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14. Correction: Establishment and application of a quadruple real-time RT-PCR for detecting avian metapneumovirus

Author

Wang, Suchun, primary, Jiang, Nan, additional, Jiang, Lijian, additional, Zhuang, Qingye, additional, Chen, Qiong, additional, Hou, Guangyu, additional, Xiao, Zhiyu, additional, Zhao, Ran, additional, Li, Yang, additional, Zhao, Chenglong, additional, Zhang, Fuyou, additional, Yu, Jianmin, additional, Li, Jinping, additional, Liu, Hualei, additional, Sun, Fuliang, additional, and Wang, Kaicheng, additional

Published
2023
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17. Identification of Cuproptosis-related key genes in seminoma using machine learning and Weighted Gene Co-expression Networks analyses

Author

Cui, Yankang, primary, Fang, Bo, additional, Zhang, Jing, additional, Bu, Hengtao, additional, Shen, Tianyi, additional, Wang, Suchun, additional, Yi, Xiaoming, additional, Shi, Changjie, additional, Tang, Hao, additional, He, Haowei, additional, Ge, Jingping, additional, Xu, Feng, additional, and Shang, Xuejun, additional

Published
2023
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19. Construction of a Cuproptosis-Related Signature for Predicting Prognosis and Immune Response in Clear Cell Renal Cell Carcinoma

Author

Cui, Yankang, primary, Zhang, Jing, additional, Shen, Tianyi, additional, Jiang, Aiming, additional, Xu, Feng, additional, Fang, Bo, additional, Shi, Changjie, additional, Yi, Xiaoming, additional, Lv, Huichen, additional, Wang, Suchun, additional, He, Haowei, additional, Tang, Hao, additional, Ge, Jingping, additional, and Qu, Le, additional

Published
2022
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20. Establishment and application of a quadruple real-time RT-PCR for detecting avian metapneumovirus

Author

Wang, Suchun, primary, Jiang, Nan, additional, Jiang, Lijian, additional, Zhuang, Qingye, additional, Chen, Qiong, additional, Hou, Guangyu, additional, Xiao, Zhiyu, additional, Zhao, Ran, additional, Li, Yang, additional, Zhao, Chenglong, additional, Zhang, Fuyou, additional, Yu, Jianmin, additional, Li, Jinping, additional, Liu, Hualei, additional, Sun, Fuliang, additional, and Wang, Kaicheng, additional

Published
2022
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21. Continuous surveillance revealing a wide distribution of class I Newcastle disease viruses in China from 2011 to 2020

Author

Wang, Jingjing, primary, Yu, Xiaohui, additional, Zheng, Dongxia, additional, Zhao, Yunling, additional, Lv, Yan, additional, Shu, Bo, additional, Jiang, Wenming, additional, Liu, Shuo, additional, Li, Jinping, additional, Hou, Guangyu, additional, Peng, Cheng, additional, Wang, Suchun, additional, Yu, Jianmin, additional, Li, Yang, additional, and Liu, Hualei, additional

Published
2022
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23. Reverse Transcription Recombinase-aided Amplification Assay for H5 Subtype avian Influenza Virus

Author

Wang, Suchun, primary, Li, Yang, additional, zhang, fuyou, additional, Jiang, Nan, additional, Zhuang, Qingye, additional, Hou, Guangyu, additional, Jiang, Lijian, additional, Yu, Jianmin, additional, Yu, Xiaohui, additional, Liu, Hualei, additional, Zhao, Chenglong, additional, Yuan, Liping, additional, Huang, Baoxu, additional, and Wang, Kaicheng, additional

Published
2021
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25. Antigenic Variant of Highly Pathogenic Avian Influenza A(H7N9) Virus, China, 2019

Author

Jiang, Wenming, Hou, Guangyu, Li, Jinping, Peng, Cheng, Wang, Suchun, Liu, Shuo, Zhuang, Qingye, Yuan, Liping, Yu, Xiaohui, Li, Yang, Wang, Jingjing, and Liu, Hualei

Subjects
Health aspects, Vaccines -- Health aspects, Avian influenza -- Health aspects, Infection -- Health aspects, Intelligence gathering, Influenza, Public health, Public health movements, Novels
Abstract

Since mid-2016, influenza A(H7N9), a highly pathogenic avian influenza (HPAI) virus, has led to [approximately equal to]17 outbreaks in poultry in China (1-3). Extensive use of the corresponding vaccine, H7-Re1, [...]

