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1. Management of complicated diaphragmatic hernia in the acute setting: a WSES position paper

Author: Giuffrida, M, Perrone, G, Abu-Zidan, F, Agnoletti, V, Ansaloni, L, Baiocchi, G, Bendinelli, C, Biffl, W, Bonavina, L, Bravi, F, Carcoforo, P, Ceresoli, M, Chichom-Mefire, A, Coccolini, F, Coimbra, R, De'Angelis, N, de Moya, M, De Simone, B, Di Saverio, S, Fraga, G, Galante, J, Ivatury, R, Kashuk, J, Kelly, M, Kirkpatrick, A, Kluger, Y, Koike, K, Leppaniemi, A, Maier, R, Moore, E, Peitzmann, A, Sakakushev, B, Sartelli, M, Sugrue, M, Tian, B, Broek, R, Vallicelli, C, Wani, I, Weber, D, Docimo, G, Catena, F, Giuffrida M., Perrone G., Abu-Zidan F., Agnoletti V., Ansaloni L., Baiocchi G. L., Bendinelli C., Biffl W. L., Bonavina L., Bravi F., Carcoforo P., Ceresoli M., Chichom-Mefire A., Coccolini F., Coimbra R., de'Angelis N., de Moya M., De Simone B., Di Saverio S., Fraga G. P., Galante J., Ivatury R., Kashuk J., Kelly M. D., Kirkpatrick A. W., Kluger Y., Koike K., Leppaniemi A., Maier R. V., Moore E. E., Peitzmann A., Sakakushev B., Sartelli M., Sugrue M., Tian B. W. C. A., Broek R. T., Vallicelli C., Wani I., Weber D. G., Docimo G., Catena F., Giuffrida, M, Perrone, G, Abu-Zidan, F, Agnoletti, V, Ansaloni, L, Baiocchi, G, Bendinelli, C, Biffl, W, Bonavina, L, Bravi, F, Carcoforo, P, Ceresoli, M, Chichom-Mefire, A, Coccolini, F, Coimbra, R, De'Angelis, N, de Moya, M, De Simone, B, Di Saverio, S, Fraga, G, Galante, J, Ivatury, R, Kashuk, J, Kelly, M, Kirkpatrick, A, Kluger, Y, Koike, K, Leppaniemi, A, Maier, R, Moore, E, Peitzmann, A, Sakakushev, B, Sartelli, M, Sugrue, M, Tian, B, Broek, R, Vallicelli, C, Wani, I, Weber, D, Docimo, G, Catena, F, Giuffrida M., Perrone G., Abu-Zidan F., Agnoletti V., Ansaloni L., Baiocchi G. L., Bendinelli C., Biffl W. L., Bonavina L., Bravi F., Carcoforo P., Ceresoli M., Chichom-Mefire A., Coccolini F., Coimbra R., de'Angelis N., de Moya M., De Simone B., Di Saverio S., Fraga G. P., Galante J., Ivatury R., Kashuk J., Kelly M. D., Kirkpatrick A. W., Kluger Y., Koike K., Leppaniemi A., Maier R. V., Moore E. E., Peitzmann A., Sakakushev B., Sartelli M., Sugrue M., Tian B. W. C. A., Broek R. T., Vallicelli C., Wani I., Weber D. G., Docimo G., and Catena F.
Abstract: BACKGROUND: Diaphragmatic hernia (DH) presenting acutely can be a potentially life-threatening condition. Its management continues to be debatable. METHODS: A bibliographic search using major databases was performed using the terms "emergency surgery" "diaphragmatic hernia," "traumatic diaphragmatic rupture" and "congenital diaphragmatic hernia." GRADE methodology was used to evaluate the evidence and give recommendations. RESULTS: CT scan of the chest and abdomen is the diagnostic gold standard to evaluate complicated DH. Appropriate preoperative assessment and prompt surgical intervention are important for a clinical success. Complicated DH repair is best performed via the use of biological and bioabsorbable meshes which have proven to reduce recurrence. The laparoscopic approach is the preferred technique in hemodynamically stable patients without significant comorbidities because it facilitates early diagnosis of small diaphragmatic injuries from traumatic wounds in the thoraco-abdominal area and reduces postoperative complications. Open surgery should be reserved for situations when skills and equipment for laparoscopy are not available, where exploratory laparotomy is needed, or if the patient is hemodynamically unstable. Damage Control Surgery is an option in the management of critical and unstable patients. CONCLUSIONS: Complicated diaphragmatic hernia is a rare life-threatening condition. CT scan of the chest and abdomen is the gold standard for diagnosing the diaphragmatic hernia. Laparoscopic repair is the best treatment option for stable patients with complicated diaphragmatic hernias. Open repair is considered necessary in majority of unstable patients in whom Damage Control Surgery can be life-saving.
Published: 2023

2. Enhanced perioperative care in emergency general surgery: the WSES position paper

Author: Ceresoli, M, Braga, M, Zanini, N, Abu-Zidan, F, Parini, D, Langer, T, Sartelli, M, Damaskos, D, Biffl, W, Amico, F, Ansaloni, L, Balogh, Z, Bonavina, L, Civil, I, Cicuttin, E, Chirica, M, Cui, Y, De Simone, B, Di Carlo, I, Fette, A, Foti, G, Fogliata, M, Fraga, G, Fugazzola, P, Galante, J, Beka, S, Hecker, A, Jeekel, J, Kirkpatrick, A, Koike, K, Leppaniemi, A, Marzi, I, Moore, E, Picetti, E, Pikoulis, E, Pisano, M, Podda, M, Sakakushev, B, Shelat, V, Tan, E, Tebala, G, Velmahos, G, Weber, D, Agnoletti, V, Kluger, Y, Baiocchi, G, Catena, F, Coccolini, F, Ceresoli M., Braga M., Zanini N., Abu-Zidan F. M., Parini D., Langer T., Sartelli M., Damaskos D., Biffl W. L., Amico F., Ansaloni L., Balogh Z. J., Bonavina L., Civil I., Cicuttin E., Chirica M., Cui Y., De Simone B., Di Carlo I., Fette A., Foti G., Fogliata M., Fraga G. P., Fugazzola P., Galante J. M., Beka S. G., Hecker A., Jeekel J., Kirkpatrick A. W., Koike K., Leppaniemi A., Marzi I., Moore E. E., Picetti E., Pikoulis E., Pisano M., Podda M., Sakakushev B. E., Shelat V. G., Tan E., Tebala G. D., Velmahos G., Weber D. G., Agnoletti V., Kluger Y., Baiocchi G., Catena F., Coccolini F., Ceresoli, M, Braga, M, Zanini, N, Abu-Zidan, F, Parini, D, Langer, T, Sartelli, M, Damaskos, D, Biffl, W, Amico, F, Ansaloni, L, Balogh, Z, Bonavina, L, Civil, I, Cicuttin, E, Chirica, M, Cui, Y, De Simone, B, Di Carlo, I, Fette, A, Foti, G, Fogliata, M, Fraga, G, Fugazzola, P, Galante, J, Beka, S, Hecker, A, Jeekel, J, Kirkpatrick, A, Koike, K, Leppaniemi, A, Marzi, I, Moore, E, Picetti, E, Pikoulis, E, Pisano, M, Podda, M, Sakakushev, B, Shelat, V, Tan, E, Tebala, G, Velmahos, G, Weber, D, Agnoletti, V, Kluger, Y, Baiocchi, G, Catena, F, Coccolini, F, Ceresoli M., Braga M., Zanini N., Abu-Zidan F. M., Parini D., Langer T., Sartelli M., Damaskos D., Biffl W. L., Amico F., Ansaloni L., Balogh Z. J., Bonavina L., Civil I., Cicuttin E., Chirica M., Cui Y., De Simone B., Di Carlo I., Fette A., Foti G., Fogliata M., Fraga G. P., Fugazzola P., Galante J. M., Beka S. G., Hecker A., Jeekel J., Kirkpatrick A. W., Koike K., Leppaniemi A., Marzi I., Moore E. E., Picetti E., Pikoulis E., Pisano M., Podda M., Sakakushev B. E., Shelat V. G., Tan E., Tebala G. D., Velmahos G., Weber D. G., Agnoletti V., Kluger Y., Baiocchi G., Catena F., and Coccolini F.
Abstract: Enhanced perioperative care protocols become the standard of care in elective surgery with a significant improvement in patients’ outcome. The key element of the enhanced perioperative care protocol is the multimodal and interdisciplinary approach targeted to the patient, focused on a holistic approach to reduce surgical stress and improve perioperative recovery. Enhanced perioperative care in emergency general surgery is still a debated topic with little evidence available. The present position paper illustrates the existing evidence about perioperative care in emergency surgery patients with a focus on each perioperative intervention in the preoperative, intraoperative and postoperative phase. For each item was proposed and approved a statement by the WSES collaborative group.
Published: 2023

3. ECLAPTE: Effective Closure of LAParoTomy in Emergency-2023 World Society of Emergency Surgery guidelines for the closure of laparotomy in emergency settings

Author: Frassini, S, Cobianchi, L, Fugazzola, P, Biffl, W, Coccolini, F, Damaskos, D, Moore, E, Kluger, Y, Ceresoli, M, Coimbra, R, Davies, J, Kirkpatrick, A, Di Carlo, I, Hardcastle, T, Isik, A, Chiarugi, M, Gurusamy, K, Maier, R, Segovia Lohse, H, Jeekel, H, Boermeester, M, Abu-Zidan, F, Inaba, K, Weber, D, Augustin, G, Bonavina, L, Velmahos, G, Sartelli, M, Di Saverio, S, Ten Broek, R, Granieri, S, Dal Mas, F, Fare, C, Peverada, J, Zanghi, S, Vigano, J, Tomasoni, M, Dominioni, T, Cicuttin, E, Hecker, A, Tebala, G, Galante, J, Wani, I, Khokha, V, Sugrue, M, Scalea, T, Tan, E, Malangoni, M, Pararas, N, Podda, M, De Simone, B, Ivatury, R, Cui, Y, Kashuk, J, Peitzman, A, Kim, F, Pikoulis, E, Sganga, G, Chiara, O, Kelly, M, Marzi, I, Picetti, E, Agnoletti, V, De'Angelis, N, Campanelli, G, de Moya, M, Litvin, A, Martinez-Perez, A, Sall, I, Rizoli, S, Tomadze, G, Sakakushev, B, Stahel, P, Civil, I, Shelat, V, Costa, D, Chichom-Mefire, A, Latifi, R, Chirica, M, Amico, F, Pardhan, A, Seenarain, V, Boyapati, N, Hatz, B, Ackermann, T, Abeyasundara, S, Fenton, L, Plani, F, Sarvepalli, R, Rouhbakhshfar, O, Caleo, P, Ho-Ching Yau, V, Clement, K, Christou, E, Castillo, A, Gosal, P, Balasubramaniam, S, Hsu, J, Banphawatanarak, K, Pisano, M, Adriana, T, Michele, A, Cioffi, S, Spota, A, Catena, F, Ansaloni, L, Frassini S., Cobianchi L., Fugazzola P., Biffl W. L., Coccolini F., Damaskos D., Moore E. E., Kluger Y., Ceresoli M., Coimbra R., Davies J., Kirkpatrick A., Di Carlo I., Hardcastle T. C., Isik A., Chiarugi M., Gurusamy K., Maier R. V., Segovia Lohse H. A., Jeekel H., Boermeester M. A., Abu-Zidan F., Inaba K., Weber D. G., Augustin G., Bonavina L., Velmahos G., Sartelli M., Di Saverio S., Ten Broek R. P. G., Granieri S., Dal Mas F., Fare C. N., Peverada J., Zanghi S., Vigano J., Tomasoni M., Dominioni T., Cicuttin E., Hecker A., Tebala G. D., Galante J. M., Wani I., Khokha V., Sugrue M., Scalea T. M., Tan E., Malangoni M. A., Pararas N., Podda M., De Simone B., Ivatury R., Cui Y., Kashuk J., Peitzman A., Kim F., Pikoulis E., Sganga G., Chiara O., Kelly M. D., Marzi I., Picetti E., Agnoletti V., De'Angelis N., Campanelli G., de Moya M., Litvin A., Martinez-Perez A., Sall I., Rizoli S., Tomadze G., Sakakushev B., Stahel P. F., Civil I., Shelat V., Costa D., Chichom-Mefire A., Latifi R., Chirica M., Amico F., Pardhan A., Seenarain V., Boyapati N., Hatz B., Ackermann T., Abeyasundara S., Fenton L., Plani F., Sarvepalli R., Rouhbakhshfar O., Caleo P., Ho-Ching Yau V., Clement K., Christou E., Castillo A. M. G., Gosal P. K. S., Balasubramaniam S., Hsu J., Banphawatanarak K., Pisano M., Adriana T., Michele A., Cioffi S. P. B., Spota A., Catena F., Ansaloni L., Frassini, S, Cobianchi, L, Fugazzola, P, Biffl, W, Coccolini, F, Damaskos, D, Moore, E, Kluger, Y, Ceresoli, M, Coimbra, R, Davies, J, Kirkpatrick, A, Di Carlo, I, Hardcastle, T, Isik, A, Chiarugi, M, Gurusamy, K, Maier, R, Segovia Lohse, H, Jeekel, H, Boermeester, M, Abu-Zidan, F, Inaba, K, Weber, D, Augustin, G, Bonavina, L, Velmahos, G, Sartelli, M, Di Saverio, S, Ten Broek, R, Granieri, S, Dal Mas, F, Fare, C, Peverada, J, Zanghi, S, Vigano, J, Tomasoni, M, Dominioni, T, Cicuttin, E, Hecker, A, Tebala, G, Galante, J, Wani, I, Khokha, V, Sugrue, M, Scalea, T, Tan, E, Malangoni, M, Pararas, N, Podda, M, De Simone, B, Ivatury, R, Cui, Y, Kashuk, J, Peitzman, A, Kim, F, Pikoulis, E, Sganga, G, Chiara, O, Kelly, M, Marzi, I, Picetti, E, Agnoletti, V, De'Angelis, N, Campanelli, G, de Moya, M, Litvin, A, Martinez-Perez, A, Sall, I, Rizoli, S, Tomadze, G, Sakakushev, B, Stahel, P, Civil, I, Shelat, V, Costa, D, Chichom-Mefire, A, Latifi, R, Chirica, M, Amico, F, Pardhan, A, Seenarain, V, Boyapati, N, Hatz, B, Ackermann, T, Abeyasundara, S, Fenton, L, Plani, F, Sarvepalli, R, Rouhbakhshfar, O, Caleo, P, Ho-Ching Yau, V, Clement, K, Christou, E, Castillo, A, Gosal, P, Balasubramaniam, S, Hsu, J, Banphawatanarak, K, Pisano, M, Adriana, T, Michele, A, Cioffi, S, Spota, A, Catena, F, Ansaloni, L, Frassini S., Cobianchi L., Fugazzola P., Biffl W. L., Coccolini F., Damaskos D., Moore E. E., Kluger Y., Ceresoli M., Coimbra R., Davies J., Kirkpatrick A., Di Carlo I., Hardcastle T. C., Isik A., Chiarugi M., Gurusamy K., Maier R. V., Segovia Lohse H. A., Jeekel H., Boermeester M. A., Abu-Zidan F., Inaba K., Weber D. G., Augustin G., Bonavina L., Velmahos G., Sartelli M., Di Saverio S., Ten Broek R. P. G., Granieri S., Dal Mas F., Fare C. N., Peverada J., Zanghi S., Vigano J., Tomasoni M., Dominioni T., Cicuttin E., Hecker A., Tebala G. D., Galante J. M., Wani I., Khokha V., Sugrue M., Scalea T. M., Tan E., Malangoni M. A., Pararas N., Podda M., De Simone B., Ivatury R., Cui Y., Kashuk J., Peitzman A., Kim F., Pikoulis E., Sganga G., Chiara O., Kelly M. D., Marzi I., Picetti E., Agnoletti V., De'Angelis N., Campanelli G., de Moya M., Litvin A., Martinez-Perez A., Sall I., Rizoli S., Tomadze G., Sakakushev B., Stahel P. F., Civil I., Shelat V., Costa D., Chichom-Mefire A., Latifi R., Chirica M., Amico F., Pardhan A., Seenarain V., Boyapati N., Hatz B., Ackermann T., Abeyasundara S., Fenton L., Plani F., Sarvepalli R., Rouhbakhshfar O., Caleo P., Ho-Ching Yau V., Clement K., Christou E., Castillo A. M. G., Gosal P. K. S., Balasubramaniam S., Hsu J., Banphawatanarak K., Pisano M., Adriana T., Michele A., Cioffi S. P. B., Spota A., Catena F., and Ansaloni L.
Abstract: Laparotomy incisions provide easy and rapid access to the peritoneal cavity in case of emergency surgery. Incisional hernia (IH) is a late manifestation of the failure of abdominal wall closure and represents frequent complication of any abdominal incision: IHs can cause pain and discomfort to the patients but also clinical serious sequelae like bowel obstruction, incarceration, strangulation, and necessity of reoperation. Previous guidelines and indications in the literature consider elective settings and evidence about laparotomy closure in emergency settings is lacking. This paper aims to present the World Society of Emergency Surgery (WSES) project called ECLAPTE (Effective Closure of LAParoTomy in Emergency): the final manuscript includes guidelines on the closure of emergency laparotomy.
Published: 2023

4. Assessing and managing frailty in emergency laparotomy: a WSES position paper

Author: Tian, B, Stahel, P, Picetti, E, Campanelli, G, Di Saverio, S, Moore, E, Bensard, D, Sakakushev, B, Galante, J, Fraga, G, Koike, K, Di Carlo, I, Tebala, G, Leppaniemi, A, Tan, E, Damaskos, D, De'Angelis, N, Hecker, A, Pisano, M, Yunfengcui, Maier, R, De Simone, B, Amico, F, Ceresoli, M, Pikoulis, M, Weber, D, Biffl, W, Beka, S, Abu-Zidan, F, Valentino, M, Coccolini, F, Kluger, Y, Sartelli, M, Agnoletti, V, Chirica, M, Bravi, F, Sall, I, Catena, F, Tian B. W. C. A., Stahel P. F., Picetti E., Campanelli G., Di Saverio S., Moore E., Bensard D., Sakakushev B., Galante J., Fraga G. P., Koike K., Di Carlo I., Tebala G. D., Leppaniemi A., Tan E., Damaskos D., De'Angelis N., Hecker A., Pisano M., YunfengCui, Maier R. V., De Simone B., Amico F., Ceresoli M., Pikoulis M., Weber D. G., Biffl W., Beka S. G., Abu-Zidan F. M., Valentino M., Coccolini F., Kluger Y., Sartelli M., Agnoletti V., Chirica M., Bravi F., Sall I., Catena F., Tian, B, Stahel, P, Picetti, E, Campanelli, G, Di Saverio, S, Moore, E, Bensard, D, Sakakushev, B, Galante, J, Fraga, G, Koike, K, Di Carlo, I, Tebala, G, Leppaniemi, A, Tan, E, Damaskos, D, De'Angelis, N, Hecker, A, Pisano, M, Yunfengcui, Maier, R, De Simone, B, Amico, F, Ceresoli, M, Pikoulis, M, Weber, D, Biffl, W, Beka, S, Abu-Zidan, F, Valentino, M, Coccolini, F, Kluger, Y, Sartelli, M, Agnoletti, V, Chirica, M, Bravi, F, Sall, I, Catena, F, Tian B. W. C. A., Stahel P. F., Picetti E., Campanelli G., Di Saverio S., Moore E., Bensard D., Sakakushev B., Galante J., Fraga G. P., Koike K., Di Carlo I., Tebala G. D., Leppaniemi A., Tan E., Damaskos D., De'Angelis N., Hecker A., Pisano M., YunfengCui, Maier R. V., De Simone B., Amico F., Ceresoli M., Pikoulis M., Weber D. G., Biffl W., Beka S. G., Abu-Zidan F. M., Valentino M., Coccolini F., Kluger Y., Sartelli M., Agnoletti V., Chirica M., Bravi F., Sall I., and Catena F.
Abstract: Many countries are facing an aging population. As people live longer, surgeons face the prospect of operating on increasingly older patients. Traditional teaching is that with older age, these patients face an increased risk of mortality and morbidity, even to a level deemed too prohibitive for surgery. However, this is not always true. An active 90-year-old patient can be much fitter than an overweight, sedentary 65-year-old patient with comorbidities. Recent literature shows that frailty—an age-related cumulative decline in multiple physiological systems, is therefore a better predictor of mortality and morbidity than chronological age alone. Despite recognition of frailty as an important tool in identifying vulnerable surgical patients, many surgeons still shun objective tools. The aim of this position paper was to perform a review of the existing literature and to provide recommendations on emergency laparotomy and in frail patients. This position paper was reviewed by an international expert panel composed of 37 experts who were asked to critically revise the manuscript and position statements. The position paper was conducted according to the WSES methodology. We shall present the derived statements upon which a consensus was reached, specifying the quality of the supporting evidence and suggesting future research directions.
Published: 2023

