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1. POS1428 GIANT CELL ARTERITIS SIGNS AND SYMPTOMS LEXICON: AN INTERNATIONAL EXPERT CONSENSUS

Author

Soowamber, M., primary, Bond, M., additional, Touma, Z., additional, Ramiro, S., additional, Langford, C., additional, Sanchez-Alvarez, C., additional, Abril, A., additional, Aydin, S., additional, Buttgereit, F., additional, Camellino, D., additional, Cid, M. C., additional, Grayson, P., additional, Hellmich, B., additional, Kermani, T., additional, Khalidi, N., additional, Lichliter, W., additional, Mackie, S., additional, Matteson, E., additional, Maz, M., additional, Merkel, P. A., additional, Monach, P. A., additional, Neill, L., additional, Ponte, C., additional, Salvarani, C., additional, Schmidt, W. A., additional, Villiger, P., additional, Warrington, K. J., additional, Whitlock, M., additional, and Dejaco, C., additional

Published
2024
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3. The provisional OMERACT ultrasonography score for giant cell arteritis

Author

Dejaco, C, Ponte, C, Monti, S, Rozza, D, Scire, C, Terslev, L, Bruyn, G, Boumans, D, Hartung, W, Hocevar, A, Milchert, M, Dohn, U, Mukhtyar, C, Aschwanden, M, Bosch, P, Camellino, D, Chrysidis, S, Ciancio, G, D'Agostino, M, Daikeler, T, Dasgupta, B, De Miguel, E, Diamantopoulos, A, Duftner, C, Agueda, A, Fredberg, U, Hanova, P, Hansen, I, Hauge, E, Iagnocco, A, Inanc, N, Juche, A, Karalilova, R, Kawamoto, T, Keller, K, Keen, H, Kermani, T, Kohler, M, Koster, M, Luqmani, R, Macchioni, P, Mackie, S, Naredo, E, Nielsen, B, Ogasawara, M, Pineda, C, Schafer, V, Seitz, L, Tomelleri, A, Torralba, K, Van Der Geest, K, Warrington, K, Schmidt, W, Dejaco C., Ponte C., Monti S., Rozza D., Scire C. A., Terslev L., Bruyn G. A. W., Boumans D., Hartung W., Hocevar A., Milchert M., Dohn U. Mo., Mukhtyar C. B., Aschwanden M., Bosch P., Camellino D., Chrysidis S., Ciancio G., D'Agostino M. A., Daikeler T., Dasgupta B., De Miguel E., Diamantopoulos A. P., Duftner C., Agueda A., Fredberg U., Hanova P., Hansen I. To., Hauge E. -M., Iagnocco A., Inanc N., Juche A., Karalilova R., Kawamoto T., Keller K. K., Keen H. I., Kermani T. A., Kohler M. J., Koster M., Luqmani R. A., Macchioni P., Mackie S. L., Naredo E., Nielsen B. D., Ogasawara M., Pineda C., Schafer V. S., Seitz L., Tomelleri A., Torralba K. D., Van Der Geest K. S. M., Warrington K. J., Schmidt W. A., Dejaco, C, Ponte, C, Monti, S, Rozza, D, Scire, C, Terslev, L, Bruyn, G, Boumans, D, Hartung, W, Hocevar, A, Milchert, M, Dohn, U, Mukhtyar, C, Aschwanden, M, Bosch, P, Camellino, D, Chrysidis, S, Ciancio, G, D'Agostino, M, Daikeler, T, Dasgupta, B, De Miguel, E, Diamantopoulos, A, Duftner, C, Agueda, A, Fredberg, U, Hanova, P, Hansen, I, Hauge, E, Iagnocco, A, Inanc, N, Juche, A, Karalilova, R, Kawamoto, T, Keller, K, Keen, H, Kermani, T, Kohler, M, Koster, M, Luqmani, R, Macchioni, P, Mackie, S, Naredo, E, Nielsen, B, Ogasawara, M, Pineda, C, Schafer, V, Seitz, L, Tomelleri, A, Torralba, K, Van Der Geest, K, Warrington, K, Schmidt, W, Dejaco C., Ponte C., Monti S., Rozza D., Scire C. A., Terslev L., Bruyn G. A. W., Boumans D., Hartung W., Hocevar A., Milchert M., Dohn U. Mo., Mukhtyar C. B., Aschwanden M., Bosch P., Camellino D., Chrysidis S., Ciancio G., D'Agostino M. A., Daikeler T., Dasgupta B., De Miguel E., Diamantopoulos A. P., Duftner C., Agueda A., Fredberg U., Hanova P., Hansen I. To., Hauge E. -M., Iagnocco A., Inanc N., Juche A., Karalilova R., Kawamoto T., Keller K. K., Keen H. I., Kermani T. A., Kohler M. J., Koster M., Luqmani R. A., Macchioni P., Mackie S. L., Naredo E., Nielsen B. D., Ogasawara M., Pineda C., Schafer V. S., Seitz L., Tomelleri A., Torralba K. D., Van Der Geest K. S. M., Warrington K. J., and Schmidt W. A.

