4,263 results on '"Wang, Paul"'
Search Results
2. Is RISC-V ready for HPC prime-time: Evaluating the 64-core Sophon SG2042 RISC-V CPU
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Brown, Nick, Jamieson, Maurice, Lee, Joseph, and Wang, Paul
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Computer Science - Distributed, Parallel, and Cluster Computing - Abstract
The Sophon SG2042 is the world's first commodity 64-core RISC-V CPU for high performance workloads and an important question is whether the SG2042 has the potential to encourage the HPC community to embrace RISC-V. In this paper we undertaking a performance exploration of the SG2042 against existing RISC-V hardware and high performance x86 CPUs in use by modern supercomputers. Leveraging the RAJAPerf benchmarking suite, we discover that on average, the SG2042 delivers, per core, between five and ten times the performance compared to the nearest widely available RISC-V hardware. We found that, on average, the x86 high performance CPUs under test outperform the SG2042 by between four and eight times for multi-threaded workloads, although some individual kernels do perform faster on the SG2042. The result of this work is a performance study that not only contrasts this new RISC-V CPU against existing technologies, but furthermore shares performance best practice., Comment: Author accepted version of paper in ACM Workshops of The International Conference on High Performance Computing, Network, Storage, and Analysis (SC-W 2023)
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- 2023
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3. Diffusion-based Time Series Data Imputation for Microsoft 365
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Yang, Fangkai, Yin, Wenjie, Wang, Lu, Li, Tianci, Zhao, Pu, Liu, Bo, Wang, Paul, Qiao, Bo, Liu, Yudong, Björkman, Mårten, Rajmohan, Saravan, Lin, Qingwei, and Zhang, Dongmei
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Computer Science - Distributed, Parallel, and Cluster Computing ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
Reliability is extremely important for large-scale cloud systems like Microsoft 365. Cloud failures such as disk failure, node failure, etc. threaten service reliability, resulting in online service interruptions and economic loss. Existing works focus on predicting cloud failures and proactively taking action before failures happen. However, they suffer from poor data quality like data missing in model training and prediction, which limits the performance. In this paper, we focus on enhancing data quality through data imputation by the proposed Diffusion+, a sample-efficient diffusion model, to impute the missing data efficiently based on the observed data. Our experiments and application practice show that our model contributes to improving the performance of the downstream failure prediction task.
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- 2023
4. Comparative arrhythmia patterns among patients on tyrosine kinase inhibitors
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Wei, Chen, Fazal, Muhammad, Loh, Alexander, Kapoor, Ridhima, Gomez, Sofia Elena, Shah, Shayena, Rogers, Albert J., Narayan, Sanjiv M., Wang, Paul J., Witteles, Ronald M., Perino, Alexander C., Cheng, Paul, Rhee, June-Wha, and Baykaner, Tina
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- 2024
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5. Task formulation for Extracting Social Determinants of Health from Clinical Narratives
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Torii, Manabu, Finn, Ian M., Doan, Son, Wang, Paul, Yang, Elly W., and Zisook, Daniel S.
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Computer Science - Computation and Language ,I.2.7 - Abstract
Objective: The 2022 n2c2 NLP Challenge posed identification of social determinants of health (SDOH) in clinical narratives. We present three systems that we developed for the Challenge and discuss the distinctive task formulation used in each of the three systems. Materials and Methods: The first system identifies target pieces of information independently using machine learning classifiers. The second system uses a large language model (LLM) to extract complete structured outputs per document. The third system extracts candidate phrases using machine learning and identifies target relations with hand-crafted rules. Results: The three systems achieved F1 scores of 0.884, 0.831, and 0.663 in the Subtask A of the Challenge, which are ranked third, seventh, and eighth among the 15 participating teams. The review of the extraction results from our systems reveals characteristics of each approach and those of the SODH extraction task. Discussion: Phrases and relations annotated in the task is unique and diverse, not conforming to the conventional event extraction task. These annotations are difficult to model with limited training data. The system that extracts information independently, ignoring the annotated relations, achieves the highest F1 score. Meanwhile, LLM with its versatile capability achieves the high F1 score, while respecting the annotated relations. The rule-based system tackling relation extraction obtains the low F1 score, while it is the most explainable approach. Conclusion: The F1 scores of the three systems vary in this challenge setting, but each approach has advantages and disadvantages in a practical application. The selection of the approach depends not only on the F1 score but also on the requirements in the application.
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- 2023
6. The group configuration theorem for generically stable types
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Wang, Paul Z.
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Mathematics - Logic ,03C45 - Abstract
We generalize Hrushovski's group configuration theorem to the case where the type of the configuration is generically stable, without assuming tameness of the ambient theory. The properties of generically stable types, which we recall in the first section, enable us to adapt the proof known in the stable context., Comment: 42 pages, 7 figures. This version contains more detailed proofs and a rearranged structure. Many changes were suggested by a referee
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- 2022
7. Women Trainees in Electrophysiology and the Effect of Role Models
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Baykaner, Tina, Greif, Shana, Vajapey, Ramya S., Albert, Christine M., Aziz, Zaid, Badhwar, Nitish, Bunch, T. Jared, Cheung, Jim W., Chrispin, Jonathan, Chung, Mina K., Clopton, Paul, Cooper, Daniel H., Cooper, Joshua M., Costea, Alexandru, Huang, Henry D., Hurwitz, Jodie L., Jankelson, Lior, Kapoor, Ridhima, Kroman, Anne, Latchamsetty, Rakesh, Liang, Jackson J., Mansour, Moussa, Marrouche, Nassir F., Merchant, Faisal M., Miller, John M., Mountantonakis, Stavros, Piccini, Jonathan P., Russo, Andrea M., Steinberg, Benjamin A., Tedrow, Usha, Tzou, Wendy S., Wan, Elaine Y., Wang, Paul J., and Han, Janet K.
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- 2024
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8. Worldwide survey on implantation of and outcomes for conduction system pacing with His bundle and left bundle branch area pacing leads
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Perino, Alexander C., Wang, Paul J., Lloyd, Michael, Zanon, Francesco, Fujiu, Katsuhito, Osman, Faizel, Briongos-Figuero, Sem, Sato, Toshiaki, Aksu, Tolga, Jastrzebski, Marek, Sideris, Skevos, Rao, Praveen, Boczar, Krzysztof, Yuan-ning, Xu, Wu, Michael, Namboodiri, Narayanan, Garcia, Rodrigue, Kataria, Vikas, De Pooter, Jan, Przibille, Oliver, Gehi, Anil K., Cano, Oscar, Katsouras, Grigorios, Cai, Binni, Astheimer, Klaus, Tanawuttiwat, Tanyanan, Datino, Tomas, Rizkallah, Jacques, Alasti, Mohammad, Feld, Gregory, Barrio-Lopez, Maria Teresa, Gilmore, Mark, Conti, Sergio, Yanagisawa, Satoshi, Indik, Julia H., Zou, Jiangang, Saha, Sandeep A., Rodriguez-Munoz, Daniel, Chang, Kuan-Cheng, Lebedev, Dmitry S., Leal, Miguel A., Haeberlin, Andreas, Forno, Alexander R. J. Dal, Orlov, Michael, Frutos, Manuel, Cabanas-Grandio, Pilar, Lyne, Jonathan, Leyva, Francisco, Tolosana, Jose Maria, Ollitrault, Pierre, Vergara, Pasquale, Balla, Cristina, Devabhaktuni, Subodh R., Forleo, Giovanni, Letsas, Konstantinos P., Verma, Atul, Moak, Jeffrey P., Shelke, Abhijeet B., Curila, Karol, Cronin, Edmond M., Futyma, Piotr, Wan, Elaine Y., Lazzerini, Pietro Enea, Bisbal, Felipe, Casella, Michela, Turitto, Gioia, Rosenthal, Lawrence, Bunch, T. Jared, Baszko, Artur, Clementy, Nicolas, Cha, Yong-Mei, Chen, Huang-Chung, Galand, Vincent, Schaller, Robert, Jarman, Julian W. E., Harada, Masahide, Wei, Yong, Kusano, Kengo, Schmidt, Constanze, Hurtado, Marco Antonio Arguello, Naksuk, Niyada, Hoshiyama, Tadashi, Kancharla, Krishna, Iida, Yoji, Mizobuchi, Mashiro, Morin, Daniel P., Cay, Serkan, Paglino, Gabriele, Dahme, Tillman, Agarwal, Sharad, Vijayaraman, Pugazhendhi, and Sharma, Parikshit S.