5. Assessing and managing frailty in emergency laparotomy: a WSES position paper

Author: Tian B. W. C. A., Stahel P. F., Picetti E., Campanelli G., Di Saverio S., Moore E., Bensard D., Sakakushev B., Galante J., Fraga G. P., Koike K., Di Carlo I., Tebala G. D., Leppaniemi A., Tan E., Damaskos D., De'Angelis N., Hecker A., Pisano M., YunfengCui, Maier R. V., De Simone B., Amico F., Ceresoli M., Pikoulis M., Weber D. G., Biffl W., Beka S. G., Abu-Zidan F. M., Valentino M., Coccolini F., Kluger Y., Sartelli M., Agnoletti V., Chirica M., Bravi F., Sall I., Catena F., Tian, B, Stahel, P, Picetti, E, Campanelli, G, Di Saverio, S, Moore, E, Bensard, D, Sakakushev, B, Galante, J, Fraga, G, Koike, K, Di Carlo, I, Tebala, G, Leppaniemi, A, Tan, E, Damaskos, D, De'Angelis, N, Hecker, A, Pisano, M, Yunfengcui, Maier, R, De Simone, B, Amico, F, Ceresoli, M, Pikoulis, M, Weber, D, Biffl, W, Beka, S, Abu-Zidan, F, Valentino, M, Coccolini, F, Kluger, Y, Sartelli, M, Agnoletti, V, Chirica, M, Bravi, F, Sall, I, and Catena, F
Subjects: Laparotomy, Elderly, Frail, Frailty, Emergency surgery
Abstract: Many countries are facing an aging population. As people live longer, surgeons face the prospect of operating on increasingly older patients. Traditional teaching is that with older age, these patients face an increased risk of mortality and morbidity, even to a level deemed too prohibitive for surgery. However, this is not always true. An active 90-year-old patient can be much fitter than an overweight, sedentary 65-year-old patient with comorbidities. Recent literature shows that frailty—an age-related cumulative decline in multiple physiological systems, is therefore a better predictor of mortality and morbidity than chronological age alone. Despite recognition of frailty as an important tool in identifying vulnerable surgical patients, many surgeons still shun objective tools. The aim of this position paper was to perform a review of the existing literature and to provide recommendations on emergency laparotomy and in frail patients. This position paper was reviewed by an international expert panel composed of 37 experts who were asked to critically revise the manuscript and position statements. The position paper was conducted according to the WSES methodology. We shall present the derived statements upon which a consensus was reached, specifying the quality of the supporting evidence and suggesting future research directions.
Published: 2023

6. Laparoscopic lavage versus surgical resection for acute diverticulitis with generalised peritonitis: a systematic review and meta-analysis

Author: Cirocchi, R., Di Saverio, S., Weber, D. G., Taboła, R., Abraha, I., Randolph, J., Arezzo, A., and Binda, G. A.
Published: 2017
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7. Postoperative pain management in non-traumatic emergency general surgery: WSES-GAIS-SIAARTI-AAST guidelines

Author: Coccolini, F, Corradi, F, Sartelli, M, Coimbra, R, Kryvoruchko, I, Leppaniemi, A, Doklestic, K, Bignami, E, Biancofiore, G, Bala, M, Ceresoli, M, Damaskos, D, Biffl, W, Fugazzola, P, Santonastaso, D, Agnoletti, V, Sbarbaro, C, Nacoti, M, Hardcastle, T, Mariani, D, De Simone, B, Tolonen, M, Ball, C, Podda, M, Di Carlo, I, Di Saverio, S, Navsaria, P, Bonavina, L, Abu-Zidan, F, Soreide, K, Fraga, G, Carvalho, V, Batista, S, Hecker, A, Cucchetti, A, Ercolani, G, Tartaglia, D, Galante, J, Wani, I, Kurihara, H, Tan, E, Litvin, A, Melotti, R, Sganga, G, Zoro, T, Isirdi, A, De'Angelis, N, Weber, D, Hodonou, A, Tenbroek, R, Parini, D, Khan, J, Sbrana, G, Coniglio, C, Giarratano, A, Gratarola, A, Zaghi, C, Romeo, O, Kelly, M, Forfori, F, Chiarugi, M, Moore, E, Catena, F, Malbrain, M, Coccolini F., Corradi F., Sartelli M., Coimbra R., Kryvoruchko I. A., Leppaniemi A., Doklestic K., Bignami E., Biancofiore G., Bala M., Ceresoli M., Damaskos D., Biffl W. L., Fugazzola P., Santonastaso D., Agnoletti V., Sbarbaro C., Nacoti M., Hardcastle T. C., Mariani D., De Simone B., Tolonen M., Ball C., Podda M., Di Carlo I., Di Saverio S., Navsaria P., Bonavina L., Abu-Zidan F., Soreide K., Fraga G. P., Carvalho V. H., Batista S. F., Hecker A., Cucchetti A., Ercolani G., Tartaglia D., Galante J. M., Wani I., Kurihara H., Tan E., Litvin A., Melotti R. M., Sganga G., Zoro T., Isirdi A., De'Angelis N., Weber D. G., Hodonou A. M., tenBroek R., Parini D., Khan J., Sbrana G., Coniglio C., Giarratano A., Gratarola A., Zaghi C., Romeo O., Kelly M., Forfori F., Chiarugi M., Moore E. E., Catena F., Malbrain M. L. N. G., Coccolini, F, Corradi, F, Sartelli, M, Coimbra, R, Kryvoruchko, I, Leppaniemi, A, Doklestic, K, Bignami, E, Biancofiore, G, Bala, M, Ceresoli, M, Damaskos, D, Biffl, W, Fugazzola, P, Santonastaso, D, Agnoletti, V, Sbarbaro, C, Nacoti, M, Hardcastle, T, Mariani, D, De Simone, B, Tolonen, M, Ball, C, Podda, M, Di Carlo, I, Di Saverio, S, Navsaria, P, Bonavina, L, Abu-Zidan, F, Soreide, K, Fraga, G, Carvalho, V, Batista, S, Hecker, A, Cucchetti, A, Ercolani, G, Tartaglia, D, Galante, J, Wani, I, Kurihara, H, Tan, E, Litvin, A, Melotti, R, Sganga, G, Zoro, T, Isirdi, A, De'Angelis, N, Weber, D, Hodonou, A, Tenbroek, R, Parini, D, Khan, J, Sbrana, G, Coniglio, C, Giarratano, A, Gratarola, A, Zaghi, C, Romeo, O, Kelly, M, Forfori, F, Chiarugi, M, Moore, E, Catena, F, Malbrain, M, Coccolini F., Corradi F., Sartelli M., Coimbra R., Kryvoruchko I. A., Leppaniemi A., Doklestic K., Bignami E., Biancofiore G., Bala M., Ceresoli M., Damaskos D., Biffl W. L., Fugazzola P., Santonastaso D., Agnoletti V., Sbarbaro C., Nacoti M., Hardcastle T. C., Mariani D., De Simone B., Tolonen M., Ball C., Podda M., Di Carlo I., Di Saverio S., Navsaria P., Bonavina L., Abu-Zidan F., Soreide K., Fraga G. P., Carvalho V. H., Batista S. F., Hecker A., Cucchetti A., Ercolani G., Tartaglia D., Galante J. M., Wani I., Kurihara H., Tan E., Litvin A., Melotti R. M., Sganga G., Zoro T., Isirdi A., De'Angelis N., Weber D. G., Hodonou A. M., tenBroek R., Parini D., Khan J., Sbrana G., Coniglio C., Giarratano A., Gratarola A., Zaghi C., Romeo O., Kelly M., Forfori F., Chiarugi M., Moore E. E., Catena F., and Malbrain M. L. N. G.
Abstract: Background: Non-traumatic emergency general surgery involves a heterogeneous population that may present with several underlying diseases. Timeous emergency surgical treatment should be supplemented with high-quality perioperative care, ideally performed by multidisciplinary teams trained to identify and handle complex postoperative courses. Uncontrolled or poorly controlled acute postoperative pain may result in significant complications. While pain management after elective surgery has been standardized in perioperative pathways, the traditional perioperative treatment of patients undergoing emergency surgery is often a haphazard practice. The present recommended pain management guidelines are for pain management after non-traumatic emergency surgical intervention. It is meant to provide clinicians a list of indications to prescribe the optimal analgesics even in the absence of a multidisciplinary pain team. Material and methods: An international expert panel discussed the different issues in subsequent rounds. Four international recognized scientific societies: World Society of Emergency Surgery (WSES), Global Alliance for Infection in Surgery (GAIS), Italian Society of Anesthesia, Analgesia Intensive Care (SIAARTI), and American Association for the Surgery of Trauma (AAST), endorsed the project and approved the final manuscript. Conclusion: Dealing with acute postoperative pain in the emergency abdominal surgery setting is complex, requires special attention, and should be multidisciplinary. Several tools are available, and their combination is mandatory whenever is possible. Analgesic approach to the various situations and conditions should be patient based and tailored according to procedure, pathology, age, response, and available expertise. A better understanding of the patho-mechanisms of postoperative pain for short- and long-term outcomes is necessary to improve prophylactic and treatment strategies.
Published: 2022

8. Operative management of acute abdomen after bariatric surgery in the emergency setting: the OBA guidelines

Author: De Simone, B, Chouillard, E, Ramos, A, Donatelli, G, Pintar, T, Gupta, R, Renzi, F, Mahawar, K, Madhok, B, Maccatrozzo, S, Abu-Zidan, F, E. Moore, E, Weber, D, Coccolini, F, Di Saverio, S, Kirkpatrick, A, Shelat, V, Amico, F, Pikoulis, E, Ceresoli, M, Galante, J, Wani, I, De' Angelis, N, Hecker, A, Sganga, G, Tan, E, Balogh, Z, Bala, M, Coimbra, R, Damaskos, D, Ansaloni, L, Sartelli, M, Parasas, N, Kluger, Y, Chahine, E, Agnoletti, V, Fraga, G, Biffl, W, Catena, F, De Simone B., Chouillard E., Ramos A. C., Donatelli G., Pintar T., Gupta R., Renzi F., Mahawar K., Madhok B., Maccatrozzo S., Abu-Zidan F. M., E. Moore E., Weber D. G., Coccolini F., Di Saverio S., Kirkpatrick A., Shelat V. G., Amico F., Pikoulis E., Ceresoli M., Galante J. M., Wani I., De' Angelis N., Hecker A., Sganga G., Tan E., Balogh Z. J., Bala M., Coimbra R., Damaskos D., Ansaloni L., Sartelli M., Parasas N., Kluger Y., Chahine E., Agnoletti V., Fraga G., Biffl W. L., Catena F., De Simone, B, Chouillard, E, Ramos, A, Donatelli, G, Pintar, T, Gupta, R, Renzi, F, Mahawar, K, Madhok, B, Maccatrozzo, S, Abu-Zidan, F, E. Moore, E, Weber, D, Coccolini, F, Di Saverio, S, Kirkpatrick, A, Shelat, V, Amico, F, Pikoulis, E, Ceresoli, M, Galante, J, Wani, I, De' Angelis, N, Hecker, A, Sganga, G, Tan, E, Balogh, Z, Bala, M, Coimbra, R, Damaskos, D, Ansaloni, L, Sartelli, M, Parasas, N, Kluger, Y, Chahine, E, Agnoletti, V, Fraga, G, Biffl, W, Catena, F, De Simone B., Chouillard E., Ramos A. C., Donatelli G., Pintar T., Gupta R., Renzi F., Mahawar K., Madhok B., Maccatrozzo S., Abu-Zidan F. M., E. Moore E., Weber D. G., Coccolini F., Di Saverio S., Kirkpatrick A., Shelat V. G., Amico F., Pikoulis E., Ceresoli M., Galante J. M., Wani I., De' Angelis N., Hecker A., Sganga G., Tan E., Balogh Z. J., Bala M., Coimbra R., Damaskos D., Ansaloni L., Sartelli M., Parasas N., Kluger Y., Chahine E., Agnoletti V., Fraga G., Biffl W. L., and Catena F.
Abstract: Background: Patients presenting with acute abdominal pain that occurs after months or years following bariatric surgery may present for assessment and management in the local emergency units. Due to the large variety of surgical bariatric techniques, emergency surgeons have to be aware of the main functional outcomes and long-term surgical complications following the most performed bariatric surgical procedures. The purpose of these evidence-based guidelines is to present a consensus position from members of the WSES in collaboration with IFSO bariatric experienced surgeons, on the management of acute abdomen after bariatric surgery focusing on long-term complications in patients who have undergone laparoscopic sleeve gastrectomy and laparoscopic Roux-en-Y gastric bypass. Method: A working group of experienced general, acute care, and bariatric surgeons was created to carry out a systematic review of the literature following the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols (PRISMA-P) and to answer the PICO questions formulated after the Operative management in bariatric acute abdomen survey. The literature search was limited to late/long-term complications following laparoscopic sleeve gastrectomy and laparoscopic Roux-en-Y gastric bypass. Conclusions: The acute abdomen after bariatric surgery is a common cause of admission in emergency departments. Knowledge of the most common late/long-term complications (> 4 weeks after surgical procedure) following sleeve gastrectomy and Roux-en-Y gastric bypass and their anatomy leads to a focused management in the emergency setting with good outcomes and decreased morbidity and mortality rates. A close collaboration between emergency surgeons, radiologists, endoscopists, and anesthesiologists is mandatory in the management of this group of patients in the emergency setting.
Published: 2022

9. Two years later: Is the SARS-CoV-2 pandemic still having an impact on emergency surgery? An international cross-sectional survey among WSES members

