189 results on '"Weaver, Richard J"'
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2. Acceptable intakes (AIs) for 11 small molecule N-nitrosamines (NAs)
3. The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro
4. Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models
5. Differential toxic effects of bile acid mixtures in isolated mitochondria and physiologically relevant HepaRG cells
6. A ligand-induced structural change in fatty acid–binding protein 1 is associated with potentiation of peroxisome proliferator–activated receptor α agonists
7. Human OATP1B1 (SLCO1B1) transports sulfated bile acids and bile salts with particular efficiency
8. Kinetic characterization of bile salt transport by human NTCP (SLC10A1)
9. A systems approach reveals species differences in hepatic stress response capacity
10. A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity
11. PPAR agonists reduce steatosis in oleic acid-overloaded HepaRG cells
12. Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man
13. ATP-dependent transport of statins by human and rat MRP2/Mrp2
14. A Dynamic Mathematical Model of Bile Acid Clearance in HepaRG Cells
15. Stem cell–derived models to improve mechanistic understanding and prediction of human drug‐induced liver injury
16. A systems approach reveals species differences in hepatic stress response capacity
17. The immediate early genes, c-fos, c-jun and AP-1, are early markers of platinum analogue toxicity in human proximal tubular cell primary cultures
18. Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells
19. Challenges and approaches for the development of safer immunomodulatory biologics
20. Cisplatin nephrotoxicity is mediated by gamma glutamyltranspeptidase, not via a C-S lyase governed biotransformation pathway
21. Fatty acid binding proteins shape the cellular response to activation of the glucocorticoid receptor
22. ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood–brain barrier
23. Trovafloxacin-Induced Liver Injury: Lack in Regulation of Inflammation by Inhibition of Nucleotide Release and Neutrophil Movement
24. Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models
25. The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro
26. Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models
27. Optimizing drug discovery by Investigative Toxicology: Current and future trends
28. Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models
29. Identification and characterization of a naïve CD 8+ T cell repertoire for benzylpenicillin
30. Optimizing drug discovery by Investigative Toxicology: Current and future trends
31. Optimizing drug discovery by Investigative Toxicology: Current and future trends
32. Trovafloxacin-Induced Liver Injury: Lack in Regulation of Inflammation by Inhibition of Nucleotide Release and Neutrophil Movement
33. Tissue influx of neutrophils and monocytes is delayed during development of trovafloxacin-induced tumor necrosis factor-dependent liver injury in mice
34. The expression of cytochrome P-450, epoxide hydrolase, and glutathione S-transferase in hepatocellular carcinoma
35. Today’s Challenges to De-Risk and Predict Drug Safety in Human “Mind-the-Gap”
36. Trovafloxacin-Induced Liver Injury: Lack in Regulation of Inflammation by Inhibition of Nucleotide Release and Neutrophil Movement
37. Tissue influx of neutrophils and monocytes is delayed during development of trovafloxacin-induced tumor necrosis factor-dependent liver injury in mice
38. Tissue influx of neutrophils and monocytes is delayed during development of trovafloxacin‐induced tumor necrosis factor‐dependent liver injury in mice
39. A Dynamic Mathematical Model of Bile Acid Clearance in HepaRG Cells
40. Test systems in drug discovery for hazard identification and risk assessment of human drug-induced liver injury
41. Identification and characterization of a naïve CD8+ T cell repertoire for benzylpenicillin.
42. Today's Challenges to De-Risk and Predict Drug Safety in Human "Mind-the-Gap".
43. Stem cell–derived models to improve mechanistic understanding and prediction of human drug‐induced liver injury
44. A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity
45. Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans
46. Mechanism-Based Markers of Drug-Induced Liver Injury to Improve the Physiological Relevance and Predictivity of In Vitro Models
47. Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication
48. Development and use of in vitro alternatives to animal testing by the pharmaceutical industry 1980–2013
49. A prospective view towards investigative safety assessment
50. Transcriptional regulation of the rat Ntcp and Bsep by PXR and FXR in vivo
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