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- 2023
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9. Association between parental autoimmune disease and childhood atopic dermatitis varied by sex: a nationwide case–control study
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Hung, Yu-Hsuan, Liu, Hsin-Yu, Chang, Renin, Huang, Jing-Yang, Wu, Cheng-Dong, Yen, Man-Syuan, Hung, Yao-Min, Wei, James Cheng-Chung, and Wang, Paul Yung-Pou
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- 2023
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10. Tyrosine kinase inhibitor–associated ventricular arrhythmias: a case series and review of literature
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Fazal, Muhammad, Wei, Chen, Chuy, Katherine Lee, Hussain, Kifah, Gomez, Sofia E., BA, Shayena Shah, Pietrasik, Grzegorz, Yadav, Neha, Ghazizadeh, Zaniar, Kapoor, Ridhima, Witteles, Ronald M., Blackmon, Amanda, Wang, Paul J., John, Roy M., Narayan, Sanjiv M., Cheng, Paul, Rhee, June-Wha, and Baykaner, Tina
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- 2023
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11. Rare variant analyses across multiethnic cohorts identify novel genes for refractive error
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Musolf, Anthony M., Haarman, Annechien E. G., Luben, Robert N., Ong, Jue-Sheng, Patasova, Karina, Trapero, Rolando Hernandez, Marsh, Joseph, Jain, Ishika, Jain, Riya, Wang, Paul Zhiping, Lewis, Deyana D., Tedja, Milly S., Iglesias, Adriana I., Li, Hengtong, Cowan, Cameron S., Biino, Ginevra, Klein, Alison P., Duggal, Priya, Mackey, David A., Hayward, Caroline, Haller, Toomas, Metspalu, Andres, Wedenoja, Juho, Pärssinen, Olavi, Cheng, Ching-Yu, Saw, Seang-Mei, Stambolian, Dwight, Hysi, Pirro G., Khawaja, Anthony P., Vitart, Veronique, Hammond, Christopher J., van Duijn, Cornelia M., Verhoeven, Virginie J. M., Klaver, Caroline C. W., and Bailey-Wilson, Joan E.
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- 2023
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12. Safety of transvenous cardiac defibrillator and magnetic titanium beads system for gastroesophageal reflux disease: a case report
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Vasireddi, Sunil K., Greif, Shana, Fazal, Muhammad, Wei, Chen, Gomez, Sofia, Shah, Shayena, Rogers, Albert J., Narayan, Sanjiv M., Wang, Paul J., Kapoor, Ridhima, and Baykaner, Tina
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- 2023
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13. Needle-Tipped Catheter Ablation of Papillary Muscle Results in Deeper and Larger Ablation Lesions
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Nussinovitch, Udi, Wang, Paul, Babakhanian, Meghedi, Narayan, Sanjiv M., Viswanathan, Mohan, Badhwar, Nitish, Zheng, Lijun, Sauer, William H., and Nguyen, Duy T.
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- 2023
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14. Knowledge Gaps, Challenges, and Opportunities in Health and Prevention Research for Asian Americans, Native Hawaiians, and Pacific Islanders: A Report From the 2021 National Institutes of Health Workshop.
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Kanaya, Alka M, Hsing, Ann W, Panapasa, Sela V, Kandula, Namratha R, Araneta, Maria Rosario G, Shimbo, Daichi, Wang, Paul, Gomez, Scarlett L, Lee, Jinkook, Narayan, KM Venkat, Mau, Marjorie KL Mala, Bose, Sonali, Daviglus, Martha L, Hu, Frank B, Islam, Nadia, Jackson, Chandra L, Kataoka-Yahiro, Merle, Kauwe, John SK, Liu, Simin, Ma, Grace X, Nguyen, Tung, Palaniappan, Latha, Setiawan, V Wendy, Trinh-Shevrin, Chau, Tsoh, Janice Y, Vaidya, Dhananjay, Vickrey, Barbara, Wang, Thomas J, Wong, Nathan D, Coady, Sean, and Hong, Yuling
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Biomedical and Clinical Sciences ,Clinical Sciences ,Prevention ,Cardiovascular ,Good Health and Well Being ,Asian ,Hawaii ,Health Promotion ,Humans ,National Institutes of Health (U.S.) ,Native Hawaiian or Other Pacific Islander ,United States ,Public Health and Health Services - Abstract
Asian Americans (AsA), Native Hawaiians, and Pacific Islanders (NHPI) comprise 7.7% of the U.S. population, and AsA have had the fastest growth rate since 2010. Yet the National Institutes of Health (NIH) has invested only 0.17% of its budget on AsA and NHPI research between 1992 and 2018. More than 40 ethnic subgroups are included within AsA and NHPI (with no majority subpopulation), which are highly diverse culturally, demographically, linguistically, and socioeconomically. However, data for these groups are often aggregated, masking critical health disparities and their drivers. To address these issues, in March 2021, the National Heart, Lung, and Blood Institute, in partnership with 8 other NIH institutes, convened a multidisciplinary workshop to review current research, knowledge gaps, opportunities, barriers, and approaches for prevention research for AsA and NHPI populations. The workshop covered 5 domains: 1) sociocultural, environmental, psychological health, and lifestyle dimensions; 2) metabolic disorders; 3) cardiovascular and lung diseases; 4) cancer; and 5) cognitive function and healthy aging. Two recurring themes emerged: Very limited data on the epidemiology, risk factors, and outcomes for most conditions are available, and most existing data are not disaggregated by subgroup, masking variation in risk factors, disease occurrence, and trajectories. Leveraging the vast phenotypic differences among AsA and NHPI groups was identified as a key opportunity to yield novel clues into etiologic and prognostic factors to inform prevention efforts and intervention strategies. Promising approaches for future research include developing collaborations with community partners, investing in infrastructure support for cohort studies, enhancing existing data sources to enable data disaggregation, and incorporating novel technology for objective measurement. Research on AsA and NHPI subgroups is urgently needed to eliminate disparities and promote health equity in these populations.