Author: Reichert, M, Sartelli, M, Weigand, M, Hecker, M, Oppelt, P, Noll, J, Askevold, I, Liese, J, Padberg, W, Coccolini, F, Catena, F, Hecker, A, Peckham-Cooper, A, Camacho-Ortiz, A, Mastoraki, A, Landaluce-Olavarria, A, Pal, A, Kuriyama, A, Chichom-Mefire, A, Porcu, A, Martinez-Perez, A, Karamarkovic, A, Osipov, A, Coppola, A, Cucchetti, A, Spolini, A, Giordano, A, Reinisch-Liese, A, Kavalakat, A, Vasilescu, A, Alamin, A, Gupta, A, Dascalu, A, Musina, A, Bakopoulos, A, Zakaria, A, Vereczkei, A, Balla, A, Bottari, A, Baumann, A, Fette, A, Litvin, A, Reichert, A, Guariniello, A, Paspala, A, Schneck, A, Brillantino, A, Pesce, A, Isik, A, Leppaniemi, A, Papadopoulos, A, Kechagias, A, Mohamed, A, Mitul, A, Marinis, A, Syllaios, A, Mantoglu, B, De Simone, B, Weiss, B, Posentrup, B, Picardi, B, Zampogna, B, Sakakushev, B, Atanasov, B, Nardo, B, Calik, B, Cremonini, C, Ordonez, C, Seretis, C, Cascone, C, Chouliaras, C, Bendinelli, C, Lopes, C, Guerci, C, Weber, C, Nastos, C, Mesina, C, Caputo, D, Massalou, D, Cavaliere, D, Mcnamara, D, Demetriades, D, Pantalone, D, Coletta, D, Sasia, D, Visconti, D, Weber, D, Corallino, D, Chatzipetris, D, Manatakis, D, Ntourakis, D, Papaconstantinou, D, Schizas, D, Chrysikos, D, Adamovich, D, Elkafrawy, D, Seban, D, Garcia, E, Baldini, E, Picetti, E, Tan, E, Baili, E, Lostoridis, E, Toma, E, Colak, E, Cerutti, E, Steyn, E, Hsabo, E, Kapetanakis, E, Kaouras, E, Schneck, E, Akin, E, Gonullu, E, Celik, E, Cicuttin, E, Pinotti, E, Johnsson, E, Moore, E, Agastra, E, Dimitrov, E, Griffiths, E, D'Acapito, F, Saraceno, F, Alconchel, F, Zeppernick, F, Rodriguez, F, Abu-Zidan, F, Pecchini, F, Favi, F, Ferrara, F, Fleres, F, Pata, F, Roscio, F, Mulita, F, Dor, F, Linder, F, Dimofte, G, Rodrigues, G, Nita, G, Sganga, G, Martines, G, Mazzarella, G, Perrone, G, Velmahos, G, Lianos, G, Tomadze, G, Baiocchi, G, D'Ambrosio, G, Pellino, G, Pattacini, G, Giraudo, G, Lisi, G, Tebala, G, Pirozzolo, G, Montori, G, Argenio, G, Brisinda, G, Curro, G, Giuliani, G, Palomba, G, Roscitano, G, Avsar, G, Augustin, G, Clarizia, G, Vega, G, Fraga, G, Sethi, H, Eltyeb, H, Lohse, H, Bayhan, H, Hamid, H, Kryvoruchko, I, Iannone, I, Wani, I, Lazaridis, I, Katsaros, I, Nikolopoulos, I, Negoi, I, Reccia, I, Di Carlo, I, Olaoye, I, Czepiel, J, Kim, J, Meyer, J, Terrazas, J, Tochie, J, Galante, J, Davies, J, Sugand, K, Gonfa, K, Rasa, K, Kok, K, Apostolou, K, Lasithiotakis, K, Tsekouras, K, Angamuthu, K, Akhmeteli, L, Sydorchuk, L, Fortuna, L, Siragusa, L, Pagani, L, Solaini, L, Miller, L, Bains, L, Ansaloni, L, Ferrario, L, Bonavina, L, Conti, L, Buonomo, L, Tallon-Aguilar, L, Tomczyk, L, Widmer, L, Waledziak, M, Gachabayov, M, Bulanauca, M, Malbrain, M, Maegele, M, Catarci, M, Ceresoli, M, Ranucci, M, Antonopoulou, M, Papadoliopoulou, M, Valenti, M, Sotiropoulou, M, D'Oria, M, Martin, M, Hirschburger, M, Veroux, M, Fantoni, M, Nardi, M, Tolonen, M, Montuori, M, Podda, M, Scheiterle, M, Frountzas, M, Sarikaya, M, Yildirim, M, Bender, M, Vailas, M, Teuben, M, Campanelli, M, Ammendola, M, Malerba, M, Pisano, M, Pertea, M, Slavchev, M, Ukkonen, M, Bala, M, Chirica, M, Barone, M, Shaat, M, Mohammed, M, Abuelgasim, M, Gureh, M, Ouadii, M, Balkan, M, Mohamed, M, Hakseven, M, Velenciuc, N, Cillara, N, De'Angelis, N, Tamini, N, Zavras, N, Machairas, N, Michalopoulos, N, Koliakos, N, Pararas, N, Donlon, N, Medappil, N, Ben-Ishay, O, Stefano, O, Islam, O, Tammo, O, Ioannidis, O, Aparicio, O, Baraket, O, Kumar, P, Cianci, P, Ortenwall, P, Uchikov, P, de Reuver, P, Stahel, P, Barie, P, Piccoli, M, Major, P, Navsaria, P, Sasmal, P, Coimbra, R, Rahim, R, Capoglu, R, Koshy, R, Gonsaga, R, Pertile, R, Mohamed, R, Deryol, R, Sawyer, R, Angelico, R, Ragozzino, R, Bini, R, Cammarata, R, Scaramuzzo, R, Gioco, R, Sydorchuk, R, Ahmed, S, Di Saverio, S, Emile, S, Delibegovic, S, Marwah, S, Symeonidis, S, Thomas, S, Demir, S, Awad, S, Atici, S, Chooklin, S, Meric, S, Sarikaya, S, Chowdhury, S, Mirghani, S, Wren, S, Gargarella, S, Del Monte, S, Esposito, S, Xenaki, S, Mohamed, S, Beka, S, Lunca, S, Delis, S, Dritsas, S, Morarasu, S, Magnone, S, Rossi, S, Bitsianis, S, Kykalos, S, Baral, S, Jain, S, Ali, S, Pintar, T, Triantafyllou, T, Delko, T, Perra, T, Sidiropoulos, T, Scalea, T, Vilz, T, Hardcastle, T, Wannatoop, T, Herzog, T, Mishra, T, Boggi, U, Calu, V, Tomajer, V, Agnoletti, V, Lohsiriwat, V, Kong, V, Munoz-Cruzado, V, Shelat, V, Khokha, V, Ghannam, W, Biffl, W, Zuidema, W, Kara, Y, Kobe, Y, Demetrashvili, Z, Memish, Z, Madrazo, Z, Balogh, Z, Bayhan, Z, Reichert M., Sartelli M., Weigand M. A., Hecker M., Oppelt P. U., Noll J., Askevold I. H., Liese J., Padberg W., Coccolini F., Catena F., Hecker A., Peckham-Cooper A., Camacho-Ortiz A., Mastoraki A. T., Landaluce-Olavarria A., Pal A. K., Kuriyama A., Chichom-Mefire A., Porcu A., Martinez-Perez A., Karamarkovic A. R., Osipov A. V., Coppola A., Cucchetti A., Spolini A., Giordano A., Reinisch-Liese A., Kavalakat A. J., Vasilescu A., Alamin A., Gupta A., Dascalu A. M., Musina A. -M., Bakopoulos A., Zakaria A. D., Vereczkei A., Balla A., Bottari A., Baumann A., Fette A., Litvin A., Reichert A. K., Guariniello A., Paspala A., Schneck A. -S., Brillantino A., Pesce A., Isik A., Leppaniemi A. K., Papadopoulos A., Kechagias A., Mohamed A. Y. A., Mitul A. R., Marinis A., Syllaios A., Mantoglu B., De Simone B., Weiss B. S., Posentrup B., Picardi B., Zampogna B., Sakakushev B. E., Atanasov B. C., Nardo B., Calik B., Cremonini C., Ordonez C. A., Seretis C., Cascone C., Chouliaras C., Bendinelli C., Lopes C., Guerci C., Weber C., Nastos C., Mesina C., Caputo D., Massalou D., Cavaliere D., McNamara D. A., Demetriades D., Pantalone D., Coletta D., Sasia D., Visconti D., Weber D. G., Corallino D., Chatzipetris D., Manatakis D. K., Ntourakis D., Papaconstantinou D., Schizas D., Chrysikos D., Adamovich D. M., Elkafrawy D., Seban D., Garcia E. F. H., Baldini E., Picetti E., Tan E. C. T. H., Baili E., Lostoridis E., Toma E. A., Colak E., Cerutti E., Steyn E., Hsabo E. A., Kapetanakis E. I., Kaouras E., Schneck E., Akin E., Gonullu E., celik E., Cicuttin E., Pinotti E., Johnsson E., Moore E. E., Agastra E., Dimitrov E. N., Griffiths E. A., D'Acapito F., Saraceno F., Alconchel F., Zeppernick F. A., Rodriguez F. M., Abu-Zidan F., Pecchini F., Favi F., Ferrara F., Fleres F., Pata F., Roscio F. P. M., Mulita F., Dor F. J. M. F., Linder F., Dimofte G., Rodrigues G., Nita G., Sganga G., Martines G., Mazzarella G., Perrone G., Velmahos G., Lianos G. D., Tomadze G., Baiocchi G. L., D'Ambrosio G., Pellino G., Pattacini G. C., Giraudo G., Lisi G., Tebala G. D., Pirozzolo G., Montori G., Argenio G., Brisinda G., Curro G., Giuliani G., Palomba G., Roscitano G., Avsar G., Augustin G., Clarizia G., Vega G. M. M., Fraga G. P., Sethi H., Eltyeb H. A., Lohse H. A. S., Lohse H. R. S., Bayhan H., Hamid H. K. S., Kryvoruchko I. A., Iannone I., Wani I., Lazaridis I. I., Katsaros I., Nikolopoulos I., Negoi I., Reccia I., Di Carlo I., Olaoye I. O., Czepiel J., Kim J. I., Meyer J., Terrazas J. M. S., Tochie J. N., Galante J. M., Davies J., Sugand K., Gonfa K. B., Rasa K., Kok K. Y. Y., Apostolou K. G., Lasithiotakis K., Tsekouras K., Angamuthu K., Akhmeteli L., Sydorchuk L., Fortuna L., Siragusa L., Pagani L., Solaini L., Miller L. A., Bains L., Ansaloni L., Ferrario L., Bonavina L., Conti L., Buonomo L. A., Tallon-Aguilar L., Tomczyk L., Widmer L. W., Waledziak M., Gachabayov M., Bulanauca M. M., Malbrain M. L. N. G., Maegele M., Catarci M., Ceresoli M., Ranucci M. C., Antonopoulou M. I., Papadoliopoulou M., Valenti M. R., Sotiropoulou M., D'Oria M., Martin M. S., Hirschburger M., Veroux M., Fantoni M., Nardi M., Tolonen M., Montuori M., Podda M., Scheiterle M., Frountzas M., Sarikaya M., Yildirim M., Bender M., Vailas M., Teuben M., Campanelli M., Ammendola M., Malerba M., Pisano M., Pertea M., Slavchev M., Ukkonen M., Bala M., Chirica M., Barone M., Shaat M. M., Mohammed M. J. S., Abuelgasim M. A. A., Gureh M., Ouadii M., Balkan M., Mohamed M., Hakseven M., Velenciuc N., Cillara N., de'Angelis N., Tamini N., Zavras N. J., Machairas N., Michalopoulos N., Koliakos N. N., Pararas N., Donlon N. E., Medappil N., Ben-Ishay O., Stefano O., Islam O., Tammo O., Ioannidis O., Aparicio O., Baraket O., Kumar P., Cianci P., Ortenwall P., Uchikov P. A., de Reuver P., Stahel P. F., Barie P. S., Piccoli M., Major P., Navsaria P. H., Sasmal P. K., Coimbra R., Rahim R., Capoglu R., Koshy R. M., Gonsaga R. A. T., Pertile R., Mohamed R. R. M., Deryol R., Sawyer R. G., Angelico R., Ragozzino R., Bini R., Cammarata R., Scaramuzzo R., Gioco R., Sydorchuk R., Ahmed S., Di Saverio S., Emile S. H., Delibegovic S., Marwah S., Symeonidis S., Thomas S. G., Demir S., Awad S. S., Atici S. D., Chooklin S., Meric S., Sarikaya S., Chowdhury S., Mirghani S. F., Wren S. M., Gargarella S., Del Monte S. R., Esposito S., Xenaki S., Mohamed S. F. G., Beka S. G., Lunca S., Delis S. G., Dritsas S., Morarasu S., Magnone S., Rossi S., Bitsianis S., Kykalos S., Baral S., Jain S. A., Ali S. M., Pintar T., Triantafyllou T., Delko T., Perra T., Sidiropoulos T. A., Scalea T. M., Vilz T. O., Hardcastle T. C., Wannatoop T., Herzog T., Mishra T. S., Boggi U., Calu V., Tomajer V., Agnoletti V., Lohsiriwat V., Kong V., Munoz-Cruzado V. D., Shelat V. G., Khokha V., Ghannam W. M., Biffl W. L., Zuidema W., Kara Y., Kobe Y., Demetrashvili Z., Memish Z. A., Madrazo Z., Balogh Z. J., Bayhan Z., Reichert, M, Sartelli, M, Weigand, M, Hecker, M, Oppelt, P, Noll, J, Askevold, I, Liese, J, Padberg, W, Coccolini, F, Catena, F, Hecker, A, Peckham-Cooper, A, Camacho-Ortiz, A, Mastoraki, A, Landaluce-Olavarria, A, Pal, A, Kuriyama, A, Chichom-Mefire, A, Porcu, A, Martinez-Perez, A, Karamarkovic, A, Osipov, A, Coppola, A, Cucchetti, A, Spolini, A, Giordano, A, Reinisch-Liese, A, Kavalakat, A, Vasilescu, A, Alamin, A, Gupta, A, Dascalu, A, Musina, A, Bakopoulos, A, Zakaria, A, Vereczkei, A, Balla, A, Bottari, A, Baumann, A, Fette, A, Litvin, A, Reichert, A, Guariniello, A, Paspala, A, Schneck, A, Brillantino, A, Pesce, A, Isik, A, Leppaniemi, A, Papadopoulos, A, Kechagias, A, Mohamed, A, Mitul, A, Marinis, A, Syllaios, A, Mantoglu, B, De Simone, B, Weiss, B, Posentrup, B, Picardi, B, Zampogna, B, Sakakushev, B, Atanasov, B, Nardo, B, Calik, B, Cremonini, C, Ordonez, C, Seretis, C, Cascone, C, Chouliaras, C, Bendinelli, C, Lopes, C, Guerci, C, Weber, C, Nastos, C, Mesina, C, Caputo, D, Massalou, D, Cavaliere, D, Mcnamara, D, Demetriades, D, Pantalone, D, Coletta, D, Sasia, D, Visconti, D, Weber, D, Corallino, D, Chatzipetris, D, Manatakis, D, Ntourakis, D, Papaconstantinou, D, Schizas, D, Chrysikos, D, Adamovich, D, Elkafrawy, D, Seban, D, Garcia, E, Baldini, E, Picetti, E, Tan, E, Baili, E, Lostoridis, E, Toma, E, Colak, E, Cerutti, E, Steyn, E, Hsabo, E, Kapetanakis, E, Kaouras, E, Schneck, E, Akin, E, Gonullu, E, Celik, E, Cicuttin, E, Pinotti, E, Johnsson, E, Moore, E, Agastra, E, Dimitrov, E, Griffiths, E, D'Acapito, F, Saraceno, F, Alconchel, F, Zeppernick, F, Rodriguez, F, Abu-Zidan, F, Pecchini, F, Favi, F, Ferrara, F, Fleres, F, Pata, F, Roscio, F, Mulita, F, Dor, F, Linder, F, Dimofte, G, Rodrigues, G, Nita, G, Sganga, G, Martines, G, Mazzarella, G, Perrone, G, Velmahos, G, Lianos, G, Tomadze, G, Baiocchi, G, D'Ambrosio, G, Pellino, G, Pattacini, G, Giraudo, G, Lisi, G, Tebala, G, Pirozzolo, G, Montori, G, Argenio, G, Brisinda, G, Curro, G, Giuliani, G, Palomba, G, Roscitano, G, Avsar, G, Augustin, G, Clarizia, G, Vega, G, Fraga, G, Sethi, H, Eltyeb, H, Lohse, H, Bayhan, H, Hamid, H, Kryvoruchko, I, Iannone, I, Wani, I, Lazaridis, I, Katsaros, I, Nikolopoulos, I, Negoi, I, Reccia, I, Di Carlo, I, Olaoye, I, Czepiel, J, Kim, J, Meyer, J, Terrazas, J, Tochie, J, Galante, J, Davies, J, Sugand, K, Gonfa, K, Rasa, K, Kok, K, Apostolou, K, Lasithiotakis, K, Tsekouras, K, Angamuthu, K, Akhmeteli, L, Sydorchuk, L, Fortuna, L, Siragusa, L, Pagani, L, Solaini, L, Miller, L, Bains, L, Ansaloni, L, Ferrario, L, Bonavina, L, Conti, L, Buonomo, L, Tallon-Aguilar, L, Tomczyk, L, Widmer, L, Waledziak, M, Gachabayov, M, Bulanauca, M, Malbrain, M, Maegele, M, Catarci, M, Ceresoli, M, Ranucci, M, Antonopoulou, M, Papadoliopoulou, M, Valenti, M, Sotiropoulou, M, D'Oria, M, Martin, M, Hirschburger, M, Veroux, M, Fantoni, M, Nardi, M, Tolonen, M, Montuori, M, Podda, M, Scheiterle, M, Frountzas, M, Sarikaya, M, Yildirim, M, Bender, M, Vailas, M, Teuben, M, Campanelli, M, Ammendola, M, Malerba, M, Pisano, M, Pertea, M, Slavchev, M, Ukkonen, M, Bala, M, Chirica, M, Barone, M, Shaat, M, Mohammed, M, Abuelgasim, M, Gureh, M, Ouadii, M, Balkan, M, Mohamed, M, Hakseven, M, Velenciuc, N, Cillara, N, De'Angelis, N, Tamini, N, Zavras, N, Machairas, N, Michalopoulos, N, Koliakos, N, Pararas, N, Donlon, N, Medappil, N, Ben-Ishay, O, Stefano, O, Islam, O, Tammo, O, Ioannidis, O, Aparicio, O, Baraket, O, Kumar, P, Cianci, P, Ortenwall, P, Uchikov, P, de Reuver, P, Stahel, P, Barie, P, Piccoli, M, Major, P, Navsaria, P, Sasmal, P, Coimbra, R, Rahim, R, Capoglu, R, Koshy, R, Gonsaga, R, Pertile, R, Mohamed, R, Deryol, R, Sawyer, R, Angelico, R, Ragozzino, R, Bini, R, Cammarata, R, Scaramuzzo, R, Gioco, R, Sydorchuk, R, Ahmed, S, Di Saverio, S, Emile, S, Delibegovic, S, Marwah, S, Symeonidis, S, Thomas, S, Demir, S, Awad, S, Atici, S, Chooklin, S, Meric, S, Sarikaya, S, Chowdhury, S, Mirghani, S, Wren, S, Gargarella, S, Del Monte, S, Esposito, S, Xenaki, S, Mohamed, S, Beka, S, Lunca, S, Delis, S, Dritsas, S, Morarasu, S, Magnone, S, Rossi, S, Bitsianis, S, Kykalos, S, Baral, S, Jain, S, Ali, S, Pintar, T, Triantafyllou, T, Delko, T, Perra, T, Sidiropoulos, T, Scalea, T, Vilz, T, Hardcastle, T, Wannatoop, T, Herzog, T, Mishra, T, Boggi, U, Calu, V, Tomajer, V, Agnoletti, V, Lohsiriwat, V, Kong, V, Munoz-Cruzado, V, Shelat, V, Khokha, V, Ghannam, W, Biffl, W, Zuidema, W, Kara, Y, Kobe, Y, Demetrashvili, Z, Memish, Z, Madrazo, Z, Balogh, Z, Bayhan, Z, Reichert M., Sartelli M., Weigand M. A., Hecker M., Oppelt P. U., Noll J., Askevold I. H., Liese J., Padberg W., Coccolini F., Catena F., Hecker A., Peckham-Cooper A., Camacho-Ortiz A., Mastoraki A. T., Landaluce-Olavarria A., Pal A. K., Kuriyama A., Chichom-Mefire A., Porcu A., Martinez-Perez A., Karamarkovic A. R., Osipov A. V., Coppola A., Cucchetti A., Spolini A., Giordano A., Reinisch-Liese A., Kavalakat A. J., Vasilescu A., Alamin A., Gupta A., Dascalu A. M., Musina A. -M., Bakopoulos A., Zakaria A. D., Vereczkei A., Balla A., Bottari A., Baumann A., Fette A., Litvin A., Reichert A. K., Guariniello A., Paspala A., Schneck A. -S., Brillantino A., Pesce A., Isik A., Leppaniemi A. K., Papadopoulos A., Kechagias A., Mohamed A. Y. A., Mitul A. R., Marinis A., Syllaios A., Mantoglu B., De Simone B., Weiss B. S., Posentrup B., Picardi B., Zampogna B., Sakakushev B. E., Atanasov B. C., Nardo B., Calik B., Cremonini C., Ordonez C. A., Seretis C., Cascone C., Chouliaras C., Bendinelli C., Lopes C., Guerci C., Weber C., Nastos C., Mesina C., Caputo D., Massalou D., Cavaliere D., McNamara D. A., Demetriades D., Pantalone D., Coletta D., Sasia D., Visconti D., Weber D. G., Corallino D., Chatzipetris D., Manatakis D. K., Ntourakis D., Papaconstantinou D., Schizas D., Chrysikos D., Adamovich D. M., Elkafrawy D., Seban D., Garcia E. F. H., Baldini E., Picetti E., Tan E. C. T. H., Baili E., Lostoridis E., Toma E. A., Colak E., Cerutti E., Steyn E., Hsabo E. A., Kapetanakis E. I., Kaouras E., Schneck E., Akin E., Gonullu E., celik E., Cicuttin E., Pinotti E., Johnsson E., Moore E. E., Agastra E., Dimitrov E. N., Griffiths E. A., D'Acapito F., Saraceno F., Alconchel F., Zeppernick F. A., Rodriguez F. M., Abu-Zidan F., Pecchini F., Favi F., Ferrara F., Fleres F., Pata F., Roscio F. P. M., Mulita F., Dor F. J. M. F., Linder F., Dimofte G., Rodrigues G., Nita G., Sganga G., Martines G., Mazzarella G., Perrone G., Velmahos G., Lianos G. D., Tomadze G., Baiocchi G. L., D'Ambrosio G., Pellino G., Pattacini G. C., Giraudo G., Lisi G., Tebala G. D., Pirozzolo G., Montori G., Argenio G., Brisinda G., Curro G., Giuliani G., Palomba G., Roscitano G., Avsar G., Augustin G., Clarizia G., Vega G. M. M., Fraga G. P., Sethi H., Eltyeb H. A., Lohse H. A. S., Lohse H. R. S., Bayhan H., Hamid H. K. S., Kryvoruchko I. A., Iannone I., Wani I., Lazaridis I. I., Katsaros I., Nikolopoulos I., Negoi I., Reccia I., Di Carlo I., Olaoye I. O., Czepiel J., Kim J. I., Meyer J., Terrazas J. M. S., Tochie J. N., Galante J. M., Davies J., Sugand K., Gonfa K. B., Rasa K., Kok K. Y. Y., Apostolou K. G., Lasithiotakis K., Tsekouras K., Angamuthu K., Akhmeteli L., Sydorchuk L., Fortuna L., Siragusa L., Pagani L., Solaini L., Miller L. A., Bains L., Ansaloni L., Ferrario L., Bonavina L., Conti L., Buonomo L. A., Tallon-Aguilar L., Tomczyk L., Widmer L. W., Waledziak M., Gachabayov M., Bulanauca M. M., Malbrain M. L. N. G., Maegele M., Catarci M., Ceresoli M., Ranucci M. C., Antonopoulou M. I., Papadoliopoulou M., Valenti M. R., Sotiropoulou M., D'Oria M., Martin M. S., Hirschburger M., Veroux M., Fantoni M., Nardi M., Tolonen M., Montuori M., Podda M., Scheiterle M., Frountzas M., Sarikaya M., Yildirim M., Bender M., Vailas M., Teuben M., Campanelli M., Ammendola M., Malerba M., Pisano M., Pertea M., Slavchev M., Ukkonen M., Bala M., Chirica M., Barone M., Shaat M. M., Mohammed M. J. S., Abuelgasim M. A. A., Gureh M., Ouadii M., Balkan M., Mohamed M., Hakseven M., Velenciuc N., Cillara N., de'Angelis N., Tamini N., Zavras N. J., Machairas N., Michalopoulos N., Koliakos N. N., Pararas N., Donlon N. E., Medappil N., Ben-Ishay O., Stefano O., Islam O., Tammo O., Ioannidis O., Aparicio O., Baraket O., Kumar P., Cianci P., Ortenwall P., Uchikov P. A., de Reuver P., Stahel P. F., Barie P. S., Piccoli M., Major P., Navsaria P. H., Sasmal P. K., Coimbra R., Rahim R., Capoglu R., Koshy R. M., Gonsaga R. A. T., Pertile R., Mohamed R. R. M., Deryol R., Sawyer R. G., Angelico R., Ragozzino R., Bini R., Cammarata R., Scaramuzzo R., Gioco R., Sydorchuk R., Ahmed S., Di Saverio S., Emile S. H., Delibegovic S., Marwah S., Symeonidis S., Thomas S. G., Demir S., Awad S. S., Atici S. D., Chooklin S., Meric S., Sarikaya S., Chowdhury S., Mirghani S. F., Wren S. M., Gargarella S., Del Monte S. R., Esposito S., Xenaki S., Mohamed S. F. G., Beka S. G., Lunca S., Delis S. G., Dritsas S., Morarasu S., Magnone S., Rossi S., Bitsianis S., Kykalos S., Baral S., Jain S. A., Ali S. M., Pintar T., Triantafyllou T., Delko T., Perra T., Sidiropoulos T. A., Scalea T. M., Vilz T. O., Hardcastle T. C., Wannatoop T., Herzog T., Mishra T. S., Boggi U., Calu V., Tomajer V., Agnoletti V., Lohsiriwat V., Kong V., Munoz-Cruzado V. D., Shelat V. G., Khokha V., Ghannam W. M., Biffl W. L., Zuidema W., Kara Y., Kobe Y., Demetrashvili Z., Memish Z. A., Madrazo Z., Balogh Z. J., and Bayhan Z.
Abstract: Background: The SARS-CoV-2 pandemic is still ongoing and a major challenge for health care services worldwide. In the first WSES COVID-19 emergency surgery survey, a strong negative impact on emergency surgery (ES) had been described already early in the pandemic situation. However, the knowledge is limited about current effects of the pandemic on patient flow through emergency rooms, daily routine and decision making in ES as well as their changes over time during the last two pandemic years. This second WSES COVID-19 emergency surgery survey investigates the impact of the SARS-CoV-2 pandemic on ES during the course of the pandemic. Methods: A web survey had been distributed to medical specialists in ES during a four-week period from January 2022, investigating the impact of the pandemic on patients and septic diseases both requiring ES, structural problems due to the pandemic and time-to-intervention in ES routine. Results: 367 collaborators from 59 countries responded to the survey. The majority indicated that the pandemic still significantly impacts on treatment and outcome of surgical emergency patients (83.1% and 78.5%, respectively). As reasons, the collaborators reported decreased case load in ES (44.7%), but patients presenting with more prolonged and severe diseases, especially concerning perforated appendicitis (62.1%) and diverticulitis (57.5%). Otherwise, approximately 50% of the participants still observe a delay in time-to-intervention in ES compared with the situation before the pandemic. Relevant causes leading to enlarged time-to-intervention in ES during the pandemic are persistent problems with in-hospital logistics, lacks in medical staff as well as operating room and intensive care capacities during the pandemic. This leads not only to the need for triage or transferring of ES patients to other hospitals, reported by 64.0% and 48.8% of the collaborators, respectively, but also to paradigm shifts in treatment modalities to non-operative approach
Published: 2022

