Search

Your search keyword '"Waters, Ian"' showing total 207 results
Start Over Author "Waters, Ian"
207 results on '"Waters, Ian"'

2. Incipient slip detection and grasping automation for robotic surgery

Author

Waters, Ian George Cameron, Culmer, Peter, and Alazmani, Ali

Abstract

Robotic minimally invasive surgery provides multiple improvements over traditional laparoscopic procedures, but one significant issue still encountered is their limited force control during the grasping and retraction of tissue, as the surgeon is separated from the instrument, and therefore denuded of their sense of touch and the applied forces. Prior solutions have largely looked towards haptic feedback to resolve this issue, but an alternative approach is to detect and monitor the occurrence of tissue slip events. This would allow the force to be automatically adjusted to prevent slip, minimising the clamp force used to maintain control, thus reducing the probability of tissue trauma. The aim of this work is to develop a method for the early detection and mitigation of tissue slip during robotic surgical manipulation tasks, helping to reduce tissue trauma and minimise tissue slip events. Initial investigations into literature, and evaluation of the slip mechanics when grasping soft, lubricated, deformable materials, indicated that small localised slips occur before the onset of macro slip. Two phenomena were identified in the slip mechanics investigation that could be employed to induce these slip in a measurable and repeatable manner. Firstly through using the tissue's deformable properties to create slip differentials between the front and rear of the grasper face, and secondly through using a curved surface to create a variation in the normal force, and thus frictional force, across the surface. Two instrumented grasper faces were developed, based on each of these phenomena, that were capable of monitoring the occurrence of localised tissue slip through monitoring the displacement of a series of independent movable islands that made up the grasper face. These were then demonstrated to be capable of automatically detecting slip events for a range of test conditions with tissue simulants, before being utilised to automatically control the grasping forces during a tissue retraction task. Both sensor systems provided similar levels of tissue control to one which utilised the maximum clamp force throughout the task, whilst applying lower forces during the early stages of retraction, reducing the probability of tissue damage. In addition the normal force based method, with the curved grasper face, was demonstrated to be effective for the early detection of slip when grasping porcine liver tissue, successfully detecting incipient slip in 77% of cases. This work provides a strong basis for further development of incipient slip sensing for surgical applications. It provides novel contributions in the understanding of slip mechanics of soft tissues, as well as presenting two separate novel sensing approaches for the automatic detection and mitigation of slip events, offering an opportunity for reducing the occurrence of tissue slip events whilst minimising tissue trauma, as well as surgeon fatigue.

Published
2022

25. Age-dependent SMN expression in disease-relevant tissue and implications for SMA treatment

Author

Ramos, Daniel M., d'Ydewalle, Constantin, Gabbeta, Vijayalakshmi, Dakka, Amal, Klein, Stephanie K., Norris, Daniel A., Matson, John, Taylor, Shannon J., Zaworski, Phillip G., Prior, Thomas W., Snyder, Pamela J., Valdivia, David, Hatem, Christine L., Waters, Ian, Gupte, Nikhil, Swoboda, Kathryn J., Rigo, Frank, Bennett, C. Frank, Naryshkin, Nikolai, Paushkin, Sergey, Crawford, Thomas O., and Sumner, Charlotte J.

Subjects
Thermo Fisher Scientific Inc., Nusinersen, Pregnant women, RNA, Scientific equipment industry, Spinal muscular atrophy, Messenger RNA, Neurons, Muscular atrophy, Brain, Retirement benefits, Health care industry, Johns Hopkins University. School of Medicine
Abstract

BACKGROUND. Spinal muscular atrophy (SMA) is caused by deficient expression of survival motor neuron (SMN) protein. New SMN-enhancing therapeutics are associated with variable clinical benefits. Limited knowledge of baseline and drug-induced SMN levels in disease-relevant tissues hinders efforts to optimize these treatments. METHODS. SMN mRNA and protein levels were quantified in human tissues isolated during expedited autopsies. RESULTS. SMN protein expression varied broadly among prenatal control spinal cord samples, but was restricted at relatively low levels in controls and SMA patients after 3 months of life. A 2.3-fold perinatal decrease in median SMN protein levels was not paralleled by comparable changes in SMN mRNA. In tissues isolated from nusinersen-treated SMA patients, antisense oligonucleotide (ASO) concentration and full-length (exon 7 including) SMN2 (SMN2-FL) mRNA level increases were highest in lumbar and thoracic spinal cord. An increased number of cells showed SMN immunolabeling in spinal cord of treated patients, but was not associated with an increase in whole-tissue SMN protein levels. CONCLUSIONS. A normally occurring perinatal decrease in whole-tissue SMN protein levels supports efforts to initiate SMN-inducing therapies as soon after birth as possible. Limited ASO distribution to rostral spinal and brain regions in some patients likely limits clinical response of motor units in these regions for those patients. These results have important implications for optimizing treatment of SMA patients and warrant further investigations to enhance bioavailability of intrathecally administered ASOs. FUNDING. SMA Foundation, SMART, NIH (R01-NS096770, R01-NS062869), Ionis Pharmaceuticals, and PTC Therapeutics. Biogen provided support for absolute real-time RT-PCR., Introduction The neuromuscular disease spinal muscular atrophy (SMA), affecting approximately 1 in 10,000 individuals, is the most common inherited cause of infant death (1). The most frequent and severe type [...]