Abstract

Objectives To develop an Outcome Measures in Rheumatology (OMERACT) ultrasonography score for monitoring disease activity in giant cell arteritis (GCA) and evaluate its metric properties. Methods The OMERACT Instrument Selection Algorithm was followed. Forty-nine members of the OMERACT ultrasonography large vessel vasculitis working group were invited to seven Delphi rounds. An online reliability exercise was conducted using images of bilateral common temporal arteries, parietal and frontal branches as well as axillary arteries from 16 patients with GCA and 7 controls. Sensitivity to change and convergent construct validity were tested using data from a prospective cohort of patients with new GCA in which ultrasound-based intima-media thickness (IMT) measurements were conducted at weeks 1, 3, 6, 12 and 24. Results Agreement was obtained (92.7%) for the OMERACT GCA Ultrasonography Score (OGUS), calculated as follows: sum of IMT measured in every segment divided by the rounded cut-off values of IMTs in each segment. The resulting value is then divided by the number of segments available. Thirty-five members conducted the reliability exercise, the interrater intraclass correlation coefficient (ICC) for the OGUS was 0.72-0.84 and the median intrareader ICC was 0.91. The prospective cohort consisted of 52 patients. Sensitivity to change between baseline and each follow-up visit up to week 24 yielded standardised mean differences from -1.19 to -2.16, corresponding to large and very large magnitudes of change, respectively. OGUS correlated moderately with erythrocyte sedimentation rate, C reactive protein and Birmingham Vasculitis Activity Score (corr coeff 0.37-0.48). Conclusion We developed a provisional OGUS for potential use in clinical trials.

Published
2023

8. Association between age at disease onset of anti-neutrophil cytoplasmic antibody-associated vasculitis and clinical presentation and short-term outcomes

