32 results on '"Weijia Tan"'
Search Results
2. Early Identification and Dynamic Stability Evaluation of High-Locality Landslides in Yezhi Site Area, China by the InSAR Method
- Author
-
Baoqin Lian, Daozheng Wang, Xingang Wang, and Weijia Tan
- Subjects
InSAR ,high-locality landslides ,time series deformation ,small baseline interferometry ,early identification ,Agriculture - Abstract
In mountainous regions, high-locality landslides have the characteristics of a latent disaster process with a wide disaster range, which can easily cause large casualties. Therefore, early landslide identification and dynamic stability evaluation are significant. We first used multi-temporal synthetic aperture radar data to detect potential landslides at Yezhi Site Area during the 2015–2020 period, identifying and mapping a total of 18 active landslides. The study area was found to have an average deformation rate between −15 and 10 mm/y during the period. Then, time series and spatiotemporal deformation characteristics of landslides were examined using interferogram stacking and small baseline interferometry techniques. The results show that the majority of the landslide deformations detected exhibit a periodic variation trend, and the study area was in a slow deformation state before 2017. Finally, combined with detection results, Google Earth optical images, and field investigations, it is concluded that the main factors affecting the time series deformation and spatial distribution of landslides in the study area are rainfall, geological factors, and engineering activities. The results of this study provide valuable technical references and support for early identification and dynamic stability evaluation of regional active landslides in complex terrain, especially for high-locality landslides.
- Published
- 2024
- Full Text
- View/download PDF
3. The Duncan-Chang statistical damage correction model of unsaturated soil considering matric suction
- Author
-
Weijia TAN, Yunjie WEI, Junhao WANG, and GAO Jingxuan
- Subjects
unsaturated soil ,matric suction ,initial tangent modulus ,duncan-chang model ,statistical damage ,Geology ,QE1-996.5 - Abstract
In order to reflect the whole deformation process of unsaturated foundation soil, the consolidated drained triaxial compression test is carried out on the unsaturated soil of a foundation project. It is found that the partial stress-strain curve of unsaturated soil is similar to hyperbola, and the matrix suction has an obvious influence on the mechanical behavior of soil. The greater the matrix suction, the higher the partial stress of soil. According to the deformation characteristics and engineering characteristics of unsaturated soil, the Duncan-Chang hyperbolic model is selected as the basic model, and the statistical damage theory is introduced. Assuming that the micro element strength of unsaturated soil obeys the Weibull probability density distribution, the Duncan-Chang statistical damage model is established. By establishing the relationship between the initial tangent modulus and matrix suction, a new Duncan-Chang statistical damage model of the unsaturated soil considering matrix suction is established. The parameter analysis method is given, and the empirical expression of the Weibull distribution parameters is obtained, which is used to modify the model. The damage accumulation law of unsaturated soil under different matrix suction conditions is analyzed, and the partial stress-strain test curve of unsaturated soil is compared with the traditional Duncan-Chang model, which proves the feasibility and rationality of the model. The research results provide a certain reference for the study of mechanical properties and identification simulation of unsaturated soil.
- Published
- 2022
- Full Text
- View/download PDF
4. Physical Model Test on the Interface of Loess Fill Slope
- Author
-
Weijia Tan, Qiangbing Huang, and Xing Chen
- Subjects
loess ,filled slope ,physical model test ,interface effect ,stability ,Agriculture - Abstract
The interface between the filling slope and the original slope is inevitable in the process of building a city in the loess area, which will affect the deformation and stability of the filling slope. In this paper, the loess fill slope of mountain excavation and city construction project in Yan’an City, China, is taken as the research object, and, based on field investigation and sampling, the effect of Loess Fill Slope Interface (LFSI) under rainfall is revealed by physical model test. The test samples were taken from a Loess Fill in Qilipu community, Yan’an, and three layers of sensors were arranged at the left and right interfaces of the original slope and the filled slope to monitor the water content, pore water pressure and deformation and failure characteristics during the experiment. The results show that ILFS is a rainfall dominant seepage channel, and the infiltration of rainfall along the interface lags behind. In addition, the variation laws of water content and pore water pressure at the interface between fill slope and original slope under rainfall are obtained. Finally, the failure process of loess fill slope under rainfall is summarized: local mud flow failure at the toe of the slope → erosion in the middle of the slope → crack initiation on the shoulder of the slope → local slip on the slope → crack propagation on the shoulder of the slope → shallow slip on the shoulder of the slope, and the instability mechanism of loess fill slope under rainfall is further revealed. The research results can provide theoretical and experimental reference for the protection of fill slopes in loess areas.