10. The WSES/SICG/ACOI/SICUT/AcEMC/SIFIPAC guidelines for diagnosis and treatment of acute left colonic diverticulitis in the elderly

Author: Fugazzola, P, Ceresoli, M, Coccolini, F, Gabrielli, F, Puzziello, A, Monzani, F, Amato, B, Sganga, G, Sartelli, M, Menichetti, F, Puglisi, G, Tartaglia, D, Carcoforo, P, Avenia, N, Kluger, Y, Paolillo, C, Zago, M, Leppaniemi, A, Tomasoni, M, Cobianchi, L, Dal Mas, F, Improta, M, Moore, E, Peitzman, A, Sugrue, M, Agnoletti, V, Fraga, G, Weber, D, Damaskos, D, Abu-Zidan, F, Wani, I, Kirkpatrick, A, Pikoulis, M, Pararas, N, Tan, E, Broek, R, Maier, R, Davies, R, Kashuk, J, Shelat, V, Mefire, A, Augustin, G, Magnone, S, Poiasina, E, De Simone, B, Chiarugi, M, Biffl, W, Baiocchi, G, Catena, F, Ansaloni, L, Fugazzola P., Ceresoli M., Coccolini F., Gabrielli F., Puzziello A., Monzani F., Amato B., Sganga G., Sartelli M., Menichetti F., Puglisi G. A., Tartaglia D., Carcoforo P., Avenia N., Kluger Y., Paolillo C., Zago M., Leppaniemi A., Tomasoni M., Cobianchi L., Dal Mas F., Improta M., Moore E. E., Peitzman A. B., Sugrue M., Agnoletti V., Fraga G. P., Weber D. G., Damaskos D., Abu-Zidan F. M., Wani I., Kirkpatrick A. W., Pikoulis M., Pararas N., Tan E., Broek R. T., Maier R. V., Davies R. J., Kashuk J., Shelat V. G., Mefire A. C., Augustin G., Magnone S., Poiasina E., De Simone B., Chiarugi M., Biffl W., Baiocchi G. L., Catena F., Ansaloni L., Fugazzola, P, Ceresoli, M, Coccolini, F, Gabrielli, F, Puzziello, A, Monzani, F, Amato, B, Sganga, G, Sartelli, M, Menichetti, F, Puglisi, G, Tartaglia, D, Carcoforo, P, Avenia, N, Kluger, Y, Paolillo, C, Zago, M, Leppaniemi, A, Tomasoni, M, Cobianchi, L, Dal Mas, F, Improta, M, Moore, E, Peitzman, A, Sugrue, M, Agnoletti, V, Fraga, G, Weber, D, Damaskos, D, Abu-Zidan, F, Wani, I, Kirkpatrick, A, Pikoulis, M, Pararas, N, Tan, E, Broek, R, Maier, R, Davies, R, Kashuk, J, Shelat, V, Mefire, A, Augustin, G, Magnone, S, Poiasina, E, De Simone, B, Chiarugi, M, Biffl, W, Baiocchi, G, Catena, F, Ansaloni, L, Fugazzola P., Ceresoli M., Coccolini F., Gabrielli F., Puzziello A., Monzani F., Amato B., Sganga G., Sartelli M., Menichetti F., Puglisi G. A., Tartaglia D., Carcoforo P., Avenia N., Kluger Y., Paolillo C., Zago M., Leppaniemi A., Tomasoni M., Cobianchi L., Dal Mas F., Improta M., Moore E. E., Peitzman A. B., Sugrue M., Agnoletti V., Fraga G. P., Weber D. G., Damaskos D., Abu-Zidan F. M., Wani I., Kirkpatrick A. W., Pikoulis M., Pararas N., Tan E., Broek R. T., Maier R. V., Davies R. J., Kashuk J., Shelat V. G., Mefire A. C., Augustin G., Magnone S., Poiasina E., De Simone B., Chiarugi M., Biffl W., Baiocchi G. L., Catena F., and Ansaloni L.
Abstract: Acute left colonic diverticulitis (ALCD) in the elderly presents with unique epidemiological features when compared with younger patients. The clinical presentation is more nuanced in the elderly population, having higher in-hospital and postoperative mortality. Furthermore, geriatric comorbidities are a risk factor for complicated diverticulitis. Finally, elderly patients have a lower risk of recurrent episodes and, in case of recurrence, a lower probability of requiring urgent surgery than younger patients. The aim of the present work is to study age-related factors that may support a unique approach to the diagnosis and treatment of this problem in the elderly when compared with the WSES guidelines for the management of acute left-sided colonic diverticulitis. During the 1° Pisa Workshop of Acute Care & Trauma Surgery held in Pisa (Italy) in September 2019, with the collaboration of the World Society of Emergency Surgery (WSES), the Italian Society of Geriatric Surgery (SICG), the Italian Hospital Surgeons Association (ACOI), the Italian Emergency Surgery and Trauma Association (SICUT), the Academy of Emergency Medicine and Care (AcEMC) and the Italian Society of Surgical Pathophysiology (SIFIPAC), three panel members presented a number of statements developed for each of the four themes regarding the diagnosis and management of ALCD in older patients, formulated according to the GRADE approach, at a Consensus Conference where a panel of experts participated. The statements were subsequently debated, revised, and finally approved by the Consensus Conference attendees. The current paper is a summary report of the definitive guidelines statements on each of the following topics: diagnosis, management, surgical technique and antibiotic therapy.
Published: 2022

11. Correction: Operative management of acute abdomen after bariatric surgery in the emergency setting: the OBA guidelines (World Journal of Emergency Surgery, (2022), 17, 1, (51), 10.1186/s13017-022-00452-w)

Author: De Simone B., Chouillard E., Ramos A. C., Donatelli G., Pintar T., Gupta R., Renzi F., Mahawar K., Madhok B., Maccatrozzo S., Abu-Zidan F. M., Moore E. E., Weber D. G., Coccolini F., Di Saverio S., Kirkpatrick A., Shelat V. G., Amico F., Pikoulis E., Ceresoli M., Galante J. M., Wani I., De'Angelis N., Hecker A., Sganga G., Tan E., Balogh Z. J., Bala M., Coimbra R., Damaskos D., Ansaloni L., Sartelli M., Pararas N., Kluger Y., Chahine E., Agnoletti V., Fraga G., Biffl W. L., Catena F., De Simone B., Chouillard E., Ramos A.C., Donatelli G., Pintar T., Gupta R., Renzi F., Mahawar K., Madhok B., Maccatrozzo S., Abu-Zidan F.M., Moore E.E., Weber D.G., Coccolini F., Di Saverio S., Kirkpatrick A., Shelat V.G., Amico F., Pikoulis E., Ceresoli M., Galante J.M., Wani I., De'Angelis N., Hecker A., Sganga G., Tan E., Balogh Z.J., Bala M., Coimbra R., Damaskos D., Ansaloni L., Sartelli M., Pararas N., Kluger Y., Chahine E., Agnoletti V., Fraga G., Biffl W.L., and Catena F.
Subjects: acute abdomen, bariatric surgery, emergency, guidelines
Abstract: Following publication of the original article [1], the co-author “Nikolaos Pararas” has misspelled wrongly as “Nikolaos Parasas”. The original article has been corrected.
Published: 2022

12. Performance of biomarkers SMRP, CA125, and CYFRA 21-1 as potential tumor markers for malignant mesothelioma and lung cancer in a cohort of workers formerly exposed to asbestos

Author: Gube, M., Taeger, D., Weber, D. G., Pesch, B., Brand, P., Johnen, G., Müller-Lux, A., Gross, I. M., Wiethege, T., Weber, A., Raithel, H. J., Kraus, T., and Brüning, T.
Published: 2011
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13. Damage control surgery for abdominal emergencies

Author: Weber, D. G., Bendinelli, C., and Balogh, Z. J.
Published: 2014
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14. Management of intra-abdominal-infections: 2017 World Society of Emergency Surgery guidelines summary focused on remote areas and low-income nations

Author: Perrone, G, Sartelli, M, Giuffrida, M, Chichom-Mefire, A, Labricciosa, F, Abu-Zidan, F, Ansaloni, L, Biffl, W, Ceresoli, M, Coccolini, F, Coimbra, R, Demetrashvili, Z, Di Saverio, S, Fraga, G, Khokha, V, Kirkpatrick, A, Kluger, Y, Leppaniemi, A, Maier, R, Moore, E, Negoi, I, Ordonez, C, Sakakushev, B, Lohse, H, Velmahos, G, Wani, I, Weber, D, Bonati, E, Catena, F, Perrone G., Sartelli M., Giuffrida M., Chichom-Mefire A., Labricciosa F. M., Abu-Zidan F. M., Ansaloni L., Biffl W. L., Ceresoli M., Coccolini F., Coimbra R., Demetrashvili Z., Di Saverio S., Fraga G. P., Khokha V., Kirkpatrick A. W., Kluger Y., Leppaniemi A., Maier R. V., Moore E. E., Negoi I., Ordonez C. A., Sakakushev B., Lohse H. A. S., Velmahos G. C., Wani I., Weber D. G., Bonati E., Catena F., Perrone, G, Sartelli, M, Giuffrida, M, Chichom-Mefire, A, Labricciosa, F, Abu-Zidan, F, Ansaloni, L, Biffl, W, Ceresoli, M, Coccolini, F, Coimbra, R, Demetrashvili, Z, Di Saverio, S, Fraga, G, Khokha, V, Kirkpatrick, A, Kluger, Y, Leppaniemi, A, Maier, R, Moore, E, Negoi, I, Ordonez, C, Sakakushev, B, Lohse, H, Velmahos, G, Wani, I, Weber, D, Bonati, E, Catena, F, Perrone G., Sartelli M., Giuffrida M., Chichom-Mefire A., Labricciosa F. M., Abu-Zidan F. M., Ansaloni L., Biffl W. L., Ceresoli M., Coccolini F., Coimbra R., Demetrashvili Z., Di Saverio S., Fraga G. P., Khokha V., Kirkpatrick A. W., Kluger Y., Leppaniemi A., Maier R. V., Moore E. E., Negoi I., Ordonez C. A., Sakakushev B., Lohse H. A. S., Velmahos G. C., Wani I., Weber D. G., Bonati E., and Catena F.
Abstract: Background: Most remote areas have restricted access to healthcare services and are too small and remote to sustain specialist services. In 2017, the World Society of Emergency Surgery (WSES) published guidelines for the management of intra-abdominal infections. Many hospitals, especially those in remote areas, continue to face logistical barriers, leading to an overall poorer adherence to international guidelines. Methods: The aim of this paper is to report and amend the 2017 WSES guidelines for the management of intra-abdominal infections, extending these recommendations for remote areas and low-income countries. A literature search of the PubMed/MEDLINE databases was conducted covering the period up until June 2020. Results: The critical shortages of healthcare workers and material resources in remote areas require the use of a robust triage system. A combination of abdominal signs and symptoms with early warning signs may be used to screen patients needing immediate acute care surgery. A tailored diagnostic step-up approach based on the hospital's resources is recommended. Ultrasound and plain X-ray may be useful diagnostic tools in remote areas. The source of infection should be totally controlled as soon as possible. Conclusions: The cornerstones of effective treatment for intra-abdominal infections in remote areas include early diagnosis, prompt resuscitation, early source control, and appropriate antimicrobial therapy. Standardization in applying the guidelines is mandatory to adequately manage intra-abdominal infections.
Published: 2020

15. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines

Author: Di Saverio, S, Podda, M, De Simone, B, Ceresoli, M, Augustin, G, Gori, A, Boermeester, M, Sartelli, M, Coccolini, F, Tarasconi, A, De' Angelis, N, Weber, D, Tolonen, M, Birindelli, A, Biffl, W, Moore, E, Kelly, M, Soreide, K, Kashuk, J, Ten Broek, R, Gomes, C, Sugrue, M, Davies, R, Damaskos, D, Leppaniemi, A, Kirkpatrick, A, Peitzman, A, Fraga, G, Maier, R, Coimbra, R, Chiarugi, M, Sganga, G, Pisanu, A, De' Angelis, G, Tan, E, Van Goor, H, Pata, F, Di Carlo, I, Chiara, O, Litvin, A, Campanile, F, Sakakushev, B, Tomadze, G, Demetrashvili, Z, Latifi, R, Abu-Zidan, F, Romeo, O, Segovia-Lohse, H, Baiocchi, G, Costa, D, Rizoli, S, Balogh, Z, Bendinelli, C, Scalea, T, Ivatury, R, Velmahos, G, Andersson, R, Kluger, Y, Ansaloni, L, Catena, F, Di Saverio S., Podda M., De Simone B., Ceresoli M., Augustin G., Gori A., Boermeester M., Sartelli M., Coccolini F., Tarasconi A., De' Angelis N., Weber D. G., Tolonen M., Birindelli A., Biffl W., Moore E. E., Kelly M., Soreide K., Kashuk J., Ten Broek R., Gomes C. A., Sugrue M., Davies R. J., Damaskos D., Leppaniemi A., Kirkpatrick A., Peitzman A. B., Fraga G. P., Maier R. V., Coimbra R., Chiarugi M., Sganga G., Pisanu A., De' Angelis G. L., Tan E., Van Goor H., Pata F., Di Carlo I., Chiara O., Litvin A., Campanile F. C., Sakakushev B., Tomadze G., Demetrashvili Z., Latifi R., Abu-Zidan F., Romeo O., Segovia-Lohse H., Baiocchi G., Costa D., Rizoli S., Balogh Z. J., Bendinelli C., Scalea T., Ivatury R., Velmahos G., Andersson R., Kluger Y., Ansaloni L., Catena F., Di Saverio, S, Podda, M, De Simone, B, Ceresoli, M, Augustin, G, Gori, A, Boermeester, M, Sartelli, M, Coccolini, F, Tarasconi, A, De' Angelis, N, Weber, D, Tolonen, M, Birindelli, A, Biffl, W, Moore, E, Kelly, M, Soreide, K, Kashuk, J, Ten Broek, R, Gomes, C, Sugrue, M, Davies, R, Damaskos, D, Leppaniemi, A, Kirkpatrick, A, Peitzman, A, Fraga, G, Maier, R, Coimbra, R, Chiarugi, M, Sganga, G, Pisanu, A, De' Angelis, G, Tan, E, Van Goor, H, Pata, F, Di Carlo, I, Chiara, O, Litvin, A, Campanile, F, Sakakushev, B, Tomadze, G, Demetrashvili, Z, Latifi, R, Abu-Zidan, F, Romeo, O, Segovia-Lohse, H, Baiocchi, G, Costa, D, Rizoli, S, Balogh, Z, Bendinelli, C, Scalea, T, Ivatury, R, Velmahos, G, Andersson, R, Kluger, Y, Ansaloni, L, Catena, F, Di Saverio S., Podda M., De Simone B., Ceresoli M., Augustin G., Gori A., Boermeester M., Sartelli M., Coccolini F., Tarasconi A., De' Angelis N., Weber D. G., Tolonen M., Birindelli A., Biffl W., Moore E. E., Kelly M., Soreide K., Kashuk J., Ten Broek R., Gomes C. A., Sugrue M., Davies R. J., Damaskos D., Leppaniemi A., Kirkpatrick A., Peitzman A. B., Fraga G. P., Maier R. V., Coimbra R., Chiarugi M., Sganga G., Pisanu A., De' Angelis G. L., Tan E., Van Goor H., Pata F., Di Carlo I., Chiara O., Litvin A., Campanile F. C., Sakakushev B., Tomadze G., Demetrashvili Z., Latifi R., Abu-Zidan F., Romeo O., Segovia-Lohse H., Baiocchi G., Costa D., Rizoli S., Balogh Z. J., Bendinelli C., Scalea T., Ivatury R., Velmahos G., Andersson R., Kluger Y., Ansaloni L., and Catena F.
Abstract: Background and aims: Acute appendicitis (AA) is among the most common causes of acute abdominal pain. Diagnosis of AA is still challenging and some controversies on its management are still present among different settings and practice patterns worldwide. In July 2015, the World Society of Emergency Surgery (WSES) organized in Jerusalem the first consensus conference on the diagnosis and treatment of AA in adult patients with the intention of producing evidence-based guidelines. An updated consensus conference took place in Nijemegen in June 2019 and the guidelines have now been updated in order to provide evidence-based statements and recommendations in keeping with varying clinical practice: Use of clinical scores and imaging in diagnosing AA, indications and timing for surgery, use of non-operative management and antibiotics, laparoscopy and surgical techniques, intra-operative scoring, and peri-operative antibiotic therapy. Methods: This executive manuscript summarizes the WSES guidelines for the diagnosis and treatment of AA. Literature search has been updated up to 2019 and statements and recommendations have been developed according to the GRADE methodology. The statements were voted, eventually modified, and finally approved by the participants to the consensus conference and by the board of co-authors, using a Delphi methodology for voting whenever there was controversy on a statement or a recommendation. Several tables highlighting the research topics and questions, search syntaxes, and the statements and the WSES evidence-based recommendations are provided. Finally, two different practical clinical algorithms are provided in the form of a flow chart for both adults and pediatric (< 16 years old) patients. Conclusions: The 2020 WSES guidelines on AA aim to provide updated evidence-based statements and recommendations on each of the following topics: (1) diagnosis, (2) non-operative management for uncomplicated AA, (3) timing of appendectomy and in-hospi
Published: 2020

16. American Association for the Surgery of Trauma-World Society of Emergency Surgery guidelines on diagnosis and management of peripheral vascular injuries

Author: Kobayashi, L, Coimbra, R, Goes, A, Reva, V, Santorelli, J, Moore, E, Galante, J, Abu-Zidan, F, Peitzman, A, Ordonez, C, Maier, R, Di Saverio, S, Ivatury, R, De Angelis, N, Scalea, T, Catena, F, Kirkpatrick, A, Khokha, V, Parry, N, Civil, I, Leppaniemi, A, Chirica, M, Pikoulis, E, Fraga, G, Chiarugi, M, Damaskos, D, Cicuttin, E, Ceresoli, M, De Simone, B, Vega-Rivera, F, Sartelli, M, Biffl, W, Ansaloni, L, Weber, D, Coccolini, F, Kobayashi L., Coimbra R., Goes A. M. O., Reva V., Santorelli J., Moore E. E., Galante J., Abu-Zidan F., Peitzman A. B., Ordonez C., Maier R. V., Di Saverio S., Ivatury R., De Angelis N., Scalea T., Catena F., Kirkpatrick A., Khokha V., Parry N., Civil I., Leppaniemi A., Chirica M., Pikoulis E., Fraga G. P., Chiarugi M., Damaskos D., Cicuttin E., Ceresoli M., De Simone B., Vega-Rivera F., Sartelli M., Biffl W., Ansaloni L., Weber D. G., Coccolini F., Kobayashi, L, Coimbra, R, Goes, A, Reva, V, Santorelli, J, Moore, E, Galante, J, Abu-Zidan, F, Peitzman, A, Ordonez, C, Maier, R, Di Saverio, S, Ivatury, R, De Angelis, N, Scalea, T, Catena, F, Kirkpatrick, A, Khokha, V, Parry, N, Civil, I, Leppaniemi, A, Chirica, M, Pikoulis, E, Fraga, G, Chiarugi, M, Damaskos, D, Cicuttin, E, Ceresoli, M, De Simone, B, Vega-Rivera, F, Sartelli, M, Biffl, W, Ansaloni, L, Weber, D, Coccolini, F, Kobayashi L., Coimbra R., Goes A. M. O., Reva V., Santorelli J., Moore E. E., Galante J., Abu-Zidan F., Peitzman A. B., Ordonez C., Maier R. V., Di Saverio S., Ivatury R., De Angelis N., Scalea T., Catena F., Kirkpatrick A., Khokha V., Parry N., Civil I., Leppaniemi A., Chirica M., Pikoulis E., Fraga G. P., Chiarugi M., Damaskos D., Cicuttin E., Ceresoli M., De Simone B., Vega-Rivera F., Sartelli M., Biffl W., Ansaloni L., Weber D. G., and Coccolini F.
Abstract: The peripheral arteries and veins of the extremities are among the most commonly injured vessels in both civilian and military vascular trauma. Blunt causes are more frequent than penetrating except during military conflicts and in certain geographic areas. Physical examination and simple bedside investigations of pulse pressures are key in early identification of these injuries. In stable patients with equivocal physical examinations, computed tomography angiograms have become the mainstay of screening and diagnosis. Immediate open surgical repair remains the first-line therapy in most patients. However, advances in endovascular therapies and more widespread availability of this technology have resulted in an increase in the range of injuries and frequency of utilization of minimally invasive treatments for vascular injuries in stable patients. Prevention of and early detection and treatment of compartment syndrome remain essential in the recovery of patients with significant peripheral vascular injuries. The decision to perform amputation in patients with mangled extremities remains difficult with few clear indicators. The American Association for the Surgery of Trauma in conjunction with the World Society of Emergency Surgery seeks to summarize the literature to date and provide guidelines on the presentation, diagnosis, and treatment of peripheral vascular injuries. LEVEL OF EVIDENCE Review study, level IV.
Published: 2020

17. American Association for the Surgery of Trauma-World Society of Emergency Surgery guidelines on diagnosis and management of abdominal vascular injuries

Author: Kobayashi, L, Coimbra, R, Goes, A, Reva, V, Santorelli, J, Moore, E, Galante, J, Abu-Zidan, F, Peitzman, A, Ordonez, C, Maier, R, Di Saverio, S, Ivatury, R, De Angelis, N, Scalea, T, Catena, F, Kirkpatrick, A, Khokha, V, Parry, N, Civil, I, Leppaniemi, A, Chirica, M, Pikoulis, E, Fraga, G, Chiarugi, M, Damaskos, D, Cicuttin, E, Ceresoli, M, De Simone, B, Vega-Rivera, F, Sartelli, M, Biffl, W, Ansaloni, L, Weber, D, Coccolini, F, Kobayashi L., Coimbra R., Goes A. M. O., Reva V., Santorelli J., Moore E. E., Galante J. M., Abu-Zidan F., Peitzman A. B., Ordonez C. A., Maier R. V., Di Saverio S., Ivatury R., De Angelis N., Scalea T., Catena F., Kirkpatrick A., Khokha V., Parry N., Civil I., Leppaniemi A., Chirica M., Pikoulis E., Fraga G. P., Chiarugi M., Damaskos D., Cicuttin E., Ceresoli M., De Simone B., Vega-Rivera F., Sartelli M., Biffl W., Ansaloni L., Weber D. G., Coccolini F., Kobayashi, L, Coimbra, R, Goes, A, Reva, V, Santorelli, J, Moore, E, Galante, J, Abu-Zidan, F, Peitzman, A, Ordonez, C, Maier, R, Di Saverio, S, Ivatury, R, De Angelis, N, Scalea, T, Catena, F, Kirkpatrick, A, Khokha, V, Parry, N, Civil, I, Leppaniemi, A, Chirica, M, Pikoulis, E, Fraga, G, Chiarugi, M, Damaskos, D, Cicuttin, E, Ceresoli, M, De Simone, B, Vega-Rivera, F, Sartelli, M, Biffl, W, Ansaloni, L, Weber, D, Coccolini, F, Kobayashi L., Coimbra R., Goes A. M. O., Reva V., Santorelli J., Moore E. E., Galante J. M., Abu-Zidan F., Peitzman A. B., Ordonez C. A., Maier R. V., Di Saverio S., Ivatury R., De Angelis N., Scalea T., Catena F., Kirkpatrick A., Khokha V., Parry N., Civil I., Leppaniemi A., Chirica M., Pikoulis E., Fraga G. P., Chiarugi M., Damaskos D., Cicuttin E., Ceresoli M., De Simone B., Vega-Rivera F., Sartelli M., Biffl W., Ansaloni L., Weber D. G., and Coccolini F.
Abstract: Abdominal vascular trauma accounts for a small percentage of military and a moderate percentage of civilian trauma, affecting all age ranges and impacting young adult men most frequently. Penetrating causes are more frequent than blunt in adults, while blunt mechanisms are more common among pediatric populations. High rates of associated injuries, bleeding, and hemorrhagic shock ensure that, despite advances in both diagnostic and therapeutic technologies, immediate open surgical repair remains the mainstay of treatment for traumatic abdominal vascular injuries. Because of their devastating nature, abdominal vascular injuries remain a significant source of morbidity and mortality among trauma patients. The American Association for the Surgery of Trauma in conjunction with the World Society of Emergency Surgery seek to summarize the literature to date and provide guidelines on the presentation, diagnosis, and treatment of abdominal vascular injuries. LEVEL OF EVIDENCE Review study, level IV.
Published: 2020

18. 2020 World Society of Emergency Surgery updated guidelines for the diagnosis and treatment of acute calculus cholecystitis

Author: Pisano, M, Allievi, N, Gurusamy, K, Borzellino, G, Cimbanassi, S, Boerna, D, Coccolini, F, Tufo, A, Di Martino, M, Leung, J, Sartelli, M, Ceresoli, M, Maier, R, Poiasina, E, De Angelis, N, Magnone, S, Fugazzola, P, Paolillo, C, Coimbra, R, Di Saverio, S, De Simone, B, Weber, D, Sakakushev, B, Lucianetti, A, Kirkpatrick, A, Fraga, G, Wani, I, Biffl, W, Chiara, O, Abu-Zidan, F, Moore, E, Leppaniemi, A, Kluger, Y, Catena, F, Ansaloni, L, Pisano M., Allievi N., Gurusamy K., Borzellino G., Cimbanassi S., Boerna D., Coccolini F., Tufo A., Di Martino M., Leung J., Sartelli M., Ceresoli M., Maier R. V., Poiasina E., De Angelis N., Magnone S., Fugazzola P., Paolillo C., Coimbra R., Di Saverio S., De Simone B., Weber D. G., Sakakushev B. E., Lucianetti A., Kirkpatrick A. W., Fraga G. P., Wani I., Biffl W. L., Chiara O., Abu-Zidan F., Moore E. E., Leppaniemi A., Kluger Y., Catena F., Ansaloni L., Pisano, M, Allievi, N, Gurusamy, K, Borzellino, G, Cimbanassi, S, Boerna, D, Coccolini, F, Tufo, A, Di Martino, M, Leung, J, Sartelli, M, Ceresoli, M, Maier, R, Poiasina, E, De Angelis, N, Magnone, S, Fugazzola, P, Paolillo, C, Coimbra, R, Di Saverio, S, De Simone, B, Weber, D, Sakakushev, B, Lucianetti, A, Kirkpatrick, A, Fraga, G, Wani, I, Biffl, W, Chiara, O, Abu-Zidan, F, Moore, E, Leppaniemi, A, Kluger, Y, Catena, F, Ansaloni, L, Pisano M., Allievi N., Gurusamy K., Borzellino G., Cimbanassi S., Boerna D., Coccolini F., Tufo A., Di Martino M., Leung J., Sartelli M., Ceresoli M., Maier R. V., Poiasina E., De Angelis N., Magnone S., Fugazzola P., Paolillo C., Coimbra R., Di Saverio S., De Simone B., Weber D. G., Sakakushev B. E., Lucianetti A., Kirkpatrick A. W., Fraga G. P., Wani I., Biffl W. L., Chiara O., Abu-Zidan F., Moore E. E., Leppaniemi A., Kluger Y., Catena F., and Ansaloni L.
Abstract: Background: Acute calculus cholecystitis (ACC) has a high incidence in the general population. The presence of several areas of uncertainty, along with the availability of new evidence, prompted the current update of the 2016 WSES (World Society of Emergency Surgery) Guidelines on ACC. Materials and methods: The WSES president appointed four members as a scientific secretariat, four members as an organization committee and four members as a scientific committee, choosing them from the expert affiliates of WSES. Relevant key questions were constructed, and the task force produced drafts of each section based on the best scientific evidence from PubMed and EMBASE Library; recommendations were developed in order to answer these key questions. The quality of evidence and strength of recommendations were reviewed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria (see https://www.gradeworkinggroup.org/). All the statements were presented, discussed and voted upon during the Consensus Conference at the 6th World Congress of the World Society of Emergency Surgery held in Nijmegen (NL) in May 2019. A revised version of the statements was voted upon via an online questionnaire until consensus was reached. Results: The pivotal role of surgery is confirmed, including in high-risk patients. When compared with the WSES 2016 guidelines, the role of gallbladder drainage is reduced, despite the considerable technical improvements available. Early laparoscopic cholecystectomy (ELC) should be the standard of care whenever possible, even in subgroups of patients who are considered fragile, such as the elderly; those with cardiac disease, renal disease and cirrhosis; or those who are generally at high risk for surgery. Subtotal cholecystectomy is safe and represents a valuable option in cases of difficult gallbladder removal. Conclusions, knowledge gaps and research recommendations: ELC has a central role in the management of patients with ACC.
Published: 2020

19. Perforated and bleeding peptic ulcer: WSES guidelines

Author: Tarasconi, A, Coccolini, F, Biffl, W, Tomasoni, M, Ansaloni, L, Picetti, E, Molfino, S, Shelat, V, Cimbanassi, S, Weber, D, Abu-Zidan, F, Campanile, F, Di Saverio, S, Baiocchi, G, Casella, C, Kelly, M, Kirkpatrick, A, Leppaniemi, A, Moore, E, Peitzman, A, Fraga, G, Ceresoli, M, Maier, R, Wani, I, Pattonieri, V, Perrone, G, Velmahos, G, Sugrue, M, Sartelli, M, Kluger, Y, Catena, F, Tarasconi A., Coccolini F., Biffl W. L., Tomasoni M., Ansaloni L., Picetti E., Molfino S., Shelat V., Cimbanassi S., Weber D. G., Abu-Zidan F. M., Campanile F. C., Di Saverio S., Baiocchi G. L., Casella C., Kelly M. D., Kirkpatrick A. W., Leppaniemi A., Moore E. E., Peitzman A., Fraga G. P., Ceresoli M., Maier R. V., Wani I., Pattonieri V., Perrone G., Velmahos G., Sugrue M., Sartelli M., Kluger Y., Catena F., Tarasconi, A, Coccolini, F, Biffl, W, Tomasoni, M, Ansaloni, L, Picetti, E, Molfino, S, Shelat, V, Cimbanassi, S, Weber, D, Abu-Zidan, F, Campanile, F, Di Saverio, S, Baiocchi, G, Casella, C, Kelly, M, Kirkpatrick, A, Leppaniemi, A, Moore, E, Peitzman, A, Fraga, G, Ceresoli, M, Maier, R, Wani, I, Pattonieri, V, Perrone, G, Velmahos, G, Sugrue, M, Sartelli, M, Kluger, Y, Catena, F, Tarasconi A., Coccolini F., Biffl W. L., Tomasoni M., Ansaloni L., Picetti E., Molfino S., Shelat V., Cimbanassi S., Weber D. G., Abu-Zidan F. M., Campanile F. C., Di Saverio S., Baiocchi G. L., Casella C., Kelly M. D., Kirkpatrick A. W., Leppaniemi A., Moore E. E., Peitzman A., Fraga G. P., Ceresoli M., Maier R. V., Wani I., Pattonieri V., Perrone G., Velmahos G., Sugrue M., Sartelli M., Kluger Y., and Catena F.
Abstract: Background : Peptic ulcer disease is common with a lifetime prevalence in the general population of 5-10% and an incidence of 0.1-0.3% per year. Despite a sharp reduction in incidence and rates of hospital admission and mortality over the past 30 years, complications are still encountered in 10-20% of these patients. Peptic ulcer disease remains a significant healthcare problem, which can consume considerable financial resources. Management may involve various subspecialties including surgeons, gastroenterologists, and radiologists. Successful management of patients with complicated peptic ulcer (CPU) involves prompt recognition, resuscitation when required, appropriate antibiotic therapy, and timely surgical/radiological treatment. Methods: The present guidelines have been developed according to the GRADE methodology. To create these guidelines, a panel of experts was designed and charged by the board of the WSES to perform a systematic review of the available literature and to provide evidence-based statements with immediate practical application. All the statements were presented and discussed during the 5th WSES Congress, and for each statement, a consensus among the WSES panel of experts was reached. Conclusions: The population considered in these guidelines is adult patients with suspected complicated peptic ulcer disease. These guidelines present evidence-based international consensus statements on the management of complicated peptic ulcer from a collaboration of a panel of experts and are intended to improve the knowledge and the awareness of physicians around the world on this specific topic. We divided our work into the two main topics, bleeding and perforated peptic ulcer, and structured it into six main topics that cover the entire management process of patients with complicated peptic ulcer, from diagnosis at ED arrival to post-discharge antimicrobial therapy, to provide an up-to-date, easy-to-use tool that can help physicians and surgeons during the d
Published: 2020