Author

Monti, S., Craven, A., Klersy, C., Montecucco, C., Caporali, R., Watts, R., Merkel, P. A., Luqmani, R., Achilleos, K., Adler, M., Alba, M. A., Albert, D. A., Alibaz-Oner, F., Allcoat, P., Amano, K., Amarasuriya, M., Amudala, N. A., Andrews, J., Archer, A. M., Arimura, Y., Atukorala, I., Azevedo, E., Bajad, S., Baldwin, C., Barra, L. J., Baslund, B., Basu, N., Baykal, M., Berger, C., Berglin, E., Besada, E., Bhardwaj, M., Bischof, A., Blockmans, D., Blood, J., Draibe, J. B., Brand, S., Brandao, M., Bruce, I. N., Butler, A., Calabrese, L. H., Ferrer, D. C., Carette, S., Carmona, D., Ceunen, H., Chakravarty, K., Chapman, P. T., Chocova, Z., Chung, S. A., Ci, W., Cid, M. C., Clark, T. M., Clarkson, M. R., De Jesus Contreras-Rodriguez, F., Conway, R., Cooke, K., Viros, X. C., Cordeiro, A., Costa, A., Culfear, K., Daikeler, T., Danda, D., Das, S. K., Dasgupta, B., De Castro, A. M., Dehghan, N., Devassy, R., Dhindsa, N., Diamantopoulos, A. P., Direskeneli, H., Dobashi, H., Juan, D., Durrani, M., Edelsten, C., Eifert, J., Elhayek, S., Elsideeg, S., Endo, T., Erden, A., Erer, B., Eriksson, P., Erturk, Z., Espigol-Frigole, G., Felicetti, M., Ferraro, A., Ferro, J. M., Fifi-Mah, A., Flores-Suarez, L. F., Flossmann, O., Flynn, D., Fonseca, J. E., Foot, J., Foote, M., Forbess, L., Fujimoto, S., Fukuoka, K., Furtado, C., Furuta, S., Gaffo, A. L., Gallagher, P., Gao, N., Gatenby, P., Gendi, N., Geraldes, R., Gerits, A., Gioffredi, A., Gomples, L., Goncalves, M. J., Gondo, P., Graham, A., Grainger, R., Gray, D. T., Grayson, P. C., Griffiths, L., Guo, Y., Gupta, R., Gylling, M., Hajj-Ali, R. A., Hammam, N., Harigai, M., Hartley, L., Haslett, J., Hassan, A., Hatemi, G., Hellmich, B., Henckaerts, L., Henes, J. C., Hepburn, J., Herd, V., Hess, C., Hill, C., Hinojosa-Azaola, A., Hirahashi, J., Hirano, F., Hocevar, A., Holle, J., Hollinger, N., Homma, S., Howard, T., Hoyles, R. K., Hruskova, Z., Hutcheon, G., Ignacak, M., Igney-Oertel, A., Ikeda, K., Ikegaya, N., Jagadeesh, S., Jaquith, J., Jayne, D. R. W., Jewell, T., Jones, C., Joshi, A., Kalyoncu, U., Kamall, S., Kamath, S., Lai, K. S., Kaname, S., Kanchinadham, S., Karadag, O., Karube, M., Kaszuba, M., Kaur, R., Kawakami, T., Kawashima, S., Khalidi, N., Khan, A., Kikuchi, M., Kilic, L., Kimura, M., King, M. J., Klapa, S., Klocke, R., Kobayashi, T., Kobayashi, S., Komagata, Y., Kronbichler, A., Kuczia, P., Kumar, M. S., Kurosawa, M., Lamprecht, P., Langford, C. A., Lanyon, P., Laversuch, C., Lee, S. J., Leoni, S., Li, J., Liang, K., Liang, P., Liao, H., Lee, L. A., Luqmani, R. A., Lyle, A., Macdonald, M., Mackie, S. L., Madden, L., Magliano, M., Makino, H., Makol, A., Malaiya, R., Malaviya, A., Manthri, R., Maritati, F., Da Silva, A. M., Mason, J. C., Matara, C., Matsui, K., Matteson, E. L., Mcbride, D., Mccullough, K., Mcgeoch, L., Mclaren, J., Mcmillian, C., Mendiratta, N., Menon, A., Merinopoulos, D., Merkel, P., Messier, S., Micheletti, R. G., Mills, K., Milman, N., Minoda, M., Minz, R. W., Mock, C., Mohammad, A. J., Moiseev, S., Moitinho, M., Molloy, E., Monach, P. A., Montgomery, M., Moosig, F., Moradizadeh, M., Morgan, M., Morgan, A. W., Morgan, A. -M., Muir, A., Mukhtyar, C., Muller, A., Muratore, F., Muso, E., Nada, R., Nakajima, H., Nakajima, T., Nakano, H., Nandagudi, A., Neumann, T., Y. F., Ng, K. H., Ng, Nogueira, E. L., Nolkha, N., Nordstrom, D., Novikov, P., Nugaliyadde, A., O'Donnell, J. L., O'Donoghue, J., O'Neill, L., O'Riordan, E., Oatley, M., Okubo, K., Oliva, E., Oshikawa, H., Ota, Y., Padoan, R., Pagnoux, C., Pan, L., Panaritis, K., Park, J. K., Patel, S., Patil, P., Pazzola, G., Peall, A., Pearce, F., Pehlevan, S., Pereira, L., Pettersson, T., Pineau, C. A., Pirila, L., Poglodek, B., Ponte, C., Prieto-Gonzalez, S., Priya, S. R., Purewal, B., Purschke, S., Putaala, J., Quickert, S., Quincey, V., Raghuvanshi, S., Rajasekhar, L., Ranganathan, D., Rathi, M., Rees, D., Rees, F., Renken, U., Restuccia, G., Rhee, R. L., Rice, B., Robins, D., Robson, J., Rodrigues, M., Romao, V. C., Rotar, C., Ruediger, C., Rutgers, A., A. C., Sa, Saavedra, M. J., Sada, K. -E., Sahbudin, I., Salvarani, C., Sandhu, N., Santos, E., Sato, Y., Schafer, V. S., Schiavon, F., Schmidt, W. A., Segelmark, M., Shahin, A., Sharma, A., Shotton, J., Silva, C., Singer, O. G., Sivasuthan, G., Smolen, S., Solanich-Moreno, X., Boixader, L. S., Song, Y. W., Springer, J., Sreih, A. G., Srivastava, R., Stamp, L. K., Stevens, R., Strbian, D., Sugino, K., Sunderkotter, C., Suppiah, R., Suzuki, K., Szekanecz, Z., Sznajd, J., Taimen, K., Tak, P. P., Takeuchi, T., Takizawa, N., Tames, L., Tan, B. E., Tanaka, M., Tang, M. W., Tatlisumak, T., Tesar, V., Thomas, A., Tian, X., Tokunaga, K., Tombetti, E., Tomsic, M., Toz, B., Tsukamoto, T., Uchida, S., Unal, A. U., Urban, M. L., Usui, J., Vaglio, A., Venkatachalam, S., Vermaak, E., Viswanath, V., Wada, T., Wagh, S., Wallace, D. J., Walters, G., Walz, B., Wan, J., Wang, T., Wang, G., Warrington, K. J., Watts, R. A., Wawrzycka-Adamczyk, K., Weeratunga, P., Weisman, M. H., Wickramasinghe, S., Williams, M., Wojcik, K., Woodruff, L., Xenitidis, T., Yamada, H., Yamagata, K., Yee, C. -S., Yoon, M., Yoshida, K., Yoshifuji, H., Ytterberg, S. R., Yumura, W., Zayed, H., Zeng, X., Zhao, M. -H., Zugaj, A., Zuk, J., İç Hastalıkları, Clinical Haematology, and Translational Immunology Groningen (TRIGR)