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- 2022
15. Points to consider when initiating clinical investigations in autistic paediatric populations–A White Paper
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Ham, Lindsay M., Staunton, Hannah, Schulz, Jan Michael, Tillmann, Julian, Volz, Dietmar, Murtagh, Lorraine, Chatham, Christopher, O'Connor, Eoin C., Chamberlain, Stormy, Schoenenberger, Philipp, Pandina, Gahan, Wang, Paul, Kas, Martien J.H., Arango, Celso, and Murphy, Declan
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- 2024
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16. N‐Terminal Pro‐B‐Type Natriuretic Peptide as a Biomarker for the Severity and Outcomes With COVID‐19 in a Nationwide Hospitalized Cohort
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O’Donnell, Christian, Ashland, Melanie D, Vasti, Elena C, Lu, Ying, Chang, Andrew Y, Wang, Paul, Daniels, Lori B, de Lemos, James A, Morrow, David A, Rodriguez, Fatima, and O’Brien, Connor G
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Patient Safety ,Prevention ,Heart Disease ,Cardiovascular ,Clinical Research ,Good Health and Well Being ,Biomarkers ,COVID-19 ,Heart Failure ,Hospital Mortality ,Humans ,Natriuretic Peptide ,Brain ,Peptide Fragments ,Prognosis ,Prospective Studies ,biomarker ,critical care ,mortality ,survival ,NT-proBNP ,COVID‐19 ,NT‐proBNP ,mortality/survival ,Cardiorespiratory Medicine and Haematology - Abstract
Background Currently, there is limited research on the prognostic value of NT-proBNP (N-terminal pro-B-type natriuretic peptide) as a biomarker in COVID-19. We proposed the a priori hypothesis that an elevated NT-proBNP concentration at admission is associated with increased in-hospital mortality. Methods and Results In this prospective, observational cohort study of the American Heart Association's COVID-19 Cardiovascular Disease Registry, 4675 patients hospitalized with COVID-19 were divided into normal and elevated NT-proBNP cohorts by standard age-adjusted heart failure thresholds, as well as separated by quintiles. Patients with elevated NT-proBNP (n=1344; 28.7%) were older, with more cardiovascular risk factors, and had a significantly higher rate of in-hospital mortality (37% versus 16%; P
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- 2021
17. Author Correction: Genomic autopsy to identify underlying causes of pregnancy loss and perinatal death
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Byrne, Alicia B., Arts, Peer, Ha, Thuong T., Kassahn, Karin S., Pais, Lynn S., O’Donnell-Luria, Anne, Babic, Milena, Frank, Mahalia S. B., Feng, Jinghua, Wang, Paul, Lawrence, David M., Eshraghi, Leila, Arriola, Luis, Toubia, John, Nguyen, Hung, McGillivray, George, Pinner, Jason, McKenzie, Fiona, Morrow, Rebecca, Lipsett, Jill, Manton, Nick, Khong, T. Yee, Moore, Lynette, Liebelt, Jan E., Schreiber, Andreas W., King-Smith, Sarah L., Hardy, Tristan S. E., Jackson, Matilda R., Barnett, Christopher P., and Scott, Hamish S.
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- 2024
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18. Research Priorities in the Secondary Prevention of Atrial Fibrillation: A National Heart, Lung, and Blood Institute Virtual Workshop Report
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Benjamin, Emelia J, Al‐Khatib, Sana M, Desvigne‐Nickens, Patrice, Alonso, Alvaro, Djoussé, Luc, Forman, Daniel E, Gillis, Anne M, Hendriks, Jeroen ML, Hills, Mellanie True, Kirchhof, Paulus, Link, Mark S, Marcus, Gregory M, Mehra, Reena, Murray, Katherine T, Parkash, Ratika, Piña, Ileana L, Redline, Susan, Rienstra, Michiel, Sanders, Prashanthan, Somers, Virend K, Van Wagoner, David R, Wang, Paul J, Cooper, Lawton S, and Go, Alan S
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Research ,Comparative Effectiveness Research ,Cardiovascular ,Prevention ,Clinical Trials and Supportive Activities ,Heart Disease ,Stroke ,Good Health and Well Being ,Animals ,Anti-Arrhythmia Agents ,Atrial Fibrillation ,Biomedical Research ,Body Composition ,Cardiac Rehabilitation ,Comorbidity ,Disease Progression ,Health Priorities ,Health Services Needs and Demand ,Healthy Lifestyle ,Humans ,National Heart ,Lung ,and Blood Institute (U.S.) ,Needs Assessment ,Recurrence ,Research Design ,Risk Assessment ,Risk Factors ,Secondary Prevention ,Treatment Outcome ,United States ,Weight Loss ,atrial fibrillation ,cardiac rehabilitation ,prevention ,research ,risk factors ,sleep ,Cardiorespiratory Medicine and Haematology ,Cardiovascular medicine and haematology - Abstract
There has been sustained focus on the secondary prevention of coronary heart disease and heart failure; yet, apart from stroke prevention, the evidence base for the secondary prevention of atrial fibrillation (AF) recurrence, AF progression, and AF-related complications is modest. Although there are multiple observational studies, there are few large, robust, randomized trials providing definitive effective approaches for the secondary prevention of AF. Given the increasing incidence and prevalence of AF nationally and internationally, the AF field needs transformative research and a commitment to evidenced-based secondary prevention strategies. We report on a National Heart, Lung, and Blood Institute virtual workshop directed at identifying knowledge gaps and research opportunities in the secondary prevention of AF. Once AF has been detected, lifestyle changes and novel models of care delivery may contribute to the prevention of AF recurrence, AF progression, and AF-related complications. Although benefits seen in small subgroups, cohort studies, and selected randomized trials are impressive, the widespread effectiveness of AF secondary prevention strategies remains unknown, calling for development of scalable interventions suitable for diverse populations and for identification of subpopulations who may particularly benefit from intensive management. We identified critical research questions for 6 topics relevant to the secondary prevention of AF: (1) weight loss; (2) alcohol intake, smoking cessation, and diet; (3) cardiac rehabilitation; (4) approaches to sleep disorders; (5) integrated, team-based care; and (6) nonanticoagulant pharmacotherapy. Our goal is to stimulate innovative research that will accelerate the generation of the evidence to effectively pursue the secondary prevention of AF.
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- 2021
19. Abstract 17493: Racial/Ethnic Under-Representation in Early Phase Clinical Trials
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White, Halima, Idris, Muhammed, Onwuanyi, Anekwe, Palaniappan, Latha, Lewis, Eldrin F, Pemu, Priscilla, Clark, Kira, Ritter, Victor, Shen, Sa, Qin, FeiFei, Igwe, Joseph-Kelvin, Cruz, Erin R, Johnson, Cati Brown, Cross, Jo Ann, Stefanick, Marcia L, and Wang, Paul J
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- 2023
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20. Abstract 14122: Evaluating Gender Diversity in Principal Investigators of Cardiac Electrophysiology Clinical Trials
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Sadri, Shirin, Soontornviwath, Grace A, Ku, Alice, Bernardez, Crystal O, Ali, Tawfique, Khosla, Ananya, Adhikari, Khusbu K, Duran, Angelina S, Igwe, Joseph-Kelvin, Clark, Kira, Cruz, Erin Rose R, Idris, Muhammed Y, Poullos, Peter, Periyakoil, VJ, Lin, Bryant, Palaniappan, Latha, Yong, Celina M, Onwuanyi, Anekwe, Echols, Melvin, Wang, Paul J, and Kapoor, Ridhima
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- 2023
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21. Mesenchymal Stromal Cell Delivery Via Cardiopulmonary Bypass Provides Neuroprotection in a Juvenile Porcine Model
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Sarkislali, Kamil, Kobayashi, Kei, Sarić, Nemanja, Maeda, Takuya, Henmi, Soichiro, Somaa, Fahad A., Bansal, Ankush, Tu, Shao Ching, Leonetti, Camille, Hsu, Chao-Hsiung, Li, Jingang, Vyas, Pranav, Kawasawa, Yuka Imamura, Tu, Tsang-Wei, Wang, Paul C., Hanley, Patrick J., Hashimoto-Torii, Kazue, Frank, Joseph A., Jonas, Richard A., and Ishibashi, Nobuyuki
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- 2023
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22. Dose Effect of Mesenchymal Stromal Cell Delivery Through Cardiopulmonary Bypass
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Kobayashi, Kei, Maeda, Takuya, Ayodeji, Mobolanle, Tu, Shao Ching, Chen, Alice, Rajtboriraks, May, Hsu, Chao-Hsiung, Tu, Tsang-Wei, Wang, Paul C., Hanley, Patrick J., Jonas, Richard A., and Ishibashi, Nobuyuki
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- 2023
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23. Development of a compact NMR system to measure pO2 in a tissue-engineered graft
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Torres, Efraín, Wang, Paul, Kantesaria, Saurin, Jenkins, Parker, DelaBarre, Lance, Cosmo Pizetta, Daniel, Froelich, Taylor, Steyn, Leah, Tannús, Alberto, Papas, Klearchos K., Sakellariou, Dimitrios, and Garwood, Michael
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- 2023
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24. Generalizable Machine Learning in Neuroscience using Graph Neural Networks
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Wang, Paul Y., Sapra, Sandalika, George, Vivek Kurien, and Silva, Gabriel A.
