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147 results on '"Wang, Ruo-Nan"'

5. Wide-range Prandtl/Schmidt number power spectrum of optical turbulence and its application to oceanic light propagation

Author

Yao, Jin-Ren, Zhang, Hua-Jun, Wang, Ruo-Nan, Cai, Jian-Dong, Zhang, Yu, and Korotkova, Olga

Subjects
Physics - Atmospheric and Oceanic Physics, Physics - Optics
Abstract

Light influenced by the turbulent ocean can be fully characterized with the help of the power spectrum of the water's refractive index fluctuations, resulting from the combined effect of two scalars, temperature and salinity concentration advected by the velocity field. The Nikishovs' model [ Fluid Mech. Res. 27, 8298 (2000)] frequently used in the analysis of light evolution through the turbulent ocean channels is the linear combination of the temperature spectrum, the salinity spectrum and their co-spectrum, each being described by an approximate expression developed by Hill [ J. Fluid Mech. 88, 541562 (1978)] in the first of his four suggested models. The fourth of the Hill's models provides much more precise power spectrum than the first one expressed via a non-linear differential equation that does not have a closed-form solution. We develop an accurate analytic approximation to the fourth Hill's model valid for Prandtl/Schmidt numbers in the interval [3, 3000] and use it for the development of a more precise oceanic power spectrum. To illustrate the advantage of our model, we include numerical examples relating to the spherical wave scintillation index evolving in the underwater turbulent channels with different average temperatures, and, hence, different Prandtl numbers for temperature and different Schmidt numbers for salinity. Since our model is valid for a large range of Prandtl number (or/and Schmidt number), it can be readily adjusted to oceanic waters with seasonal or extreme average temperature and/or salinity or any other turbulent fluid with one or several advected quantities.

Published
2019
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8. Repression of rRNA gene transcription by endothelial SPEN deficiency normalizes tumor vasculature via nucleolar stress

Author

Yang, Zi-Yan, Yan, Xian-Chun, Zhang, Jia-Yu-Lin, Liang, Liang, Gao, Chun-Chen, Zhang, Pei-Ran, Liu, Yuan, Sun, Jia-Xing, Ruan, Bai, Duan, Juan-Li, Wang, Ruo-Nan, Feng, Xing-Xing, Che, Bo, Xiao, Tian, and Han, Hua

Subjects
Tumor proteins -- Genetic aspects, Genes -- Physiological aspects -- Genetic aspects, Metastasis -- Genetic aspects, Biosynthesis -- Genetic aspects -- Physiological aspects, Endothelium -- Physiological aspects -- Genetic aspects, Ablation (Surgery) -- Physiological aspects, B cells -- Physiological aspects -- Genetic aspects, RNA -- Physiological aspects -- Genetic aspects, Cancer -- Genetic aspects, Genetic transcription -- Genetic aspects -- Physiological aspects, Health care industry
Abstract

Human cancers induce a chaotic, dysfunctional vasculature that promotes tumor growth and blunts most current therapies; however, the mechanisms underlying the induction of a dysfunctional vasculature have been unclear. Here, we show that split end (SPEN), a transcription repressor, coordinates rRNA synthesis in endothelial cells (ECs) and is required for physiological and tumor angiogenesis. SPEN deficiency attenuated EC proliferation and blunted retinal angiogenesis, which was attributed to p53 activation. Furthermore, SPEN knockdown activated p53 by upregulating noncoding promoter RNA (pRNA), which represses rRNA transcription and triggers p53-mediated nucleolar stress. In human cancer biopsies, a low endothelial SPEN level correlated with extended overall survival. In mice, endothelial SPEN deficiency compromised rRNA expression and repressed tumor growth and metastasis by normalizing tumor vessels, and this was abrogated by p53 haploinsufficiency. rRNA gene transcription is driven by RNA polymerase I (RNPI). We found that CX-5461, an RNPI inhibitor, recapitulated the effect of Spen ablation on tumor vessel normalization and combining CX-5461 with cisplatin substantially improved the efficacy of treating tumors in mice. Together, these results demonstrate that SPEN is required for angiogenesis by repressing pRNA to enable rRNA gene transcription and ribosomal biogenesis and that RNPI represents a target for tumor vessel normalization therapy of cancer., Introduction Angiogenesis, the growth of new vessels from existing ones, is required for vascularization of both physiological and pathological tissues (1). Tumor angiogenesis, however, is driven by abnormally high level [...]

