional distress, stress, and cardiovascular health in adult survivors of childhood cancer.

Author

Lubas, Margaret M., primary, Wang, Mingjuan, additional, Jefferies, John L., additional, Ness, Kirsten K., additional, Ehrhardt, Matthew J., additional, Krull, Kevin R., additional, Mulrooney, Daniel A., additional, Srivastava, Deo Kumar, additional, Robison, Leslie L., additional, Hudson, Melissa M., additional, Armstrong, Gregory T., additional, and Brinkman, Tara M., additional

Published
2020
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44. Longitudinal evaluation of alanine aminotransferase after treatment for childhood cancer. A report from the St. Jude Lifetime Cohort Study.

Author

Green, Daniel M., primary, Wang, Mingjuan, additional, Krasin, Matthew J., additional, Srivastava, Deokumar, additional, Relling, Mary V., additional, Howell, Carrie R., additional, Ness, Kirsten K., additional, Kaste, Sue C., additional, Greene, William, additional, Jay, Dennis W., additional, Davidoff, Andrew M., additional, Pui, Ching-Hon, additional, Jeha, Sima, additional, Bishop, Michael William, additional, Furman, Wayne Lee, additional, Robison, Leslie L., additional, and Hudson, Melissa M., additional

Published
2020
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45. Neurocognitive and psychosocial outcomes in adult survivors of childhood soft‐tissue sarcoma: A report from the St. Jude Lifetime Cohort

Author

Tonning Olsson, Ingrid, primary, Brinkman, Tara M., additional, Wang, Mingjuan, additional, Ehrhardt, Matthew J., additional, Banerjee, Pia, additional, Mulrooney, Daniel A., additional, Huang, I‐Chan, additional, Ness, Kirsten K., additional, Bishop, Michael W., additional, Srivastava, Deokumar, additional, Robison, Leslie L., additional, Hudson, Melissa M., additional, and Krull, Kevin R., additional

Published
2020
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47. Serum ALT elevations in survivors of childhood cancer. A report from the St. Jude Lifetime Cohort Study

Author

Green, Daniel M., Wang, Mingjuan, Krasin, Matthew J., Srivastava, DeoKumar, Relling, Mary V., Howell, Carrie R., Ness, Kirsten K., Kaste, Sue C., Greene, William, Jay, Dennis W., Fernandez-Pineda, Israel, Pui, Ching-Hon, Jeha, Sima, Bishop, Michael W., Furman, Wayne L., Robison, Leslie L., and Hudson, Melissa M.

Subjects
Adult, Male, Adolescent, Infant, Alanine Transaminase, Middle Aged, Risk Assessment, Article, Cohort Studies, Young Adult, Cancer Survivors, Child, Preschool, Prevalence, Humans, Female, Child
Abstract

The purpose of this study was to define the prevalence of and risk factors for elevated serum alanine aminotransferase (ALT) level among adult childhood cancer survivors (CCS). The study cohort comprised 2,751 CCS from the St. Jude Lifetime Cohort Study (10 years postdiagnosis, age ≥18 years). Serum ALT level was graded using the Common Terminology Criteria for Adverse Events v. 4.03. Modified Poisson regression models were used to estimate relative risks and 95% confidence intervals for the association between demographic and clinical factors and grades 1-4 ALT on the selected models. A total of 1,339 (48.7%) CCS were female; 2,271 (82.6%) were non-Hispanic white. Median age at evaluation was 31.4 years (interquartile range [IQR] = 25.8-37.8); median elapsed time from diagnosis to evaluation was 23.2 years (IQR = 17.6-29.7). A total of 1,137 (41.3%) CSS had ALTupper limit of normal (Common Terminology Criteria for Adverse Events v. 4.03 grade 1-1,058 (38.5%); grade 2-56 (2.0%); grade 3-23 (0.8%); grade 4-none). Multivariable models demonstrated non-Hispanic white race/ethnicity, age at evaluation in years, being overweight or obese, presence of the metabolic syndrome, current treatment with atorvastatin or rosuvastatin or simvastatin, hepatitis C virus infection, prior treatment with busulfan or thioguanine, history of hepatic surgery, and the percentage of liver treated with ≥10 Gray, ≥15 Gray, or ≥20 Gray were associated with elevated ALT. Conclusion: Grade 3 or 4 hepatic injury is infrequent in CCS. Mild hepatic injury in this group may be amenable to lifestyle modifications.

Published
2018

48. Renal function after treatment for childhood cancer: A report from the St. Jude Lifetime Cohort Study.

Author

Green, Daniel M., primary, Wang, Mingjuan, additional, Krasin, Matthew J., additional, Srivastava, Deokumar, additional, Howell, Carrie R., additional, Jay, Dennis W., additional, Ness, Kirsten K., additional, Greene, William, additional, Lanctot, Jennifer Q., additional, Shelton, Kyla C., additional, Davidoff, Andrew M., additional, Ehrhardt, Matthew J., additional, Mulrooney, Daniel A., additional, Robison, Leslie L., additional, and Hudson, Melissa M., additional

Published
2019
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49. Temporal trends among survivors of rhabdomyosarcoma: A report from the Childhood Cancer Survivor Study (CCSS).

Author

Hingorani, Pooja, primary, Wang, Mingjuan, additional, Srivastava, Deokumar, additional, Nathan, Paul C., additional, Oeffinger, Kevin C., additional, Yasui, Yutaka, additional, Leisenring, Wendy M., additional, Howell, Rebecca M., additional, Mueller, Emily L., additional, Gibson, Todd M., additional, Wolden, Suzanne L., additional, Bjornard, Kari L., additional, Meyer, William H., additional, Arndt, Carola A. S., additional, Robison, Leslie L., additional, Green, Daniel M., additional, Armstrong, Gregory T., additional, and Ness, Kirsten K., additional

Published
2019
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