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23 results on '"Wannachalee, Taweesak"'

6. PSAT264 Effectiveness of Thyroid Gland Size Determination by Ultrasonography versus Manual Palpation in Success of Radioactive Iodine Therapy for Graves’ Disease

Author

Choksakunwong, Sawaraj, primary, Phitakwanich, Kanokorn, additional, Khiewvan, Benjapa, additional, Chiewvit, Sunanta, additional, Kunavisarut, Tada, additional, Laipiriyakul, Aunchalee, additional, Chanphibun, Pornnapa, additional, Wannachalee, Taweesak, additional, Sriussadaporn, Sutin, additional, and Sirinvaravong, Sirinart, additional

Published
2022
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17. Preventive medicine of von Hippel–Lindau disease-associated pancreatic neuroendocrine tumors

Author

Krauss, Tobias, primary, Ferrara, Alfonso Massimiliano, additional, Links, Thera P, additional, Wellner, Ulrich, additional, Bancos, Irina, additional, Kvachenyuk, Andrey, additional, Villar Gómez de las Heras, Karina, additional, Yukina, Marina Y, additional, Petrov, Roman, additional, Bullivant, Garrett, additional, von Duecker, Laura, additional, Jadhav, Swati, additional, Ploeckinger, Ursula, additional, Welin, Staffan, additional, Schalin-Jäntti, Camilla, additional, Gimm, Oliver, additional, Pfeifer, Marija, additional, Ngeow, Joanne, additional, Hasse-Lazar, Kornelia, additional, Sansó, Gabriela, additional, Qi, Xiaoping, additional, Ugurlu, M Umit, additional, Diaz, Rene E, additional, Wohllk, Nelson, additional, Peczkowska, Mariola, additional, Aberle, Jens, additional, Lourenço, Delmar M, additional, Pereira, Maria A A, additional, Fragoso, Maria C B V, additional, Hoff, Ana O, additional, Almeida, Madson Q, additional, Violante, Alice H D, additional, Quidute, Ana R P, additional, Zhang, Zhewei, additional, Recasens, Mònica, additional, Díaz, Luis Robles, additional, Kunavisarut, Tada, additional, Wannachalee, Taweesak, additional, Sirinvaravong, Sirinart, additional, Jonasch, Eric, additional, Grozinsky-Glasberg, Simona, additional, Fraenkel, Merav, additional, Beltsevich, Dmitry, additional, Egorov, Viacheslav I, additional, Bausch, Dirk, additional, Schott, Matthias, additional, Tiling, Nikolaus, additional, Pennelli, Gianmaria, additional, Zschiedrich, Stefan, additional, Därr, Roland, additional, Ruf, Juri, additional, Denecke, Timm, additional, Link, Karl-Heinrich, additional, Zovato, Stefania, additional, von Dobschuetz, Ernst, additional, Yaremchuk, Svetlana, additional, Amthauer, Holger, additional, Makay, Özer, additional, Patocs, Attila, additional, Walz, Martin K, additional, Huber, Tobias B, additional, Seufert, Jochen, additional, Hellman, Per, additional, Kim, Raymond H, additional, Kuchinskaya, Ekaterina, additional, Schiavi, Francesca, additional, Malinoc, Angelica, additional, Reisch, Nicole, additional, Jarzab, Barbara, additional, Barontini, Marta, additional, Januszewicz, Andrzej, additional, Shah, Nalini, additional, Young, William F, additional, Opocher, Giuseppe, additional, Eng, Charis, additional, Neumann, Hartmut P H, additional, and Bausch, Birke, additional

Published
2018
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19. Preventive medicine of von Hippel-Lindau disease-associated pancreatic neuroendocrine tumors

