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Objective To analyze the clinicopathological characteristics and prognosis of oligodendroglioma with IDH mutation and 1p/19q codeletion. Methods We collected the data of 54 oligodendroglioma patients with IDH mutation and 1p/19q codeletion.The patients'clinicopathological data, including age, histological grade, and tumor site, were analyzed for the effects on progression-free and overall survival. Results Among the 54 patients, 46 cases were with tumor sites in one lobe, and eight cases involved tumor sites in more than two lobes.A total of 12 and 42 cases had WHO grades 2 and 3 oligodendroglioma, respectively.Detection by fluorescence in situ hybridization showed 1p/19q co-deletion in all cases.Immunohistochemical tests revealed diffuse and strong positive results for Olig2.All glial fibrillary acidic proteins were positive.p53 was strongly positive in six cases.ATRX was expressed in all 48 cases.Ki-67 proliferation index ranged from 5% to 60%.Sanger sequencing showed that all 54 cases had IDH gene mutations (40 cases were IDH1 mutations, and 14 were IDH2 mutations), and 33 cases had telomerase reverse transcriptase promoter mutations.Relapse and metastasis occurred in 16 patients during treatment.Univariate analysis indicated that the postoperative recurrence and metastasis interval of more than two years can prolong the progression-free and overall survival of patients.All 54 patients had a mean progression-free survival of 33.5 months and the mean overall survival of 40.7 months. Conclusion For oligodendroglioma with IDH mutation and 1p/19q codeletion, precision chemoradiotherapy after surgery can reduce the risk of progression, and the postoperative recurrence and metastasis interval is associated with the prognosis.

Excessive visceral adipose tissue (VAT) is a significant risk factor for various diseases. Diet plays a crucial role in controlling obesity. This study examined the association between the Dietary Approaches to Stop Hypertension (DASH) diet and VAT in 9027 adults using data from the National Health and Nutrition Examination Survey. Linear regression models were used to explore this association, with subgroup analyses included. Results showed a significant inverse association between DASH scores and VAT area, even after adjusting for covariates (β = −2.18, 95% CI: −3.10, −1.27). Participants in the highest DASH score tertile had significantly lower VAT areas compared to those in the lowest tertile (β = −7.2, 95% CI: −10.40, −4.01). This inverse association was most pronounced in middle-aged participants. Further prospective cohort studies are necessary to confirm these findings. [ABSTRACT FROM AUTHOR]

Worldwide organic amendments have received much attention to improve soil fertility and crop productivity. Partial substitution of inorganic fertilizer through organic manure is a promising approach to decrease chemical fertilizer input while stabilizing or increasing crop yield. Field experiments were conducted in Hubei and Hunan provinces to assess the impact of partial substitution of chemical fertilizer through organic manure on cotton yield and soil properties during 2016 and 2017. The experimental plots (50 m2) were arranged in a randomized block design, with six treatments, and three replicates for each treatment. Our results revealed that the yield of 100% chemical fertilizer treatments was significantly higher than no fertilizer treatment in 2016, and the yield of organic fertilizer substitution treatments was higher than 100% chemical fertilizer and no fertilizer in 2017 in Hubei province. In Hunan province, the yield of replacing part of chemical fertilizer with organic fertilizer and 100% chemical fertilizer treatment was higher than those of 100% organic fertilizer and no fertilizer treatment over 2 years. Application of 100% organic fertilizer was found to be more beneficial in terms of improving soil fertility in Hubei provinces during both years. The substitution of chemical fertilizer by 50% organic fertilizer was effective to improve soil fertility and exerted a significant effect on soil available phosphorus, potassium in Hunan provinces during both years. Collectively, these results indicate that replace 100% chemical fertilizer through organic fertilizer in Hubei province and substitution of 50% chemical fertilizer in Hunan province could increase the cotton yield, improve soil fertility and reduce inorganic fertilizers, which have a potential impact on sustainable production of cotton. [ABSTRACT FROM AUTHOR]