Published
2020
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26. Traceable Surveillance and Genetic Diversity Analysis of Coronaviruses in Poultry from China in 2019

Author

Li, Yang, primary, Zhuang, Qingye, additional, Jiang, Lijian, additional, Jiang, Wenming, additional, Peng, Cheng, additional, Jiang, Nan, additional, Zhang, Fuyou, additional, Yu, Xiaohui, additional, Wang, Suchun, additional, Yuan, Liping, additional, Hou, Guangyu, additional, Liu, Shuo, additional, Wang, Jingjing, additional, Yu, Jianmin, additional, Li, Jinping, additional, Zhao, Chenglong, additional, Huang, Baoxu, additional, Liu, Hualei, additional, and Wang, Kaicheng, additional

Published
2021
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28. Reverse-transcription recombinase-aided amplification assay for H5 subtype avian influenza virus

Author

Wang, Suchun, primary, Li, Yang, additional, Jiang, Nan, additional, Zhang, Fuyou, additional, Zhuang, Qingye, additional, Hou, Guangyu, additional, Jiang, Lijian, additional, Yu, Jianmin, additional, Yu, Xiaohui, additional, Liu, Hualei, additional, Zhao, Chenglong, additional, Yuan, Liping, additional, Huang, Baoxu, additional, and Wang, Kaicheng, additional

Published
2020
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29. Surveillance and Taxonomic Analysis of the Coronavirus Dominant in Pigeons in China

Author

Zhuang, Qingye, primary, Liu, Shuo, additional, Zhang, Xiaochun, additional, Jiang, Wenming, additional, Wang, Kaicheng, additional, Wang, Suchun, additional, Peng, Cheng, additional, Hou, Guangyu, additional, Li, Jinping, additional, Yu, Xiaohui, additional, Yuan, Liping, additional, Wang, Jingjing, additional, Li, Yang, additional, Liu, Hualei, additional, and Chen, Jiming, additional

Published
2020
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30. Control of avian influenza in China: Strategies and lessons

Author

Liu, Shuo, primary, Zhuang, Qingye, additional, Wang, Suchun, additional, Jiang, Wenming, additional, Jin, Jihui, additional, Peng, Cheng, additional, Hou, Guangyu, additional, Li, Jinping, additional, Yu, Jianmin, additional, Yu, Xiaohui, additional, Liu, Hualei, additional, Sun, Shufang, additional, Yuan, Liping, additional, and Chen, Jiming, additional

Published
2020
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31. Analysis of Correlation Between Vertebral Endplate Change and Lumbar Disc Degeneration

Author

Jianwei Zhang, Zhirong Wang, Wang Suchun, Ni Chunlin, Lu Aiqing, Xiao Long, and Shi Jiandong

Subjects
Adult, Male, Lumbar disc degeneration, Intervertebral Disc Degeneration, Degeneration (medical), Correlation, 03 medical and health sciences, 0302 clinical medicine, Clinical Research, medicine, Humans, Intervertebral Disc, skin and connective tissue diseases, Aged, 030222 orthopedics, Lumbar Vertebrae, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, Modic changes, Intervertebral disc, General Medicine, Anatomy, Middle Aged, Magnetic Resonance Imaging, Hospitals, Sagittal plane, Vertebra, medicine.anatomical_structure, Back Pain, Female, sense organs, business, Low Back Pain, Intervertebral Disc Displacement, 030217 neurology & neurosurgery
Abstract

BACKGROUND To evaluate the correlation between vertebral endplate change and the level of lumbar disc degeneration via magnetic resonance imaging (MRI). MATERIAL AND METHODS A total of 345 patients who were recruited from our hospital from May 2012 to May 2016 were evaluated for the presence of intervertebral disc degeneration or herniation. The degree of degeneration was assessed according to Pfirrmann grade. Vertebral endplate change was evaluated based on the endplate concave angle (ECA), and Modic change on sagittal MRI. The correlation between ECA and lumbar disc degeneration or Modic change and lumbar disc degeneration was analyzed. RESULTS The results showed that there was no statistically significant difference in comparison of the ECAs in adjacent L3-5 vertebra between males and females. With the aggravation in degenerative changes of L3-5 discs, the ECAs of adjacent L3 superior endplate, L4 inferior and superior endplates and L5 inferior endplate were gradually enlarged, indicating the positive correlation between the lumbar disc degeneration and ECAs. The rate of Modic change in females was higher than that in males without a statistically significant difference. Area of Modic change was positively correlated with the degree of lumbar disc degeneration. Additionally, we also identified the positive correlation between the rate of Modic change and the degree of lumbar disc degeneration. CONCLUSIONS Endplate angle and lumbar disc degeneration are positively correlated. The endplates and endplate signal changes can reflect the degree of disc degeneration and Modic changes can reflect the rate of clinical lumbar disc degeneration degree.

