1. Surgical Treatment of Osteosarcoma Induced Distant Pre‐Metastatic Niche in Lung to Facilitate the Colonization of Circulating Tumor Cells
- Author
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Fan Tang, Yan Tie, Tian‐Xia Lan, Jing‐Yun Yang, Wei‐Qi Hong, Si‐Yuan Chen, Hou‐Hui Shi, Long‐Qing Li, Hao Zeng, Li Min, Yu‐Quan Wei, Chong‐Qi Tu, and Xia‐Wei Wei
- Subjects
circulating tumor cells ,osteosarcoma ,pre‐metastatic niche ,pulmonary metastasis ,surgical treatment ,Science - Abstract
Abstract Recently, the major challenge in treating osteosarcoma patients is the metastatic disease, most commonly in the lungs. However, the underlying mechanism of recurrence and metastasis of osteosarcoma after surgical resection of primary tumor remains unclear. This study aims to investigate whether the pulmonary metastases characteristic of osteosarcoma is associated with surgical treatment and whether surgery contributes to the formation of pre‐metastatic niche in the distant lung tissue. In the current study, the authors observe the presence of circulating tumor cells in patients undergoing surgical resection of osteosarcoma which is correlated to tumor recurrence. The pulmonary infiltrations of neutrophils and Gr‐1+ myeloid cells are characterized to form a pre‐metastatic niche upon the exposure of circulating tumor cells after surgical resection. It is found that mitochondrial damage‐associated molecular patterns released from surgical resection contribute to the formation of pre‐metastatic niche in lung through IL‐1β secretion. This study reveals that surgical management for osteosarcoma, irrespective of the primary tumor, might promote the formation of postoperative pre‐metastatic niche in lung which is with important implications for developing rational therapies during peri‐operative period.
- Published
- 2023
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