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The stimulator of interferon genes (STING) pathway is a potent therapeutic target for innate immunity. Despite the efforts to develop pocket‐dependent small‐molecule STING agonists that mimic the endogenous STING ligand, cyclic guanosine monophosphate–adenosine monophosphate (cGAMP), most of these agonists showed disappointing results in clinical trials owing to the limitations of the STING pocket. In this study, we developed novel pocket‐independent STING‐activating agonists (piSTINGs), which act through multivalency‐driven oligomerization to activate STING. Additionally, a piSTING‐adjuvanted vaccine elicited a significant antibody response and inhibited tumour growth in therapeutic models. Moreover, a piSTING‐based vaccine combination with aPD‐1 showed remarkable potential to enhance the effectiveness of immune checkpoint blockade (ICB) immunotherapy. In particular, piSTING can strengthen the impact of STING pathway in immunotherapy and accelerate the clinical translation of STING agonists. [ABSTRACT FROM AUTHOR]

An emerging "one stone, three birds" strategy was proposed to realize the value‐added disposal of solid waste coal gangue (CG), the synthesis of superb adsorbent and the efficient decontamination of pollutants (i. e. dyes, heavy metals). In this process, the metal ions extrated from calcined coal gangue (CCG) was reconstituted by a one‐step hydrothermal process to yield porous polymetallic silicate adsorbent (named HECCGA8h). The adsorbent has a high adsorption capacity of 270.27 and 185.53 mg/g for methylene blue (MB) and Cd(II), respectively. In the actual waters, the removal rate of MB by this adsorbent reaches 99.8% (in Yangtze River water) and 99.42% (in Seawater), and the removal rate of Cd(II) reaches 99.11% (in Yangtze River water) and 92.52% (in Seawater), respectively. Thermokinetic analysis showed that the adsorption of MB by HECCGA8h is spontaneous and endothermic with increased entropy, and the adsorption of Cd(II) is spontaneous and exothermic. The adsorption of MB is mainly driven by synergism of hydrogen bond, electrostatic attraction and ion exchange, and the adsorption of Cd(II) is mainly driven by the complexation and ion exchange between the surface group of the adsorbent and Cd(II). This research provides a new way for the realization of "treating waste with waste". [ABSTRACT FROM AUTHOR]

Novel pocket‐independent STING‐activating agonists (piSTINGs), which act through multivalency‐driven oligomerization to activate downstream signalling pathways, were developed by Yan‐Mei Li et al. in their Research Article (e202407037). piSTINGs could serve as novel STING agonists for vaccines and combination therapies. STING oligomerization is a useful strategy for the development of a new generation of STING agonists...By Shao‐Hua Zhuo; Tian‐Yang Wang; Lang Zhao; Jing‐Yun Su; Jin‐Jian Hu; Yu‐Fen Zhao and Yan‐Mei LiReported by Author; Author; Author; Author; Author; Author; Author [Extracted from the article]

Novel pocket‐independent STING‐activating agonists (piSTINGs), which act through multivalency‐driven oligomerization to activate downstream signalling pathways, were developed by Yan‐Mei Li et al. in their Research Article (e202407037). piSTINGs could serve as novel STING agonists for vaccines and combination therapies. STING oligomerization is a useful strategy for the development of a new generation of STING agonists...By Shao‐Hua Zhuo; Tian‐Yang Wang; Lang Zhao; Jing‐Yun Su; Jin‐Jian Hu; Yu‐Fen Zhao and Yan‐Mei LiReported by Author; Author; Author; Author; Author; Author; Author [Extracted from the article]

The "Cretaceous oceanic red beds (CORBs)" associated with "oceanic oxic events" have become a hot topic for geologists from around the world. In southern Tibet, the CORBs are widely distributed in the Upper Cretaceous of the northern Tethys Himalayas, but they have never been reported from the southern Tethyan Himalaya (Tibet, China). A mixed Upper Cretaceous carbonate‐shale succession is well exposed in the Gyabukeqing section of Guru town, Yadong County, southern Tibet, which tectonically belongs to the southern Tethyan Himalaya. These sedimentary strata constitute the transition from the Gangbacunkou Formation shale towards the Zongshan Formation limestone through the Jiubao Formation alternations of marl and shale. The Gangbacunkou Formation is characterized by grey‐greenish shales occasionally interspersed with laminated marls, followed by the Jiubao Formation composed of marls with interbeds of shales, which is overlain by the limestones of the Zongshan Formation. A 5‐m‐thick purplish marl bed was found from the lower Jiubao Formation in the Gyabukeqing section, and these reddish marls are assignable to shallow marine red beds. Detailed foraminifer biostratigraphy established five planktic foraminifer zones: Dicarinella covcavata, D. asymetrica, Globotruncanita elevata, G. ventricosa, and Radotruncana calcarata throughout the entire Upper Cretaceous succession in the Gyabukeqing section. The reddish marl beds are constrained as middle Campanian in age as they are calibrated to the middle part of the foraminifer Radotruncana calcarata Zone. As a comparison, the typical CORBs of pelagic–hemipelagic settings are also documented from the Upper Cretaceous of the northern Tethys Himalayas in southern Tibet. A total of 10 microfacies were recognized from the entire sequence of the Upper Cretaceous outer shelf‐slope settings in the Yadong area, southern Tibet. The Yadong red marl beds represent the sedimentation of the foraminiferal biomicrite/foraminiferal wackestone and mudstone/mudrock microfacies, pointing to a shallow marine continental shelf margin setting. Global biostratigraphic correlations indicate that the Yadong red marl beds are coeval with the typical CORBs of the Gyangze and Kangmar documented from the northern Tethys Himalayas in this study or reported previously from the same region as well as elsewhere in the world. The Yadong red beds also are comparable in lithology and biostratigraphy with the shallow marine red beds documented from Europe, and they all may represent the contemporaneous deposition of the CORBs in shallow shelf. These shallow marine CORBs share similar depositional mechanisms: undergoing a phase of iron and manganese enrichment in seawater due to injection of deep sea anoxic water to shallow shelf, followed by oxidization in shallow settings or being oxidized during diagenetic process or a response to the oxygenation of coeval CORBs in deep seas. [ABSTRACT FROM AUTHOR]

Abstract: A kind of novel n–n combined ordered mesoporous WO3/ZnO (OM‐WO3/ZnO) sensor are successfully fabricated in this study. A soft‐template method is used to synthesize the ordered mesoporous ZnO matrix. Surfaces of the ZnO matrix are innovatively modified using silane coupling agent (mark as: OM‐ZnO‐Si), and then a layer of WO3 film is assembled on the surfaces of the OM‐ZnO‐Si by chemical plating method for the first time, and the OM‐WO3/ZnO material is obtained. The prepared OM‐WO3/ZnO sample shows a kind of regular hexagon‐sheet structure. The prepared OM‐WO3/ZnO sensor shows the much better response, much shorter response time, much lower detection limit, and the more excellent selectivity toward NOx gas. When oxynitride (NOx) gas concentration is 100 ppm, the response reaches to 82.64%, the response time is only 6 s at room temperature. The detection limit is only 0.01 ppm. The unique loose porous structure and the synergistic effect of the n–n heterojunction structure endow the prepared OM‐WO3/ZnO material with the superior gas sensing properties. The n–n combined OM‐WO3/ZnO material shows the vast development potential in gas sensor field. [ABSTRACT FROM AUTHOR]