Published
2017
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32. Application of esophageal radiography technique in the treatment of herniation of cervical disc with radiofrequency thermocoagulation and target ablation

Author

Wang Suchun, Zhirong Wang, Yu Jingcheng, Ji Ke, and Miao Wei

Subjects
Adult, Male, medicine.medical_specialty, business.industry, Radiography, medicine.medical_treatment, Treatment outcome, Middle Aged, Ablation, Treatment Outcome, Radiofrequency thermocoagulation, Cervical Vertebrae, Electrocoagulation, medicine, Humans, Female, Surgery, Neurology (clinical), Radiology, business, Cervical disc, Intervertebral Disc Displacement
Published
2019
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37. Effects of lower lumbar single-segment fusion on sagittal parameters of lumbar vertebra with different Roussouly types and its clinical efficacy

Author

Wang Suchun, Ji Ke, Shi Jiandong, Lu Aiqing, and Zhirong Wang

Subjects
030222 orthopedics, medicine.medical_specialty, Sacrum, Lumbar Vertebrae, business.industry, Treatment outcome, Lumbar vertebrae, Intervertebral Disc Degeneration, Single segment, Sagittal plane, 03 medical and health sciences, 0302 clinical medicine, Lumbar, medicine.anatomical_structure, Spinal Fusion, Treatment Outcome, medicine, Humans, Surgery, Clinical efficacy, Radiology, business, 030217 neurology & neurosurgery
Published
2017

38. Role of miR-589-3p in human lumbar disc degeneration and its potential mechanism

Author

Zhirong Wang, Wang Suchun, and Lu Aiqing

Subjects
Cancer Research, medicine.diagnostic_test, Chemistry, Cell, General Medicine, SMAD, Articles, Cell cycle, Molecular biology, Flow cytometry, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Immunology and Microbiology (miscellaneous), Western blot, Apoptosis, Cell culture, 030220 oncology & carcinogenesis, medicine, Tumor necrosis factor alpha, 030217 neurology & neurosurgery
Abstract

The present study aimed to investigate the role of miR-589-3p in lumbar disc degeneration (LDD) and to explore the underlying mechanisms. Nucleus pulposus (NP) cells were stimulated with lipopolysaccharide (LPS) to simulate an in vitro model of intervertebral disc degeneration. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to detect the expression level of microRNA (miR)-589-3p in the NP cells, and the results demonstrated that the increased expression of miR-589-3p in LPS stimulated NP cells compared with the control. To further investigate the role of miR-589-3p in LDD, a human NP cell line with high/low miR-589-3p expression was generated using miR-589-3p mimics/inhibitors. In addition, a human NP cell inflammation model was conducted by LPS (10 µM) treatment. Western blot analysis and RT-qPCR were performed for detection of associated genes and proteins. Protein levels of pro-inflammatory factors, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and IL-6 were evaluated by ELISA. Flow cytometry was used for cell apoptosis determination. Furthermore, Targetscan was used to predict potential targets of miR-589-3p, and a dual luciferase reporter assay was used to verify the prediction. The findings verified that miR-589-3p was significantly upregulated in LDD. In vitro, miR-589-3p mimics/inhibitors significantly increased/reduced the production of TNF-α, IL-1β and IL-6 in LPS stimulated NP cells. Furthermore, miR-589-3p mimics/inhibitors significantly promoted/inhibited LPS stimulated NP cell apoptosis. MiR-589-3p mimics/inhibitors significantly repressed/enhanced type II collagen and aggrecan expression in LPS stimulated NP cells. In addition, it was demonstrated that mothers against decapentaplegic homolog (Smad) 4 was a direct target gene of miR-589-3p, and was negatively regulated by miR-589-3p in NP cells. In conclusion, miR-589-3p may function as a promoter in LDD development via the regulation of Smad4.