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Computer Science - Machine Learning ,Quantitative Biology - Neurons and Cognition - Abstract
Although a number of studies have explored deep learning in neuroscience, the application of these algorithms to neural systems on a microscopic scale, i.e. parameters relevant to lower scales of organization, remains relatively novel. Motivated by advances in whole-brain imaging, we examined the performance of deep learning models on microscopic neural dynamics and resulting emergent behaviors using calcium imaging data from the nematode C. elegans. We show that neural networks perform remarkably well on both neuron-level dynamics prediction, and behavioral state classification. In addition, we compared the performance of structure agnostic neural networks and graph neural networks to investigate if graph structure can be exploited as a favorable inductive bias. To perform this experiment, we designed a graph neural network which explicitly infers relations between neurons from neural activity and leverages the inferred graph structure during computations. In our experiments, we found that graph neural networks generally outperformed structure agnostic models and excel in generalization on unseen organisms, implying a potential path to generalizable machine learning in neuroscience.
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- 2020
25. Extending Hrushovski's groupoid-cover correspondence using simplicial groupoids
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Wang, Paul Z.
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Mathematics - Logic ,03C45 - Abstract
Hrushovski's suggestion, given in ["Groupoids, imaginaries and internal covers," Turkish Journal of Mathematics , 2012], to capture the structure of the 1-analysable covers of a theory T using simplicial groupoids definable in T is realized here. The ideas of Haykazyan and Moosa, found in ["Functoriality and uniformity in Hrushovski's groupoid-cover correspondence," Annals of Pure and Applied Logic , 2018] are used, and extended, to define an equivalence of categories. Finally, a couple of examples are studied with these new tools., Comment: 55 pages, made the author name consistent with other submissions
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- 2020
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26. Genomic autopsy to identify underlying causes of pregnancy loss and perinatal death
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Byrne, Alicia B., Arts, Peer, Ha, Thuong T., Kassahn, Karin S., Pais, Lynn S., O’Donnell-Luria, Anne, Babic, Milena, Frank, Mahalia S. B., Feng, Jinghua, Wang, Paul, Lawrence, David M., Eshraghi, Leila, Arriola, Luis, Toubia, John, Nguyen, Hung, McGillivray, George, Pinner, Jason, McKenzie, Fiona, Morrow, Rebecca, Lipsett, Jill, Manton, Nick, Khong, T. Yee, Moore, Lynette, Liebelt, Jan E., Schreiber, Andreas W., King-Smith, Sarah L., Hardy, Tristan S. E., Jackson, Matilda R., Barnett, Christopher P., and Scott, Hamish S.
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- 2023
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27. Patient Education Strategies to Improve Risk of Stroke in Patients with Atrial Fibrillation
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Nunes, Julio C., Shah, Shayena, Fazal, Muhammad, Gomez, Sofia Elena, Wei, Chen, Wang, Paul J., Stafford, Randall S., and Baykaner, Tina
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- 2022
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28. Worldwide Survey of COVID-19–Associated Arrhythmias
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Coromilas, Ellie J, Kochav, Stephanie, Goldenthal, Isaac, Biviano, Angelo, Garan, Hasan, Goldbarg, Seth, Kim, Joon-Hyuk, Yeo, Ilhwan, Tracy, Cynthia, Ayanian, Shant, Akar, Joseph, Singh, Avinainder, Jain, Shashank, Zimerman, Leandro, Pimentel, Maurício, Osswald, Stefan, Twerenbold, Raphael, Schaerli, Nicolas, Crotti, Lia, Fabbri, Daniele, Parati, Gianfranco, Li, Yi, Atienza, Felipe, Zatarain, Eduardo, Tse, Gary, Leung, Keith Sai Kit, Guevara-Valdivia, Milton E, Rivera-Santiago, Carlos A, Soejima, Kyoko, De Filippo, Paolo, Ferrari, Paola, Malanchini, Giovanni, Kanagaratnam, Prapa, Khawaja, Saud, Mikhail, Ghada W, Scanavacca, Mauricio, Hajjar, Ludhmila Abrahão, Rizerio, Brenno, Sacilotto, Luciana, Mollazadeh, Reza, Eslami, Masoud, far, Vahideh Laleh, Mattioli, Anna Vittoria, Boriani, Giuseppe, Migliore, Federico, Cipriani, Alberto, Donato, Filippo, Compagnucci, Paolo, Casella, Michela, Dello Russo, Antonio, Coromilas, James, Aboyme, Andrew, O’Brien, Connor Galen, Rodriguez, Fatima, Wang, Paul J, Naniwadekar, Aditi, Moey, Melissa, Kow, Chia Siang, Cheah, Wee Kooi, Auricchio, Angelo, Conte, Giulio, Hwang, Jongmin, Han, Seongwook, Lazzerini, Pietro Enea, Franchi, Federico, Santoro, Amato, Capecchi, Pier Leopoldo, Joglar, Jose A, Rosenblatt, Anna G, Zardini, Marco, Bricoli, Serena, Bonura, Rosario, Echarte-Morales, Julio, Benito-González, Tomás, Minguito-Carazo, Carlos, Fernández-Vázquez, Felipe, and Wan, Elaine Y
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Biomedical and Clinical Sciences ,Medical Physiology ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Aged ,Arrhythmias ,Cardiac ,COVID-19 ,Cardiac Electrophysiology ,Comorbidity ,Electrophysiologic Techniques ,Cardiac ,Female ,Global Health ,Health Care Surveys ,Healthcare Disparities ,Humans ,Incidence ,Male ,Middle Aged ,Practice Patterns ,Physicians' ,Prevalence ,Prognosis ,Retrospective Studies ,Risk Assessment ,Time Factors ,arrhythmia ,atrial fibrillation ,atrial flutter ,bradycardia ,tachycardia ,torsade de pointes ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences ,Medical physiology - Abstract
[Figure: see text].
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- 2021
29. Electrical Substrate Ablation for Refractory Ventricular Fibrillation: Results of the AVATAR Study.
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Krummen, David E, Ho, Gordon, Hoffmayer, Kurt S, Schweis, Franz N, Baykaner, Tina, Rogers, AJ, Han, Frederick T, Hsu, Jonathan C, Viswanathan, Mohan N, Wang, Paul J, Rappel, Wouter-Jan, and Narayan, Sanjiv M
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Humans ,Ventricular Premature Complexes ,Ventricular Fibrillation ,Anti-Arrhythmia Agents ,Electrophysiologic Techniques ,Cardiac ,Catheter Ablation ,Treatment Outcome ,Electric Countershock ,Case-Control Studies ,Prospective Studies ,Defibrillators ,Implantable ,Action Potentials ,Heart Rate ,Time Factors ,Adult ,Aged ,Middle Aged ,California ,Female ,Male ,cardiomyopathies ,catheter ablation ,follow-up studies ,rotation ,ventricular fibrillation ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Medical Physiology ,Cardiovascular System & Hematology - Abstract
[Figure: see text].
