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293 results on '"Wei, Xiaolei"'

6. Autologous hematopoietic stem cell transplantation activity for lymphoma and multiple myeloma in China

Author

Liu, Weiping, Ji, Jie, Zou, Dehui, Cao, Yang, Xu, Yajing, Zhou, Jian, Gao, Sujun, Wang, Fengrong, Chen, Wenming, Du, Juan, Zhou, Hui, Zhou, Fuling, Shi, Jimin, Zhang, Xi, Yang, Jianmin, Jing, Hongmei, Jiang, Zhongxing, Liu, Hui, Li, Caixia, Peng, Hongling, Jiang, Songfu, Wei, Xiaolei, He, Pengcheng, Liu, Yao, Yang, Haiyan, Li, Zengjun, Huang, Xiaobing, Liu, Lin, Shen, Lijing, Liu, Chuanfang, Song, Yuqin, Qiu, Lugui, Wang, Xiaopei, Ma, Jun, and Zhu, Jun

Published
2023
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10. HVEM in acute lymphocytic leukemia facilitates tumour immune escape by inhibiting CD8+ T cell function.

Author

Liu, Yujia, Wang, Lixiang, Li, Yiyi, Zhong, Cheng, Wang, Xiumei, Wang, Xinyu, Xia, Zijin, Liao, Jing, Huang, Chunliu, Mao, Chengzhou, Feng, Yongyi, Luo, Congzhou, Mai, Wenhao, Song, Hongrui, Li, Hongyu, Bao, Lin, Chen, Danchun, Sheng, Yue, Zhang, Hui, and Wei, Xiaolei

Subjects
LYMPHOBLASTIC leukemia, ACUTE myeloid leukemia, ACUTE leukemia, IMMUNOLOGIC memory, CELL physiology, T cells
Abstract

Purpose: Leukaemia remains a major contributor to global mortality, representing a significant health risk for a substantial number of cancer patients. Despite notable advancements in the field, existing treatments frequently exhibit limited efficacy or recurrence. Here, we explored the potential of abolishing HVEM (herpes virus entry mediator, TNFRSF14) expression in tumours as an effective approach to treat acute lymphoblastic leukaemia (ALL) and prevent its recurrence. Methods: The clinical correlations between HVEM and leukaemia were revealed by public data analysis. HVEM knockout (KO) murine T cell lymphoblastic leukaemia cell line EL4 were generated using CRISPR-Cas9 technology, and syngeneic subcutaneous tumour models were established to investigate the in vivo function of HVEM. Immunohistochemistry (IHC), RNA-seq and flow cytometry were used to analyse the tumour immune microenvironment (TIME) and tumour draining lymph nodes (dLNs). Immune functions were investigated by depletion of immune subsets in vivo and T cell functional assays in vitro. The HVEM mutant EL4 cell lines were constructed to investigate the functional domain responsible for immune escape. Results: According to public databases, HVEM is highly expressed in patients with ALL and acute myeloid leukemia (AML) and is negatively correlated with patient prognosis. Genetic deletion of HVEM in EL4 cells markedly inhibited tumour progression and prolonged the survival of tumour-bearing mice. Our experiments proved that HVEM exerted its immunosuppressive effect by inhibiting antitumour function of CD8+ T cell through CRD1 domain both in vivo and in vitro. Additionally, we identified a combination therapy capable of completely eradicating ALL tumours, which induces immune memory toward tumour protection. Conclusions: Our study reveals the potential mechanisms by which HVEM facilitates ALL progression, and highlights HVEM as a promising target for clinical applications in relapsed ALL therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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19. P635: AN UPDATE OF SAFETY AND EFFICACY RESULTS FROM PHASE 1 STUDY OF LP-108, A NOVEL AND SELECTIVE BCL-2 INHIBITOR, IN PATIENTS WITH RELAPSED OR REFRACTORY B-CELL NON-HODGKIN LYMPHOMAS

Author

Xu, Wei, primary, Feng, Ru, additional, Wang, LI, additional, Zhu, Huayuan, additional, Zhou, Keshu, additional, Fu, Xiaorui, additional, Jing, Hongmei, additional, Song, Yuqin, additional, Qi, Junyuan, additional, Cui, Guohui, additional, LI, Fei, additional, Wang, Shaoyuan, additional, Zhou, Hui, additional, Qian, Wenbin, additional, Cai, Qingqing, additional, Zhao, Xielan, additional, Guo, Xutao, additional, Wei, Xiaolei, additional, Lin, Ningjing, additional, Xu, Zhongyuan, additional, Wang, Zheng, additional, Xiao, Xiang, additional, Dong, Jiale, additional, Lou, Yejiang, additional, Shen, Yue, additional, Chen, Yi, additional, Chen, Yu, additional, Tan, Fenlai, additional, Anthony, Stephen, additional, and LI, Jianyong, additional

