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903 results on '"Wang, Xitao"'

2. Nitric oxide synthase and reduced arterial tone contribute to arteriovenous malformation

Author

Huang, Lawrence, Cheng, Feng, Zhang, Xuetao, Zielonka, Jacek, Nystoriak, Matthew A, Xiang, Weiwei, Raygor, Kunal, Wang, Shaoxun, Lakshmanan, Aditya, Jiang, Weiya, Yuan, Sai, Hou, Kevin S, Zhang, Jiayi, Wang, Xitao, Syed, Arsalan U, Juric, Matea, Takahashi, Takamune, Navedo, Manuel F, and Wang, Rong A

Subjects
Medical Physiology, Biomedical and Clinical Sciences, Cardiovascular, Animals, Mice, Arteries, Arteriovenous Malformations, Hydrogen Peroxide, Nitric Oxide Synthase, Nitroarginine, Nitric Oxide Synthase Type III
Abstract

Mechanisms underlying arteriovenous malformations (AVMs) are poorly understood. Using mice with endothelial cell (EC) expression of constitutively active Notch4 (Notch4*EC), we show decreased arteriolar tone in vivo during brain AVM initiation. Reduced vascular tone is a primary effect of Notch4*EC, as isolated pial arteries from asymptomatic mice exhibited reduced pressure-induced arterial tone ex vivo. The nitric oxide (NO) synthase (NOS) inhibitor NG-nitro-l-arginine (L-NNA) corrected vascular tone defects in both assays. L-NNA treatment or endothelial NOS (eNOS) gene deletion, either globally or specifically in ECs, attenuated AVM initiation, assessed by decreased AVM diameter and delayed time to moribund. Administering nitroxide antioxidant 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl also attenuated AVM initiation. Increased NOS-dependent production of hydrogen peroxide, but not NO, superoxide, or peroxynitrite was detected in isolated Notch4*EC brain vessels during AVM initiation. Our data suggest that eNOS is involved in Notch4*EC-mediated AVM formation by up-regulating hydrogen peroxide and reducing vascular tone, thereby permitting AVM initiation and progression.

Published
2023

49. Morphology Modulation of ZnMn 2 O 4 Nanoparticles Deposited In Situ on Carbon Cloth for Supercapacitors.

Author

Li, Changxing, Feng, Xuansheng, Zhou, Jixue, Zhao, Guochen, Cheng, Kaiming, Yu, Huan, Li, Hang, Yang, Huabing, Zhao, Dongqing, and Wang, Xitao

Subjects
CARBON fibers, ENERGY density, POWER density, STRUCTURAL design, NANOPARTICLES, SUPERCAPACITORS, SUPERCAPACITOR electrodes
Abstract

As a typical spinel structure material, ZnMn2O4 has been widely researched in the field of electrode materials. However, ZnMn2O4 nanoparticles as electrode materials for supercapacitors have the disadvantages of low conductivity, inferior structural integrity, and easy aggregation, resulting in unsatisfying electrochemical performance. In this work, we use a hydrothermal method and high-temperature calcination to deposit ZnMn2O4 nanoparticles on carbon cloth and explore the influence of hydrothermal reaction time on the deposition morphology and distribution of ZnMn2O4 nanoparticles on carbon cloth. The deposition process of ZnMn2O4 nanoparticles on carbon cloth was analyzed, and a ZMO-9 electrode was deduced to be the most suitable electrode for supercapacitors. A series of electrochemical performance tests show that the ZMO-9 electrode has excellent specific capacitance (specific capacity) (499 F·g−1 (299.4 C·g−1) at a current density of 1 A·g−1) and rate performance (75% capacitance retention at a current density of 12 A·g−1). The assembled asymmetric supercapacitor has an energy density of 46.6 Wh·kg−1 when the power density is 800.1 W·kg−1. This work provides a reference for the structural design of ZnMn2O4 supercapacitor electrode materials and the improvement of electrochemical properties. [ABSTRACT FROM AUTHOR]

Published
2024
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