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161 results on '"Warta, R."'

2. Combinatorial drug screening identifies synergistic interactions of Bcl-2 inhibitor Navitoclax with MELK inhibitor OTSSP167 and HDAC inhibitor Panobinostat for the treatment of aggressive meningiomas

Author

Cao, J, Jungwirth, G, Warta, R, Unterberg, AW, and Herold-Mende, C

Subjects
ddc: 610, Medicine and health
Abstract

Objective: Combinatorial targeted therapy has been suggested as a powerful approach to overcome drug resistance and also might lead to a dose reduction of the single drugs. Based on a previous drug screening in meningioma cell lines, we identified OTSSP167 (MELK inhibitor) and Panobinostat (HDAC inhibitor) [for full text, please go to the a.m. URL]

Published
2022
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3. Identification of synergistic drug combinations for therapy of IDH-mutated glioma

Author

Stammler, F, Warta, R, Herold-Mende, C, and Unterberg, AW

Subjects
ddc: 610, Medicine and health
Abstract

Objective: Isocitrate Dehydrogenase-mutated (IDHmut) and wildtype (IDHwt) gliomas are regarded as separate tumor entities with the need for accordingly adjusted therapies. IDHmut tumors have a better prognosis than the wildtype. Nevertheless they are still not curable since there is no effective drug [for full text, please go to the a.m. URL]

Published
2022
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4. Towards precision medicine – automated drug screening platform utilising Tumour-Organoids to identify patient-specific drug-responses

Author

Jungwirth, G, Paul, A, Cao, J, Warta, R, Abdollahi, A, Unterberg, AW, and Herold-Mende, C

Subjects
ddc: 610, Medicine and health
Abstract

Objective: Tumor-organoids (TO) are mini-tumors generated from tumor tissue preserving its genotype and phenotype by maintaining the cellular heterogeneity and important components of the tumor microenvironment. We recently developed a protocol to reliably establish TOs from meningioma (MGM) in large [for full text, please go to the a.m. URL]

Published
2022
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8. Large-scale drug screening of FDA-approved antineoplastic drugs identifies Ixabepilone for the treatment of aggressive meningiomas

Author

Jungwirth, G, Yu, T, Liu, F, Warta, R, Unterberg, AW, and Herold-Mende, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: The management of aggressive meningiomas remains challenging due to limited treatment options beside surgical removal and radiotherapy. High recurrence rates and lack of effective chemotherapies may be reasons for unfavorable prognosis of these patients. Consequently, there is an urgent need[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Published
2021
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9. Tumour-associated macrophages are independent prognostic markers in meningiomas

Author

Liu, F, Jungwirth, G, Warta, R, Herold-Mende, C, and Unterberg, AW

Subjects
ddc: 610, stomatognathic system, 610 Medical sciences, Medicine, skin and connective tissue diseases, hormones, hormone substitutes, and hormone antagonists
Abstract

Objective: Tumour-associated macrophages (TAMs) play an emerging role in tumour progression by creating an immunosuppressive tumour microenvironment. Therefore, we investigated TAM numbers and their activation (M1/2) in primary (p‑) and recurrent (r‑) meningiomas and evaluated their[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Published
2021
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10. Cancer-derived organoids as novel drug screening platform identifies panobinostat and OTSSP167 as highly potent drugs in meningioma

Author

Jungwirth, G, Cao, J, Yu, T, Warta, R, Unterberg, AW, and Herold-Mende, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Cancer-derived organoids (CDOs) are novel, complex three-dimensional ex vivo tissue cultures that accurately reflect genotype and phenotype of the original tumor with preserved cellular heterogeneity and structural architecture. They offer a new and exciting platform for studying cancer biology[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Published
2021
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13. Large-scale drug screen in patient-derived IDHmut glioma stem cells identifies several FDA-approved antineoplastic agents

Author

Dao Trong, P, Jungwirth, G, Yu, T, Pusch, S, Herold-Mende, C, Warta, R, and Unterberg, AW

