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9 results on '"Watanabe, Shiharu"'

6. Efficacy of Alaska Pollock Gelatin Sealant for Pulmonary Air Leakage in Porcine Models

Author

Yanagihara, Takahiro, primary, Maki, Naoki, additional, Wijesinghe, A.I., additional, Sato, Shoko, additional, Saeki, Yusuke, additional, Kitazawa, Shinsuke, additional, Yamaoka, Masatoshi, additional, Kobayashi, Naohiro, additional, Kikuchi, Shinji, additional, Goto, Yukinobu, additional, Ichimura, Hideo, additional, Watanabe, Shiharu, additional, Taguchi, Tetsushi, additional, and Sato, Yukio, additional

Published
2022
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8. Comparative study of hydrophobically modified gelatin‐based sealant with commercially available sealants.

Author

Mizuno, Yosuke, Watanabe, Shiharu, Katano, Mayumi, Yanagihara, Takahiro, Maki, Naoki, Sato, Yukio, and Taguchi, Tetsushi

Abstract

Air leakage is one of the major complications related to pulmonary surgeries. To reduce this complication, we developed a decyl group (C10)‐modified Alaska pollock gelatin (ApGltn) (C10‐ApGltn) sealant and evaluated its practical performance against commercially available sealants, Beriplast® and DuraSeal®. C10‐ApGltn was synthesized by reductive amination of the amino groups in ApGltn with decanal. C10‐ApGltn was crosslinked with a poly(ethylene glycol)‐based crosslinker to form a tissue sealant. The crosslinking time of the C10‐ApGltn sealant was fast enough for curing on tissue and application as a spray system. Although the percent swelling of C10‐ApGltn and DuraSeal was significantly greater than Beriplast, C10‐ApGltn and DuraSeal exhibited excellent tissue sealing properties on pleura tissue under a long‐term moist condition. Additionally, C10‐ApGltn and DuraSeal did not cause severe inflammatory responses in a rat subcutaneous example. Therefore, C10‐ApGltn sealant had comparable tissue sealing properties to DuraSeal under a moist condition, indicating the potential of C10‐ApGltn sealant for pulmonary surgeries. [ABSTRACT FROM AUTHOR]

Published
2022
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