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- 2021
30. Sex classification of 3D skull images using deep neural networks
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Noel, Lake, Fat, Shelby Chun, Causey, Jason L., Dong, Wei, Stubblefield, Jonathan, Szymanski, Kathryn, Chang, Jui-Hsuan, Wang, Paul Zhiping, Moore, Jason H., Ray, Edward, and Huang, Xiuzhen
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- 2024
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31. Somatic mutational landscape of hereditary hematopoietic malignancies caused by germline variants in RUNX1, GATA2, and DDX41
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Homan, Claire C., Drazer, Michael W., Yu, Kai, Lawrence, David M., Feng, Jinghua, Arriola-Martinez, Luis, Pozsgai, Matthew J., McNeely, Kelsey E., Ha, Thuong, Venugopal, Parvathy, Arts, Peer, King-Smith, Sarah L., Cheah, Jesse, Armstrong, Mark, Wang, Paul, Bödör, Csaba, Cantor, Alan B., Cazzola, Mario, Degelman, Erin, DiNardo, Courtney D., Duployez, Nicolas, Favier, Remi, Fröhling, Stefan, Rio-Machin, Ana, Klco, Jeffery M., Krämer, Alwin, Kurokawa, Mineo, Lee, Joanne, Malcovati, Luca, Morgan, Neil V., Natsoulis, Georges, Owen, Carolyn, Patel, Keyur P., Preudhomme, Claude, Raslova, Hana, Rienhoff, Hugh, Ripperger, Tim, Schulte, Rachael, Tawana, Kiran, Velloso, Elvira, Yan, Benedict, Kim, Erika, Sood, Raman, Hsu, Amy P., Holland, Steven M., Phillips, Kerry, Poplawski, Nicola K., Babic, Milena, Wei, Andrew H., Forsyth, Cecily, Mar Fan, Helen, Lewis, Ian D., Cooney, Julian, Susman, Rachel, Fox, Lucy C., Blombery, Piers, Singhal, Deepak, Hiwase, Devendra, Phipson, Belinda, Schreiber, Andreas W., Hahn, Christopher N., Scott, Hamish S., Liu, Paul, Godley, Lucy A., and Brown, Anna L.
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- 2023
- Full Text
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32. Diversity in Atrial Fibrillation Trials: Assessing the Role of Language Proficiency as a Recruitment Barrier
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Lan, Roy H., primary, Guerrero, Eduardo Perez, additional, Shen, Sa, additional, Qin, FeiFei, additional, Ritter, Victor, additional, Brown-Johnson, Cati, additional, Clark, Kira, additional, Rose, Erin, additional, Lewis, Eldrin F., additional, and Wang, Paul J., additional
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- 2024
- Full Text
- View/download PDF
33. Machine Learned Cellular Phenotypes in Cardiomyopathy Predict Sudden Death.
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Rogers, Albert, Selvalingam, Anojan, Alhusseini, Mahmood, Krummen, David, Corrado, Cesare, Abuzaid, Firas, Baykaner, Tina, Meyer, Christian, Clopton, Paul, Giles, Wayne, Bailis, Peter, Niederer, Steven, Wang, Paul, Rappel, Wouter-Jan, Zaharia, Matei, and Narayan, Sanjiv
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artificial intelligence ,coronary disease ,death ,sudden ,cardiac ,heart failure ,ion channels ,systems biology ,Action Potentials ,Aged ,Aged ,80 and over ,Cardiomyopathies ,Death ,Sudden ,Cardiac ,Diagnosis ,Computer-Assisted ,Electrophysiologic Techniques ,Cardiac ,Female ,Humans ,Male ,Middle Aged ,Myocardial Infarction ,Neural Networks ,Computer ,Phenotype ,Predictive Value of Tests ,Prognosis ,Prospective Studies ,Risk Assessment ,Risk Factors ,Signal Processing ,Computer-Assisted ,Support Vector Machine ,Tachycardia ,Ventricular ,Time Factors ,Ventricular Fibrillation - Abstract
RATIONALE: Susceptibility to VT/VF (ventricular tachycardia/fibrillation) is difficult to predict in patients with ischemic cardiomyopathy either by clinical tools or by attempting to translate cellular mechanisms to the bedside. OBJECTIVE: To develop computational phenotypes of patients with ischemic cardiomyopathy, by training then interpreting machine learning of ventricular monophasic action potentials (MAPs) to reveal phenotypes that predict long-term outcomes. METHODS AND RESULTS: We recorded 5706 ventricular MAPs in 42 patients with coronary artery disease and left ventricular ejection fraction ≤40% during steady-state pacing. Patients were randomly allocated to independent training and testing cohorts in a 70:30 ratio, repeated K=10-fold. Support vector machines and convolutional neural networks were trained to 2 end points: (1) sustained VT/VF or (2) mortality at 3 years. Support vector machines provided superior classification. For patient-level predictions, we computed personalized MAP scores as the proportion of MAP beats predicting each end point. Patient-level predictions in independent test cohorts yielded c-statistics of 0.90 for sustained VT/VF (95% CI, 0.76-1.00) and 0.91 for mortality (95% CI, 0.83-1.00) and were the most significant multivariate predictors. Interpreting trained support vector machine revealed MAP morphologies that, using in silico modeling, revealed higher L-type calcium current or sodium-calcium exchanger as predominant phenotypes for VT/VF. CONCLUSIONS: Machine learning of action potential recordings in patients revealed novel phenotypes for long-term outcomes in ischemic cardiomyopathy. Such computational phenotypes provide an approach which may reveal cellular mechanisms for clinical outcomes and could be applied to other conditions.
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- 2021
34. Phrenic Relocation by Endoscopy, Intentional Pneumothorax Using Carbon Dioxide, and Single Lung Ventilation (PHRENICS) Technique
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Shah, Rajan L., Perino, Alexander, Wang, Paul, Lee, Anson, and Badhwar, Nitish
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- 2023
- Full Text
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35. Correction to: Association between parental autoimmune disease and childhood atopic dermatitis varied by sex: a nationwide case–control study
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Hung, Yu-Hsuan, Liu, Hsin-Yu, Chang, Renin, Huang, Jing-Yang, Wu, Cheng-Dong, Yen, Man-Syuan, Hung, Yao-Min, Wei, James Cheng-Chung, and Wang, Paul Yung-Pou
- Published
- 2023
- Full Text
- View/download PDF
36. Machine Learning to Classify Intracardiac Electrical Patterns During Atrial Fibrillation: Machine Learning of Atrial Fibrillation.
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Alhusseini, Mahmood, Abuzaid, Firas, Rogers, Albert, Zaman, Junaid, Baykaner, Tina, Clopton, Paul, Bailis, Peter, Zaharia, Matei, Wang, Paul, Rappel, Wouter-Jan, and Narayan, Sanjiv
- Subjects
atrial fibrillation ,machine learning ,pulmonary veins ,support vector machine ,Action Potentials ,Aged ,Atrial Fibrillation ,Atrial Function ,Left ,Atrial Function ,Right ,Diagnosis ,Computer-Assisted ,Electrophysiologic Techniques ,Cardiac ,Female ,Heart Rate ,Humans ,Male ,Middle Aged ,Neural Networks ,Computer ,Pattern Recognition ,Automated ,Predictive Value of Tests ,Registries ,Reproducibility of Results ,Signal Processing ,Computer-Assisted ,Support Vector Machine ,Time Factors - Abstract
BACKGROUND: Advances in ablation for atrial fibrillation (AF) continue to be hindered by ambiguities in mapping, even between experts. We hypothesized that convolutional neural networks (CNN) may enable objective analysis of intracardiac activation in AF, which could be applied clinically if CNN classifications could also be explained. METHODS: We performed panoramic recording of bi-atrial electrical signals in AF. We used the Hilbert-transform to produce 175 000 image grids in 35 patients, labeled for rotational activation by experts who showed consistency but with variability (kappa [κ]=0.79). In each patient, ablation terminated AF. A CNN was developed and trained on 100 000 AF image grids, validated on 25 000 grids, then tested on a separate 50 000 grids. RESULTS: In the separate test cohort (50 000 grids), CNN reproducibly classified AF image grids into those with/without rotational sites with 95.0% accuracy (CI, 94.8%-95.2%). This accuracy exceeded that of support vector machines, traditional linear discriminant, and k-nearest neighbor statistical analyses. To probe the CNN, we applied gradient-weighted class activation mapping which revealed that the decision logic closely mimicked rules used by experts (C statistic 0.96). CONCLUSIONS: CNNs improved the classification of intracardiac AF maps compared with other analyses and agreed with expert evaluation. Novel explainability analyses revealed that the CNN operated using a decision logic similar to rules used by experts, even though these rules were not provided in training. We thus describe a scaleable platform for robust comparisons of complex AF data from multiple systems, which may provide immediate clinical utility to guide ablation. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02997254. Graphic Abstract: A graphic abstract is available for this article.