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: The discovery of the Isocitrate Dehydrogenase (IDH) mutation in glioma has led to a paradigm shift on how we see glioma biology. While it is clear that IDH mutated (IDHmut) and wildtype (IDHwt) tumors have to be viewed as separate entities, the underlying biological differences are still [for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Published
2020
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14. High-throughput drug screening of FDA-approved antineoplastic drugs for the treatment of aggressive meningiomas

Author

Jungwirth, G, Yu, T, Liu, F, Warta, R, Herold-Mende, C, and Unterberg, AW

Subjects
ddc: 610, otorhinolaryngologic diseases, 610 Medical sciences, Medicine, neoplasms, nervous system diseases
Abstract

Objective: Treatment of aggressive meningiomas is still challenging for a couple of reasons, including high rate of recurrence of higher-grade meningiomas, impossible total resection and a lack of effective chemotherapies. To address this urgent need for more successful treatments of aggressive[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Published
2020
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15. Non-NF2 intraventricular meningiomas lack the common genetic alterations of TRAF7, AKT1, SMO, KLF4, PIK3CA and TERT

Author

Jungwirth, G, Warta, R, von Deimling, A, Sahm, F, Unterberg, A, Herold-Mende, C, and Jungk, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Intraventricular meningiomas (IVMs) are rare tumors which only account for 0.5–3% of all meningiomas (MGMs) and up to 14% of all intraventricular tumors. Although there is increasing knowledge about the clinical and molecular features of MGMs per se, little is known about[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Published
2019
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18. Expression and functional role of kinesin family members in meningioma

Author

Jungwirth, G, Warta, R, Simon, M, Lamszus, K, Unterberg, A, and Herold-Mende, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: The kinesin superfamily (KIF) members are highly conserved motor proteins, which are classified into 14 families. Kinesins play an important role in cellular functions including transport of vesicles and mitosis. Overexpression of the motor protein KIF11 can induce premature sister chromatid[for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)

Published
2017
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22. Optical absorption and fluorescence spectroscopy of stable diacetylene oligomer molecules.

Author

Warta, R. and Sixl, H.

Subjects
*FLUORESCENCE spectroscopy, *ACETYLENE compounds, *OLIGOMERS, *SOLID state physics
Abstract

The first fluorescence emission spectra of polydiacetylene oligomer molecules are presented. The spectral features of the low temperature absorption and emission spectra of monomer, dimer, trimer, tetramer, and polymer molecules are discussed. The preparation of the stable oligomer molecules via the reactive intermediates of the solid state polymerization is described. [ABSTRACT FROM AUTHOR]

Published
1988
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23. Transient absorption of polydiacetylene molecules.

Author

Sixl, H., Jost, R., and Warta, R.

Subjects
NUCLEAR excitation, ACETYLENE, ABSORPTION, CRYSTALS
Abstract

During excitation with ultraviolet light, polydiacetylene crystals show a photoinduced absorption which is ascribed to a triplet excited state of the individual polymer chains. We have measured this absorption using partially and fully polymerized TS and FBS single crystals. The results of stationary and time-resolved experiments are discussed. [ABSTRACT FROM AUTHOR]

Published
1987
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26. Identification of epigenetic prognosticators of adjuvant radiochemotherapy in HPV-negative squamous cell carcinomas of the head and neck (SCCHN) via genome-wide methylation analysis : A multicenter biomarker study of the German Cancer Consortium Radiation

Author

Debus, J., Schwager, C., Warta, R., Tawk, B., Hauswald, H., Wirkner, U., Lohaus, F., Linge, A., Tinhofer, I., Gkikac, E., Balermpas, P., Avlar, M., Bayer, C., Pigorsch, S., Moennich, D., Grosu, A. -. L., Zips, D., Krause, M., Combs, S. E., Roedel, C., Budach, V., Belka, C., Stuschke, Martin, Weichert, W., Baumann, M., Dyckhoff, G., Herold-Mende, C., Abdollahi, A., and DKTK-ROG

Subjects
Medizin
Published
2015

28. Comparative analysis of transcriptomics based hypoxia signatures in head- and neck squamous cell carcinoma.

Author

Tawk, B., Schwager, C., Deffaa, O., Dyckhoff, G., Warta, R., Linge, A., Krause, M., Weichert, W., Baumann, M., Herold-Mende, C., Debus, J., Abdollahi, A., Tawk, B., Schwager, C., Deffaa, O., Dyckhoff, G., Warta, R., Linge, A., Krause, M., Weichert, W., Baumann, M., Herold-Mende, C., Debus, J., and Abdollahi, A.