Published
2023
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22. PIF1 Promotes Autophagy to Inhibit Chronic Hypoxia Induced Apoptosis of Pulmonary Artery Endothelial Cells

Author

Zhao,Yujing, Wu,Juan, Guan,Shuai, Xue,Ting, Wei,Xiaolei, Cao,Dawei, Kong,Pengzhou, Zhang,Xinri, Zhao,Yujing, Wu,Juan, Guan,Shuai, Xue,Ting, Wei,Xiaolei, Cao,Dawei, Kong,Pengzhou, and Zhang,Xinri

Abstract

Yujing Zhao,1– 4 Juan Wu,2– 4 Shuai Guan,5 Ting Xue,2– 4 Xiaolei Wei,1– 4 Dawei Cao,2– 4 Pengzhou Kong,6 Xinri Zhang2– 4 1Department of the First Clinical Medicine, Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 2Department of NHC Key Laboratory of Pneumoconiosis, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 3Department of Shanxi Key Laboratory of Respiratory Diseases, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 4Department of Pulmonary and Critical Care Medicine, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 5Department of Pediatric Infectious Diseases, The First People’s Hospital of Datong, Datong, Shanxi, People’s Republic of China; 6Department of Translational Medicine Research Center, Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of ChinaCorrespondence: Pengzhou Kong, Department of Translational Medicine Research Center, Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China, Email kongpengzhou@sxmu.edu.cn Xinri Zhang, Department of Pulmonary and Critical Care Medicine, NHC Key Laboratory of Pneumoconiosis; Shanxi Key Laboratory of Respiratory Diseases, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China, Email ykdzxr61@163.comPurpose: Pulmonary artery hypertension (PAH) is a common complication of chronic obstructive pulmonary disease and obstructive sleep apnea/hypopnea syndrome worldwide. Pulmonary vascular alterations associated with PAH have multifactorial causes, in which endothelial cells play an important role. Autophagy is closely related to endothelial cell injury and the development of PAH. PIF1 is a multifunctional helicase crucial for cell survival. The present study investigated the effect of PIF1 on autophagy and apoptosis in human pulmonary artery endothelial cells (HPAECs) u

Published
2023

26. Autologous hematopoietic stem cell transplantation activity for lymphoma and multiple myeloma in China

Author

Liu, Weiping, primary, Ji, Jie, additional, Zou, Dehui, additional, Cao, Yang, additional, Xu, Yajing, additional, Zhou, Jian, additional, Gao, Sujun, additional, Wang, Fengrong, additional, Chen, Wenming, additional, Du, Juan, additional, Zhou, Hui, additional, Zhou, Fuling, additional, Shi, Jimin, additional, Zhang, Xi, additional, Yang, Jianmin, additional, Jing, Hongmei, additional, Jiang, Zhongxing, additional, Liu, Hui, additional, Li, Caixia, additional, Peng, Hongling, additional, Jiang, Songfu, additional, Wei, Xiaolei, additional, He, Pengcheng, additional, Liu, Yao, additional, Yang, Haiyan, additional, Li, Zengjun, additional, Huang, Xiaobing, additional, Liu, Lin, additional, Shen, Lijing, additional, Liu, Chuanfang, additional, Song, Yuqin, additional, Qiu, Lugui, additional, Wang, Xiaopei, additional, Ma, Jun, additional, and Zhu, Jun, additional

Published
2022
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27. Additional file 2 of Klf4-Sirt3/Pparα-Lcad pathway contributes to high phosphate-induced lipid degradation

Author

Yu, Angen, Xu, Yichuang, Hogstrand, Christer, Zhao, Tao, Tan, Xiao-Ying, Wei, Xiaolei, Song, Yu-Feng, and Luo, Zhi

Abstract

Additional file 1: Supplemental Text S1. Yellow catfish primary intestinal epithelial cells (IECs) isolation and culture. Supplemental Table S1. Feed formulation and proximate analysis of experimental diets. Supplemental Table S2. Primers used for quantitative real-time PCR analysis. Supplemental Table S3. Primers used for plasmid construction of expression vector. Supplemental Table S4. Primers used for plasmid construction of si-klf4. Supplemental Table S5. Primers used for plasmid construction of promoters. Supplemental Table S6. Primers used for site-mutation analysis. Supplemental Table S7. Primers used for electrophoretic mobility-shift assay. Supplemental Table S8. Effects of dietary phosphorus supplementation on growth performance and feed utilization of yellow catfish. Supplemental Figure S1. MTT assay of primary IECs under Pi incubation. Supplemental Figure S2. Immunofluorescent staining of KLF4 protein under Pi incubation. Supplemental Figure S3. Nucleotide sequence of yellow catfish sirt3 promoter. Numbers are relative to the transcription start site (+1). Supplemental Figure S4. ERRα response elements (ERE) located at −1443 bp to −1457 bp and KLF4 response elements (KRE) located at −406 bp to −419 bp of pparα promoter. Supplemental Figure S5. Relative luciferase activity of sirt3 promoter after the incubation with different overexpression vectors. Supplemental Figure S6. The immunoprecipitation experiment for the analysis of KLF4 and ERRα binding with SIRT3. Supplemental Figure S7. Nucleotide sequence of yellow catfish pparα promoter. Numbers are relative to the transcription start site (+1). Supplemental Figure S8. KLF4 response elements (ERE) located at −1443 bp to −1457 bp (KRE1) and −406 bp to −419 bp (KRE2) of pparα promoter. Supplemental Figure S9. Nucleotide sequence of yellow catfish lcad promoter. Numbers are relative to the transcription start site (+1).