Author

Krauss, Tobias, Ferrara, Alfonso Massimiliano, Links, Thera P., Wellner, Ulrich, Bancoss, Irina, Kvachenyuk, Andrey, Gomez de las Heras, Karim Villar, Yukina, Marina Y., Petrov, Roman, Bullivant, Garrett, von Duecker, Laura, Jadhav, Swati, Ploeckinger, Ursula, Welin, Staffan, Schalin-Jantti, Camilla, Gimm, Oliver, Pfeifer, Marija, Ngeow, Joanne, Hasse-Lazar, Kornelia, Sanso, Gabriela, Qi, Xiaoping, Ugurlu, M. Umit, Diaz, Rene E., Wohllk, Nelson, Peczkowska, Mariola, Aberle, Jens, Lourenco Jr, Delmar M., Pereira, Maria A. A., Fragoso, Maria C. B., V, Hoff, Ana O., Almeida, Madson Q., Violante, Alice H. D., Ouidute, Ana R. P., Zhang, Zhewei, Recasens, Monica, Robles Diaz, Luis, Kunavisarut, Tada, Wannachalee, Taweesak, Sirinvaravong, Sirinart, Jonasch, Eric, Grozinsky-Glasberg, Simona, Fraenkel, Merav, Beltsevich, Dmitry, Egorov, Viacheslav, I, Bausch, Dirk, Schott, Matthias, Tiling, Nikolaus, Pennelli, Gianmaria, Zschiedrich, Stefan, Daerr, Roland, Ruf, Juri, Denecke, Timm, Link, Karl-Heinrich, Zovato, Stefania, von Dobschuetz, Ernst, Yaremchuk, Svetlana, Amthauer, Holger, Makay, Ozer, Patocs, Attila, Walz, Martin K., Huber, Tobias B., Seufert, Jochen, Hellman, Per, Ekaterina, Raymond H., Kuchinskaya, Ekaterina, Schiavi, Francesca, Malinoc, Angelica, Reisch, Nicole, Jarzab, Barbara, Barontini, Marta, Januszewicz, Andrzej, Shah, Nalini, Young, William F., Jr., Opocher, Giuseppe, Eng, Charis, Neumann, Hartmut P. H., Bausch, Birke, Krauss, Tobias, Ferrara, Alfonso Massimiliano, Links, Thera P., Wellner, Ulrich, Bancoss, Irina, Kvachenyuk, Andrey, Gomez de las Heras, Karim Villar, Yukina, Marina Y., Petrov, Roman, Bullivant, Garrett, von Duecker, Laura, Jadhav, Swati, Ploeckinger, Ursula, Welin, Staffan, Schalin-Jantti, Camilla, Gimm, Oliver, Pfeifer, Marija, Ngeow, Joanne, Hasse-Lazar, Kornelia, Sanso, Gabriela, Qi, Xiaoping, Ugurlu, M. Umit, Diaz, Rene E., Wohllk, Nelson, Peczkowska, Mariola, Aberle, Jens, Lourenco Jr, Delmar M., Pereira, Maria A. A., Fragoso, Maria C. B., V, Hoff, Ana O., Almeida, Madson Q., Violante, Alice H. D., Ouidute, Ana R. P., Zhang, Zhewei, Recasens, Monica, Robles Diaz, Luis, Kunavisarut, Tada, Wannachalee, Taweesak, Sirinvaravong, Sirinart, Jonasch, Eric, Grozinsky-Glasberg, Simona, Fraenkel, Merav, Beltsevich, Dmitry, Egorov, Viacheslav, I, Bausch, Dirk, Schott, Matthias, Tiling, Nikolaus, Pennelli, Gianmaria, Zschiedrich, Stefan, Daerr, Roland, Ruf, Juri, Denecke, Timm, Link, Karl-Heinrich, Zovato, Stefania, von Dobschuetz, Ernst, Yaremchuk, Svetlana, Amthauer, Holger, Makay, Ozer, Patocs, Attila, Walz, Martin K., Huber, Tobias B., Seufert, Jochen, Hellman, Per, Ekaterina, Raymond H., Kuchinskaya, Ekaterina, Schiavi, Francesca, Malinoc, Angelica, Reisch, Nicole, Jarzab, Barbara, Barontini, Marta, Januszewicz, Andrzej, Shah, Nalini, Young, William F., Jr., Opocher, Giuseppe, Eng, Charis, Neumann, Hartmut P. H., and Bausch, Birke