Abstract

BACKGROUND AND PURPOSE: Hypoxia renders tumors resistant to radiotherapy. However, the paucity of sensitive and reliable methods for detection of tumor hypoxia limits the translation of novel therapy strategies targeting this well-known resistance factor. We sought to investigate the ability of three previously discovered transcriptomics based hypoxia signatures to identify hypoxic tumors and consequently discriminate between patients with poor- vs. good prognosis. MATERIAL AND METHODS: Three different hypoxia gene signatures developed by Toustrup et al., Eustace et al. and Lendahl et al. were evaluated in an independent cohort consisting of 302 patients with head and neck squamous cell carcinoma (HNSCC). Clinical data as well as genome-wide RNA-sequencing based gene expression data were retrieved from The Cancer Genome Atlas (TCGA). Clustering and statistical analysis were performed using Statistical Utilities for Microarray and Omics data (SUMO) software package. RESULTS: The 15 gene hypoxia signature developed by Toustrup et al. as well as the 30 gene signature by Lendahl et al. successfully discriminated between HNSCC patients with poor vs. good prognosis. The 26 gene signature developed by Eustace et al. was prognostic in HNSCC patients treated with radiotherapy. The best prognostic value was achieved when a consensus cohort of patients was assigned, i.e., low- or high- degree of tumor hypoxia was found, by all three signatures. Interestingly, the number of signature genes could be successfully reduced to the only common gene across all three signatures, i.e., P4HA1, encoding prolyl-4-hydroxylase, alpha polypeptide I. CONCLUSIONS: This is the first independent proof for the feasibility of hypoxia gene expression signatures as a prognostic tool in HNSCC patients.

Published
2016

30. Identification of a gene signature distinctive of primary glioblastomas with spatial relationship to the subventricular zone

Author

Dictus, C, Mock, A, Warta, R, Friauf, S, Herold-Mende, C, and Unterberg, A

Subjects
ddc: 610, nervous system, animal diseases, glioblastoma, subventricular zone, 610 Medical sciences, Medicine, gene signature, nervous system diseases
Abstract

Objective: We have recently reported that spatial relationship of primary glioblastomas (pGBMs) to the subventricular zone (SVZ), the predominant neurogenic region of the adult brain, is associated with inferior patient survival and significantly increased protein expression of neural stem cell (NSC)[for full text, please go to the a.m. URL], 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Published
2013
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31. Differential DNA methylation in long-term surviving GBM patients

Author

Mock, A, Warta, R, Schmezer, P, Plass, C, Herold-Mende, CH, and Unterberg, A

Subjects
Methylierung, Langzeitüberleben, ddc: 610, glioblastoma, methylation, 610 Medical sciences, Medicine, Glioblastom, long-term survival
Abstract

Objective: Despite unfavorable diagnosis, 3–5% of glioblastoma patients show long-term survival of 36 months or longer after diagnosis. Recent publications indicate that this survival benefit bases on altered gene expression. Epigenetic modifications, e.g. DNA methylation are known to be[for full text, please go to the a.m. URL], 63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS)

Published
2012
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32. Investigation of retinoic acid signaling in glioma stem-like cells

Author

Ratliff, M., Campos, B., Centner, F.S., Warta, R., Herold-Mende, C., and Unterberg, A.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: In many cell types retinoic acid (RA) leads to differentiation and growth inhibition. Due to aberrant distribution of the RA binding proteins FABP5 and CRABP2 breast cancer cells do not differentiate but instead enter a prosurvival pathway after RA exposure. Similarly, glioblastoma stem-like[for full text, please go to the a.m. URL], 62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH)