Subjects
Male, Outcome, Antineutrophil Cytoplasmic, 030232 urology & nephrology, 0302 clinical medicine, Risk Factors, 80 and over, Pharmacology (medical), Age of Onset, Young adult, Aged, 80 and over, education.field_of_study, age, anti-neutrophil cytoplasmic antibody-associated vasculitis, outcome, Adolescent, Adult, Aged, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Antibodies, Antineutrophil Cytoplasmic, Female, Humans, Middle Aged, Morbidity, Prognosis, Retrospective Studies, Risk Assessment, Survival Rate, United Kingdom, Young Adult, Vasculitis, Systemic vasculitis, medicine.medical_specialty, Population, anti-neutrophil cytoplasmic antibody–associated vasculitis, Antibodies, 03 medical and health sciences, Rheumatology, Internal medicine, medicine, education, Anti-neutrophil cytoplasmic antibody–associated vasculitis, Survival rate, Anti-neutrophil cytoplasmic antibody, 030203 arthritis & rheumatology, business.industry, Retrospective cohort study, medicine.disease, Age of onset, business
Abstract

Objectives ANCA-associated vasculitis (AAV) can affect all age groups. We aimed to show that differences in disease presentation and 6 month outcome between younger- and older-onset patients are still incompletely understood. Methods We included patients enrolled in the Diagnostic and Classification Criteria for Primary Systemic Vasculitis (DCVAS) study between October 2010 and January 2017 with a diagnosis of AAV. We divided the population according to age at diagnosis: Results A total of 1338 patients with AAV were included: 66% had disease onset at Conclusion Within 6 months of diagnosis of AAV, patients >65 years of age display a different pattern of organ involvement and an increased risk of significant damage and mortality compared with younger patients.

Published
2021

9. POS1377 LUNG INVOLVEMENT IN VEXAS SYNDROME

Author

Casal Moura, M., primary, Baqir, M., additional, Tandon, Y., additional, Samec, M., additional, Reichard, K., additional, Mangaonkar, A., additional, Go, R., additional, Warrington, K. J., additional, Patnaik, M., additional, Koster, M., additional, and Ryu, J. H., additional

Published
2022
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11. LB0006 SARILUMAB IN PATIENTS WITH RELAPSING POLYMYALGIA RHEUMATICA: A PHASE 3, MULTICENTER, RANDOMIZED, DOUBLE BLIND, PLACEBO CONTROLLED TRIAL (SAPHYR)

Author

Dasgupta, B., primary, Unizony, S., additional, Warrington, K. J., additional, Sloane Lazar, J., additional, Giannelou, A., additional, Nivens, C., additional, Akinlade, B., additional, Wong, W., additional, Lin, Y., additional, Buttgereit, F., additional, Devauchelle-Pensec, V., additional, Rubbert-Roth, A., additional, and Spiera, R., additional

Published
2022
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22. AB0370 UTILITY OF CRP AND ESR IN THE DIAGNOSIS OF GIANT CELL ARTERITIS RELAPSE IN A PHASE 2 TRIAL OF MAVRILIMUMAB

Author

Unizony, S., primary, Cid, M. C., additional, Brouwer, E., additional, Dagna, L., additional, Dasgupta, B., additional, Hellmich, B., additional, Molloy, E., additional, Salvarani, C., additional, Trapnell, B. C., additional, Warrington, K. J., additional, Wicks, I., additional, Samant, M., additional, Zhou, T., additional, Pupim, L., additional, and Paolini, J. F., additional

Published
2021
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23. Definitions and reliability assessment of elementary ultrasound lesions in giant cell arteritis: A study from the OMERACT large vessel vasculitis ultrasound working group

