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Small proline-rich protein 1A (SPRR1A) plays a critical role in regulating squamous cell differentiation. SPRR1A overexpression was reported to be closely related to the progression of some tumors, such as gastric cancer and colon cancer. However, the function of SPRR1A in lung adenocarcinoma (LUAD) has not been elucidated. Here, we first examined the expression pattern of SPRR1A in LUAD tissues, which indicated that the SPRR1A expression level was significantly elevated in LUAD tissues compared with normal lung tissues. High expression of SPRR1A was closely related to larger tumor size. LUAD patients with higher SPRR1A expression had poorer overall survival and SPRR1A was identified as an independent unfavorable prognosis factor. In addition, the effects of SPRR1A on lung cancer cells were tested through cellular experiments and the result demonstrated that knockdown of SPRR1A can suppress the proliferation and invasion capacities of tumor cells, while overexpressing SPRR1A exerted opposite effects. Finally, our findings were substantiated by the data obtained from in vivo xenografts using a mice model. In conclusion, LUAD patients with higher SPRR1A expression were more predisposed to poorer clinical outcomes and unfavorable prognoses, indicating the potential role of SPRR1A as a novel clinical biomarker and therapeutic target. Key words: small proline-rich protein 1A, lung adenocarcinoma, prognosis, proliferation, invasion La petite protéine riche en proline 1A (SPRR1A) joue un rôle essentiel dans la régulation de la différenciation des cellules squameuses. On a signalé que la surexpression de SPRR1A était étroitement liée à la progression de certaines tumeurs telles que le cancer gastrique et le cancer du côlon. Cependant, la fonction de SPRR1A dans l'adénocarcinome pulmonaire (ACP) n'a pas été élucidée. Ici, les auteurs ont d'abord examiné le profil d'expression de SPRR1A dans les tissus d'ACP, révélant que le niveau d'expression de SPRR1A était significativement accru dans les tissus d'ACP par rapport aux tissus pulmonaires normaux. Une forte expression de SPRR1A était étroitement liée à une taille plus importante de la tumeur. Les patients atteints d'ACP présentant une expression élevée de SPRR1A avaient une survie globale plus faible, SPRR1A étant identifiée comme un facteur indépendant de pronostic défavorable. En outre, les effets de SPRR1A sur les cellules cancéreuses du poumon ont été testés au moyen d'expériences cellulaires et les résultats ont démontré que le knockdown de SPRR1A pouvait réprimer les capacités de prolifération et d'invasion des cellules tumorales, tandis que la surexpression de SPRR1A exerçait des effets opposés. Enfin, ces résultats ont été corroborés par les données obtenues à partir de xénogreffes in vivo chez la souris. En conclusion, les patients atteints d'ACP présentant une plus forte expression de SPRR1A étaient davantage prédisposés à présenter de moins bons résultats cliniques et un pronostic défavorable, ce qui indique le rôle potentiel de SPRR1A en tant que nouveau biomarqueur clinique et cible thérapeutique. [Traduit par la Rédaction] Mots-clés: petite protéine riche en proline 1A, adénocarcinome pulmonaire, pronostic, prolifération, invasion, Introduction Lung cancer is one of the most common tumors with an unclear cause (Reck and Rabe 2017; Herbst et al. 2018). Due to the high incidence and mortality of [...]

Prolonged and excessive accumulation of β2-microglobulin (β2m) in the blood can lead to various kidney-related and other diseases. Currently, the most effective method of removing β2m from the blood is hemoperfusion. Although some traditional hemoperfusion adsorbents such as cellulose and polystyrene microspheres have been used for the removal of β2m, their selectivity still needs improvement. Immunosorbents have been developed to address this issue, but high cost and limited application are concerns. TiO2 nanotube arrays (TNTAs) have shown great potential in adsorption-related biomedical applications. In this study, we designed and developed a novel TNTA-based hemoperfusion adsorbent for the removal of β2m, which has demonstrated good biocompatibility, selectivity, and reusability. We investigated the β2m adsorption capacities of TNTAs with different pore sizes. The results indicate that TNTAs with a pore size matching the size of β2m exhibit higher adsorption capacity while also having lower adsorption capacity for albumin, showing the importance of pore size on the selectivity of adsorbents. Additionally, green regeneration of TNTAs is achieved via the photocatalytic activity originating from TiO2. Even after five cycles, the adsorption capacity of TNTAs remained above 70%. Our work demonstrates that inorganic materials with ordered pores are capable to be candidates for hemoperfusion, possessing advantages over traditional organic materials such as high stability, security, and low cost. [ABSTRACT FROM AUTHOR]

Background: Clinically amyopathic dermatomyositis (CADM) is characterized by typical skin lesions with no (amyopathic) or subclinical (hypomyopathic) evidence of muscle involvement. Patients with CADM may also develop rapidly progressive interstitial lung disease (ILD), and have a poor prognosis. However, the diagnosis of rapidly progressive ILD faces a challenge during the severe acute respiratory syndrome coronavirus 2 pandemic. Severe acute respiratory syndrome and ground‐glass attenuation on a chest computed tomography scan are the presenting features in both conditions. Case presentation: A 45‐year‐old woman with amyopathic dermatomyositis had acute onset of fever and dyspnea in February 2020. She had abnormal lung findings on CT scan. Polymerase chain reaction testing for SARS‐CoV‐2 was not available at that time. Chest CT revealed non‐specific manifestations that could be either the signs of ILD or SARS‐CoV‐2 infection. Antiviral therapy was initiated with oseltamivir. Three days later, she had erythema on face, palm, and back. The ratio of lactate dehydrogenase (LDH) isoenzyme 3 to total LDH was elevated. The ratio of LDH isoenzyme 1 to total LDH was declined. Therefore, she was transferred to the rheumatology ward for further treatment. However, she died from respiratory failure 2 weeks later. Conclusions: We speculate that the altered LDH isoenzyme pattern may be an early biomarker for co‐occurrence of CADM and ILD. [ABSTRACT FROM AUTHOR]