Published
2011

33. Überlebensanalysen beim cervicalen Carcinoma of Unknown Primary (cCUP)

Author

Dyckhoff, G, Warta, R, Herold-Mende, C, and Plinkert, PK

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Im Deutschen Ärzteblatt wurde im Sommer 2008 in einer Übersichtsarbeit eine Überlebenszeit von „weniger als 12 Monaten für die meisten CUP-Patienten“ angegeben; laut großen retrospektiven Studien liege das mediane Überleben bei 3 bis 6 Monaten,[for full text, please go to the a.m. URL], 81. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie

Published
2010
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41. OMICS AND PROGNSTIC MARKERS

Author

Adachi, K., primary, Sasaki, H., additional, Nagahisa, S., additional, Yoshida, K., additional, Hattori, N., additional, Nishiyama, Y., additional, Kawase, T., additional, Hasegawa, M., additional, Abe, M., additional, Hirose, Y., additional, Alentorn, A., additional, Marie, Y., additional, Poggioli, S., additional, Alshehhi, H., additional, Boisselier, B., additional, Carpentier, C., additional, Mokhtari, K., additional, Capelle, L., additional, Figarella-Branger, D., additional, Hoang-Xuan, K., additional, Sanson, M., additional, Delattre, J.-Y., additional, Idbaih, A., additional, Yust-Katz, S., additional, Anderson, M., additional, Olar, A., additional, Eterovic, A., additional, Ezzeddine, N., additional, Chen, K., additional, Zhao, H., additional, Fuller, G., additional, Aldape, K., additional, de Groot, J., additional, Andor, N., additional, Harness, J., additional, Lopez, S. G., additional, Fung, T. L., additional, Mewes, H. W., additional, Petritsch, C., additional, Arivazhagan, A., additional, Somasundaram, K., additional, Thennarasu, K., additional, Pandey, P., additional, Anandh, B., additional, Santosh, V., additional, Chandramouli, B., additional, Hegde, A., additional, Kondaiah, P., additional, Rao, M., additional, Bell, R., additional, Kang, R., additional, Hong, C., additional, Song, J., additional, Costello, J., additional, Nagarajan, R., additional, Zhang, B., additional, Diaz, A., additional, Wang, T., additional, Bie, L., additional, Li, Y., additional, Liu, H., additional, Luyo, W. F. C., additional, Carnero, M. H., additional, Iruegas, M. E. P., additional, Morell, A. R., additional, Figueiras, M. C., additional, Lopez, R. L., additional, Valverde, C. F., additional, Chan, A. K.-Y., additional, Pang, J. C.-S., additional, Chung, N. Y.-F., additional, Li, K. K.-W., additional, Poon, W. S., additional, Chan, D. T.-M., additional, Wang, Y., additional, Ng, H.-a. K., additional, Chaumeil, M., additional, Larson, P., additional, Yoshihara, H., additional, Vigneron, D., additional, Nelson, S., additional, Pieper, R., additional, Phillips, J., additional, Ronen, S., additional, Clark, V., additional, Omay, Z. E., additional, Serin, A., additional, Gunel, J., additional, Omay, B., additional, Grady, C., additional, Youngblood, M., additional, Bilguvar, K., additional, Baehring, J., additional, Piepmeier, J., additional, Gutin, P., additional, Vortmeyer, A., additional, Brennan, C., additional, Pamir, M. N., additional, Kilic, T., additional, Krischek, B., additional, Simon, M., additional, Yasuno, K., additional, Gunel, M., additional, Cohen, A. L., additional, Sato, M., additional, Aldape, K. D., additional, Mason, C., additional, Diefes, K., additional, Heathcock, L., additional, Abegglen, L., additional, Shrieve, D., additional, Couldwell, W., additional, Schiffman, J. D., additional, Colman, H., additional, D'Alessandris, Q. G., additional, Cenci, T., additional, Martini, M., additional, Ricci-Vitiani, L., additional, De Maria, R., additional, Larocca, L. M., additional, Pallini, R., additional, Theeler, B., additional, Lang, F., additional, Rao, G., additional, Gilbert, M., additional, Sulman, E., additional, Luthra, R., additional, Eterovic, K., additional, Routbort, M., additional, Verhaak, R., additional, Mills, G., additional, Mendelsohn, J., additional, Meric-Bernstam, F., additional, Yung, A., additional, MacArthur, K., additional, Hahn, S., additional, Kao, G., additional, Lustig, R., additional, Alonso-Basanta, M., additional, Chandrasekaran, S., additional, Wileyto, E. P., additional, Reyes, E., additional, Dorsey, J., additional, Fujii, K., additional, Kurozumi, K., additional, Ichikawa, T., additional, Onishi, M., additional, Ishida, J., additional, Shimazu, Y., additional, Kaur, B., additional, Chiocca, E. A., additional, Date, I., additional, Geisenberger, C., additional, Mock, A., additional, Warta, R., additional, Schwager, C., additional, Hartmann, C., additional, von