Published
2019
Full Text
View/download PDF

29. The estrogen receptor-alpha S118P variant does not affect breast cancer incidence or response to endocrine therapies

Author

Button, Berry, Croessmann, Sarah, Chu, David, Rosen, D. Marc, Zabransky, Daniel J., Dalton, W. Brian, Cravero, Karen, Kyker-Snowman, Kelly, Waters, Ian, Karthikeyan, Swathi, Christenson, Eric S., Donaldson, Josh, Hunter, Tasha, Dennison, Lauren, Ramin, Cody, May, Betty, Roden, Richard, Petry, Dana, Armstrong, Deborah K., Visvanathan, Kala, and Park, Ben Ho

Published
2019
Full Text
View/download PDF

30. First use of a new frugal CPAP device: the LeVe CPAP System, in adult patients with COVID-19 pneumonitis at Mengo Hospital, Kampala, Uganda

Author

Littlejohns, Anna, primary, Please, Helen, additional, Musasizi, Racheal, additional, Murdoch, Stuart, additional, Nampiina, Gorret, additional, Waters, Ian, additional, Birch, William Davis, additional, De Boer, Gregory, additional, Kapur, Nikil, additional, Ambrozi, Tumwesigye, additional, Carol, Ninsiima, additional, Noel, Nakigudde, additional, Parmar, Jiten, additional, Culmer, Peter, additional, Lawton, Tom, additional, and Namulema, Edith, additional

Published
2023
Full Text
View/download PDF

31. Data from Biomarkers for Personalizing Omega-3 Fatty Acid Dosing

Author

Jiang, Yan, primary, Djuric, Zora, primary, Sen, Ananda, primary, Ren, Jianwei, primary, Kuklev, Dmitry, primary, Waters, Ian, primary, Zhao, Lili, primary, Uhlson, Charis L., primary, Hong, Yu H., primary, Murphy, Robert C., primary, Normolle, Daniel P., primary, Smith, William L., primary, and Brenner, Dean E., primary

Published
2023
Full Text
View/download PDF

34. Supplementary Tables from HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2+ Breast Cancer

Author

Xu, Xiaowei, primary, De Angelis, Carmine, primary, Burke, Kathleen A., primary, Nardone, Agostina, primary, Hu, Huizhong, primary, Qin, Lanfang, primary, Veeraraghavan, Jamunarani, primary, Sethunath, Vidyalakshmi, primary, Heiser, Laura M., primary, Wang, Nicholas, primary, Ng, Charlotte K.Y., primary, Chen, Edward S., primary, Renwick, Alexander, primary, Wang, Tao, primary, Nanda, Sarmistha, primary, Shea, Martin, primary, Mitchell, Tamika, primary, Rajendran, Mahitha, primary, Waters, Ian, primary, Zabransky, Daniel J., primary, Scott, Kenneth L., primary, Gutierrez, Carolina, primary, Nagi, Chandandeep, primary, Geyer, Felipe C., primary, Chamness, Gary C., primary, Park, Ben H., primary, Shaw, Chad A., primary, Hilsenbeck, Susan G., primary, Rimawi, Mothaffar F., primary, Gray, Joe W., primary, Weigelt, Britta, primary, Reis-Filho, Jorge S., primary, Osborne, C. Kent, primary, and Schiff, Rachel, primary

Published
2023
Full Text
View/download PDF

35. Supplementary information from HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2+ Breast Cancer

Author

Xu, Xiaowei, primary, De Angelis, Carmine, primary, Burke, Kathleen A., primary, Nardone, Agostina, primary, Hu, Huizhong, primary, Qin, Lanfang, primary, Veeraraghavan, Jamunarani, primary, Sethunath, Vidyalakshmi, primary, Heiser, Laura M., primary, Wang, Nicholas, primary, Ng, Charlotte K.Y., primary, Chen, Edward S., primary, Renwick, Alexander, primary, Wang, Tao, primary, Nanda, Sarmistha, primary, Shea, Martin, primary, Mitchell, Tamika, primary, Rajendran, Mahitha, primary, Waters, Ian, primary, Zabransky, Daniel J., primary, Scott, Kenneth L., primary, Gutierrez, Carolina, primary, Nagi, Chandandeep, primary, Geyer, Felipe C., primary, Chamness, Gary C., primary, Park, Ben H., primary, Shaw, Chad A., primary, Hilsenbeck, Susan G., primary, Rimawi, Mothaffar F., primary, Gray, Joe W., primary, Weigelt, Britta, primary, Reis-Filho, Jorge S., primary, Osborne, C. Kent, primary, and Schiff, Rachel, primary