Author

Chrysidis, S, Duftner, C, Dejaco, C, Schafer, V, Ramiro, S, Carrara, G, Scire, C, Hocevar, A, Diamantopoulos, A, Iagnocco, A, Mukhtyar, C, Ponte, C, Naredo, E, De Miguel, E, Bruyn, G, Warrington, K, Terslev, L, Milchert, M, D'Agostino, M, Koster, M, Rastalsky, N, Hanova, P, Macchioni, P, Kermani, T, Lorenzen, T, Dohn, U, Fredberg, U, Hartung, W, Dasgupta, B, Schmidt, W, Chrysidis S., Duftner C., Dejaco C., Schafer V. S., Ramiro S., Carrara G., Scire C. A., Hocevar A., Diamantopoulos A. P., Iagnocco A., Mukhtyar C., Ponte C., Naredo E., De Miguel E., Bruyn G. A., Warrington K. J., Terslev L., Milchert M., D'Agostino M. A., Koster M. J., Rastalsky N., Hanova P., Macchioni P., Kermani T. A., Lorenzen T., Dohn U. Mo., Fredberg U., Hartung W., Dasgupta B., Schmidt W. A., Chrysidis, S, Duftner, C, Dejaco, C, Schafer, V, Ramiro, S, Carrara, G, Scire, C, Hocevar, A, Diamantopoulos, A, Iagnocco, A, Mukhtyar, C, Ponte, C, Naredo, E, De Miguel, E, Bruyn, G, Warrington, K, Terslev, L, Milchert, M, D'Agostino, M, Koster, M, Rastalsky, N, Hanova, P, Macchioni, P, Kermani, T, Lorenzen, T, Dohn, U, Fredberg, U, Hartung, W, Dasgupta, B, Schmidt, W, Chrysidis S., Duftner C., Dejaco C., Schafer V. S., Ramiro S., Carrara G., Scire C. A., Hocevar A., Diamantopoulos A. P., Iagnocco A., Mukhtyar C., Ponte C., Naredo E., De Miguel E., Bruyn G. A., Warrington K. J., Terslev L., Milchert M., D'Agostino M. A., Koster M. J., Rastalsky N., Hanova P., Macchioni P., Kermani T. A., Lorenzen T., Dohn U. Mo., Fredberg U., Hartung W., Dasgupta B., and Schmidt W. A.

Abstract

Objectives To define the elementary ultrasound (US) lesions in giant cell arteritis (GCA) and to evaluate the reliability of the assessment of US lesions according to these definitions in a web-based reliability exercise. Methods Potential definitions of normal and abnormal US findings of temporal and extracranial large arteries were retrieved by a systematic literature review. As a subsequent step, a structured Delphi exercise was conducted involving an expert panel of the Outcome Measures in Rheumatology (OMERACT) US Large Vessel Vasculitis Group to agree definitions of normal US appearance and key elementary US lesions of vasculitis of temporal and extracranial large arteries. The reliability of these definitions on normal and abnormal blood vessels was tested on 150 still images and videos in a web-based reliability exercise. Results Twenty-four experts participated in both Delphi rounds. From originally 25 statements, nine definitions were obtained for normal appearance, vasculitis and arteriosclerosis of cranial and extracranial vessels. The 'halo' and 'compression' signs were the key US lesions in GCA. The reliability of the definitions for normal temporal and axillary arteries, the 'halo' sign and the 'compression' sign was excellent with inter-rater agreements of 91-99% and mean kappa values of 0.83-0.98 for both inter-rater and intra-rater reliabilities of all 25 experts. Conclusions The 'halo' and the 'compression' signs are regarded as the most important US abnormalities for GCA. The inter-rater and intra-rater agreement of the new OMERACT definitions for US lesions in GCA was excellent.

Published
2018

24. Assessing vasculitis in giant cell arteritis by ultrasound: Results of OMERACT patient-based reliability exercises

Author

Schafer, V, Chrysidis, S, Dejaco, C, Duftner, C, Iagnocco, A, Bruyn, G, Carrara, G, D'Agostino, M, De Miguel, E, Diamantopoulos, A, Fredberg, U, Hartung, W, Hocevar, A, Juche, A, Kermani, T, Koster, M, Lorenzen, T, Macchioni, P, Milchert, M, Dohn, U, Mukhtyar, C, Ponte, C, Ramiro, S, Scire, C, Terslev, L, Warrington, K, Dasgupta, B, Schmidt, W, Schafer V. S., Chrysidis S., Dejaco C., Duftner C., Iagnocco A., Bruyn G. A., Carrara G., D'Agostino M. A., De Miguel E., Diamantopoulos A. P., Fredberg U., Hartung W., Hocevar A., Juche A., Kermani T. A., Koster M. J., Lorenzen T., Macchioni P., Milchert M., Dohn U. M., Mukhtyar C., Ponte C., Ramiro S., Scire C. A., Terslev L., Warrington K. J., Dasgupta B., Schmidt W. A., Schafer, V, Chrysidis, S, Dejaco, C, Duftner, C, Iagnocco, A, Bruyn, G, Carrara, G, D'Agostino, M, De Miguel, E, Diamantopoulos, A, Fredberg, U, Hartung, W, Hocevar, A, Juche, A, Kermani, T, Koster, M, Lorenzen, T, Macchioni, P, Milchert, M, Dohn, U, Mukhtyar, C, Ponte, C, Ramiro, S, Scire, C, Terslev, L, Warrington, K, Dasgupta, B, Schmidt, W, Schafer V. S., Chrysidis S., Dejaco C., Duftner C., Iagnocco A., Bruyn G. A., Carrara G., D'Agostino M. A., De Miguel E., Diamantopoulos A. P., Fredberg U., Hartung W., Hocevar A., Juche A., Kermani T. A., Koster M. J., Lorenzen T., Macchioni P., Milchert M., Dohn U. M., Mukhtyar C., Ponte C., Ramiro S., Scire C. A., Terslev L., Warrington K. J., Dasgupta B., and Schmidt W. A.