Deimling, A., additional, Abdollahi, A., additional, Herold-Mende, C., additional, Gevaert, O., additional, Achrol, A., additional, Gholamin, S., additional, Mitra, S., additional, Westbroek, E., additional, Loya, J., additional, Mitchell, L., additional, Chang, S., additional, Steinberg, G., additional, Plevritis, S., additional, Cheshier, S., additional, Xu, J., additional, Napel, S., additional, Zaharchuk, G., additional, Harsh, G., additional, Gutman, D., additional, Holder, C., additional, Colen, R., additional, Dunn, W., additional, Jain, R., additional, Cooper, L., additional, Hwang, S., additional, Flanders, A., additional, Brat, D., additional, Hayes, J., additional, Droop, A., additional, Thygesen, H., additional, Boissinot, M., additional, Westhead, D., additional, Short, S., additional, Lawler, S., additional, Bady, P., additional, Kurscheid, S., additional, Delorenzi, M., additional, Hegi, M. E., additional, Crosby, C., additional, Faulkner, C., additional, Smye-Rumsby, T., additional, Kurian, K., additional, Williams, M., additional, Hopkins, K., additional, Palmer, A., additional, Williams, H., additional, Wragg, C., additional, Haynes, H. R., additional, Kurian, K. M., additional, White, P., additional, Oka, T., additional, Jalbert, L., additional, Elkhaled, A., additional, Jensen, R., additional, Salzman, K., additional, Schabel, M., additional, Gillespie, D., additional, Mumert, M., additional, Johnson, B., additional, Mazor, T., additional, Barnes, M., additional, Yamamoto, S., additional, Ueda, H., additional, Tatsuno, K., additional, Aihara, K., additional, Bollen, A., additional, Hirst, M., additional, Marra, M., additional, Mukasa, A., additional, Saito, N., additional, Aburatani, H., additional, Berger, M., additional, Taylor, B., additional, Popov, S., additional, Mackay, A., additional, Ingram, W., additional, Burford, A., additional, Jury, A., additional, Vinci, M., additional, Jones, C., additional, Jones, D. T. W., additional, Hovestadt, V., additional, Picelli, S., additional, Wang, W., additional, Northcott, P. A., additional, Kool, M., additional, Reifenberger, G., additional, Pietsch, T., additional, Sultan, M., additional, Lehrach, H., additional, Yaspo, M.-L., additional, Borkhardt, A., additional, Landgraf, P., additional, Eils, R., additional, Korshunov, A., additional, Zapatka, M., additional, Radlwimmer, B., additional, Pfister, S. M., additional, Lichter, P., additional, Joy, A., additional, Smirnov, I., additional, Reiser, M., additional, Shapiro, W., additional, Kim, S., additional, Feuerstein, B., additional, Jungk, C., additional, Friauf, S., additional, Unterberg, A., additional, Juratli, T. A., additional, McElroy, J., additional, Meng, W., additional, Huebner, A., additional, Geiger, K. D., additional, Krex, D., additional, Schackert, G., additional, Chakravarti, A., additional, Lautenschlaeger, T., additional, Kim, B. Y., additional, Jiang, W., additional, Beiko, J., additional, Prabhu, S., additional, DeMonte, F., additional, Sawaya, R., additional, Cahill, D., additional, McCutcheon, I., additional, Lau, C., additional, Wang, L., additional, Terashima, K., additional, Yamaguchi, S., additional, Burstein, M., additional, Sun, J., additional, Suzuki, T., additional, Nishikawa, R., additional, Nakamura, H., additional, Natsume, A., additional, Terasaka, S., additional, Ng, H.-K., additional, Muzny, D., additional, Gibbs, R., additional, Wheeler, D., additional, Zhang, X.-q., additional, Sun, S., additional, Lam, K.-f., additional, Kiang, K. M. Y., additional, Pu, J. K. S., additional, Ho, A. S. W., additional, Leung, G. K. K., additional, Loebel, F., additional, Curry, W. T., additional, Barker, F. G., additional, Lelic, N., additional, Chi, A. S., additional, Cahill, D. P., additional, Lu, D., additional, Yin, J., additional, Teo, C., additional, McDonald, K., additional, Madhankumar, A., additional, Weston, C., additional, Slagle-Webb, B., additional, Sheehan, J., additional, Patel, A., additional, Glantz, M., additional, Connor, J., additional, Maire, C., additional, Francis, J., additional, Zhang, C.