20. 2020 update of the WSES guidelines for the management of acute colonic diverticulitis in the emergency setting

Author: Sartelli, M, Weber, D, Kluger, Y, Ansaloni, L, Coccolini, F, Abu-Zidan, F, Augustin, G, Ben-Ishay, O, Biffl, W, Bouliaris, K, Catena, R, Ceresoli, M, Chiara, O, Chiarugi, M, Coimbra, R, Cortese, F, Cui, Y, Damaskos, D, De' Angelis, G, Delibegovic, S, Demetrashvili, Z, De Simone, B, Di Marzo, F, Di Saverio, S, Duane, T, Faro, M, Fraga, G, Gkiokas, G, Gomes, C, Hardcastle, T, Hecker, A, Karamarkovic, A, Kashuk, J, Khokha, V, Kirkpatrick, A, Kok, K, Inaba, K, Isik, A, Labricciosa, F, Latifi, R, Leppaniemi, A, Litvin, A, Mazuski, J, Maier, R, Marwah, S, Mcfarlane, M, Moore, E, Moore, F, Negoi, I, Pagani, L, Rasa, K, Rubio-Perez, I, Sakakushev, B, Sato, N, Sganga, G, Siquini, W, Tarasconi, A, Tolonen, M, Ulrych, J, Zachariah, S, Catena, F, Sartelli M., Weber D. G., Kluger Y., Ansaloni L., Coccolini F., Abu-Zidan F., Augustin G., Ben-Ishay O., Biffl W. L., Bouliaris K., Catena R., Ceresoli M., Chiara O., Chiarugi M., Coimbra R., Cortese F., Cui Y., Damaskos D., De' Angelis G. L., Delibegovic S., Demetrashvili Z., De Simone B., Di Marzo F., Di Saverio S., Duane T. M., Faro M. P., Fraga G. P., Gkiokas G., Gomes C. A., Hardcastle T. C., Hecker A., Karamarkovic A., Kashuk J., Khokha V., Kirkpatrick A. W., Kok K. Y. Y., Inaba K., Isik A., Labricciosa F. M., Latifi R., Leppaniemi A., Litvin A., Mazuski J. E., Maier R. V., Marwah S., McFarlane M., Moore E. E., Moore F. A., Negoi I., Pagani L., Rasa K., Rubio-Perez I., Sakakushev B., Sato N., Sganga G., Siquini W., Tarasconi A., Tolonen M., Ulrych J., Zachariah S. K., Catena F., Sartelli, M, Weber, D, Kluger, Y, Ansaloni, L, Coccolini, F, Abu-Zidan, F, Augustin, G, Ben-Ishay, O, Biffl, W, Bouliaris, K, Catena, R, Ceresoli, M, Chiara, O, Chiarugi, M, Coimbra, R, Cortese, F, Cui, Y, Damaskos, D, De' Angelis, G, Delibegovic, S, Demetrashvili, Z, De Simone, B, Di Marzo, F, Di Saverio, S, Duane, T, Faro, M, Fraga, G, Gkiokas, G, Gomes, C, Hardcastle, T, Hecker, A, Karamarkovic, A, Kashuk, J, Khokha, V, Kirkpatrick, A, Kok, K, Inaba, K, Isik, A, Labricciosa, F, Latifi, R, Leppaniemi, A, Litvin, A, Mazuski, J, Maier, R, Marwah, S, Mcfarlane, M, Moore, E, Moore, F, Negoi, I, Pagani, L, Rasa, K, Rubio-Perez, I, Sakakushev, B, Sato, N, Sganga, G, Siquini, W, Tarasconi, A, Tolonen, M, Ulrych, J, Zachariah, S, Catena, F, Sartelli M., Weber D. G., Kluger Y., Ansaloni L., Coccolini F., Abu-Zidan F., Augustin G., Ben-Ishay O., Biffl W. L., Bouliaris K., Catena R., Ceresoli M., Chiara O., Chiarugi M., Coimbra R., Cortese F., Cui Y., Damaskos D., De' Angelis G. L., Delibegovic S., Demetrashvili Z., De Simone B., Di Marzo F., Di Saverio S., Duane T. M., Faro M. P., Fraga G. P., Gkiokas G., Gomes C. A., Hardcastle T. C., Hecker A., Karamarkovic A., Kashuk J., Khokha V., Kirkpatrick A. W., Kok K. Y. Y., Inaba K., Isik A., Labricciosa F. M., Latifi R., Leppaniemi A., Litvin A., Mazuski J. E., Maier R. V., Marwah S., McFarlane M., Moore E. E., Moore F. A., Negoi I., Pagani L., Rasa K., Rubio-Perez I., Sakakushev B., Sato N., Sganga G., Siquini W., Tarasconi A., Tolonen M., Ulrych J., Zachariah S. K., and Catena F.
Abstract: Acute colonic diverticulitis is one of the most common clinical conditions encountered by surgeons in the acute setting. An international multidisciplinary panel of experts from the World Society of Emergency Surgery (WSES) updated its guidelines for management of acute left-sided colonic diverticulitis (ALCD) according to the most recent available literature. The update includes recent changes introduced in the management of ALCD. The new update has been further integrated with advances in acute right-sided colonic diverticulitis (ARCD) that is more common than ALCD in select regions of the world.
Published: 2020

21. 2020 update of the WSES guidelines for the management of acute colonic diverticulitis in the emergency setting

Author: Sartelli, M., Weber, D. G., Kluger, Y., Ansaloni, L., Coccolini, F., Abu-Zidan, F., Augustin, G., Ben-Ishay, O., Biffl, W. L., Bouliaris, K., Catena, R., Ceresoli, M., Chiara, O., Chiarugi, M., Coimbra, R., Cortese, F., Cui, Y., Damaskos, D., De' Angelis, G. L., Delibegovic, S., Demetrashvili, Z., De Simone, B., Di Marzo, F., Di Saverio, S., Duane, T. M., Faro, M. P., Fraga, G. P., Gkiokas, G., Gomes, C. A., Hardcastle, T. C., Hecker, A., Karamarkovic, A., Kashuk, J., Khokha, V., Kirkpatrick, A. W., Kok, K. Y. Y., Inaba, K., Isik, A., Labricciosa, F. M., Latifi, R., Leppaniemi, A., Litvin, A., Mazuski, J. E., Maier, R. V., Marwah, S., Mcfarlane, M., Moore, E. E., Moore, F. A., Negoi, I., Pagani, L., Rasa, K., Rubio-Perez, I., Sakakushev, B., Sato, N., Sganga, Gabriele, Siquini, W., Tarasconi, A., Tolonen, M., Ulrych, J., Zachariah, S. K., Catena, F., Sganga G. (ORCID:0000-0001-5079-0395), Sartelli, M., Weber, D. G., Kluger, Y., Ansaloni, L., Coccolini, F., Abu-Zidan, F., Augustin, G., Ben-Ishay, O., Biffl, W. L., Bouliaris, K., Catena, R., Ceresoli, M., Chiara, O., Chiarugi, M., Coimbra, R., Cortese, F., Cui, Y., Damaskos, D., De' Angelis, G. L., Delibegovic, S., Demetrashvili, Z., De Simone, B., Di Marzo, F., Di Saverio, S., Duane, T. M., Faro, M. P., Fraga, G. P., Gkiokas, G., Gomes, C. A., Hardcastle, T. C., Hecker, A., Karamarkovic, A., Kashuk, J., Khokha, V., Kirkpatrick, A. W., Kok, K. Y. Y., Inaba, K., Isik, A., Labricciosa, F. M., Latifi, R., Leppaniemi, A., Litvin, A., Mazuski, J. E., Maier, R. V., Marwah, S., Mcfarlane, M., Moore, E. E., Moore, F. A., Negoi, I., Pagani, L., Rasa, K., Rubio-Perez, I., Sakakushev, B., Sato, N., Sganga, Gabriele, Siquini, W., Tarasconi, A., Tolonen, M., Ulrych, J., Zachariah, S. K., Catena, F., and Sganga G. (ORCID:0000-0001-5079-0395)
Abstract: Acute colonic diverticulitis is one of the most common clinical conditions encountered by surgeons in the acute setting. An international multidisciplinary panel of experts from the World Society of Emergency Surgery (WSES) updated its guidelines for management of acute left-sided colonic diverticulitis (ALCD) according to the most recent available literature. The update includes recent changes introduced in the management of ALCD. The new update has been further integrated with advances in acute right-sided colonic diverticulitis (ARCD) that is more common than ALCD in select regions of the world.
Published: 2020

22. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines

Author: Di Saverio, S., Podda, M., De Simone, B., Ceresoli, M., Augustin, G., Gori, A., Boermeester, M., Sartelli, M., Coccolini, F., Tarasconi, A., De' Angelis, N., Weber, D. G., Tolonen, M., Birindelli, A., Biffl, W., Moore, E. E., Kelly, M., Soreide, K., Kashuk, J., Ten Broek, R., Gomes, C. A., Sugrue, M., Davies, R. J., Damaskos, D., Leppaniemi, A., Kirkpatrick, A., Peitzman, A. B., Fraga, G. P., Maier, R. V., Coimbra, R., Chiarugi, M., Sganga, Gabriele, Pisanu, A., De' Angelis, G. L., Tan, E., Van Goor, H., Pata, F., Di Carlo, I., Chiara, O., Litvin, A., Campanile, F. C., Sakakushev, B., Tomadze, G., Demetrashvili, Z., Latifi, R., Abu-Zidan, F., Romeo, O., Segovia-Lohse, H., Baiocchi, G., Costa, D., Rizoli, S., Balogh, Z. J., Bendinelli, C., Scalea, T., Ivatury, R., Velmahos, G., Andersson, R., Kluger, Y., Ansaloni, L., Catena, F., Sganga G. (ORCID:0000-0001-5079-0395), Di Saverio, S., Podda, M., De Simone, B., Ceresoli, M., Augustin, G., Gori, A., Boermeester, M., Sartelli, M., Coccolini, F., Tarasconi, A., De' Angelis, N., Weber, D. G., Tolonen, M., Birindelli, A., Biffl, W., Moore, E. E., Kelly, M., Soreide, K., Kashuk, J., Ten Broek, R., Gomes, C. A., Sugrue, M., Davies, R. J., Damaskos, D., Leppaniemi, A., Kirkpatrick, A., Peitzman, A. B., Fraga, G. P., Maier, R. V., Coimbra, R., Chiarugi, M., Sganga, Gabriele, Pisanu, A., De' Angelis, G. L., Tan, E., Van Goor, H., Pata, F., Di Carlo, I., Chiara, O., Litvin, A., Campanile, F. C., Sakakushev, B., Tomadze, G., Demetrashvili, Z., Latifi, R., Abu-Zidan, F., Romeo, O., Segovia-Lohse, H., Baiocchi, G., Costa, D., Rizoli, S., Balogh, Z. J., Bendinelli, C., Scalea, T., Ivatury, R., Velmahos, G., Andersson, R., Kluger, Y., Ansaloni, L., Catena, F., and Sganga G. (ORCID:0000-0001-5079-0395)
Abstract: Background and aims: Acute appendicitis (AA) is among the most common causes of acute abdominal pain. Diagnosis of AA is still challenging and some controversies on its management are still present among different settings and practice patterns worldwide. In July 2015, the World Society of Emergency Surgery (WSES) organized in Jerusalem the first consensus conference on the diagnosis and treatment of AA in adult patients with the intention of producing evidence-based guidelines. An updated consensus conference took place in Nijemegen in June 2019 and the guidelines have now been updated in order to provide evidence-based statements and recommendations in keeping with varying clinical practice: Use of clinical scores and imaging in diagnosing AA, indications and timing for surgery, use of non-operative management and antibiotics, laparoscopy and surgical techniques, intra-operative scoring, and peri-operative antibiotic therapy. Methods: This executive manuscript summarizes the WSES guidelines for the diagnosis and treatment of AA. Literature search has been updated up to 2019 and statements and recommendations have been developed according to the GRADE methodology. The statements were voted, eventually modified, and finally approved by the participants to the consensus conference and by the board of co-authors, using a Delphi methodology for voting whenever there was controversy on a statement or a recommendation. Several tables highlighting the research topics and questions, search syntaxes, and the statements and the WSES evidence-based recommendations are provided. Finally, two different practical clinical algorithms are provided in the form of a flow chart for both adults and pediatric (< 16 years old) patients. Conclusions: The 2020 WSES guidelines on AA aim to provide updated evidence-based statements and recommendations on each of the following topics: (1) diagnosis, (2) non-operative management for uncomplicated AA, (3) timing of appendectomy and in-hospi
Published: 2020

23. Oligonucleotide microarrays for the detection and identification of viable beer spoilage bacteria

Author: Weber, D. G., Sahm, K., Polen, T., Wendisch, V. F., and Antranikian, G.
Published: 2008

24. APICAL LEFT VENTRICULAR TO AORTIC CONDUIT - AN ALTERNATIVE TECHNIQUE FOR THE DELICATE AORTA: CT16

Author: Weber, D. G., Blackham, R. E., and Alvarez, J. M.
Published: 2008

25. Erratum: Antimicrobials: A global alliance for optimizing their rational use in intra-abdominal infections (AGORA). [World J Emerg Surg. 11, (2016) (33)] DOI: 10.1186/s13017-016-0089-y

Author: Sartelli, M., Weber, D. G., Ruppé, E., Bassetti, M., Wright, B. J., Ansaloni, L., Catena, F., Coccolini, F., Abu-Zidan, F. M., Coimbra, R., Moore, E. E., Moore, F. A., Maier, R. V., De Waele, J. J., Kirkpatrick, A. W., Griffiths, E. A., Eckmann, C., Brink, A. J., Mazuski, J. E., May, A. K., Sawyer, R. G., Mertz, D., Montravers, P., Kumar, A., Roberts, J. A., Vincent, J. L., Watkins, R. R., Lowman, W., Spellberg, B., Abbott, I. J., Adesunkanmi, A. K., Al-Dahir, S., Al-Hasan, M. N., Agresta, F., Althani, A. A., Ansari, S., Ansumana, R., Augustin, G., Bala, M., Balogh, Z. J., Baraket, O., Bhangu, A., Beltrán, M. A., Bernhard, M., Biffl, W. L., Boermeester, M. A., Brecher, S. M., Cherry-Bukowiec, J. R., Buyne, O. R., Cainzos, M. A., Cairns, K. A., Camacho-Ortiz, A., Chandy, S. J., Che Jusoh, A., Chichom-Mefire, A., Colijn, C., Corcione, F., Cui, Y., Curcio, D., Delibegovic, S., Demetrashvili, Z., De Simone, B., Dhingra, S., Diaz, J. J., Di Carlo, I., Dillip, A., Di Saverio, S., Doyle, M. P., Dorj, G., Dogjani, A., Dupont, H., Eachempati, S. R., Enani, M. A., Egiev, V. N., Elmangory, M. M., Ferrada, P., Fitchett, J. R., Fraga, G. P., Guessennd, N., Giamarellou, H., Ghnnam, W., Gkiokas, G., Goldberg, S. R., Gomes, C. A., Gomi, H., Guzmán-Blanco, M., Haque, M., Hansen, S., Hecker, A., Heizmann, W. R., Herzog, T., Hodonou, A. M., Hong, S. K., Kafka-Ritsch, R., Kaplan, L. J., Kapoor, G., Karamarkovic, A., Kees, M. G., Kenig, J., Kiguba, R., Kim, P. K., Kluger, Y., Khokha, V., Koike, K., Kok, K. Y., Kong, V., Knox, M. C., Inaba, K., Isik, A., Iskandar, K., Ivatury, R. R., Labbate, M., Labricciosa, F. M., Laterre, P. F., Latifi, R., Lee, J. G., Lee, Y. R., Leone, M., Leppaniemi, A., Li, Y., Liang, S. Y., Loho, T., Maegele, M., Malama, S., Marei, H. E., Martin-Loeches, I., Marwah, S., Massele, A., Mcfarlane, M., Melo, R. B., Negoi, I., Nicolau, D. P., Nord, C. E., Ofori-Asenso, R., Omari, A. H., Ordonez, C. A., Ouadii, M., Pereira Júnior, G. A., Piazza, D., Pupelis, G., Rawson, T. M., Rems, M., Rizoli, S., Rocha, C., Sakakushev, B., Sanchez-Garcia, M., Sato, N., Segovia Lohse, H. A., Sganga, G., Siribumrungwong, B., Shelat, V. G., Soreide, K., Soto, R., Talving, P., Tilsed, J. V., Timsit, J. F., Trueba, G., Trung, N. T., Ulrych, J., van Goor, H., Vereczkei, A., Vohra, R. S., Wani, I., Uhl, W., Xiao, Y., Yuan, K. C., Zachariah, S. K., Zahar, J. R., Zakrison, T. L., Corcione, A., Melotti, R. M., Viscoli, C., Viale, P., Sartelli, M., Weber, D. G., Ruppé, E., Bassetti, M., Wright, B. J., Ansaloni, L., Catena, F., Coccolini, F., Abu-Zidan, F. M., Coimbra, R., Moore, E. E., Moore, F. A., Maier, R. V., De Waele, J. J., Kirkpatrick, A. W., Griffiths, E. A., Eckmann, C., Brink, A. J., Mazuski, J. E., May, A. K., Sawyer, R. G., Mertz, D., Montravers, P., Kumar, A., Roberts, J. A., Vincent, J. L., Watkins, R. R., Lowman, W., Spellberg, B., Abbott, I. J., Adesunkanmi, A. K., Al-Dahir, S., Al-Hasan, M. N., Agresta, F., Althani, A. A., Ansari, S., Ansumana, R., Augustin, G., Bala, M., Balogh, Z. J., Baraket, O., Bhangu, A., Beltrán, M. A., Bernhard, M., Biffl, W. L., Boermeester, M. A., Brecher, S. M., Cherry-Bukowiec, J. R., Buyne, O. R., Cainzos, M. A., Cairns, K. A., Camacho-Ortiz, A., Chandy, S. J., Che Jusoh, A., Chichom-Mefire, A., Colijn, C., Corcione, F., Cui, Y., Curcio, D., Delibegovic, S., Demetrashvili, Z., De Simone, B., Dhingra, S., Diaz, J. J., Di Carlo, I., Dillip, A., Di Saverio, S., Doyle, M. P., Dorj, G., Dogjani, A., Dupont, H., Eachempati, S. R., Enani, M. A., Egiev, V. N., Elmangory, M. M., Ferrada, P., Fitchett, J. R., Fraga, G. P., Guessennd, N., Giamarellou, H., Ghnnam, W., Gkiokas, G., Goldberg, S. R., Gomes, C. A., Gomi, H., Guzmán-Blanco, M., Haque, M., Hansen, S., Hecker, A., Heizmann, W. R., Herzog, T., Hodonou, A. M., Hong, S. K., Kafka-Ritsch, R., Kaplan, L. J., Kapoor, G., Karamarkovic, A., Kees, M. G., Kenig, J., Kiguba, R., Kim, P. K., Kluger, Y., Khokha, V., Koike, K., Kok, K. Y., Kong, V., Knox, M. C., Inaba, K., Isik, A., Iskandar, K., Ivatury, R. R., Labbate, M., Labricciosa, F. M., Laterre, P. F., Latifi, R., Lee, J. G., Lee, Y. R., Leone, M., Leppaniemi, A., Li, Y., Liang, S. Y., Loho, T., Maegele, M., Malama, S., Marei, H. E., Martin-Loeches, I., Marwah, S., Massele, A., Mcfarlane, M., Melo, R. B., Negoi, I., Nicolau, D. P., Nord, C. E., Ofori-Asenso, R., Omari, A. H., Ordonez, C. A., Ouadii, M., Pereira Júnior, G. A., Piazza, D., Pupelis, G., Rawson, T. M., Rems, M., Rizoli, S., Rocha, C., Sakakushev, B., Sanchez-Garcia, M., Sato, N., Segovia Lohse, H. A., Sganga, G., Siribumrungwong, B., Shelat, V. G., Soreide, K., Soto, R., Talving, P., Tilsed, J. V., Timsit, J. F., Trueba, G., Trung, N. T., Ulrych, J., van Goor, H., Vereczkei, A., Vohra, R. S., Wani, I., Uhl, W., Xiao, Y., Yuan, K. C., Zachariah, S. K., Zahar, J. R., Zakrison, T. L., Corcione, A., Melotti, R. M., Viscoli, C., and Viale, P.
Subjects: Settore MED/18 - CHIRURGIA GENERALE, Surgery, Emergency Medicine
Published: 2017

26. Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA) (vol 11, 33, 2016)

Author: Sartelli, M., Weber, D. G., Ruppe, E., Bassetti, M., Wright, B. J., Ansaloni, L., Catena, F., Coccolini, F., Abu-Zidan, F. M., Coimbra, R., Moore, E. E., Moore, F. A., Maier, R. V., De Waele, J. J., Kirkpatrick, A. W., Griffiths, E. A., Eckmann, C., Brink, A. J., Mazuski, J. E., May, A. K., Sawyer, R. G., Mertz, D., Montravers, P., Kumar, A., Roberts, J. A., Vincent, L., Watkins, R. R., Lowman, W., Spellberg, B., Abbott, I. J., Adesunkanmi, A. K., Al-Dahir, S., Al-Hasan, M. N., Agresta, F., Althani, A. A., Ansari, S., Ansumana, R., Augustin, G., Bala, M., Balogh, Z. J., Baraket, O., Bhangu, A., Beltrán, Anna Maria, Bernhard, M., Biffl, W. L., Boermeester, M. A., Brecher, S. M., Cherry-Bukowiec, J. R., Buyne, O. R., Cainzos, M. A., Cairns, K. A., Camacho-Ortiz, A., Chandy, S. J., Jusoh, A. Che, Chichom-Mefire, A., Colijn, C., Corcione, F., Cui, Y., Curcio, D., Delibegovic, S., Demetrashvili, Z., De Simone, B., Dhingra, S., Diaz, J. J., Di Carlo, I., Dillip, A., Di Saverio, S., Doyle, M. P., Dorj, G., Dogjani, A., Dupont, H., Eachempati, S. R., Enani, M. A., Egiev, V. N., Elmangory, M. M., Ferrada, P., Fitchett, J. R., Fraga, G. P., Guessennd, N., Giamarellou, H., Ghnnam, W., Gkiokas, G., Goldberg, S. R., Gomes, C. A., Gomi, H., Guzman-Blanco, M., Haque, M., Hansen, S., Hecker, A., Heizmann, W. R., Herzog, T., Hodonou, A. M., Hong, S. K., Kafka-Ritsch, R., Kaplan, L. J., Kapoor, G., Karamarkovic, A., Kees, M. G., Kenig, J., Kiguba, R., Kim, P. K., Kluger, Y., Khokha, V., Koike, K., Kok, K. Y., Kong, V., Knox, M. C., Inaba, K., Isik, A., Iskandar, K., Ivatury, R. R., Labbate, M., Labricciosa, F. M., Laterre, P. F., Latifi, R., Lee, J. G., Lee, Y. R., Leone, M., Leppaniemi, A., Li, Y., Liang, S. Y., Loho, T., Maegele, M., Malama, S., Marei, H. E., Martin-Loeches, I., Marwah, S., Massele, A., McFarlane, M., Melo, R. B., Negoi, I., Nicolau, D. P., Nord, C. E., Ofori-Asenso, R., Omari, A. H., Ordonez, C. A., Ouadii, M., Pereira Junior, G. A., Piazza, D., Pupelis, G., Rawson, T. M., Rems, M., Rizoli, S., Rocha, C., Sakakushev, B., Sanchez-Garcia, M., Sato, N., Segovia Lohse, H. A., Sganga, G., Siribumrungwong, B., Shelat, V. G., Soreide, K., Soto, R., Talving, P., Tilsed, J. V., Timsit, J. F., Trueba, G., Trung, N. T., Ulrych, J., Van Goor, H., Vereczkei, A., Vohra, R. S., Wani, I., Uhl, W., Xiao, Y., Yuan, K. C., Zachariah, S. K., Zahar, J. R., Zakrison, T. L., Corcione, A., Melotti, R. M., Viscoli, C., Viale, P., Universita 'La Sapienza' Roma (Istituto CNR), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Universidade de Aveiro, Laboratoire matériaux et microélectronique de Provence (L2MP), Université Paul Cézanne - Aix-Marseille 3-Université de Provence - Aix-Marseille 1-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur de Côte d'Ivoire, Réseau International des Instituts Pasteur (RIIP), National Defence University of Malaysia [Kuala Lumpur], Max Planck Institute for the Physics of Complex Systems (MPI-PKS), Max-Planck-Gesellschaft, Center for Plant Molecular Biology, Plant Physiology, and Biophysical Chemistry, University of Tübingen, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Fisica 'Giuseppe Occhialini' = Department of Physics 'Giuseppe Occhialini' [Milano-Bicocca], Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB), Atmospheric and Environmental Research, Inc. (AER), Zhejiang University, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Università degli Studi di Milano-Bicocca [Milano] (UNIMIB), and COMBE, Isabelle
Subjects: [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Carbapenems, Antimicrobial Resistance, Invasive Candidiasis, Methicillin Resistant Staphylococcus Aureus, Tigecycline, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients.The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance.The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria.An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.
Published: 2017
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27. The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines for management of intra-abdominal infections

Author: Sartelli, M, Chichom-Mefire, A, Labricciosa, F, Hardcastle, T, Abu-Zidan, F, Adesunkanmi, A, Ansaloni, L, Bala, M, Balogh, Z, Beltran, M, Ben-Ishay, O, Biffl, W, Birindelli, A, Cainzos, M, Catalini, G, Ceresoli, M, Che Jusoh, A, Chiara, O, Coccolini, F, Coimbra, R, Cortese, F, Demetrashvili, Z, Di Saverio, S, Diaz, J, Egiev, V, Ferrada, P, Fraga, G, Ghnnam, W, Lee, J, Gomes, C, Hecker, A, Herzog, T, Kim, J, Inaba, K, Isik, A, Karamarkovic, A, Kashuk, J, Khokha, V, Kirkpatrick, A, Kluger, Y, Koike, K, Kong, V, Leppaniemi, A, Machain, G, Maier, R, Marwah, S, Mcfarlane, M, Montori, G, Moore, E, Negoi, I, Olaoye, I, Omari, A, Ordonez, C, Pereira, B, Pereira Junior, G, Pupelis, G, Reis, T, Sakakhushev, B, Sato, N, Segovia Lohse, H, Shelat, V, Soreide, K, Uhl, W, Ulrych, J, Van Goor, H, Velmahos, G, Yuan, K, Wani, I, Weber, D, Zachariah, S, Catena, F, Sartelli M., Chichom-Mefire A., Labricciosa F. M., Hardcastle T., Abu-Zidan F. M., Adesunkanmi A. K., Ansaloni L., Bala M., Balogh Z. J., Beltran M. A., Ben-Ishay O., Biffl W. L., Birindelli A., Cainzos M. A., Catalini G., Ceresoli M., Che Jusoh A., Chiara O., Coccolini F., Coimbra R., Cortese F., Demetrashvili Z., Di Saverio S., Diaz J. J., Egiev V. N., Ferrada P., Fraga G. P., Ghnnam W. M., Lee J. G., Gomes C. A., Hecker A., Herzog T., Kim J. I., Inaba K., Isik A., Karamarkovic A., Kashuk J., Khokha V., Kirkpatrick A. W., Kluger Y., Koike K., Kong V. Y., Leppaniemi A., Machain G. M., Maier R. V., Marwah S., McFarlane M. E., Montori G., Moore E. E., Negoi I., Olaoye I., Omari A. H., Ordonez C. A., Pereira B. M., Pereira Junior G. A., Pupelis G., Reis T., Sakakhushev B., Sato N., Segovia Lohse H. A., Shelat V. G., Soreide K., Uhl W., Ulrych J., Van Goor H., Velmahos G. C., Yuan K. -C., Wani I., Weber D. G., Zachariah S. K., Catena F., Sartelli, M, Chichom-Mefire, A, Labricciosa, F, Hardcastle, T, Abu-Zidan, F, Adesunkanmi, A, Ansaloni, L, Bala, M, Balogh, Z, Beltran, M, Ben-Ishay, O, Biffl, W, Birindelli, A, Cainzos, M, Catalini, G, Ceresoli, M, Che Jusoh, A, Chiara, O, Coccolini, F, Coimbra, R, Cortese, F, Demetrashvili, Z, Di Saverio, S, Diaz, J, Egiev, V, Ferrada, P, Fraga, G, Ghnnam, W, Lee, J, Gomes, C, Hecker, A, Herzog, T, Kim, J, Inaba, K, Isik, A, Karamarkovic, A, Kashuk, J, Khokha, V, Kirkpatrick, A, Kluger, Y, Koike, K, Kong, V, Leppaniemi, A, Machain, G, Maier, R, Marwah, S, Mcfarlane, M, Montori, G, Moore, E, Negoi, I, Olaoye, I, Omari, A, Ordonez, C, Pereira, B, Pereira Junior, G, Pupelis, G, Reis, T, Sakakhushev, B, Sato, N, Segovia Lohse, H, Shelat, V, Soreide, K, Uhl, W, Ulrych, J, Van Goor, H, Velmahos, G, Yuan, K, Wani, I, Weber, D, Zachariah, S, Catena, F, Sartelli M., Chichom-Mefire A., Labricciosa F. M., Hardcastle T., Abu-Zidan F. M., Adesunkanmi A. K., Ansaloni L., Bala M., Balogh Z. J., Beltran M. A., Ben-Ishay O., Biffl W. L., Birindelli A., Cainzos M. A., Catalini G., Ceresoli M., Che Jusoh A., Chiara O., Coccolini F., Coimbra R., Cortese F., Demetrashvili Z., Di Saverio S., Diaz J. J., Egiev V. N., Ferrada P., Fraga G. P., Ghnnam W. M., Lee J. G., Gomes C. A., Hecker A., Herzog T., Kim J. I., Inaba K., Isik A., Karamarkovic A., Kashuk J., Khokha V., Kirkpatrick A. W., Kluger Y., Koike K., Kong V. Y., Leppaniemi A., Machain G. M., Maier R. V., Marwah S., McFarlane M. E., Montori G., Moore E. E., Negoi I., Olaoye I., Omari A. H., Ordonez C. A., Pereira B. M., Pereira Junior G. A., Pupelis G., Reis T., Sakakhushev B., Sato N., Segovia Lohse H. A., Shelat V. G., Soreide K., Uhl W., Ulrych J., Van Goor H., Velmahos G. C., Yuan K. -C., Wani I., Weber D. G., Zachariah S. K., and Catena F.
Abstract: Intra-abdominal infections (IAIs) are common surgical emergencies and have been reported as major contributors to non-trauma deaths in the emergency departments worldwide. The cornerstones of effective treatment of IAIs are early recognition, adequate source control, and appropriate antimicrobial therapy. Prompt resuscitation of patients with ongoing sepsis is of utmost important. In hospitals worldwide, non-acceptance of, or lack of access to, accessible evidence-based practices and guidelines result in overall poorer outcome of patients suffering IAIs. The aim of this paper is to promote global standards of care in IAIs and update the 2013 WSES guidelines for management of intra-abdominal infections.
Published: 2017

28. Erratum to: 2016 WSES guidelines on acute calculous cholecystitis [J Emerg Surg, 11, (2016), (25)], DOI: 10.1186/s13017-016-0082-5

Author: Ansaloni, L., Pisano, M., Coccolini, F., Peitzmann, A. B., Fingerhut, A., Catena, F., Agresta, F., Allegri, A., Bailey, I., Balogh, Z. J., Bendinelli, C., Biffl, W., Bonavina, L., Borzellino, G., Brunetti, F., Burlew, C. C., Camapanelli, G., Campanile, F. C., Ceresoli, M., Chiara, O., Civil, I., Coimbra, R., Moya, M., Saverio, S., Fraga, G. P., Gupta, S., Kashuk, J., Kelly, M. D., Khokha, V., Jeekel, H., Latifi, R., Leppaniemi, A., Maier, R. V., Marzi, I., Moore, F., Piazzalunga, D., Sakakushev, B., Sartelli, M., Scalea, T., Stahel, P. F., Taviloglu, K., Tugnoli, G., Uraneus, S., Velmahos, G. C., Wani, I., Weber, D. G., Viale, P., Sugrue, M., Ivatury, R., Kluger, Y., Gurusamy, K. S., and Moore, E. E.
Published: 2016

29. Erratum to: The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines for management of intra-abdominal infections

Author: Sartelli, M., primary, Chichom-Mefire, A., additional, Labricciosa, F. M., additional, Hardcastle, T., additional, Abu-Zidan, F. M., additional, Adesunkanmi, A. K., additional, Ansaloni, L., additional, Bala, M., additional, Balogh, Z. J., additional, Beltrán, M. A., additional, Ben-Ishay, O., additional, Biffl, W. L., additional, Birindelli, A., additional, Cainzos, M. A., additional, Catalini, G., additional, Ceresoli, M., additional, Che Jusoh, A., additional, Chiara, O., additional, Coccolini, F., additional, Coimbra, R., additional, Cortese, F., additional, Demetrashvili, Z., additional, Di Saverio, S., additional, Diaz, J.J., additional, Egiev, V. N., additional, Ferrada, P., additional, Fraga, G. P., additional, Ghnnam, W. M., additional, Lee, J. G., additional, Gomes, C. A., additional, Hecker, A., additional, Herzog, T., additional, Kim, J. I., additional, Inaba, K., additional, Isik, A., additional, Karamarkovic, A., additional, Kashuk, J., additional, Khokha, V., additional, Kirkpatrick, A. W., additional, Kluger, Y., additional, Koike, K., additional, Kong, V. Y., additional, Leppaniemi, A., additional, Machain, G. M., additional, Maier, R. V., additional, Marwah, S., additional, McFarlane, M. E., additional, Montori, G., additional, Moore, E. E., additional, Negoi, I., additional, Olaoye, I., additional, Omari, A. H., additional, Ordonez, C. A., additional, Pereira, B. M., additional, Pereira Júnior, G. A., additional, Pupelis, G., additional, Reis, T., additional, Sakakushev, B., additional, Sato, N., additional, Segovia Lohse, H. A., additional, Shelat, V. G., additional, Søreide, K., additional, Uhl, W., additional, Ulrych, J., additional, Van Goor, H., additional, Velmahos, G.C., additional, Yuan, K. C., additional, Wani, I., additional, Weber, D. G., additional, Zachariah, S. K., additional, and Catena, F., additional
Published: 2017
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30. Erratum to: Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Author: Sartelli, M., primary, Weber, D. G., additional, Ruppé, E., additional, Bassetti, M., additional, Wright, B. J., additional, Ansaloni, L., additional, Catena, F., additional, Coccolini, F., additional, Abu-Zidan, F. M., additional, Coimbra, R., additional, Moore, E. E., additional, Moore, F. A., additional, Maier, R. V., additional, De Waele, J. J., additional, Kirkpatrick, A. W., additional, Griffiths, E. A., additional, Eckmann, C., additional, Brink, A. J., additional, Mazuski, J. E., additional, May, A. K., additional, Sawyer, R. G., additional, Mertz, D., additional, Montravers, P., additional, Kumar, A., additional, Roberts, J. A., additional, Vincent, J. L., additional, Watkins, R. R., additional, Lowman, W., additional, Spellberg, B., additional, Abbott, I. J., additional, Adesunkanmi, A. K., additional, Al-Dahir, S., additional, Al-Hasan, M. N., additional, Agresta, F., additional, Althani, A. A., additional, Ansari, S., additional, Ansumana, R., additional, Augustin, G., additional, Bala, M., additional, Balogh, Z. J., additional, Baraket, O., additional, Bhangu, A., additional, Beltrán, M. A., additional, Bernhard, M., additional, Biffl, W. L., additional, Boermeester, M. A., additional, Brecher, S. M., additional, Cherry-Bukowiec, J. R., additional, Buyne, O. R., additional, Cainzos, M. A., additional, Cairns, K. A, additional, Camacho-Ortiz, A., additional, Chandy, S. J., additional, Che Jusoh, A., additional, Chichom-Mefire, A., additional, Colijn, C., additional, Corcione, F., additional, Cui, Y., additional, Curcio, D., additional, Delibegovic, S., additional, Demetrashvili, Z., additional, De Simone, B., additional, Dhingra, S., additional, Diaz, J. J., additional, Di Carlo, I., additional, Dillip, A., additional, Di Saverio, S., additional, Doyle, M. P., additional, Dorj, G., additional, Dogjani, A., additional, Dupont, H., additional, Eachempati, S. R., additional, Enani, M. A., additional, Egiev, V. N., additional, Elmangory, M. M., additional, Ferrada, P., additional, Fitchett, J. R., additional, Fraga, G. P., additional, Guessennd, N., additional, Giamarellou, H., additional, Ghnnam, W., additional, Gkiokas, G., additional, Goldberg, S. R., additional, Gomes, C. A., additional, Gomi, H., additional, Guzmán-Blanco, M., additional, Haque, M., additional, Hansen, S., additional, Hecker, A., additional, Heizmann, W. R., additional, Herzog, T., additional, Hodonou, A. M., additional, Hong, S. K., additional, Kafka-Ritsch, R., additional, Kaplan, L. J., additional, Kapoor, G., additional, Karamarkovic, A., additional, Kees, M. G., additional, Kenig, J., additional, Kiguba, R., additional, Kim, P. K., additional, Kluger, Y., additional, Khokha, V., additional, Koike, K., additional, Kok, K. Y., additional, Kong, V., additional, Knox, M. C., additional, Inaba, K., additional, Isik, A., additional, Iskandar, K., additional, Ivatury, R. R., additional, Labbate, M., additional, Labricciosa, F. M., additional, Laterre, P. F., additional, Latifi, R., additional, Lee, J. G., additional, Lee, Y. R., additional, Leone, M., additional, Leppaniemi, A., additional, Li, Y., additional, Liang, S. Y., additional, Loho, T., additional, Maegele, M., additional, Malama, S., additional, Marei, H. E., additional, Martin-Loeches, I., additional, Marwah, S., additional, Massele, A., additional, McFarlane, M., additional, Melo, R. B., additional, Negoi, I., additional, Nicolau, D. P., additional, Nord, C. E., additional, Ofori-Asenso, R., additional, Omari, A. H., additional, Ordonez, C. A., additional, Ouadii, M., additional, Pereira Júnior, G. A., additional, Piazza, D., additional, Pupelis, G., additional, Rawson, T. M., additional, Rems, M., additional, Rizoli, S., additional, Rocha, C., additional, Sakakushev, B., additional, Sanchez-Garcia, M., additional, Sato, N., additional, Segovia Lohse, H. A., additional, Sganga, G., additional, Siribumrungwong, B., additional, Shelat, V. G., additional, Soreide, K., additional, Soto, R., additional, Talving, P., additional, Tilsed, J. V., additional, Timsit, J. F., additional, Trueba, G., additional, Trung, N. T., additional, Ulrych, J., additional, van Goor, H., additional, Vereczkei, A., additional, Vohra, R. S., additional, Wani, I., additional, Uhl, W., additional, Xiao, Y., additional, Yuan, K. C., additional, Zachariah, S. K., additional, Zahar, J. R., additional, Zakrison, T. L., additional, Corcione, A., additional, Melotti, R. M., additional, Viscoli, C., additional, and Viale, P., additional
Published: 2017
Full Text: View/download PDF