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- 2020
37. Systemic Tumor Necrosis Factor-Alpha Trajectories Relate to Brain Health in Typically Aging Older Adults
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Lindbergh, Cutter A, Casaletto, Kaitlin B, Staffaroni, Adam M, Elahi, Fanny, Walters, Samantha M, You, Michelle, Neuhaus, John, Contreras, Will Rivera, Wang, Paul, Karydas, Anna, Brown, Jesse, Wolf, Amy, Rosen, Howie, Cobigo, Yann, and Kramer, Joel H
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Biomedical and Clinical Sciences ,Clinical Research ,Neurosciences ,Brain Disorders ,Behavioral and Social Science ,Aging ,Neurological ,Inflammatory and immune system ,Good Health and Well Being ,Aged ,Biomarkers ,Cognition ,Executive Function ,Female ,Follow-Up Studies ,Gray Matter ,Humans ,Magnetic Resonance Imaging ,Male ,Memory ,Episodic ,Neuropsychological Tests ,Tumor Necrosis Factor-alpha ,White Matter ,Inflammation ,Brain aging ,Gray matter volume ,Neuroimaging ,Clinical Sciences ,Gerontology ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundCentral nervous system levels of tumor necrosis factor-alpha (TNF-α), a pro-inflammatory cytokine, regulate the neuroinflammatory response and may play a role in age-related neurodegenerative diseases. The longitudinal relation between peripheral levels of TNF-α and typical brain aging is understudied. We hypothesized that within-person increases in systemic TNF-α would track with poorer brain health outcomes in functionally normal adults.MethodsPlasma-based TNF-α concentrations (pg/mL; fasting morning draws) and magnetic resonance imaging were acquired in 424 functionally intact adults (mean age = 71) followed annually for up to 8.4 years (mean follow-up = 2.2 years). Brain outcomes included total gray matter volume and white matter hyperintensities. Cognitive outcomes included composites of memory, executive functioning, and processing speed, as well as Mini-Mental State Examination total scores. Longitudinal mixed-effects models were used, controlling for age, sex, education, and total intracranial volume, as appropriate.ResultsTNF-α concentrations significantly increased over time (p < .001). Linear increases in within-person TNF-α were longitudinally associated with declines in gray matter volume (p < .001) and increases in white matter hyperintensities (p = .003). Exploratory analyses suggested that the relation between TNF-α and gray matter volume was curvilinear (TNF-α 2p = .002), such that initial increases in inflammation were associated with more precipitous atrophy. There was a negative linear relationship of within-person changes in TNF-α to Mini-Mental State Examination scores over time (p = .036) but not the cognitive composites (all ps >.05).ConclusionSystemic inflammation, as indexed by plasma TNF-α, holds potential as a biomarker for age-related declines in brain health.
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- 2020
38. Termination of persistent atrial fibrillation by ablating sites that control large atrial areas.
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Bhatia, Neal K, Rogers, Albert J, Krummen, David E, Hossainy, Samir, Sauer, William, Miller, John M, Alhusseini, Mahmood I, Peszek, Adam, Armenia, Erin, Baykaner, Tina, Brachmann, Johannes, Turakhia, Mintu P, Clopton, Paul, Wang, Paul J, Rappel, Wouter-Jan, and Narayan, Sanjiv M
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Cardiovascular ,Heart Disease ,Aged ,Atrial Fibrillation ,Catheter Ablation ,Electric Countershock ,Heart Atria ,Humans ,Middle Aged ,Atrial fibrillation ,Mechanisms ,Drivers ,Rotational ,Focal ,Ablation ,Multiwavelet re-entry ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
AimsPersistent atrial fibrillation (AF) has been explained by multiple mechanisms which, while they conflict, all agree that more disorganized AF is more difficult to treat than organized AF. We hypothesized that persistent AF consists of interacting organized areas which may enlarge, shrink or coalesce, and that patients whose AF areas enlarge by ablation are more likely to respond to therapy.Methods and resultsWe mapped vectorial propagation in persistent AF using wavefront fields (WFF), constructed from raw unipolar electrograms at 64-pole basket catheters, during ablation until termination (Group 1, N = 20 patients) or cardioversion (Group 2, N = 20 patients). Wavefront field mapping of patients (age 61.1 ± 13.2 years, left atrium 47.1 ± 6.9 mm) at baseline showed 4.6 ± 1.0 organized areas, each separated by disorganization. Ablation of sites that led to termination controlled larger organized area than competing sites (44.1 ± 11.1% vs. 22.4 ± 7.0%, P
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- 2020
39. Plasma Glial Fibrillary Acidic Protein Levels Differ Along the Spectra of Amyloid Burden and Clinical Disease Stage.
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Asken, Breton M, Elahi, Fanny M, La Joie, Renaud, Strom, Amelia, Staffaroni, Adam M, Lindbergh, Cutter A, Apple, Alexandra C, You, Michelle, Weiner-Light, Sophia, Brathaban, Nivetha, Fernandes, Nicole, Karydas, Anna, Wang, Paul, Rojas, Julio C, Boxer, Adam L, Miller, Bruce L, Rabinovici, Gil D, Kramer, Joel H, and Casaletto, Kaitlin B
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Acquired Cognitive Impairment ,Brain Disorders ,Dementia ,Neurodegenerative ,Alzheimer's Disease ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Neurosciences ,Aging ,Neurological ,Aged ,Aged ,80 and over ,Alzheimer Disease ,Amyloid beta-Peptides ,Amyloidogenic Proteins ,Amyloidosis ,Aniline Compounds ,Brain ,Cognitive Dysfunction ,Cohort Studies ,Cross-Sectional Studies ,Ethylene Glycols ,Female ,Glial Fibrillary Acidic Protein ,Humans ,Male ,Positron-Emission Tomography ,Radiopharmaceuticals ,Thiazoles ,tau Proteins ,Alzheimer's disease ,amyloid ,astrocyte ,biomarker ,glial fibrillary acidic protein ,plasma ,Alzheimer’s disease ,Cognitive Sciences ,Neurology & Neurosurgery ,Clinical sciences ,Biological psychology - Abstract
BackgroundMeasuring plasma glial fibrillary acidic protein (GFAP) alongside cortical amyloid-β (Aβ) may shed light on astrocytic changes in aging and Alzheimer's disease (AD).ObjectiveTo examine associations between plasma GFAP and cortical Aβ deposition in older adults across the typical aging-to-AD dementia spectrum.MethodsWe studied two independent samples from UCSF (Cohort 1, N = 50; Cohort 2, N = 37) covering the spectra of clinical severity (CDR Sum of Boxes; CDR-SB) and Aβ-PET burden. Aβ-PET was completed with either florbetapir or Pittsburgh Compound B and standardized uptake value ratios were converted to the Centiloid (CL) scale for analyses. All participants with CDR-SB > 0 were Aβ-PET positive, while clinically normal participants (CDR-SB = 0) were a mix of Aβ-PET positive and negative. Regression analyses evaluated main effect and interaction associations between plasma GFAP, Aβ-PET, and clinical severity.ResultsIn both cohorts, plasma GFAP increased linearly with Aβ-PET CLs in clinically normal older adults. In Cohort 2, which included participants with more severe clinical dysfunction and Aβ-PET burden, the association between Aβ and GFAP became curvilinear (inverted U-shape; quadratic model R2 change = 0.165, p = 0.009), and Aβ-PET interacted with CDR-SB (R2 change = 0.164, p = 0.007): older adults with intermediate functional impairment (CDR-SB = 0.5-4.0) showed a weak (negative) association between Aβ-PET CLs and plasma GFAP, while older adults with dementia (CDR-SB > 4.0) showed a strong, negative association of higher Aβ-PET CLs with lower plasma GFAP.ConclusionThe relationship between astrocytic integrity and cortical Aβ may be highly dynamic, with linear, positive associations early in disease that diverge in more severe disease stages.