Published
2017

40. Reverse‐transcription recombinase‐aided amplification assay for H7 subtype avian influenza virus.

Author

Wang, Suchun, Huang, Baoxu, Ma, Xuejun, Liu, Ping, Wang, Yang, Zhang, Xiaoguang, Zhu, Lin, Fan, Qingying, Sun, Yawei, and Wang, Kaicheng

Subjects
*AVIAN influenza A virus, *AVIAN infectious bronchitis virus, *NEWCASTLE disease virus, *AVIAN influenza, *VIRUS diseases, *PROBIT analysis
Abstract

H7 subtype avian influenza virus infection is an emerging zoonosis in some Asian countries and an important avian disease worldwide. A rapid and simple test is needed to confirm infection in suspected cases during disease outbreaks. In this study, we developed a reverse‐transcription recombinase‐aided amplification assay for the detection of H7 subtype avian influenza virus. Assays were performed at a single temperature (39°C), and the results were obtained within 20 min. The assay showed no cross‐detection with Newcastle disease virus or infectious bronchitis virus, which are the other main respiratory viruses affecting birds. The analytical sensitivity was 102 RNA copies per reaction at a 95% probability level according to probit regression analysis, with 100% specificity. Compared with published reverse‐transcription quantitative real‐time polymerase chain reaction assays, the κ value of the reverse‐transcription recombinase‐aided amplification assay in 342 avian clinical samples was 0.988 (p <.001). The sensitivity for avian clinical sample detection was 100% (95%CI, 90.40%–100%), and the specificity was 99.96% (95%CI, 97.83%–99.98%). These results indicated that our reverse‐transcription recombinase‐aided amplification assay may be a valuable tool for detecting avian influenza H7 subtype virus. [ABSTRACT FROM AUTHOR]

Published
2020
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50. Role of miR-589-3p in human lumbar disc degeneration and its potential mechanism.

Author

Lu, Aiqing, Wang, Zhirong, and Wang, Suchun

Subjects
INTERVERTEBRAL disk diseases, NUCLEUS pulposus, LIPOPOLYSACCHARIDES, REVERSE transcriptase polymerase chain reaction, MICRORNA, WESTERN immunoblotting, THERAPEUTICS
Abstract

The present study aimed to investigate the role of miR-589-3p in lumbar disc degeneration (LDD) and to explore the underlying mechanisms. Nucleus pulposus (NP) cells were stimulated with lipopolysaccharide (LPS) to simulate an in vitro model of intervertebral disc degeneration. Reverse transcription- quantitative polymerase chain reaction (RT-qPCR) was used to detect the expression level of microRNA (miR)-589-3p in the NP cells, and the results demonstrated that the increased expression of miR-589-3p in LPS stimulated NP cells compared with the control. To further investigate the role of miR-589-3p in LDD, a human NP cell line with high/low miR-589-3p expression was generated using miR-589-3p mimics/inhibitors. In addition, a human NP cell inflammation model was conducted by LPS (10 µM) treatment. Western blot analysis and RT-qPCR were performed for detection of associated genes and proteins. Protein levels of pro-inflammatory factors, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and IL-6 were evaluated by ELISA. Flow cytometry was used for cell apoptosis determination. Furthermore, Targetscan was used to predict potential targets of miR-589-3p, and a dual luciferase reporter assay was used to verify the prediction. The findings verified that miR-589-3p was significantly upregulated in LDD. In vitro, miR-589-3p mimics/inhibitors significantly increased/reduced the production of TNF-α, IL-1β and IL-6 in LPS stimulated NP cells. Furthermore, miR-589-3p mimics/inhibitors signifi- cantly promoted/inhibited LPS stimulated NP cell apoptosis. MiR-589-3p mimics/inhibitors significantly repressed/enhanced type II collagen and aggrecan expression in LPS stimulated NP cells. In addition, it was demonstrated that mothers against decapentaplegic homolog (Smad) 4 was a direct target gene of miR-589-3p, and was negatively regulated by miR-589-3p in NP cells. In conclusion, miR-589-3p may function as a promoter in LDD development via the regulation of Smad4. [ABSTRACT FROM AUTHOR]

Published
2018
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