Search

Your search keyword '"Wawro, Mateusz"' showing total 22 results
Start Over Author "Wawro, Mateusz"
22 results on '"Wawro, Mateusz"'

4. Heme oxygenase-1 protects cells from replication stress

Author

Chudy, Patryk, Kochan, Jakub, Wawro, Mateusz, Nguyen, Phu, Gorczyca, Monika, Varanko, Aliaksandra, Retka, Aleksandra, Ghadei, Swati Sweta, Napieralska, Emilija, Grochot-Przęczek, Anna, Szade, Krzysztof, Berendes, Lea-Sophie, Park, Julien, Sokołowski, Grzegorz, Yu, Qiuliyang, Józkowicz, Alicja, Nowak, Witold N., and Krzeptowski, Wojciech

Published
2024
Full Text
View/download PDF

6. The homeostatic function of Regnase‐2 restricts neuroinflammation

Author

Sowinska, Weronika, primary, Wawro, Mateusz, additional, Biswas, Debolina D., additional, Kochan, Jakub, additional, Pustelny, Katarzyna, additional, Solecka, Aleksandra, additional, Gupta, Angela S., additional, Mockenhaupt, Karli, additional, Polak, Jarosław, additional, Kwinta, Borys, additional, Kordula, Tomasz, additional, and Kasza, Aneta, additional

Published
2023
Full Text
View/download PDF

8. Molecular Mechanisms of ZC3H12C/Reg-3 Biological Activity and Its Involvement in Psoriasis Pathology

Author

Wawro, Mateusz, primary, Kochan, Jakub, additional, Sowinska, Weronika, additional, Solecka, Aleksandra, additional, Wawro, Karolina, additional, Morytko, Agnieszka, additional, Kwiecinska, Patrycja, additional, Grygier, Beata, additional, Kwitniewski, Mateusz, additional, Fu, Mingui, additional, Cichy, Joanna, additional, and Kasza, Aneta, additional

Published
2021
Full Text
View/download PDF

22. Intact NYN/PIN-Like Domain is Crucial for the Degradation of Inflammation-Related Transcripts by ZC3H12D.

Author

Wawro M, Kochan J, Krzanik S, Jura J, and Kasza A

Subjects
Apoptosis Regulatory Proteins genetics, Apoptosis Regulatory Proteins metabolism, Cell Cycle Proteins, Cell Line, Tumor, Endonucleases, Endoribonucleases, Humans, Inflammation genetics, Inflammation metabolism, Interleukin-6 genetics, Interleukin-6 metabolism, Membrane Proteins genetics, Membrane Proteins metabolism, Protein Domains, Proteins genetics, Ribonucleases genetics, Transcription Factors genetics, Tumor Necrosis Factor-alpha genetics, Tumor Necrosis Factor-alpha metabolism, 3' Untranslated Regions, Proteins metabolism, RNA Stability physiology, Ribonucleases biosynthesis, Transcription Factors biosynthesis
Abstract

ZC3H12D belongs to a recently discovered family of proteins containing four members of which the most studied and best described is the RNase ZC3H12A (MCPIP1/Regnase-1). ZC3H12A is a crucial negative regulator of inflammation. It accelerates the turnover of transcripts of a spectrum of proinflammatory cytokines, as well as its own mRNA. The biological role of ZC3H12D is less clear, although it was shown that this member of ZC3H12 family is also involved in the regulation of inflammation. Here, we show that ZC3H12A and ZC3H12D recognize a set of common target mRNAs encoding proteins that play important roles in the course of the inflammation. Similarly to ZC3H12A, ZC3H12D participates in the 3'UTR-dependent regulation of the turnover of mRNAs encoding interleukin-6 (IL-6), tumor necrosis factor (TNF), and immediate early response 3 gene (IER3). The ZC3H12A mRNA is also among the identified ZC3H12D targets. Using the combination of immunofluorescence with single molecule RNA fluorescence in situ hybridization (smRNA FISH) we have shown that ZC3H12D protein interacts with the ZC3H12A transcript. The direct binding of these two molecules in vivo was further confirmed by RNA immunoprecipitation. Simultaneously, overexpression of ZC3H12D increases the turnover rate of transcripts containing ZC3H12A 3'UTR. Using reporter gene assays we have confirmed that the Asp95 residue present in the NYN/PIN-like domain is crucial for ZC3H12D biological activity. We have also revealed that ZC3H12D recognizes the same structural elements present in the 3'UTRs of the investigated transcripts, as ZC3H12A. J. Cell. Biochem. 118: 487-498, 2017. © 2016 Wiley Periodicals, Inc., (© 2016 Wiley Periodicals, Inc.)

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results