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42. α-Amylase and α-Glucosidase inhibitory activity assessment of Cucurbita maxima seeds – a LIBS based study

Author

Kushawaha, Devesh Kumar; Alternative Therapeutics Unit, Drug Development Division, Medicinal Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad - 211 002, U. P., India, Yadav, Manjulika; Alternative Therapeutics Unit, Drug Development Division, Medicinal Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad - 211 002, U. P., India, Chatterji, Sanjukta; Alternative Therapeutics Unit, Drug Development Division, Medicinal Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad - 211 002, U. P., India, Srivastava, Amrita Kumari; Alternative Therapeutics Unit, Drug Development Division, Medicinal Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad - 211 002, U. P., India, Watal, Geeta; Alternative Therapeutics Unit, Drug Development Division, Medicinal Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad - 211 002, U. P., India, Kushawaha, Devesh Kumar; Alternative Therapeutics Unit, Drug Development Division, Medicinal Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad - 211 002, U. P., India, Yadav, Manjulika; Alternative Therapeutics Unit, Drug Development Division, Medicinal Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad - 211 002, U. P., India, Chatterji, Sanjukta; Alternative Therapeutics Unit, Drug Development Division, Medicinal Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad - 211 002, U. P., India, Srivastava, Amrita Kumari; Alternative Therapeutics Unit, Drug Development Division, Medicinal Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad - 211 002, U. P., India, and Watal, Geeta; Alternative Therapeutics Unit, Drug Development Division, Medicinal Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad - 211 002, U. P., India

Abstract

The aim of the present study was to investigate, α-amylase and α-glucosidase inhibitory activities of the aqueous extract of Cucurbita maxima seeds in vitro and to correlate their activity with their phytoelemental profile quantitatively assessed by Laser-Induced Breakdown Spectroscopy (LIBS). Diabetes can be managed by controlling postprandial hyperglycemia which can be achieved by inhibiting carbohydrate hydrolyzing enzymes like α-amylase and α-glucosidase. Results reveal that the C. maxima seeds have appreciable α-amylase inhibitory activity of 46.03±1.37% with IC50 value at 7.00±0.29 mg ml-1 in addition to substantial α-glucosidase inhibitory effect of 35.11±1.04% with IC50 at 8.11±0.36 mg ml-1. Acarbose was used as a reference. LIBS analysis showed the presence of certain phytoelements viz. Mg, Ca, K and Na which are well known glycemic elements and hence could be responsible for inhibitory activity of carbohydrate hydrolyzing enzymes.Thus, α-amylase and α-glucosidase inhibitory action of C. maxima seeds would be responsible for their antidiabetic activity. The glycemic elemental profile further validates their role in controlling diabetes and hence C. maxima seeds could be explored as a potential herbal candidate for managing postprandial hyperglycemia causing type 2 diabetes mellitus.

Published
2016

47. Use of Laser-Induced Breakdown Spectroscopy for the Detection of Glycemic Elements in Indian Medicinal Plants

Author

Rai, Prashant Kumar, Srivastava, Amrita Kumari, Sharma, Bechan, Dhar, Preeti, Mishra, Ajay Kumar, and Watal, Geeta

Subjects
Article Subject
Abstract

The demand for interdisciplinary research is increasing in the new millennium to help us understand complex problems and find solutions by integrating the knowledge from different disciplines. The present review is an excellent example of this and shows how unique combination of physics, chemistry, and biological techniques can be used for the evaluation of Indian medicinal herbs used for treating diabetes mellitus. Laser-induced breakdown spectroscopy (LIBS) is a sensitive optical technique that is widely used for its simplicity and versatility. This review presents the most recent application of LIBS for detection of glycemic elements in medicinal plants. The characteristics of matrices, object analysis, use of laser system, and analytical performances with respect to Indian herbs are discussed.

Published
2013
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