Published
2023
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31. Pteris laetaWall. and Its New Phytochemical, Pterosinsade A, Promote Hippocampal Neurogenesis viaActivating the Wnt Signaling Pathway

Author

Shi, Yu-Sheng, Chen, Ji-Cong, Lin, Bi-Hui, Wang, Ruo-Nan, Zhao, Jie, Li, Sheng, Zhang, Yan, and Zhang, Xu-Fu

Abstract

Pteris laetaWall., as a traditional tea, is popular in Southwest China, but its role in preventing cognitive impairment is unclear. In this study, Pteris laetaWall. extracts (PW) and its active compounds were evaluated for preventive effects on Alzheimer’s disease (AD) in vivoand in vitro. The results showed that PW diminished oxidative stress damage and apoptosis of Aβ-induced HT22 cells and also rescued cognitive deficits, and ameliorated pathological injury and inflammatory response in APP/PS1 mice. Besides, a new pterosin sesquiterpene, named pterosinsade A (PA), and nine known compounds were discovered from the EtOAc extract that possessed the best neuroprotective activity. PA reduced apoptosis of APP-overexpressing neural stem cells and promoted their proliferation and neuronal differentiation. Meanwhile, PW and PA promoted hippocampal neurogenesis, which proved to be associated with activating the Wnt signaling pathway. These findings suggest that PW and PA are candidates for AD prevention.

Published
2023
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35. Diastereoselective Palladium-Catalyzed [4+1] Cycloadditions of 4-Vinyl-1,4-dihydro-2 H -3,1-benzoxazin-2-ones with In Situ Formed Carbenes.

Author

Ma, Yan-Hua, Meng, Fan-Xiao, Wang, Ruo-Nan, Fan, Ya-Xin, Su, Qing-Qiang, and Du, Ji-Yuan

Subjects
CARBENES, FUNCTIONAL groups, BENZOXAZINONES
Abstract

Herein, we present a palladium-catalyzed tandem [4+1] cyclo-addition of 4-vinyl-1,4-dihydro-2 H -3,1-benzoxazin-2-ones with -N -tosyl-hydrazones. The reaction is accomplished by merging the in situ generated aza- ortho -quinone methides (aza- o -QMs) with nucleophilic carbenes. This method enables the construction of diverse indolines with broad functional group compatibility in good yields with high levels of diastereoselectivity under mild conditions. [ABSTRACT FROM AUTHOR]

Published
2022
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42. Lewis Base-Catalyzed [4 + 3] Annulation of ortho-Quinone Methides and MBH Carbonates: Synthesis of Functionalized Benzo[b]oxepines Bearing Oxindole Scaffolds

Author

Du, Ji-Yuan, primary, Ma, Yan-Hua, additional, Meng, Fan-Xiao, additional, Zhang, Rui-Rui, additional, Wang, Ruo-Nan, additional, Shi, Hong-Liang, additional, Wang, Qi, additional, Fan, Ya-Xin, additional, Huang, Hong-Li, additional, Cui, Ji-Chun, additional, and Ma, Chun-Lin, additional

Published
2019
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48. Comparative plastid genomics of Pinus species: Insights into sequence variations and phylogenetic relationships.

Author

Zeb, Umar, Dong, Wan‐Lin, Zhang, Ting‐Ting, Wang, Ruo‐Nan, Shahzad, Khurram, Ma, Xiong‐Feng, and Li, Zhong‐Hu

Subjects
CHLOROPLAST DNA, COMPARATIVE genomics, PINE needles, PINE, CIRCULAR DNA, TANDEM repeats, POPULATION genetics, GENETIC markers
Abstract

Pinus L. is the largest genus of conifers and provides a classical model for studying species divergence and phylogenetic evolution by gymnosperms. However, our poor understanding of sequence divergence in the whole plastid genomes of Pinus species severely hinders studies of their evolution and phylogeny. Thus, we analyzed the sequences of 97 Pinus plastid genomes, including four newly sequenced genomes and 93 previously published plastomes, to explore the evolution and phylogenetic relationships in the genus Pinus. The complete chloroplast genomes of Pinus species ranged in size from 109 640 bp (P. cembra L.) to 121 976 bp (P. glabra Walter), and these genomes comprised circular DNA molecules in a similar manner to those of most gymnosperms. We identified 9108 repeats where most of the repeats comprised the dispersed type with 3983 (44%), followed by tandem repeats with 2999 (33%), and then palindromic repeats with 2126 (23%). Sixteen divergence hotspot regions were identified in Pinus plastid genomes, which could be useful molecular markers for future population genetics studies. Phylogenetic analysis showed that Pinus species could be divided into two diverged clades comprising the subgenera Strobus (single needle section) and Pinus (double needles section). Molecular dating suggested that the genus Pinus originated approximately 130.38 Mya during the late Cretaceous. The two subgenera subsequently split 85.86 Mya, which was largely consistent with the other molecular results based on partial DNA markers. These findings provide important insights into the sequence variations and phylogenetic evolution of Pinus plastid genomes. [ABSTRACT FROM AUTHOR]

Published
2020
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