Abstract

Objective: To test the reliability of Outcome Measures in Rheumatology Clinical Trials (OMERACT) consensus-based ultrasound definitions for normal and vasculitic temporal and axillary arteries in patients with giant cell arteritis (GCA) and in controls. Methods: A preliminary 1-day meeting and a full 3-day meeting fulfilling OMERACT Ultrasound Group guidelines were held. Temporal and axillary arteries were examined at 2 timepoints by 12 sonographers on 4 patients with GCA and 2 controls. The aim was to test inter- and intrareader reliability for normal findings, halo sign, and compression sign. In both meetings, patients had established GCA. Pathology was more recent in the full meeting, which was preceded by 6 h of training. Scanning time was 15-20 min instead of 10-13 min. Results: In the preliminary exercise, interreader reliabilities were fair to moderate for the overall diagnosis of GCA (Light k 0.29-0.51), and poor to fair for identifying vasculitis in the respective anatomical segments (Light k 0.02-0.46). Intrareader reliabilities were moderate (Cohen k 0.32-0.64). In the main exercise, interreader reliability was good to excellent (Light k 0.76-0.86) for the overall diagnosis of GCA, and moderate to good (Light k 0.46-0.71) for identifying vasculitis in the respective anatomical segments. Intrareader reliability was excellent for diagnosis of GCA (Cohen k 0.91) and good (Cohen k 0.71-0.80) for the anatomical segments. Conclusion: OMERACT-derived definitions of halo and compression signs of temporal and axillary arteries are reliable in recent-onset GCA if experienced sonographers (> 300 examinations) have 15-20 min for a standardized examination with prior training and apply > 15 MHz probes.

Published
2018

25. THU0318 PATTERNS OF CLINICAL PRESENTATION IN TAKAYASU’S ARTERITIS

Author

Quinn, K. A., primary, Gribbons, K. B., additional, Carette, S., additional, Cuthbertson, D., additional, Khalidi, N., additional, Koening, C., additional, Langford, C., additional, Mcalear, C., additional, Monach, P., additional, Moreland, L., additional, Pagnoux, C., additional, Seo, P., additional, Sreih, A., additional, Warrington, K. J., additional, Ytterberg, S. R., additional, Novakovich, E., additional, Merkel, P. A., additional, and Grayson, P., additional

Published
2020
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28. Facteurs prédictifs de rechute au cours de l’artérite à cellules géantes : données d’une étude rétrospective collaborative internationale

Author

Delaval, L., primary, Porcher, R., additional, Warrington, K., additional, Muratore, F., additional, Crowson, C., additional, Blockmans, D., additional, Agard, C., additional, Guillevin, L., additional, Alexis, R., additional, Samson, M., additional, Salvarani, C., additional, and Terrier, B., additional

Published
2019
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31. Definitions and reliability assessment of elementary ultrasound lesions in giant cell arteritis: A study from the OMERACT large vessel vasculitis ultrasound working group

Author

Chrysidis, S., Duftner, C., Dejaco, C., Schafer, V. S., Ramiro, S., Carrara, G., Scire, C. A., Hocevar, A., Diamantopoulos, A. P., Iagnocco, A., Mukhtyar, C., Ponte, C., Naredo, E., De Miguel, E., Bruyn, G. A., Warrington, K. J., Terslev, L., Milchert, M., D'Agostino, Maria Antonietta, Koster, M. J., Rastalsky, N., Hanova, P., Macchioni, P., Kermani, T. A., Lorenzen, T., Dohn, U. Mo., Fredberg, U., Hartung, W., Dasgupta, B., Schmidt, W. A., D'Agostino M. A. (ORCID:0000-0002-5347-0060), Chrysidis, S., Duftner, C., Dejaco, C., Schafer, V. S., Ramiro, S., Carrara, G., Scire, C. A., Hocevar, A., Diamantopoulos, A. P., Iagnocco, A., Mukhtyar, C., Ponte, C., Naredo, E., De Miguel, E., Bruyn, G. A., Warrington, K. J., Terslev, L., Milchert, M., D'Agostino, Maria Antonietta, Koster, M. J., Rastalsky, N., Hanova, P., Macchioni, P., Kermani, T. A., Lorenzen, T., Dohn, U. Mo., Fredberg, U., Hartung, W., Dasgupta, B., Schmidt, W. A., and D'Agostino M. A. (ORCID:0000-0002-5347-0060)