Abstract

Pancreatic neuroendocrine tumors (PanNETs) are rare in von Hippel-Lindau disease (VHL) but cause serious morbidity and mortality. Management guidelines for VHL-PanNETs continue to be based on limited evidence, and survival data to guide surgical management are lacking. We established the European-American-Asian-VHL-PanNET-Registry to assess data for risks for metastases, survival and long-term outcomes to provide best management recommendations. Of 2330 VHL patients, 273 had a total of 484 PanNETs. Median age at diagnosis of PanNET was 35 years (range 10-75). Fifty-five (20%) patients had metastatic PanNETs. Metastatic PanNETs were significantly larger (median size 5 vs 2 cm; P < 0.001) and tumor volume doubling time (TVDT) was faster (22 vs 126 months; P = 0.001). All metastatic tumors were >= 2.8 cm. Codons 161 and 167 were hotspots for VHL germline mutations with enhanced risk for metastatic PanNETs. Multivariate prediction modeling disclosed maximum tumor diameter and TVDT as significant predictors for metastatic disease (positive and negative predictive values of 51% and 100% for diameter cut-off >= 2.8 cm, 44% and 91% for TVDT cut-off of <= 24 months). In 117 of 273 patients, PanNETs > 1.5 cm in diameter were operated. Ten-year survival was significantly longer in operated vs non-operated patients, in particular for PanNETs < 2.8 cm vs >= 2.8 cm (94% vs 85% by 10 years; P = 0.020; 80% vs 50% at 10 years; P = 0.030). This study demonstrates that patients with PanNET approaching the cut-off diameter of 2.8 cm should be operated. Mutations in exon 3, especially of codons 161/167 are at enhanced risk for metastatic PanNETs. Survival is significantly longer in operated non-metastatic VHL-PanNETs.

Published
2018
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21. The Clinical Impact of [68Ga]‐DOTATATE PET/CT for the Diagnosis and Management of Ectopic Adrenocorticotropic Hormone – Secreting Tumours.

Author

Wannachalee, Taweesak, Turcu, Adina F., Bancos, Irina, Habra, Mouhammed Amir, Avram, Anca M., Chuang, Hubert H., Waguespack, Steven G., and Auchus, Richard J.

Subjects
*ADRENOCORTICOTROPIC hormone, *ECTOPIC hormones, *THYMUS tumors, *PANCREATIC tumors, *TUMORS, *CUSHING'S syndrome, *ADRENAL glands
Abstract

Objectives: Localization of ectopic ACTH‐secreting tumours causing Cushing syndrome (ECS) is essential for clinical management, yet often difficult. [68Ga]‐DOTATATE PET/CT ([68Ga]‐DOTA‐(Tyr3)‐octreotate)] is an FDA‐approved high‐resolution diagnostic tool for imaging neuroendocrine tumours. Data on the clinical utility of [68Ga]‐DOTATATE in patients with ECS, however, are scarce. The objectives of this study were to determine the efficacy for ECS localization and the clinical benefit of [68Ga]‐DOTATATE imaging. Method: We conducted a retrospective review of all cases with ECS evaluated with [68Ga]‐DOTATATE from November 2016 through October 2018 at three referral centres. The clinical benefit of [68Ga]‐DOTATATE was based on detection of new tumours and resultant changes in management. Results: Over the study period, 28 patients with ECS underwent [68Ga]‐DOTATATE: 17 for identification of the primary tumour and 11 during follow‐up. [68Ga]‐DOTATATE identified the suspected primary ECS in 11/17 patients (65%). Of these, nine patients underwent surgery: eight with confirmed ECS (5 bronchial, 1 thymic, 1 pancreatic and 1 metastatic neuroendocrine tumour of unknown primary origin) and one patient with a false‐positive scan (adrenal gland). Of the 11 patients with ECS who underwent [68Ga]‐DOTATATE evaluation during follow‐up, the study led to changes in clinical management in 7/11 (64%) patients. Conclusions: [68Ga]‐DOTATATE is sensitive in detecting primary and metastatic ECS, often identifies occult tumours after conventional imaging, and impacts clinical care in the majority of patients. [ABSTRACT FROM AUTHOR]