-Z., additional, Jung, J., additional, Manzo, V., additional, Adalsteinsson, V., additional, Homer, H., additional, Blumenstiel, B., additional, Pedamallu, C. S., additional, Nickerson, E., additional, Ligon, A., additional, Love, C., additional, Meyerson, M., additional, Ligon, K., additional, Jalbert, L. E., additional, Nelson, S. J., additional, Bollen, A. W., additional, Smirnov, I. V., additional, Song, J. S., additional, Olshen, A. B., additional, Berger, M. S., additional, Chang, S. M., additional, Taylor, B. S., additional, Costello, J. F., additional, Mehta, S., additional, Armstrong, B., additional, Peng, S., additional, Bapat, A., additional, Berens, M., additional, Melendez, B., additional, Mollejo, M., additional, Mur, P., additional, Hernandez-Iglesias, T., additional, Fiano, C., additional, Ruiz, J., additional, Rey, J. A., additional, Stadler, V., additional, Schulte, A., additional, Lamszus, K., additional, Schichor, C., additional, Westphal, M., additional, Tonn, J.-C., additional, Morozova, O., additional, Katzman, S., additional, Grifford, M., additional, Salama, S., additional, Haussler, D., additional, Olshen, A., additional, Fouse, S., additional, Nakamizo, S., additional, Sasayama, T., additional, Tanaka, H., additional, Tanaka, K., additional, Mizukawa, K., additional, Yoshida, M., additional, Kohmura, E., additional, Northcott, P., additional, Jones, D., additional, Pfister, S., additional, Otani, R., additional, Takayanagi, S., additional, Saito, K., additional, Tanaka, S., additional, Shin, M., additional, Ozawa, T., additional, Riester, M., additional, Cheng, Y.-K., additional, Huse, J., additional, Helmy, K., additional, Charles, N., additional, Squatrito, M., additional, Michor, F., additional, Holland, E., additional, Perrech, M., additional, Dreher, L., additional, Rohn, G., additional, Goldbrunner, R., additional, Timmer, M., additional, Pollo, B., additional, Palumbo, V., additional, Calatozzolo, C., additional, Patane, M., additional, Nunziata, R., additional, Farinotti, M., additional, Silvani, A., additional, Lodrini, S., additional, Finocchiaro, G., additional, Lopez, E., additional, Rioscovian, A., additional, Ruiz, R., additional, Siordia, G., additional, de Leon, A. P., additional, Rostomily, C., additional, Rostomily, R., additional, Silbergeld, D., additional, Kolstoe, D., additional, Chamberlain, M., additional, Silber, J., additional, Roth, P., additional, Keller, A., additional, Hoheisel, J., additional, Codo, P., additional, Bauer, A., additional, Backes, C., additional, Leidinger, P., additional, Meese, E., additional, Thiel, E., additional, Korfel, A., additional, Weller, M., additional, Nagae, G., additional, Nagane, M., additional, Sanborn, J. Z., additional, Mikkelsen, T., additional, Jhanwar, S., additional, Chin, L., additional, Nishihara, M., additional, Schliesser, M., additional, Grimm, C., additional, Weiss, E., additional, Claus, R., additional, Weichenhan, D., additional, Weiler, M., additional, Hielscher, T., additional, Sahm, F., additional, Wiestler, B., additional, Klein, A.-C., additional, Blaes, J., additional, Plass, C., additional, Wick, W., additional, Stragliotto, G., additional, Rahbar, A., additional, Soderberg-Naucler, C., additional, Won, M., additional, Ezhilarasan, R., additional, Sun, P., additional, Blumenthal, D., additional, Vogelbaum, M., additional, Jenkins, R., additional, Jeraj, R., additional, Brown, P., additional, Jaeckle, K., additional, Schiff, D., additional, Dignam, J., additional, Atkins, J., additional, Brachman, D., additional, Werner-Wasik, M., additional, Mehta, M., additional, Shen, J., additional, Luan, J., additional, Yu, A., additional, Matsutani, M., additional, Liang, Y., additional, Man, T.-K., additional, Trister, A., additional, Tokita, M., additional, Mikheeva, S., additional, Mikheev, A., additional, Friend, S., additional, van den Bent, M., additional, Erdem, L., additional, Gorlia, T., additional, Taphoorn, M., additional, Kros, J., additional, Wesseling, P., additional, Dubbink, H., additional, Ibdaih, A., additional, French, P., additional, van Thuijl, H., additional, Heimans, J., additional, Ylstra, B., additional, Reijneveld, J., additional, Prabowo, A., additional, Scheinin, I., additional, van Essen, H., additional, Spliet, W., additional, Ferrier, C., additional, van Rijen, P., additional, Veersema, T., additional, Thom, M., additional, Meeteren, A. 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P., additional, and Koul, D., additional

