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3. The effect of siderosis and ascorbic acid depletion on bone metabolism, with special reference to osteoporosis in the Bantu.

Author

Wapnick AA, Lynch SR, Seftel HC, Charlton RW, Bothwell TH, and Jowsey J

Subjects
Adult, Black or African American, Age Factors, Animals, Ascorbic Acid analysis, Black People, Bone Resorption, Bone and Bones analysis, Humans, Iron analysis, Liver analysis, Male, Middle Aged, Minerals analysis, Osteoporosis pathology, South Africa, Ascorbic Acid Deficiency complications, Bone and Bones metabolism, Osteoporosis etiology, Siderosis complications
Published
1971
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4. The role of ascorbic acid in the metabolism of storage iron.

Author

Lipschitz DA, Bothwell TH, Seftel HC, Wapnick AA, and Charlton RW

Subjects
Animals, Ascorbic Acid Deficiency metabolism, Erythrocytes metabolism, Ferritins, Guinea Pigs, Iron analysis, Iron Isotopes, Liver analysis, Male, Protein Binding, Spleen analysis, Spleen metabolism, Transferrin, Ascorbic Acid metabolism, Iron metabolism
Published
1971
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5. Some aspects of calcium metabolism in normal and osteoporotic Bantu subjects with special reference to the effects of iron overload and ascorbic acid depletion.

Author

Lynch SR, Seftel HC, Wapnick AA, Charlton RW, and Bothwell TH

Subjects
Adult, Alcohol Drinking, Animals, Ascorbic Acid Deficiency complications, Black People, Calcium analysis, Calcium Chloride metabolism, Calcium Isotopes, Calcium Metabolism Disorders complications, Female, Guinea Pigs, Humans, Intestinal Absorption, Male, Middle Aged, Osteoporosis etiology, Rats, South Africa, Sweat analysis, Black or African American, Ascorbic Acid Deficiency metabolism, Calcium metabolism, Osteoporosis metabolism, Siderosis metabolism
Published
1970

6. Effects of iron overload on ascorbic acid metabolism.

Author

Wapnick AA, Lynch SR, Krawitz P, Seftel HC, Charlton RW, and Bothwell TH

Subjects
Adolescent, Adult, Ascorbic Acid blood, Ascorbic Acid urine, Blood Platelets analysis, Blood Transfusion, Child, Diet, Humans, Leukocytes analysis, Middle Aged, Oxalates urine, Thalassemia metabolism, Ascorbic Acid metabolism, Hemochromatosis metabolism, Iron metabolism, Siderosis metabolism
Abstract

Studies of the ascorbic acid status in two subjects with idiopathic haemochromatosis and in 12 with transfusional siderosis showed that all had decreased levels of white cell ascorbic acid. The urinary excretion of ascorbic acid was also diminished in those subjects in whom such measurements were made. The administration of ascorbic acid was followed by only a small rise in the urinary ascorbic acid output, while the oxalic acid levels (measured in two subjects) showed a significant rise. These findings resemble those described in siderotic Bantu, and support the thesis that increased iron stores lead to irreversible oxidation of some of the available ascorbic acid.

Published
1968
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