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- 2020
40. Deep Item-based Collaborative Filtering for Sparse Implicit Feedback
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Galron, Daniel A., Brovman, Yuri M., Chung, Jin, Wieja, Michal, and Wang, Paul
- Subjects
Computer Science - Information Retrieval - Abstract
Recommender systems are ubiquitous in the domain of e-commerce, used to improve the user experience and to market inventory, thereby increasing revenue for the site. Techniques such as item-based collaborative filtering are used to model users' behavioral interactions with items and make recommendations from items that have similar behavioral patterns. However, there are challenges when applying these techniques on extremely sparse and volatile datasets. On some e-commerce sites, such as eBay, the volatile inventory and minimal structured information about items make it very difficult to aggregate user interactions with an item. In this work, we describe a novel deep learning-based method to address the challenges. We propose an objective function that optimizes a similarity measure between binary implicit feedback vectors between two items. We demonstrate formally and empirically that a model trained to optimize this function estimates the log of the cosine similarity between the feedback vectors. We also propose a neural network architecture optimized on this objective. We present the results of experiments comparing the output of the neural network with traditional item-based collaborative filtering models on an implicit-feedback dataset, as well as results of experiments comparing different neural network architectures on user purchase behavior on eBay. Finally, we discuss the results of an A/B test that show marked improvement of the proposed technique over eBay's existing collaborative filtering recommender system.
- Published
- 2018
41. Wavefront Field Mapping Reveals a Physiologic Network Between Drivers Where Ablation Terminates Atrial Fibrillation.
- Author
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Leef, George, Shenasa, Fatemah, Bhatia, Neal, Rogers, Albert, Sauer, William, Miller, John, Swerdlow, Mark, Tamboli, Mallika, Alhusseini, Mahmood, Armenia, Erin, Baykaner, Tina, Brachmann, Johannes, Turakhia, Mintu, Atienza, Felipe, Rappel, Wouter-Jan, Wang, Paul, and Narayan, Sanjiv
- Subjects
atrial fibrillation ,organizations ,pulmonary veins ,recurrence ,registries ,Aged ,Atrial Fibrillation ,Body Surface Potential Mapping ,Catheter Ablation ,Female ,Heart Atria ,Heart Conduction System ,Heart Rate ,Humans ,Male ,Middle Aged - Abstract
BACKGROUND: Localized drivers are proposed mechanisms for persistent atrial fibrillation (AF) from optical mapping of human atria and clinical studies of AF, yet are controversial because drivers fluctuate and ablating them may not terminate AF. We used wavefront field mapping to test the hypothesis that AF drivers, if concurrent, may interact to produce fluctuating areas of control to explain their appearance/disappearance and acute impact of ablation. METHODS: We recruited 54 patients from an international registry in whom persistent AF terminated by targeted ablation. Unipolar AF electrograms were analyzed from 64-pole baskets to reconstruct activation times, map propagation vectors each 20 ms, and create nonproprietary phase maps. RESULTS: Each patient (63.6±8.5 years, 29.6% women) showed 4.0±2.1 spatially anchored rotational or focal sites in AF in 3 patterns. First, a single (type I; n=7) or, second, paired chiral-antichiral (type II; n=5) rotational drivers controlled most of the atrial area. Ablation of 1 to 2 large drivers terminated all cases of types I or II AF. Third, interaction of 3 to 5 drivers (type III; n=42) with changing areas of control. Targeted ablation at driver centers terminated AF and required more ablation in types III versus I (P=0.02 in left atrium). CONCLUSIONS: Wavefront field mapping of persistent AF reveals a pathophysiologic network of a small number of spatially anchored rotational and focal sites, which interact, fluctuate, and control varying areas. Future work should define whether AF drivers that control larger atrial areas are attractive targets for ablation.
- Published
- 2019
42. Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy.
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Lee, Jaecheol, Termglinchan, Vittavat, Diecke, Sebastian, Itzhaki, Ilanit, Lam, Chi Keung, Garg, Priyanka, Lau, Edward, Greenhaw, Matthew, Seeger, Timon, Wu, Haodi, Zhang, Joe Z, Chen, Xingqi, Gil, Isaac Perea, Ameen, Mohamed, Sallam, Karim, Rhee, June-Wha, Churko, Jared M, Chaudhary, Rinkal, Chour, Tony, Wang, Paul J, Snyder, Michael P, Chang, Howard Y, Karakikes, Ioannis, and Wu, Joseph C
- Subjects
Cells ,Cultured ,Chromatin ,Myocytes ,Cardiac ,Humans ,Cardiomyopathy ,Dilated ,Calcium ,Receptor ,Platelet-Derived Growth Factor beta ,Platelet-Derived Growth Factor ,Lamin Type A ,RNA ,Messenger ,Signal Transduction ,Chromatin Assembly and Disassembly ,Homeostasis ,Mutation ,Models ,Biological ,Arrhythmias ,Cardiac ,Induced Pluripotent Stem Cells ,Haploinsufficiency ,Single-Cell Analysis ,Nonsense Mediated mRNA Decay ,In Vitro Techniques ,Arrhythmias ,Cardiac ,Cardiomyopathy ,Dilated ,Cells ,Cultured ,Models ,Biological ,Myocytes ,RNA ,Messenger ,Receptor ,Platelet-Derived Growth Factor beta ,General Science & Technology - Abstract
Lamin A/C (LMNA) is one of the most frequently mutated genes associated with dilated cardiomyopathy (DCM). DCM related to mutations in LMNA is a common inherited cardiomyopathy that is associated with systolic dysfunction and cardiac arrhythmias. Here we modelled the LMNA-related DCM in vitro using patient-specific induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). Electrophysiological studies showed that the mutant iPSC-CMs displayed aberrant calcium homeostasis that led to arrhythmias at the single-cell level. Mechanistically, we show that the platelet-derived growth factor (PDGF) signalling pathway is activated in mutant iPSC-CMs compared to isogenic control iPSC-CMs. Conversely, pharmacological and molecular inhibition of the PDGF signalling pathway ameliorated the arrhythmic phenotypes of mutant iPSC-CMs in vitro. Taken together, our findings suggest that the activation of the PDGF pathway contributes to the pathogenesis of LMNA-related DCM and point to PDGF receptor-β (PDGFRB) as a potential therapeutic target.
- Published
- 2019
43. Hybrid Ablation for Atrial Fibrillation: Safety & Efficacy of Unilateral Epicardial Access
- Author
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Pong, Terrence, Shah, Rajan L., Carlton, Cody, Truong, Angeline, Fann, Beatty, Cyr, Kevin, Aparicio-Valenzuela, Joy, Brodt, Chad, Wang, Paul J., and Lee, Anson M.
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- 2023
- Full Text
- View/download PDF
44. Vision Care among School-Aged Children with Autism Spectrum Disorder in North America: Findings from the Autism Treatment Network Registry Call-Back Study
- Author
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Lindly, Olivia J., Chan, James, Fenning, Rachel M., Farmer, Justin G., Neumeyer, Ann M., Wang, Paul, Swanson, Mark, Parker, Robert A., and Kuhlthau, Karen A.