- Published
- 2022
- Full Text
- View/download PDF
5. The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism.
- Author
-
Chunxing Yang, Weijia Tan, Catheryne Whittle, Linghua Qiu, Lucheng Cao, Schahram Akbarian, and Zuoshang Xu
- Subjects
Medicine ,Science - Abstract
TAR DNA binding protein 43 KD (TDP-43) is an essential gene that regulates gene transcription, mRNA splicing and stability. In amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two fatal neurodegenerative diseases, TDP-43 is fragmented, generating multiple fragments that include the C-terminal fragment of ∼25 KD. The role of these fragments in the pathogenesis of ALS and FTD is not clear. Here we investigated the aggregation propensity in various polypeptide regions of TDP-43 in mammalian cells and the effect of these fragments on cultured neurons. By expressing the full length and various TDP-43 fragments in motor neuron-derived NSC-34 cells and primary neurons, we found that both N- and C-terminal fragments of TDP-43 are prone to aggregate and the C-terminal end of RRM2 region is required, though not sufficient, for aggregation. The aggregation of the TDP-43 fragments can drive co-aggregation with the full-length TDP-43, consequently reducing the nuclear TDP-43. In addition, the TDP-43 fragments can impair neurite growth during neuronal differentiation. Importantly, overexpression of the full-length TDP-43 rescues the neurite growth phenotype whereas knockdown of the endogenous TDP-43 reproduces this phenotype. These results suggest that TDP-43 fragments, particularly the pathologically relevant C-terminal fragments, can impair neuronal differentiation by dominant-negatively interfering with the function of the full length TDP-43, thus playing a role in pathogenesis in ALS and FTD.
- Published
- 2010
- Full Text
- View/download PDF
6. Reconstructing of High-Spatial-Resolution Three-Dimensional Electron Density by Ingesting SAR-Derived VTEC Into IRI Model.
- Author
-
Wu Zhu, Jingyuan Chen, Quan Sun, Zhenhong Li 0001, Weijia Tan, and Yunjie Wei
- Published
- 2022
- Full Text
- View/download PDF
7. Everyday Experiences of Racial Discrimination Among Chinese Immigrants in Canada.
- Author
-
WEIGUO ZHANG, WEIJIA TAN, JINHUA CHEN, ZHUO JUN ZHONG, KUNPING WANG, and KEDI ZHAO
- Subjects
- *
RACE discrimination , *IMMIGRANTS , *CHINESE diaspora , *INTERSECTIONALITY , *FEMINIST theory - Abstract
This study examined the everyday experiences of racism among Chinese immigrants in Canada. Data came from nine virtual focus groups comprising 48 participants of diverse genders and ages taking place in December 2021 and January 2022. We conducted our qualitative analysis by drawing on Essed’s conceptualization of everyday racism and Crenshaw’s conceptualization of intersectionality. Thematic and content analysis showed that racism against Chinese immigrants is more pervasive than previously recognized. Three-quarters of the participants disclosed instances of racism across various settings, including workplaces, schools, shops, airports, banks, hotels, restaurants, streets, and online. Some gender and age groups reported more incidents than others. Young men, on average, encountered the greatest number, followed by young and middle-aged women, while older men reported the fewest. Types of racist incidents also varied by age and gender. Young and middle-aged women encountered unsolicited intimate remarks and racism related to gender division of labour, while older adults, both men and women, faced racism associated with service provision. Younger men reported online racism. Some older participants remained unaware of the racist nature of their encounters, and middle-aged and older men tended to deny having experienced racist encounters. Given these findings, we suggest the need to raise awareness, establish empowerment initiatives, and adopt intersectionality approaches to address and combat racism against Chinese immigrants in Canada. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
8. Multiscale Study of the Deterioration of Sandstone in the Three Gorges Reservoir Area Subjected to Cyclic Wetting–Cooling and Drying–Heating
- Author
-
Chenyang Zhang, Zhenwei Dai, Weijia Tan, Yuting Yang, and Linhao Zhang
- Subjects
Geology ,Geotechnical Engineering and Engineering Geology ,Civil and Structural Engineering - Published
- 2022
9. Online mental health resources in Wuhan amid the COVID-19 pandemic: the role of social workers
- Author
-
Weijia Tan, Kedi Zhao, and A. Ka Tat Tsang
- Subjects
2019-20 coronavirus outbreak ,Health (social science) ,Sociology and Political Science ,Coronavirus disease 2019 (COVID-19) ,Social work ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Environmental health ,Political science ,Pandemic ,Mental health - Published
- 2021
10. Exploring the Establishment of Hospice Service System Integrating Medical Care and Funeral Services
- Author
-
Yunling Wang, Weijia Tan, and Yifang Wang
- Subjects
Health (social science) ,Health Information Management ,Leadership and Management ,Health Policy ,Management, Monitoring, Policy and Law - Published
- 2022
11. A Case Study of Social Work Leadership in the Pandemic Intervention in Wuhan
- Author
-
Liya Niu, Hai Luo, Zhihong Yu, and Weijia Tan
- Subjects
leadership ,disaster response ,volunteerism ,Health (social science) ,Social work ,Nursing ,social work ,Intervention (counseling) ,Pandemic ,Original Article ,AcademicSubjects/SOC02540 ,Psychology ,Social Sciences (miscellaneous) - Abstract
Social workers in Wuhan, China were among the first to respond to the public health crisis caused by Coronavirus disease (COVID-19) in early 2020. Social workers in Wuhan developed and implemented an effective interventional model integrating online and offline volunteers of multiple professions—the ‘4 + 1’ model—to support affected individuals in the process of battling the pandemic. Transformational social work leadership played a vital role in the widely adopted model in China, characterised by idealised influence—attributed (or charisma); idealised influence—behavioural; inspirational motivation; intellectual stimulation and individual consideration. Contextual performance is also discussed, followed by a discussion on why social work can play a leadership role in inter-disciplinary intervention in the pandemic crisis. The article concludes with the areas social workers can improve on for the betterment of leadership.