Published
2023
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32. Autologous hematopoietic stem cell transplantation activity for lymphoma and multiple myeloma in China

Author

Zhu, Jun, primary, Liu, Weiping, additional, Ji, Jie, additional, Zou, Dehui, additional, Cao, Yang, additional, Xu, Yajing, additional, zhou, jian, additional, Gao, Sujun, additional, Wang, Fengr-Rong, additional, CHEN, WEN, additional, Du, Juan, additional, Zhou, Hui, additional, Zhou, Fuling, additional, Shi, Jimin, additional, Zhang, Xi, additional, Yang, Jianmin, additional, Jing, Hongmei, additional, Jiang, Zhongxing, additional, Liu, Hui, additional, Li, Caixia, additional, Peng, Hongling, additional, Jiang, Songfu, additional, Wei, Xiaolei, additional, He, Pengcheng, additional, Liu, Yao, additional, Yang, Haiyan, additional, Li, Zeng-jun, additional, Huang, xiaobing, additional, Liu, Lin, additional, Shen, Lijing, additional, Liu, Chuanfang, additional, Song, Yuqin, additional, Qiu, Lugui, additional, Wang, Xiaopei, additional, and Ma, Jun, additional

Published
2022
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39. CD44 Expression in Different Plasma Cell Diseases

Author

Ning, Xueqin, primary, Wei, Xiaolei, additional, Chen, Bingyuan, additional, Li, Zhen, additional, Zheng, Zhongxin, additional, Yi, Zhengshan, additional, Feng, Ru, additional, Wei, Yongqiang, additional, and Liu, Qifa, additional

Published
2021
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50. Hepcidin protects grass carp (Ctenopharyngodon idellus) against Flavobacterium columnare infection via regulating iron distribution and immune gene expression

Author

V. Sarath Babu, Jianguo Su, Yulei Zhang, Xiaoling Liu, Jun Li, Li Lin, Gailing Yuan, Wei Xiaolei, Yazhen Hu, and Lijuan Zhao

Subjects
Fish Proteins, 0301 basic medicine, Carps, Iron, Aquatic Science, Flavobacterium, law.invention, Microbiology, Fish Diseases, 03 medical and health sciences, 0302 clinical medicine, Hepcidins, Downregulation and upregulation, Flavobacteriaceae Infections, law, Hepcidin, medicine, Animals, Environmental Chemistry, Amino Acid Sequence, biology, medicine.diagnostic_test, Gene Expression Profiling, General Medicine, biology.organism_classification, Immunity, Innate, In vitro, Grass carp, Ferritin, 030104 developmental biology, Gene Expression Regulation, 030220 oncology & carcinogenesis, Flavobacterium columnare, biology.protein, Serum iron, Recombinant DNA
Abstract

Columnaris disease (CD) caused by Flavobacterium columnare (F. columnare) is lack of knowledge on effective treatment measures. Bacterial pathogens require iron as an essential nutrient to infect the host. While hepcidin acts as a master regulator in iron metabolism, its contribution to host defense is emerging as complex and multifaceted. In vitro, recombinant Ctenopharyngodon idellus (C. idellus) hepcidin (CiHep) and synthetic CiHep both showed the ability to increase the expression of hepcidin and ferritin in C. idellus kidney cells, especially the recombinant CiHep. In vivo, recombinant CiHep improved the survival rate of C. idellus challenged with F. columnare. In addition, the fish fed diet containing recombinant CiHep (group H-1) had a higher survival rate than other pretreatment groups. The study showed that recombinant CiHep regulated iron metabolism causing iron redistribution, decreasing serum iron levels and increasing iron accumulation in the hepatopancreas. Moreover, the expression of iron-related genes was upregulated in various degrees at a different time except for group H-1. Immune-related genes were also evaluated, showing higher expression in the groups pretreated with CiHep at an early stage of infection. Of note, a clear upregulation of more immune genes occurred in the groups pretreated with recombinant CiHep than that pretreated with synthetic CiHep in the late stage of infection. In conclusion, the recombinant CiHep has a protective effect on the host response to bacterial pathogens. We speculate that hepcidin protects C. idellus against F. columnare infection via regulating the iron distribution and immune gene expression.

Published
2018

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