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206 results on '"Wang, Minjia"'

25. A Bioactive Photosensitizer for Hypoxia‐Tolerant Molecular Targeting‐Photo‐Immunotherapy of Malignant Tumor.

Author

Fan, Lianfeng, Jian, Chuanjiang, Li, Ling, Wang, Li, Song, Xuejiao, Wang, Minjia, Liu, Chutong, Liu, Xiaoxiao, Xu, Shidang, Gao, Xihui, Shi, Xianjie, Yuan, Miaomiao, Liu, Bin, and Shi, Leilei

Subjects
PHOTODYNAMIC therapy, REACTIVE oxygen species, TUMOR microenvironment, CANCER treatment, METASTASIS
Abstract

Photosensitizers (PSs) with effective reactive oxygen species generation ability against hypoxia are of great potential for clinical treatment of malignant tumors. However, complex tumor microenvironment, such as antioxidative responses and immunosuppression, would ineluctably limit the efficiency of photodynamic therapy (PDT). Herein, a molecular‐targeting photosensitizer QTANHOH is rationally designed for histone deacetylases (HDACs‐targeting photo‐immunotherapy application. The PS QTANHOH displays excellent type‐I/II PDT performance, exhibiting significant phototoxicity toward cancer cells with half maximal inhibitory concentration (IC50) less than 10 nm in both normoxia and hypoxia conditions under blue laser irradiation. Moreover, the bioactive compound could inhibit HDACs and activate the immune microenvironment to boost PDT efficacy on the immunocompetent BALB/c mice with breast cancer, leading to the eradication of solid tumor and inhibition of metastasis. Notably, the molecular‐targeting photosensitizer introduces an alternative strategy to achieve superior phototherapy for cancer therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Modeling Uranyl Adsorption on MoS2/Mo2CTxHeterostructures Using DFT and BOMD Methods

Author

Meng, Cheng, Shu, Weihui, Zhao, Kun, Yan, Chunpei, Li, Zuojia, Wei, Qianglin, Wang, Minjia, Liu, Yunhai, and Zhang, Zhibin

Abstract

Uranium-bearing wastewaters exert a great threat to the ecological environment due to its high radiotoxicity level. The designing and fabrication of novel adsorption materials can be promoted for radionuclide elimination from wastewater. In this work, results from density functional theory and Born–Oppenheimer molecular dynamics simulations are reported for the uranyl adsorption behavior on the MoS2/Mo2CTxheterostructure in the gas phase and in an aqueous environment. Uranyl ions prefer to be adsorbed at deprotonated O sites on the Mo2COH surface and S sites on the MoS2side of the heterojunctions, resulting in the formation of bidentate configurations. In addition to coordination interaction, H-bond and van der Waals interactions can also play an important role in binding configurations. More importantly, the oxidation state U(VI) can be reduced to U(V) and then to U(IV) caused by the strong reducibility of the Mo2COH surface at room temperature, whereas the uranyl complex can move freely on the MoS2surface. However, the coordination number of U with respect to H2O in the first hydration shell on the Mo2COH surface remains unchanged and is found to be 3, which is similar to that on the MoS2surface. This work provides novel nanosorbents for the removal of uranyl from wastewater. The present viewpoint provides valuable mechanistic interpretations for uranyl adsorption and will give a supplement to the experimental research.

Published
2023
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