- Published
- 2021
12. Decentring the Majority–Minority Paradigm: A Multidimensional Conceptualization of Inter-ethnic Relations Based on a Study of Chinese Canadians
- Author
-
Weijia Tan, Ran Hu, Vivian W. Y. Leung, Deng Min Chuang, and A. Ka Tat Tsang
- Subjects
Cultural Studies ,Conceptualization ,Social distance ,05 social sciences ,0507 social and economic geography ,Ethnic group ,Cognition ,Focus group ,0506 political science ,Focus (linguistics) ,Interpersonal relationship ,Dynamics (music) ,Anthropology ,050602 political science & public administration ,Psychology ,050703 geography ,Social psychology ,Demography - Abstract
Inter-ethnic research has been dominated by studies on majority–minority relations. The limited studies on relations among ethnic minority groups are usually restricted to a focus on attitudes and the cognitive domain, with little attention to actual behaviours. As Canada becomes increasingly diverse, it calls for a greater need in examining the interpersonal relationships among ethnic minority groups. A study originally designed to look at intra-group dynamics generated results that led the authors to decentre the dominant majority–minority view and explore inter-ethnic engagements. This report examines the subjective sense-making, actual performance, and management of inter-ethnic relations from Chinese Canadians’ perspectives. Data from individual interviews and focus groups with thirty-five Chinese Canadians show a multidimensional picture: factors such as participants’ needs, circumstances, characteristics, and capacities play a more significant role in shaping relationship development and maintenance. Results also reveal the complex and contingent nature of the sense-making and management of inter-ethnic relationships. These findings call for a more holistic view of individuals’ experiences that include cognitive, affective, and behavioural dimensions.
- Published
- 2021
13. The experiences of the Good Companions Response Team during the COVID-19 pandemic in Wuhan, China: a multi-professional team led by social workers
- Author
-
Weijia Tan, Zhihong Yu, and Liya Niu
- Subjects
2019-20 coronavirus outbreak ,Social work ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,education ,05 social sciences ,050109 social psychology ,Public relations ,Multi professional ,Pandemic ,0501 psychology and cognitive sciences ,Sociology ,Form of the Good ,China ,business ,Social Sciences (miscellaneous) ,050104 developmental & child psychology - Abstract
The COVID-19 pandemic has been a worldwide crisis. During the pandemic, social workers have proactively participated in providing support. The Good Companions Response Team is a volunteer team star...
- Published
- 2020
14. Voltage response characterization of grid-forming wind power systems
- Author
-
Qun Li, Qiang Li, Weijia Tang, and Chenggen Wang
- Subjects
grid-forming ,wind power systems ,voltage response ,droop control ,voltage stability ,General Works - Abstract
The widespread integration of wind turbines poses voltage stability challenges to power systems. To enhance the ability of wind power systems to actively support grid voltage, grid-forming control techniques are increasingly being employed. However, current research primarily focuses on voltage stability challenges at the point of common coupling in wind power systems, lacking thorough investigation into system voltage response characterization. This paper establishes the voltage response model of a grid-forming wind power system. Based on this model, mathematical derivation and theoretical analysis are conducted, and the effect factors of the voltage at the point of common coupling are investigated. Furthermore, a voltage stabilization method is explored by adjusting the above effect factors. Finally, based on the MATLAB/Simulink platform, the simulation verification of each effect factor is carried out. The results indicate that voltage response characterization obtained by the theoretical analysis and simulation is similar and that the proposed method is valid.