- Abstract
Children with autism spectrum disorder have a high risk of vision problems yet little is known about their vision care. This cross-sectional survey study, therefore, examined vision care among 351 children with autism spectrum disorder ages 6-17 years in the United States or Canada who were enrolled in the Autism Treatment Network Registry. Vision care variables were vision tested with pictures, shapes, or letters in the past 2 years; vision tested by an eye care practitioner (e.g. ophthalmologist, optometrist) in the past 2 years; prescribed corrective eyeglasses; and wore eyeglasses as recommended. Covariates included sociodemographic, child functioning, and family functioning variables. Multivariable models were fit for each vision care variable. Though 78% of children with autism spectrum disorder had their vision tested, only 57% had an eye care practitioner test their vision in the past 2 years. Among the 30% of children with autism spectrum disorder prescribed corrective eyeglasses, 78% wore their eyeglasses as recommended. Multivariable analysis results demonstrated statistically significant differences in vision care among children with autism spectrum disorder by parent education, household income, communication abilities, intellectual functioning, and caregiver strain. Overall, study results suggest many school-aged children with autism spectrum disorder do not receive recommended vision care and highlight potentially modifiable disparities in vision care.
- Published
- 2021
- Full Text
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45. Feasibility of Behavioral Testing During Video EEG Monitoring with Seizure ROAR Testing Protocol (P5-1.008)
- Author
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Bai, Amerta, primary, Lykken, Lisa, additional, Wang, Paul, additional, Waldron, Eric, additional, Darrow, David, additional, Hattab, Tariq, additional, Mueller, Melissa, additional, Halverson, Megan, additional, Henry, Thomas, additional, and Patel, Sima, additional
- Published
- 2024
- Full Text
- View/download PDF
46. ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression
- Author
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Tameire, Feven, Verginadis, Ioannis I, Leli, Nektaria Maria, Polte, Christine, Conn, Crystal S, Ojha, Rani, Salas Salinas, Carlo, Chinga, Frank, Monroy, Alexandra M, Fu, Weixuan, Wang, Paul, Kossenkov, Andrew, Ye, Jiangbin, Amaravadi, Ravi K, Ignatova, Zoya, Fuchs, Serge Y, Diehl, J Alan, Ruggero, Davide, and Koumenis, Constantinos
- Subjects
Biochemistry and Cell Biology ,Biological Sciences ,Genetics ,Aetiology ,2.1 Biological and endogenous factors ,Cancer ,Activating Transcription Factor 4 ,Adaptor Proteins ,Signal Transducing ,Animals ,Cell Cycle Proteins ,Endoplasmic Reticulum Stress ,Genes ,myc ,Humans ,Mechanistic Target of Rapamycin Complex 1 ,Mice ,Transgenic ,Phosphoproteins ,Phosphorylation ,Protein Biosynthesis ,TOR Serine-Threonine Kinases ,Transcriptional Activation ,Medical and Health Sciences ,Developmental Biology ,Biochemistry and cell biology - Abstract
The c-Myc oncogene drives malignant progression and induces robust anabolic and proliferative programmes leading to intrinsic stress. The mechanisms enabling adaptation to MYC-induced stress are not fully understood. Here we reveal an essential role for activating transcription factor 4 (ATF4) in survival following MYC activation. MYC upregulates ATF4 by activating general control nonderepressible 2 (GCN2) kinase through uncharged transfer RNAs. Subsequently, ATF4 co-occupies promoter regions of over 30 MYC-target genes, primarily those regulating amino acid and protein synthesis, including eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1), a negative regulator of translation. 4E-BP1 relieves MYC-induced proteotoxic stress and is essential to balance protein synthesis. 4E-BP1 activity is negatively regulated by mammalian target of rapamycin complex 1 (mTORC1)-dependent phosphorylation and inhibition of mTORC1 signalling rescues ATF4-deficient cells from MYC-induced endoplasmic reticulum stress. Acute deletion of ATF4 significantly delays MYC-driven tumour progression and increases survival in mouse models. Our results establish ATF4 as a cellular rheostat of MYC activity, which ensures that enhanced translation rates are compatible with survival and tumour progression.
- Published
- 2019
47. The ENHANCE-AF clinical trial to evaluate an atrial fibrillation shared decision-making pathway: Rationale and study design
- Author
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Baykaner, Tina, Pundi, Krishna, Lin, Bryant, Lu, Ying, DeSutter, Katie, Lhamo, Karma, Garay, Gotzone, Nunes, Julio C., Morin, Daniel P., Sears, Samuel F., Chung, Mina K., Paasche-Orlow, Michael K., Sanders, Lee M., Bunch, Thomas Jared, Hills, Mellanie True, Mahaffey, Kenneth W., Stafford, Randall S., and Wang, Paul J.
- Published
- 2022
- Full Text
- View/download PDF
48. Access to Dental Visits and Correlates of Preventive Dental Care in Children with Autism Spectrum Disorder
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Fenning, Rachel M., Steinberg-Epstein, Robin, Butter, Eric M., Chan, James, McKinnon-Bermingham, Kelly, Hammersmith, Kimberly J., Moffitt, Jacquelyn, Shui, Amy M., Parker, Robert A., Coury, Daniel L., Wang, Paul P., and Kuhlthau, Karen A.
- Abstract
Dental care received by children in the Autism Speaks Autism Treatment Network (ATN) was compared to National Survey of Children's Health (NSCH) data for children without special healthcare needs and children with parent-reported ASD. Correlates of obtained preventive dental services were examined within the ATN sample. Participants included 375 families of children ages 4 to 17 enrolled in the ATN. ATN families reported levels of preventive dental care that were similar to, or exceeded, NSCH-reported care. However, disparities in obtained preventive dental services emerged within the ATN sample. Lower intellectual functioning was the most consistent correlate of reduced access to and completion of preventive dental care. Implications for developing system-wide supports and targeted interventions are discussed.
- Published
- 2020
- Full Text
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49. Targeted gene panels identify a high frequency of pathogenic germline variants in patients diagnosed with a hematological malignancy and at least one other independent cancer
- Author
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Singhal, Deepak, Hahn, Christopher N., Feurstein, Simone, Wee, Li Yan A., Moma, Luke, Kutyna, Monika M., Chhetri, Rakchha, Eshraghi, Leila, Schreiber, Andreas W., Feng, Jinghua, Wang, Paul P-S., Babic, Milena, Parker, Wendy T., Gao, Song, Moore, Sarah, Das, Soma, Thomas, David, Pattnaik, Swetansu, Brown, Anna L., D’Andrea, Richard J., Poplawski, Nicola K., Thomas, Daniel, Scott, Hamish S., Godley, Lucy A., and Hiwase, Devendra K.
- Published
- 2021
- Full Text
- View/download PDF
50. The Lancet Commission on the future of care and clinical research in autism
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Lord, Catherine, Charman, Tony, Havdahl, Alexandra, Carbone, Paul, Anagnostou, Evdokia, Boyd, Brian, Carr, Themba, de Vries, Petrus J, Dissanayake, Cheryl, Divan, Gauri, Freitag, Christine M, Gotelli, Marina M, Kasari, Connie, Knapp, Martin, Mundy, Peter, Plank, Alex, Scahill, Lawrence, Servili, Chiara, Shattuck, Paul, Simonoff, Emily, Singer, Alison Tepper, Slonims, Vicky, Wang, Paul P, Ysrraelit, Maria Celica, Jellett, Rachel, Pickles, Andrew, Cusack, James, Howlin, Patricia, Szatmari, Peter, Holbrook, Alison, Toolan, Christina, and McCauley, James B
- Published
- 2022
- Full Text
- View/download PDF
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