Published
2013
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48. Individualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy.

Author

Peng T, Ma X, Hua W, Wang C, Chu Y, Sun M, Fermi V, Hamelmann S, Lindner K, Shao C, Zaman J, Tian W, Zhuo Y, Harim Y, Stöffler N, Hammann L, Xiao Q, Jin X, Warta R, Lotsch C, Zhuang X, Feng Y, Fu M, Zhang X, Zhang J, Xu H, Qiu F, Xie L, Zhang Y, Zhu W, Du Z, Salgueiro L, Schneider M, Eichhorn F, Lefevre A, Pusch S, Grinevich V, Ratliff M, Loges S, Bunse L, Sahm F, Xiang Y, Unterberg A, von Deimling A, Platten M, Herold-Mende C, Wu Y, Liu HK, and Mao Y

Abstract

Tumor organoids are important tools for cancer research, but current models have drawbacks that limit their applications for predicting response to therapy. Here, we developed a fast, efficient, and complex culture system (IPTO, individualized patient tumor organoid) that accurately recapitulates the cellular and molecular pathology of human brain tumors. Patient-derived tumor explants were cultured in induced pluripotent stem cell (iPSC)-derived cerebral organoids, thus enabling culture of a wide range of human tumors in the central nervous system (CNS), including adult, pediatric, and metastatic brain cancers. Histopathological, genomic, epigenomic, and single-cell RNA sequencing (scRNA-seq) analyses demonstrated that the IPTO model recapitulates cellular heterogeneity and molecular features of original tumors. Crucially, we showed that the IPTO model predicts patient-specific drug responses, including resistance mechanisms, in a prospective patient cohort. Collectively, the IPTO model represents a major breakthrough in preclinical modeling of human cancers, which provides a path toward personalized cancer therapy., Competing Interests: Declaration of interests H.-K.L., X.M., C.W., T.P., M. Sun, W.H., C.S., and Y.M. submitted patent application PCT/CN2023/075746 related to this manuscript. M.P. is the founder of Tcelltech. H.-K.L. is the founder of AIPTO., (Copyright © 2025 The Authors. Published by Elsevier Inc. All rights reserved.)

