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1. Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities

Author

Caeneghem, Y. (Yasmine) van, De Munter, S. (Stijn), Tieppo, P. (Paola), Goetgeluk, G. (Glenn), Weening, K. (Karin), Verstichel, G. (Greet), Bonte, S. (Sarah), Taghon, T. (Tom), Leclercq, G. (Georges), Kerre, T. (Tessa), Debets, J.E.M.A. (Reno), Vermijlen, D. (David), Abken, H. (Hinrich), Vandekerckhove, B. (Bart), Caeneghem, Y. (Yasmine) van, De Munter, S. (Stijn), Tieppo, P. (Paola), Goetgeluk, G. (Glenn), Weening, K. (Karin), Verstichel, G. (Greet), Bonte, S. (Sarah), Taghon, T. (Tom), Leclercq, G. (Georges), Kerre, T. (Tessa), Debets, J.E.M.A. (Reno), Vermijlen, D. (David), Abken, H. (Hinrich), and Vandekerckhove, B. (Bart)

Abstract

Recent clinical studies indicate that adoptive T-cell therapy and especially chimeric antigen receptor (CAR) T-cell therapy is a very potent and potentially curative treatment for B-lineage hematologic malignancies. Currently, autologous peripheral blood T cells are used for adoptive T-cell therapy. Adoptive T cells derived from healthy allogeneic donors may have several advantages; however, the expected occurrence of graft versus host disease (GvHD) as a consequence of the diverse allogeneic T-cell receptor (TCR) repertoire expressed by these cells compromises this approach. Here, we generated T cells from cord

Published
2017
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