31. 2016 WSES guidelines on acute calculous cholecystitis

Author: Ansaloni, L., primary, Pisano, M., additional, Coccolini, F., additional, Peitzmann, A. B., additional, Fingerhut, A., additional, Catena, F., additional, Agresta, F., additional, Allegri, A., additional, Bailey, I., additional, Balogh, Z. J., additional, Bendinelli, C., additional, Biffl, W., additional, Bonavina, L., additional, Borzellino, G., additional, Brunetti, F., additional, Burlew, C. C., additional, Camapanelli, G., additional, Campanile, F. C., additional, Ceresoli, M., additional, Chiara, O., additional, Civil, I., additional, Coimbra, R., additional, Moya, M. De., additional, Saverio, S. Di., additional, Fraga, G. P., additional, Gupta, S., additional, Kashuk, J., additional, Kelly, M. D., additional, Koka, V., additional, Jeekel, H., additional, Latifi, R., additional, Leppaniemi, A., additional, Maier, R. V., additional, Marzi, I., additional, Moore, F., additional, Piazzalunga, D., additional, Sakakushev, B., additional, Sartelli, M., additional, Scalea, T., additional, Stahel, P. F., additional, Taviloglu, K., additional, Tugnoli, G., additional, Uraneus, S., additional, Velmahos, G. C., additional, Wani, I., additional, Weber, D. G., additional, Viale, P., additional, Sugrue, M., additional, Ivatury, R., additional, Kluger, Y., additional, Gurusamy, K. S., additional, and Moore, E. E., additional
Published: 2017
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32. Ada Formal Methods in the STARS Environment

Author: Weber, D. G., primary, Barbasch, Cheryl, primary, and Morris, James, primary
Published: 1992
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33. 2016 WSES guidelines on acute calculous cholecystitis (vol 11, 25, 2016)

Author: University of Helsinki, II kirurgian klinikka, Ansaloni, L., Pisano, M., Coccolini, F., Peitzmann, A. B., Fingerhut, A., Catena, F., Agresta, F., Allegri, A., Bailey, I., Balogh, Z. J., Bendinelli, C., Biffl, W., Bonavina, L., Borzellino, G., Brunetti, F., Burlew, C. C., Camapanelli, G., Campanile, F. C., Ceresoli, M., Chiara, O., Civil, I., Coimbra, R., De Moya, M., Di Saverio, S., Fraga, G. P., Gupta, S., Kashuk, J., Kelly, M. D., Khokha, V., Jeekel, H., Latifi, R., Leppaniemi, A., Maier, R. V., Marzi, I., Moore, F., Piazzalunga, D., Sakakushev, B., Sartelli, M., Scalea, T., Stahel, P. F., Taviloglu, K., Tugnoli, G., Uraneus, S., Velmahos, G. C., Wani, I., Weber, D. G., Viale, P., Sugrue, M., Ivatury, R., Kluger, Y., Gurusamy, K. S., Moore, E. E., University of Helsinki, II kirurgian klinikka, Ansaloni, L., Pisano, M., Coccolini, F., Peitzmann, A. B., Fingerhut, A., Catena, F., Agresta, F., Allegri, A., Bailey, I., Balogh, Z. J., Bendinelli, C., Biffl, W., Bonavina, L., Borzellino, G., Brunetti, F., Burlew, C. C., Camapanelli, G., Campanile, F. C., Ceresoli, M., Chiara, O., Civil, I., Coimbra, R., De Moya, M., Di Saverio, S., Fraga, G. P., Gupta, S., Kashuk, J., Kelly, M. D., Khokha, V., Jeekel, H., Latifi, R., Leppaniemi, A., Maier, R. V., Marzi, I., Moore, F., Piazzalunga, D., Sakakushev, B., Sartelli, M., Scalea, T., Stahel, P. F., Taviloglu, K., Tugnoli, G., Uraneus, S., Velmahos, G. C., Wani, I., Weber, D. G., Viale, P., Sugrue, M., Ivatury, R., Kluger, Y., Gurusamy, K. S., and Moore, E. E.
Published: 2016

34. 2016 WSES guidelines on acute calculous cholecystitis

Author: Ansaloni, L, Pisano, M, Coccolini, F, Peitzmann, A B, Fingerhut, A, Catena, F, Agresta, F, Allegri, A, Bailey, I, Balogh, Z J, Bendinelli, C, Biffl, W, Bonavina, L, Borzellino, G, Brunetti, F, Burlew, C C, Camapanelli, G, Campanile, F C, Ceresoli, M, Chiara, O, Civil, I, Coimbra, R, De Moya, M, Di Saverio, S, Fraga, G P, Gupta, S, Kashuk, J, Kelly, M D, Koka, V, Jeekel, H, Latifi, R, Leppaniemi, A, Maier, R V, Marzi, I, Moore, F, Piazzalunga, D, Sakakushev, B, Sartelli, M, Scalea, T, Stahel, P F, Taviloglu, K, Tugnoli, G, Uraneus, S, Velmahos, G C, Wani, I, Weber, D G, Viale, P, Sugrue, M, Ivatury, R, Kluger, Y, Gurusamy, K S, Moore, E E, Ansaloni, L, Pisano, M, Coccolini, F, Peitzmann, A B, Fingerhut, A, Catena, F, Agresta, F, Allegri, A, Bailey, I, Balogh, Z J, Bendinelli, C, Biffl, W, Bonavina, L, Borzellino, G, Brunetti, F, Burlew, C C, Camapanelli, G, Campanile, F C, Ceresoli, M, Chiara, O, Civil, I, Coimbra, R, De Moya, M, Di Saverio, S, Fraga, G P, Gupta, S, Kashuk, J, Kelly, M D, Koka, V, Jeekel, H, Latifi, R, Leppaniemi, A, Maier, R V, Marzi, I, Moore, F, Piazzalunga, D, Sakakushev, B, Sartelli, M, Scalea, T, Stahel, P F, Taviloglu, K, Tugnoli, G, Uraneus, S, Velmahos, G C, Wani, I, Weber, D G, Viale, P, Sugrue, M, Ivatury, R, Kluger, Y, Gurusamy, K S, and Moore, E E
Abstract: Acute calculus cholecystitis is a very common disease with several area of uncertainty. The World Society of Emergency Surgery developed extensive guidelines in order to cover grey areas. The diagnostic criteria, the antimicrobial therapy, the evaluation of associated common bile duct stones, the identification of "high risk" patients, the surgical timing, the type of surgery, and the alternatives to surgery are discussed. Moreover the algorithm is proposed: as soon as diagnosis is made and after the evaluation of choledocholitiasis risk, laparoscopic cholecystectomy should be offered to all patients exception of those with high risk of morbidity or mortality. These Guidelines must be considered as an adjunctive tool for decision but they are not substitute of the clinical judgement for the individual patient.
Published: 2016

35. Erratum to: 2016 WSES guidelines on acute calculous cholecystitis

Author: Ansaloni, L., primary, Pisano, M., additional, Coccolini, F., additional, Peitzmann, A. B., additional, Fingerhut, A., additional, Catena, F., additional, Agresta, F., additional, Allegri, A., additional, Bailey, I., additional, Balogh, Z. J., additional, Bendinelli, C., additional, Biffl, W., additional, Bonavina, L., additional, Borzellino, G., additional, Brunetti, F., additional, Burlew, C. C., additional, Camapanelli, G., additional, Campanile, F. C., additional, Ceresoli, M., additional, Chiara, O., additional, Civil, I., additional, Coimbra, R., additional, De Moya, M., additional, Di Saverio, S., additional, Fraga, G. P., additional, Gupta, S., additional, Kashuk, J., additional, Kelly, M. D., additional, Khokha, V., additional, Jeekel, H., additional, Latifi, R., additional, Leppaniemi, A., additional, Maier, R. V., additional, Marzi, I., additional, Moore, F., additional, Piazzalunga, D., additional, Sakakushev, B., additional, Sartelli, M., additional, Scalea, T., additional, Stahel, P. F., additional, Taviloglu, K., additional, Tugnoli, G., additional, Uraneus, S., additional, Velmahos, G. C., additional, Wani, I., additional, Weber, D. G., additional, Viale, P., additional, Sugrue, M., additional, Ivatury, R., additional, Kluger, Y., additional, Gurusamy, K. S., additional, and Moore, E. E., additional
Published: 2016
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36. 2016 WSES guidelines on acute calculous cholecystitis

Author: Ansaloni, L., primary, Pisano, M., additional, Coccolini, F., additional, Peitzmann, A. B., additional, Fingerhut, A., additional, Catena, F., additional, Agresta, F., additional, Allegri, A., additional, Bailey, I., additional, Balogh, Z. J., additional, Bendinelli, C., additional, Biffl, W., additional, Bonavina, L., additional, Borzellino, G., additional, Brunetti, F., additional, Burlew, C. C., additional, Camapanelli, G., additional, Campanile, F. C., additional, Ceresoli, M., additional, Chiara, O., additional, Civil, I., additional, Coimbra, R., additional, De Moya, M., additional, Di Saverio, S., additional, Fraga, G. P., additional, Gupta, S., additional, Kashuk, J., additional, Kelly, M. D., additional, Khokha, V., additional, Jeekel, H., additional, Latifi, R., additional, Leppaniemi, A., additional, Maier, R. V., additional, Marzi, I., additional, Moore, F., additional, Piazzalunga, D., additional, Sakakushev, B., additional, Sartelli, M., additional, Scalea, T., additional, Stahel, P. F., additional, Taviloglu, K., additional, Tugnoli, G., additional, Uraneus, S., additional, Velmahos, G. C., additional, Wani, I., additional, Weber, D. G., additional, Viale, P., additional, Sugrue, M., additional, Ivatury, R., additional, Kluger, Y., additional, Gurusamy, K. S., additional, and Moore, E. E., additional
Published: 2016
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37. Damage control surgery for abdominal emergencies

Author: Weber, D G, primary, Bendinelli, C, additional, and Balogh, Z J, additional
Published: 2013
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38. Performance of biomarkers SMRP, CA125, and CYFRA 21-1 as potential tumor markers for malignant mesothelioma and lung cancer in a cohort of workers formerly exposed to asbestos

Author: Gube, M., primary, Taeger, D., additional, Weber, D. G., additional, Pesch, B., additional, Brand, P., additional, Johnen, G., additional, Müller-Lux, A., additional, Gross, I. M., additional, Wiethege, T., additional, Weber, A., additional, Raithel, H. J., additional, Kraus, T., additional, and Brüning, T., additional
Published: 2010
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39. Ada Formal Methods in the STARS Environment

Author: PARAMAX SYSTEMS CORP RESTON VA TACTICAL SYSTEMS DIV, Weber, D. G., Barbasch, Cheryl, Morris, James, PARAMAX SYSTEMS CORP RESTON VA TACTICAL SYSTEMS DIV, Weber, D. G., Barbasch, Cheryl, and Morris, James
Abstract: This report is an interim product of Task 18. It is not intended to be a comprehensive review of work to be done on the Task, or even of work that has already been done (as the title of the deliverable might suggest). Rather, the report is a collection of several possible ways in which tools supporting formal methods might be made interoperable and/or integrated into a SEE. The possibilities discussed are merely representative, and are limited only by the effort available for completing the report. Much of the discussion relates to work being done in Ada verification at ORA, which is the STARS subcontractor primarily responsible for Task 18. SEE, formal methods, Ada, Penelope.
Published: 1992

40. Specification/Verification of Temporal Properties for Distributed Systems: Issues and Approaches. Volume 1

Author: NATIONAL RESEARCH COUNCIL WASHINGTON DC COMMISSION ON ENGINEERING AND TECHNICAL SYSTEMS, Schneider, Edward A., Weber, D. G., De Groot, Tanja, NATIONAL RESEARCH COUNCIL WASHINGTON DC COMMISSION ON ENGINEERING AND TECHNICAL SYSTEMS, Schneider, Edward A., Weber, D. G., and De Groot, Tanja
Abstract: This report identifies problems, models and solutions in the area of specification and verification of temporal properties for secure distribution systems. The temporal properties studied are security, progress, determinism, and real-time requirements. Also included is work on the specification of fault tolerance and adaptive security policies. The effort is a first look at these issues. The model of a distributed system that will be used in this report is a collection of objects that interact only by passing messages. The only state global to two or more objects is the communication channels that connect them. Every piece of data must be contained in one of the objects and cannot be directly read from another. This model fits very well with a multicomputer, in which there is no memory shared between the nodes, and the objects can be distributed arbitrarily among the nodes. However, it can also be used when objects share a node and some global memory.
Published: 1990

41. Formal specification of fault-tolerance and its relation to computer security.

Author: Weber, D. G.
Published: 1989
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42. Formal specification of fault-tolerance and its relation to computer security

Author: Weber, D. G., primary
Published: 1989
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43. Kinetics of chemotaxis, cytokine, and chemokine release of NR8383 macrophages after exposure to inflammatory and inert granular insoluble particles.

Author: Schremmer I, Brik A, Weber DG, Rosenkranz N, Rostek A, Loza K, Brüning T, Johnen G, Epple M, Bünger J, and Westphal GA
Subjects: Animals, Barium Sulfate toxicity, Cell Line, Cell Migration Assays, Macrophage, Gene Expression Profiling, Kinetics, Nanoparticles toxicity, Quartz toxicity, Rats, Silicon Dioxide toxicity, Titanium toxicity, Air Pollutants toxicity, Chemokines metabolism, Chemotaxis drug effects, Cytokines metabolism, Macrophages, Alveolar drug effects, Macrophages, Alveolar metabolism, Particulate Matter toxicity
Abstract: Accumulation of macrophages and neutrophil granulocytes in the lung are key events in the inflammatory response to inhaled particles. The present study aims at the time course of chemotaxis in vitro in response to the challenge of various biopersistent particles and its functional relation to the transcription of inflammatory mediators. NR8383 rat alveolar macrophages were challenged with particles of coarse quartz, barium sulfate, and nanosized silica for one, four, and 16h and with coarse and nanosized titanium dioxide particles (rutile and anatase) for 16h only. The cell supernatants were used to investigate the chemotaxis of unexposed NR8383 macrophages. The transcription of inflammatory mediators in cells exposed to quartz, silica, and barium sulfate was analyzed by quantitative real-time PCR. Challenge with quartz, silica, and rutile particles induced significant chemotaxis of unexposed NR8383 macrophages. Chemotaxis caused by quartz and silica was accompanied by an elevated transcription of CCL3, CCL4, CXCL1, CXCL3, and TNFα. Quartz exposure showed an earlier onset of both effects compared to the nanosized silica. The strength of this response roughly paralleled the cytotoxic effects. Barium sulfate and anatase did not induce chemotaxis and barium sulfate as well caused no elevated transcription. In conclusion, NR8383 macrophages respond to the challenge with inflammatory particles with the release of chemotactic compounds that act on unexposed macrophages. The kinetics of the response differs between the various particles., (Copyright Â© 2016 Elsevier Ireland Ltd. All rights reserved.)
Published: 2016
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44. Biomarker research with prospective study designs for the early detection of cancer.

Author: Pesch B, Brüning T, Johnen G, Casjens S, Bonberg N, Taeger D, Müller A, Weber DG, and Behrens T
Subjects: Humans, Neoplasms metabolism, Prospective Studies, Research Design, Biomarkers, Tumor analysis, Biomedical Research, Early Detection of Cancer, Neoplasm Proteins metabolism, Neoplasms diagnosis, Proteomics methods
Abstract: This article describes the principles of marker research with prospective studies along with examples for diagnostic tumor markers. A plethora of biomarkers have been claimed as useful for the early detection of cancer. However, disappointingly few biomarkers were approved for the detection of unrecognized disease, and even approved markers may lack a sound validation phase. Prospective studies aimed at the early detection of cancer are costly and long-lasting and therefore the bottleneck in marker research. They enroll a large number of clinically asymptomatic subjects and follow-up on incident cases. As invasive procedures cannot be applied to collect tissue samples from the target organ, biomarkers can only be determined in easily accessible body fluids. Marker levels increase during cancer development, with samples collected closer to the occurrence of symptoms or a clinical diagnosis being more informative than earlier samples. Only prospective designs allow the serial collection of pre-diagnostic samples. Their storage in a biobank upgrades cohort studies to serve for both, marker discovery and validation. Population-based cohort studies, which may collect a wealth of data, are commonly conducted with just one baseline investigation lacking serial samples. However, they can provide valuable information about factors that influence the marker level. Screening programs can be employed to archive serial samples but require significant efforts to collect samples and auxiliary data for marker research. Randomized controlled trials have the highest level of evidence in assessing a biomarker's benefit against usual care and present the most stringent design for the validation of promising markers as well as for the discovery of new markers. In summary, all kinds of prospective studies can benefit from a biobank as they can serve as a platform for biomarker research. This article is part of a Special Issue entitled: Biomarkers: A Proteomic Challenge., (Copyright © 2013 Elsevier B.V. All rights reserved.)
Published: 2014
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45. Clinical patient information capture: the Columbia/HCA cancer care database experience.

Author: Stanfill PH, Weber DG, and Wayne C
Subjects: Benchmarking, Demography, Disease Management, Hospitals, Proprietary, Humans, National Health Programs, Neoplasms classification, Outcome Assessment, Health Care, United States epidemiology, Databases, Factual, Multi-Institutional Systems organization & administration, Neoplasms epidemiology, Neoplasms therapy, Oncology Service, Hospital organization & administration, Registries
Abstract: Development of a cancer care database and interpretation of its contents will provide extensive information about a set of patients with a particular disease. By defining disease by stage, its associated costs of diagnosis, treatment and long term follow-up, patient outcomes and self-reported satisfaction and quality of life, a foundation for disease management evolves. Utilizing documented experience over the continuum of cancer care provides a stronger foundation for standards of care and critical pathway development as well as enhancing risk sharing capabilities in providing care for a set of cancer patients. Extensive data collection and analysis has been identified as the key to successful disease management. With the Columbia/HCA Cancer Care Database and future strategic initiatives, the development of an oncology disease management approach is aggressively moving forward.
Published: 1998

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