Abstract

Objectives To define the elementary ultrasound (US) lesions in giant cell arteritis (GCA) and to evaluate the reliability of the assessment of US lesions according to these definitions in a web-based reliability exercise. Methods Potential definitions of normal and abnormal US findings of temporal and extracranial large arteries were retrieved by a systematic literature review. As a subsequent step, a structured Delphi exercise was conducted involving an expert panel of the Outcome Measures in Rheumatology (OMERACT) US Large Vessel Vasculitis Group to agree definitions of normal US appearance and key elementary US lesions of vasculitis of temporal and extracranial large arteries. The reliability of these definitions on normal and abnormal blood vessels was tested on 150 still images and videos in a web-based reliability exercise. Results Twenty-four experts participated in both Delphi rounds. From originally 25 statements, nine definitions were obtained for normal appearance, vasculitis and arteriosclerosis of cranial and extracranial vessels. The 'halo' and 'compression' signs were the key US lesions in GCA. The reliability of the definitions for normal temporal and axillary arteries, the 'halo' sign and the 'compression' sign was excellent with inter-rater agreements of 91-99% and mean kappa values of 0.83-0.98 for both inter-rater and intra-rater reliabilities of all 25 experts. Conclusions The 'halo' and the 'compression' signs are regarded as the most important US abnormalities for GCA. The inter-rater and intra-rater agreement of the new OMERACT definitions for US lesions in GCA was excellent.

Published
2018

32. Assessing vasculitis in giant cell arteritis by ultrasound: Results of OMERACT patient-based reliability exercises

Author

Schafer, V. S., Chrysidis, S., Dejaco, C., Duftner, C., Iagnocco, A., Bruyn, G. A., Carrara, G., D'Agostino, Maria Antonietta, De Miguel, E., Diamantopoulos, A. P., Fredberg, U., Hartung, W., Hocevar, A., Juche, A., Kermani, T. A., Koster, M. J., Lorenzen, T., Macchioni, P., Milchert, M., Dohn, U. M., Mukhtyar, C., Ponte, C., Ramiro, S., Scire, C. A., Terslev, L., Warrington, K. J., Dasgupta, B., Schmidt, W. A., D'Agostino M. A. (ORCID:0000-0002-5347-0060), Schafer, V. S., Chrysidis, S., Dejaco, C., Duftner, C., Iagnocco, A., Bruyn, G. A., Carrara, G., D'Agostino, Maria Antonietta, De Miguel, E., Diamantopoulos, A. P., Fredberg, U., Hartung, W., Hocevar, A., Juche, A., Kermani, T. A., Koster, M. J., Lorenzen, T., Macchioni, P., Milchert, M., Dohn, U. M., Mukhtyar, C., Ponte, C., Ramiro, S., Scire, C. A., Terslev, L., Warrington, K. J., Dasgupta, B., Schmidt, W. A., and D'Agostino M. A. (ORCID:0000-0002-5347-0060)

Abstract

Objective: To test the reliability of Outcome Measures in Rheumatology Clinical Trials (OMERACT) consensus-based ultrasound definitions for normal and vasculitic temporal and axillary arteries in patients with giant cell arteritis (GCA) and in controls. Methods: A preliminary 1-day meeting and a full 3-day meeting fulfilling OMERACT Ultrasound Group guidelines were held. Temporal and axillary arteries were examined at 2 timepoints by 12 sonographers on 4 patients with GCA and 2 controls. The aim was to test inter- and intrareader reliability for normal findings, halo sign, and compression sign. In both meetings, patients had established GCA. Pathology was more recent in the full meeting, which was preceded by 6 h of training. Scanning time was 15-20 min instead of 10-13 min. Results: In the preliminary exercise, interreader reliabilities were fair to moderate for the overall diagnosis of GCA (Light k 0.29-0.51), and poor to fair for identifying vasculitis in the respective anatomical segments (Light k 0.02-0.46). Intrareader reliabilities were moderate (Cohen k 0.32-0.64). In the main exercise, interreader reliability was good to excellent (Light k 0.76-0.86) for the overall diagnosis of GCA, and moderate to good (Light k 0.46-0.71) for identifying vasculitis in the respective anatomical segments. Intrareader reliability was excellent for diagnosis of GCA (Cohen k 0.91) and good (Cohen k 0.71-0.80) for the anatomical segments. Conclusion: OMERACT-derived definitions of halo and compression signs of temporal and axillary arteries are reliable in recent-onset GCA if experienced sonographers (> 300 examinations) have 15-20 min for a standardized examination with prior training and apply > 15 MHz probes.