Published
2025
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49. The Molecular and Immunological Landscape of Meningiomas.

Author

Lotsch C, Warta R, and Herold-Mende C

Subjects
Humans, Biomarkers, Tumor genetics, Meningioma immunology, Meningioma genetics, Meningioma pathology, Meningioma therapy, Meningeal Neoplasms immunology, Meningeal Neoplasms genetics, Meningeal Neoplasms therapy, Meningeal Neoplasms pathology
Abstract

Meningiomas are the most common primary intracranial tumors in adults and typically have a slow-growing and benign nature. However, there is also a substantial subset of meningiomas that shows aggressive clinical behavior and is refractory to standard treatment modalities, which are still limited to surgery and/or radiotherapy. Despite intensive research, no systemic treatment options are yet available in the clinic for these challenging tumors, resulting in poor patient outcome. Intensive research on the molecular pathogenesis of meningiomas has led to improved diagnostic tools, but so far there is no standardized implementation for the molecular profiling of these tumors for clinical practice. Recent research advances have also focused on the immunophenotyping of meningiomas, leading to several clinical trials examining the use of immune checkpoint blockade therapy in patients with clinically aggressive subtypes. In this review, we aim to summarize the current knowledge on the molecular and immunological landscape of meningiomas in detail and provide current and progressive ideas for future directions.

Published
2024
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50. Prediction of WHO grade and methylation class of aggressive meningiomas: Extraction of diagnostic information from infrared spectroscopic data.

Author

Galli R, Lehner F, Richter S, Kirsche K, Meinhardt M, Juratli TA, Temme A, Kirsch M, Warta R, Herold-Mende C, Ricklefs FL, Lamszus K, Sievers P, Sahm F, Eyüpoglu IY, and Uckermann O

Abstract

Background: Infrared (IR) spectroscopy allows intraoperative, optical brain tumor diagnosis. Here, we explored it as a translational technology for the identification of aggressive meningioma types according to both, the WHO CNS grading system and the methylation classes (MC)., Methods: Frozen sections of 47 meningioma were examined by IR spectroscopic imaging and different classification approaches were compared to discern samples according to WHO grade or MC., Results: IR spectroscopic differences were more pronounced between WHO grade 2 and 3 than between MC intermediate and MC malignant, although similar spectral ranges were affected. Aggressive types of meningioma exhibited reduced bands of carbohydrates (at 1024 cm -1 ) and nucleic acids (at 1080 cm -1 ), along with increased bands of phospholipids (at 1240 and 1450 cm -1 ). While linear discriminant analysis was able to discern spectra of WHO grade 2 and 3 meningiomas (AUC 0.89), it failed for MC (AUC 0.66). However, neural network classifiers were effective for classification according to both WHO grade (AUC 0.91) and MC (AUC 0.83), resulting in the correct classification of 20/23 meningiomas of the test set., Conclusions: IR spectroscopy proved capable of extracting information about the malignancy of meningiomas, not only according to the WHO grade, but also for a diagnostic system based on molecular tumor characteristics. In future clinical use, physicians could assess the goodness of the classification by considering classification probabilities and cross-measurement validation. This might enhance the overall accuracy and clinical utility, reinforcing the potential of IR spectroscopy in advancing precision medicine for meningioma characterization., Competing Interests: None., (© The Author(s) 2024. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.)

Published
2024
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