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Synthetic-Aperture Radar (SAR) has emerged as an important tool for monitoring tropical cyclones (TCs) due to its high spatial resolution and cloud-penetrating capability. Recent advancements in SAR technology have led to smaller and lighter satellites, yet few studies have evaluated their effectiveness in TC monitoring. This paper employs an algorithm for automatic TC center location, involving three stages: coarse estimation from a whole SAR image; precise estimation from a sub-SAR image; and final identification of the center using the lowest Normalized Radar Cross-Section (NRCS) value within a smaller sub-SAR image. Using three wide-swath miniaturized SAR images of TC Noru (2022), and TCs Doksuri and Koinu (2023), the algorithm's accuracy was validated by comparing estimated TC center positions with visually located data. For TC Noru, the distances for the three stages were 21.42 km, 14.39 km, and 8.19 km; for TC Doksuri—14.36 km, 20.48 km, and 17.10 km; and for TC Koinu—47.82 km, 31.59 km, and 5.42 km. The results demonstrate the potential of miniaturized SAR in TC monitoring. [ABSTRACT FROM AUTHOR]

The terrain, such as Taiwan Island, have been shown to have complex effects on typhoons and the associated typhoon waves. Terrain effects change with typhoon tracks. In this study, three types of typhoon tracks (northern, middle and southern) were defined according to the relationship between the typhoon tracks and Taiwan Island. Typhoons on these three tracks and typhoon waves were simulated using the Weather Research and Forecasting–Simulating Waves Nearshore model. In each type of typhoon, a control case without the Taiwan topography was simulated to compare with real cases. The results showed that typhoons on different tracks were affected by the terrain of Taiwan Island in different ways. Taiwan Island had weakening, decelerating and deflective effects on typhoons. The ranking for the weakening effect was middle track (81%) > southern track (69%) > northern track (3%). The decelerating effect was 7% in the northern track and 25% in the southern track. The deflective effect of the terrain makes typhoons on the northern (southern) track deflect toward the south (north). When a typhoon on a middle track passed over Taiwan Island, a new center of low pressure would replace the former center and make the track discontinuous. In addition, the influence of typhoons on regions near Taiwan Island changed with the typhoon's tracks. The influence ranking of typhoons in Taiwan Island was the middle track > southern track > northern track, which was consistent with that of typhoons in the Taiwan Strait and opposite to that of typhoons in Fujian Province. The influence ranking of typhoons on the Taiwan Strait was the opposite of the typhoon intensity ranking, which suggests that the intensities of wind and waves in the strait were more related to typhoon tracks than typhoon intensity. The variations in the significant wave height were similar to those of the wind speed, but there was a time lag (2 h) between them due to the wave growth process and swells. In addition, the significant wave height distribution sometimes differed from the wind speed distribution under the influence of swells and terrain. [ABSTRACT FROM AUTHOR]

Antofloxacin (AFX) is a novel fluoroquinolone that has been approved in China for the treatment of infections caused by a variety of bacterial species. We investigated whether it could be repurposed for the treatment of tuberculosis by studying its in vitro activity. We determined the wild-type and non-wild-type MIC ranges for AFX as well as ofloxacin (OFX), levofloxacin (LFX), and moxifloxacin (MFX), using the microplate alamarBlue assay, of 126 clinical Mycobacterium tuberculosis strains from Beijing, China, of which 48 were OFX resistant on the basis of drug susceptibility testing on Löwenstein-Jensen medium. The MIC distributions were correlated with mutations in the quinolone resistance-determining regions of gyrA (Rv0006) and gyrB (Rv0005). Pharmacokinetic/pharmacodynamic (PK/PD) data for AFX were retrieved from the literature. AFX showed lower MIC levels than OFX but higher MIC levels than LFX and MFX on the basis of the tentative epidemiological cutoff values (ECOFFs) determined in this study. All strains with non-wild-type MICs for AFX harbored known resistance mutations that also resulted in non-wild-type MICs for LFX and MFX. Moreover, our data suggested that the current critical concentration of OFX for Löwenstein-Jensen medium that was recently revised by the World Health Organization might be too high, resulting in the misclassification of phenotypically non-wild-type strains with known resistance mutations as wild type. On the basis of our exploratory PK/PD calculations, the current dose of AFX is unlikely to be optimal for the treatment of tuberculosis, but higher doses could be effective., (Copyright © 2016 Yu et al.)