Published
2018

33. Assessment of disease activity in large-vessel vasculitis: Results of an international delphi exercise

Author

Aydin, S. Z., Direskeneli, H., Merkel, P. A., Toloza, S., Blockmans, D., Sato, E. I., De Souza, A. W. S., Cabral, D., Carette, S., Famorca, L., Khalidi, N., Milman, N., Yacyshyn, E., Tesar, V., Baslund, B., Faurschou, M., Guillevin, L., Puechal, X., Aries, P., Hellmich, B., Herlyn, K., Holle, J., Lamprecht, P., Moosig, F., Neumann, T., Zwerina, J., Tomasson, G., Bambery, P., Jois, R., Rajasekhar, L., Sharma, A., Sivakumar, R., Molloy, E., Hashkes, P., Catapano, F., Cimino, L., De Fanti, A., Pipitone, N., Salvarani, C., Vaglio, A., Kobayashi, S., Suzuki, K., Flores-Suarez, L. F., Hinojosa-Azaola, A., Brouwer, E., Rutgers, A., Stegeman, C., Suppiah, R., Hollan, I., Arguis, P., Cid, M. C., Daikeler, T., Alibaz-Oner, F., Hamuryudan, V., Hatemi, G., Hazirolan, T., Inanc, M., Kalayci, M. B., Kamali, S., Kansu, T., Karaaslan, Y., Karadag, O., Keser, G., Onat, A. M., Ozbalkan, Z., Ozen, S., Ozer, H. T. E., Pamuk, O. N., Yilmaz, S. G., Basu, N., Casian, A., Chakravarty, K., D'Cruz, D., Edelsten, C., Harper, L., Jayne, D., Levy, J., Mason, J., Robson, J., Scott, D., Stanford, M., Watts, R., Albert, D., Amudala, N., Beckman, J., Chacko, B., Chung, S., Fessler, B., Giardino, A., Grayson, P., Hunder, G., Langford, C., Lerman, M., Liang, K., Litt, H., Mason, T., Matteson, E., Mikdashi, J., Mohler, E., Monach, P., Rice, B., Sreih, A., Stone, J., Tsapatsaris, N., Villa-Forte, A., Warrington, K., Yazici, Y., Ytterberg, S., Çukurova Üniversitesi, Aydin, S.Z., Direskeneli, H., Merkel, P.A., Toloza, S., Blockmans, D., Sato, E.I., De Souza, A.W.S., and Yeditepe Üniversitesi

Subjects
Vasculitis, medicine.medical_specialty, Delphi Technique, Immunology, Delphi method, Outcomes, Severity of Illness Index, Article, Disease activity, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Large vessel vasculitis, Severity of illness, medicine, Large vessel, Humans, Immunology and Allergy, 030212 general & internal medicine, computer.programming_language, Giant cell arteritis, 030203 arthritis & rheumatology, Takayasu arteritis, business.industry, medicine.disease, Clinical trial, Physical therapy, business, computer, Delphi
Abstract

PubMedID: 28864648 Objective. To arrive at consensus for candidate outcomes for disease activity assessment in largevessel vasculitis (LVV) in clinical trials. Methods.A Delphi survey including 99 items was circulated among international experts for 3 rounds. Results. Fifty-seven items were accepted for both giant cell arteritis and Takayasu arteritis. Sixty-seven percent of experts voted to have a common approach for both diseases with additional disease-specific items such as weight loss, scalp tenderness/necrosis, morning stiffness, dizziness, visual symptoms, and imaging. Conclusion. This study highlights similarities and differences in experts' perspectives for assessing clinical activity in LVV and may guide a consensus-driven core set of validated outcomes. Copyright © 2017. All rights reserved. National Institute of Arthritis and Musculoskeletal and Skin Diseases: U01 AR51874 04, U54 AR057319 National Center for Research Resources: U54 RR019497 Sponsored by the Vasculitis Clinical Research Consortium, which has received support from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54 AR057319 and U01 AR51874 04), the National Center for Research Resources (U54 RR019497), and the Office of Rare Diseases Research. Additional support for the work of the OMERACT Vasculitis Working Group was received through a Patient-Centered Outcomes Research Institute Pilot Project Grant. S.Z. Aydin, MD, Associate Professor, Division of Rheumatology, The Ottawa Hospital Research Institute, University of Ottawa; H. Direskeneli, MD, Professor of Rheumatology, Division of Rheumatology, Marmara University Faculty of Medicine; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology, and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania. Address correspondence to Dr. P.A. Merkel, Section of Rheumatology, University of Pennsylvania, White Building, 5th Floor Penn, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: pmerkel@upenn.edu Accepted for publication June 3, 2017.

Published
2017

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