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1. Brief Report: Cannabidiol-Rich Cannabis in Children with Autism Spectrum Disorder and Severe Behavioral Problems--A Retrospective Feasibility Study

Author

Aran, Adi, Cassuto, Hanoch, Lubotzky, Asael, Wattad, Nadia, and Hazan, Esther

Abstract

Anecdotal evidence of successful cannabis treatment in autism spectrum disorder (ASD) are accumulating but clinical studies are lacking. This retrospective study assessed tolerability and efficacy of cannabidiol-rich cannabis, in 60 children with ASD and severe behavioral problems (age = 11.8 ± 3.5, range 5.0-17.5; 77% low functioning; 83% boys). Efficacy was assessed using the Caregiver Global Impression of Change scale. Adverse events included sleep disturbances (14%) irritability (9%) and loss of appetite (9%). One girl who used higher tetrahydrocannabinol had a transient serious psychotic event which required treatment with an antipsychotic. Following the cannabis treatment, behavioral outbreaks were much improved or very much improved in 61% of patients. This preliminary study supports feasibility of CBD-based cannabis trials in children with ASD.

Published
2019
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3. Brief Report: Cannabidiol-Rich Cannabis in Children with Autism Spectrum Disorder and Severe Behavioral Problems-A Retrospective Feasibility Study

Author

Aran, Adi, Cassuto, Hanoch, Lubotzky, Asael, Wattad, Nadia, and Hazan, Esther

Subjects
Pediatric research, Child behavior -- Psychological aspects, Marijuana -- Usage, Child health -- Analysis, Tetrahydrocannabinol -- Dosage and administration, Pervasive developmental disorders -- Risk factors -- Drug therapy, Health
Abstract

Anecdotal evidence of successful cannabis treatment in autism spectrum disorder (ASD) are accumulating but clinical studies are lacking. This retrospective study assessed tolerability and efficacy of cannabidiol-rich cannabis, in 60 children with ASD and severe behavioral problems (age = 11.8 ± 3.5, range 5.0-17.5; 77% low functioning; 83% boys). Efficacy was assessed using the Caregiver Global Impression of Change scale. Adverse events included sleep disturbances (14%) irritability (9%) and loss of appetite (9%). One girl who used higher tetrahydrocannabinol had a transient serious psychotic event which required treatment with an antipsychotic. Following the cannabis treatment, behavioral outbreaks were much improved or very much improved in 61% of patients. This preliminary study supports feasibility of CBD-based cannabis trials in children with ASD., Author(s): Adi Aran [sup.1] , Hanoch Cassuto [sup.2] , Asael Lubotzky [sup.1] , Nadia Wattad [sup.1] , Esther Hazan [sup.1] Author Affiliations: (Aff1) 0000 0004 0470 7791, grid.415593.f, Neuropediatric Unit, [...]

Published
2019
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7. Additional file 1: of Lower circulating endocannabinoid levels in children with autism spectrum disorder

Author

Aran, Adi, Eylon, Maya, Moria Harel, Polianski, Lola, Nemirovski, Alina, Tepper, Sigal, Schnapp, Aviad, Cassuto, Hanoch, Wattad, Nadia, and Tam, Joseph

Subjects
mental disorders, food and beverages, lipids (amino acids, peptides, and proteins), behavioral disciplines and activities
Abstract

Table S1. Serum levels of AEA, OEA, and PEA are independently associated with ASD status when adjusting for age, gender, BMI, and ADHD (logistic regression). (DOCX 64Â kb)

Published
2019
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10. Differential Effect of Transferrin Lobe Iron Occupancy on a Murine Model of Inflammation

Author

Parrow, Nermi L., George, Nisha Ajit, Ali, Faris, Wattad, Nadia, Guerra, Amaliris, Ginzburg, Yelena, Rivella, Stefano, and Fleming, Robert E.

Abstract

Introduction: Iron status is both affected by and a determinant of the inflammatory response. Several lines of evidence support a role for transferrin as a signaling as well as an iron delivery molecule. We previously demonstrated that mice with transferrin mutations that prevent iron binding to the C-lobe of transferrin (C-blocked) have increased red cell production relative to erythropoietin and increased hepcidin expression relative to iron status compared to mice with transferrin mutations that prevent iron binding to the N-lobe of transferrin (N-blocked). Based on these observations, we hypothesize that two forms of transferrin would differentially modulate the hematopoietic and iron distribution changes that occur with inflammation. We explored this hypothesis by comparing the effects of lipopolysaccharide (LPS) administered either acutely or in repeated doses to wild-type, N-lobe blocked, or C-lobe blocked transferrin mutant mice.

Published
2023
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