Background: Convergent evidence has suggested atypical relationships between brain structure and function in major psychiatric disorders, yet how the abnormal patterns coincide and/or differ across different disorders remains largely unknown. Here, we aim to investigate the common and/or unique dynamic structure–function coupling patterns across major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ). Methods: We quantified the dynamic structure–function coupling in 452 patients with psychiatric disorders (MDD/BD/SZ = 166/168/118) and 205 unaffected controls at three distinct brain network levels, such as global, meso-, and local levels. We also correlated dynamic structure–function coupling with the topological features of functional networks to examine how the structure–function relationship facilitates brain information communication over time. Results: The dynamic structure–function coupling is preserved for the three disorders at the global network level. Similar abnormalities in the rich-club organization are found in two distinct functional configuration states at the meso-level and are associated with the disease severity of MDD, BD, and SZ. At the local level, shared and unique alterations are observed in the brain regions involving the visual, cognitive control, and default mode networks. In addition, the relationships between structure–function coupling and the topological features of functional networks are altered in a manner indicative of state specificity. Conclusions: These findings suggest both transdiagnostic and illness-specific alterations in the dynamic structure–function relationship of large-scale brain networks across MDD, BD, and SZ, providing new insights and potential biomarkers into the neurodevelopmental basis underlying the behavioral and cognitive deficits observed in these disorders. [ABSTRACT FROM AUTHOR]

Effective approaches to mitigate the adverse environmental impacts of tourism development have become one of the most prevalent topics in tourism. However, limited research analyzes the role of social interactions in tourists' environmentally responsible behavior. This study is one of the first to investigate two distinct antecedents representing visitors' interactions with service providers and residents to explain tourists' behavior. Drawing on the Stimulus-Organism-Response theory, a mixed-methods sequential explanatory research design was employed by collecting quantitative data through a survey and following up with qualitative data from in-depth interviews. Based on a survey of 441 respondents, the study confirmed the positive effects of co-creation experiences between tourists and service providers, as well as emotional solidarity between visitors and residents, on tourists' environmentally responsible behavior at destinations. An analysis of 10 in-depth interviews reveals new important factors contributing to tourists' environmentally responsible behavior and its outcomes. [ABSTRACT FROM AUTHOR]

Background: Venous sinus manometry performed by microcatheter to assess candidacy for venous sinus stenting in patients with idiopathic cranial pressure (IIH) can be tiring, time-consuming and unreliable. Pressure wire is widely used to measure coronary pressure and evaluate coronary stenosis severity, but venous sinus manometry using the pressure guide wire has only been reported in one case, and few studies have examined the accuracy of this approach. Objective: To compare venous manometry performed by microcatheter with by pressure wire under awake setting in patients with IIH. Methods: The manometry results of 30 patients with IIH were recorded by Rebar-27 microcatheter and a pressure wire under awake setting. The mean venous pressures (MVPs) and trans-stenosis pressure gradients were obtained and compared between microcatheter and pressure wire. Paired t-test) were used to evaluate the data between the two groups. Results: MVPs in superior sagittal sinus (SSS) and torcula were slightly higher with microcatheter, though without statistically significant differences (p > 0.05). MVPs in transverse sinus (TS) and sigmoid sinus (SS) were significantly higher with microcatheter (p < 0.05). Trans-stenotic pressure gradient with microcatheter was significantly higher than with pressure wire (p＜0.001). Conclusions: Intracranial venous pressure measured with the microcatheter and pressure wire showed a moderate difference. Compared with the traditional microcatheter method，the pressure wire is safe, fast and effective method to identify the patient needing intervention. [ABSTRACT FROM AUTHOR]

Objective: This study aimed to identify the key factors that might affect the clinical outcome of patients with idiopathic intracranial hypertension (IIH) and Venous sinus stenting (VSS). Methods: We performed an analysis of a prospectively collected database of patients with IIH and VSS who underwent stenting. The trans-stenotic pressure gradient was measured before and after intervention. In additional, patients' baseline characteristics, procedure details and clinical outcomes at 6-month follow-up (including changes in headache, visual impairment, papilledema, etc.) were recorded. The effects of post-intervention pressure gradient on symptom-free at 6 months were explored using logistic regression analysis, generalized additive model and receiver operator characteristic (ROC) curve. Results: Of 101 patients included in this study, the median pressure gradient across stenosis decreased from 19 mmHg before intervention to 2 mmHg after intervention. At 6 months, symptom-free was observed in 58 cases (57.4%). Multivariable logistic analysis and generalized additive model showed that post-intervention pressure gradient (increased by 1 mmHg) was independently and linearly correlated with symptom-free (OR = 0.79, 95% CI = 0.67–0.94). Moreover, the post-intervention pressure gradient revealed moderate discrimination with an area under ROC curve of 0.68 (95% CI = 0.57–0.78). Similar associations were observed for the disappearance of headache and papilledema, but not for the visual recovery. Conclusion: The post-intervention pressure gradient may be a valid and reliable predictor of 6-month clinical outcome in patients with IIH and VSS treated by stenting. Nevertheless, external validation with blinded outcome is still needed to confirm its performance before clinical application. [ABSTRACT FROM AUTHOR]