Published
2019
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22. Adrenal Vein Sampling Lateralization Despite Mineralocorticoid Receptor Antagonists Exposure in Primary Aldosteronism.

Author

Nanba, Aya T, Wannachalee, Taweesak, Shields, James J, Byrd, James B, Rainey, William E, Auchus, Richard J, and Turcu, Adina F

Abstract

Many antihypertensive medications modulate the renin-angiotensin-aldosterone system, possibly skewing the diagnosis and subtyping of primary aldosteronism (PA). Particularly, mineralocorticoid receptor antagonists (MRA) might raise renin and stimulate aldosterone synthesis from nonautonomous areas, potentially obscuring lateralization on adrenal vein sampling (AVS). Withdrawal of MRA in severe PA, however, can precipitate hypokalemia and/or hypertension and therefore is not always practical.

Published
2019
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23. Prevalence, Risk Factors, and Type of Organism in Fungal Foot Infection and Toenail Onychomycosis in Thai Diabetic Patients.

Author

Assadamongkol R, Lertwattanarak R, Wannachalee, Bunyaratavej S, Leeyaphan C, and Matthapan L

Subjects
Aged, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Prevalence, Risk Factors, Thailand epidemiology, Diabetes Complications epidemiology, Onychomycosis complications, Onychomycosis epidemiology
Abstract

Background: Diabetes mellitus (DM) is a known and important predisposing factor for toenail onychomycosis and fungal foot infection. DM also increases the risk of patient developing secondary bacterial infection if fungal infection goes unrecognized and untreated., Objective: To assess the prevalence and risk factors of toenail onychomycosis and fungal foot infection in Thai diabetic patients., Material and Method: This single center cross-sectional observational study recruited type 1 and type 2 diabetic patients older than 18 years who attended Siriraj Hospital between October 1, 2012 and November 30, 2013. Patient demographic data, clinical data, and medical history were collected by questionnaire and assessed. Diagnosis of fungal infection was confirmed by potassium hydroxide investigation and fungal culture was performed to identify the type of organism., Results: One hundred forty four diabetes outpatients were enrolled and 38.9% were men. The mean (±SD) age was 59.6±12.7 years. Fungal infection was diagnosed 46 cases (31.9%). There were 28 cases (61%) with only toenail onychomycosis, two cases (4%) with only fungal foot infection, and 16 cases (35%) with co-infection (fungal foot infection and toenail onychomychosis). The organisms identified as causing fungal foot infection and toenail onychomycosis were dermatophytes (44.4% and 34.1%, respectively), non-dermatophytes (44.5% and 47.7%, respectively), and Candida species (5.6% and 4.5%, respectively). Risk factors found to be significantly correlated with toenail onychomycosis and fungal foot infection were male gender (p = 0.001), age older than 60 years (p = 0.006), agriculture-related activities (p = 0.006), family history of dermatophytosis (p = 0.034), and co-morbidity coronary heart disease (p = 0.044). No significant association was found for BMI, duration of DM, HbA1c, and diabetes related complications., Conclusion: Prevalence of fungal foot and toenail infection in Thai diabetes patient was 31.9%. We found higher prevalence of non-dermatophyte organisms as the cause of dermatomycosis and toenail onychomycosis. Accordingly, clinical diagnosis without proper culture identification may result in treatment failure.

Published
2016

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