Published
2023
Full Text
View/download PDF

36. Supplementary Figures from HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2+ Breast Cancer

Author

Xu, Xiaowei, primary, De Angelis, Carmine, primary, Burke, Kathleen A., primary, Nardone, Agostina, primary, Hu, Huizhong, primary, Qin, Lanfang, primary, Veeraraghavan, Jamunarani, primary, Sethunath, Vidyalakshmi, primary, Heiser, Laura M., primary, Wang, Nicholas, primary, Ng, Charlotte K.Y., primary, Chen, Edward S., primary, Renwick, Alexander, primary, Wang, Tao, primary, Nanda, Sarmistha, primary, Shea, Martin, primary, Mitchell, Tamika, primary, Rajendran, Mahitha, primary, Waters, Ian, primary, Zabransky, Daniel J., primary, Scott, Kenneth L., primary, Gutierrez, Carolina, primary, Nagi, Chandandeep, primary, Geyer, Felipe C., primary, Chamness, Gary C., primary, Park, Ben H., primary, Shaw, Chad A., primary, Hilsenbeck, Susan G., primary, Rimawi, Mothaffar F., primary, Gray, Joe W., primary, Weigelt, Britta, primary, Reis-Filho, Jorge S., primary, Osborne, C. Kent, primary, and Schiff, Rachel, primary

Published
2023
Full Text
View/download PDF

38. Hierarchical tumor heterogeneity mediated by cell contact between distinct genetic subclones

Author

Karthikeyan, Swathi, Waters, Ian G., Dennison, Lauren, Chu, David, Donaldson, Joshua, Shin, Dong Ho, Rosen, D. Marc, Gonzalez-Ericsson, Paula I., Sanchez, Violeta, Sanders, Melinda E., Pantone, Morgan V., Bergman, Riley E., Davidson, Brad A., Reed, Sarah C., Zabransky, Daniel J., Cravero, Karen, Kyker-Snowman, Kelly, Button, Berry, Wong, Hong Yuen, Hurley, Paula J., Croessmann, Sarah, and Park, Ben Ho

Subjects
Carcinogenesis -- Genetic aspects, Cancer cells -- Genetic aspects, Breast cancer -- Genetic aspects -- Development and progression, Health care industry
Abstract

Intratumor heterogeneity is an important mediator of poor outcomes in many cancers, including breast cancer. Genetic subclones frequently contribute to this heterogeneity; however, their growth dynamics and interactions remain poorly understood. PIK3CA and HER2 alterations are known to coexist in breast and other cancers. Herein, we present data that describe the ability of oncogenic PIK3CA mutant cells to induce the proliferation of quiescent HER2 mutant cells through a cell contact-mediated mechanism. Interestingly, the HER2 cells proliferated to become the major subclone over PIK3CA counterparts both in vitro and in vivo. Furthermore, this phenotype was observed in both hormone receptor-positive and -negative cell lines, and was dependent on the expression of fibronectin from mutant PIK3CA cells. Analysis of human tumors demonstrated similar HER2:PIK3CA clonal dynamics and fibronectin expression. Our study provides insight into nonrandom subclonal architecture of heterogenous tumors, which may aid the understanding of tumor evolution and inform future strategies for personalized medicine., Introduction Breast cancer is the most common cancer among women worldwide and the second leading cause of cancer related deaths (1). Like many other cancers, breast cancer has been shown [...]

Published
2021
Full Text
View/download PDF

39. Quality of service and the policing function : a view from the top

Author

Waters, Ian

Subjects
340, Law
Abstract

This thesis focuses on the origins and development of the Quality of Service (QOS) initiative in the Police Service of England and Wales. Interlinked with the analysis of that initiative is an assessment of the police reforms which were introduced by government from 1993 onward. It is argued that the QOS initiative has become increasingly embroiled in the politics of police reform, and that the 'consumerist' dimension of quality has taken precedence over what might be termed a public sector 'professional' model. It is concluded that the centralisation of policing continues apace, and that this is inevitable given the need for the central state to augment its monitoring and surveillance capabilities. The empirical research itself entailed well over 100 interviews with senior staff in the policing environment, as well as a survey of Chief Inspectors and Superintendents in three participating forces.

Published
1997

44. NOTCH1 PEST domain variants are responsive to standard of care treatments despite distinct transformative properties in a breast cancer model

Author

Cravero, Karen, primary, Pantone, Morgan V., additional, Shin, Dong Ho, additional, Bergman, Riley, additional, Cochran, Rory, additional, Chu, David, additional, Zabransky, Daniel J., additional, Karthikeyan, Swathi, additional, Waters, Ian G., additional, Hunter, Natasha, additional, Rosen, D. Marc, additional, Kyker-Snowman, Kelly, additional, Dalton, W. Brian, additional, Button, Berry, additional, Shinn, Dan, additional, Wong, Hong Yuen, additional, Donaldson, Joshua, additional, Hurley, Paula J., additional, Croessmann, Sarah, additional, and Park, Ben Ho, additional

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results