- Published
- 2024
- Full Text
- View/download PDF
15. Reactivation mechanism of a large-scale ancient landslide
- Author
-
Zhihua Zhang, Bolin Huang, Weijia Tan, Chenyang Zhang, Zhenwei Dai, Luqi Wang, Yueping Yin, and Xiannian Jiang
- Subjects
021110 strategic, defence & security studies ,Water table ,Lithology ,0211 other engineering and technologies ,Drilling ,Landslide ,Excavation ,02 engineering and technology ,Geotechnical Engineering and Engineering Geology ,Tectonics ,Mining engineering ,Natural hazard ,Scale (map) ,Geology ,021101 geological & geomatics engineering - Abstract
This paper presents details of the recently reactivated landslide in Wushan Town, Chongqing, China. The landslide was reactivated on July 17, 2019, by slope cutting, and thereafter, entered a state of imminent sliding. The landslide involved 4 million m3 of rock and soil masses, thereby threatening National Road G348 and the safety of 588 residents in 136 households in Xiping Village and over 1000 residents in the Jinke Community. Field investigations, drilling, and in situ monitoring were performed to determine the landslide deformation characteristics and reactivation mechanism. The results show that the regional abundant rainfall, formation lithology, and tectonic effects were responsible for the formation of the ancient Baiyangwan landslide. Moreover, the building load on the rear and middle parts increased the sliding force. Open excavation at the toe decreased the anti-sliding force and directly promoted landslide reactivation. In particular, the groundwater table rise caused by gully filling in recent years also played a key role in the reactivation of the ancient landslide.
- Published
- 2020
16. Capacitor virtual inertia control and equivalent inertia analysis for a grid-forming wind generation system
- Author
-
Qun Li, Qiang Li, Weijia Tang, and Chenggen Wang
- Subjects
wind generation system ,grid-forming control ,capacitor virtual inertia control ,system frequency response ,Philips–Heffron model ,equivalent inertia ,General Works - Abstract
A grid-forming wind generation system exhibits exceptional grid frequency support abilities. The DC capacitor of the grid-forming wind generation system, which is characterized by rapid response and high sensitivity to minor disturbances, can provide short-term inertia support for the power system. This paper proposes the capacitor virtual inertia control for the grid-forming wind generation system, coupling the DC capacitor voltage with the power system frequency, which enables the DC capacitor to participate in the system frequency response process and reduces the rate of change of the system frequency during the disturbance. To analyze the inertia of the wind power generation system, this paper establishes an equivalent Philips–Heffron model for the grid-forming wind generation system and uses the equivalent inertia constant to quantify the inertia of the wind power generation system. The effectiveness of the proposed control strategy and the reasonableness of the inertia assessment method are verified through simulations in the single-turbine system and the IEEE four-machine two-area system.
- Published
- 2024
- Full Text
- View/download PDF
17. Indigenization and authentization of epistemology in China’s social work: Moving beyond Confucianism, Taoism, and Chinese Buddhism
- Author
-
Kedi Zhao, A. Ka Tat Tsang, and Weijia Tan
- Subjects
Indigenization ,Sociology and Political Science ,Social work ,Sociology ,Taoism ,China ,Chinese buddhism ,Social Sciences (miscellaneous) ,Chinese culture ,Epistemology - Abstract
How China’s social work can establish its own epistemology has remained largely unexplored. This article focuses on Confucianism, Taoism, and Chinese Buddhism to start this epistemological exploration, as they represent Chinese culture and can provide valuable epistemological elements for China’s social work. Moving beyond epistemological elements from these philosophies, how social workers in China can further develop social work research and practice based on the unique Chinese context is also discussed, specifically through the processes of indigenization and authentization of epistemology in China’s social work. Limitations and future research directions are also presented to guide future discussion.
- Published
- 2021
18. Social Work in Funeral Homes, a Unique Chinese Practice?
- Author
-
A. Ka Tat Tsang, Weijia Tan, and Yunxian Huang
- Subjects
Service (business) ,China ,Social Work ,Health (social science) ,Social work ,business.industry ,Palliative Care ,Social Welfare ,Public relations ,Critical Care and Intensive Care Medicine ,Professionalization ,Bridge (interpersonal) ,Mental health ,Funeral Homes ,Hospice Care ,Funeral home ,Humans ,Sociology ,Life-span and Life-course Studies ,business - Abstract
Social workers were introduced to funeral homes in China amid the transition and expansion of both the funeral home industry and the social work profession and are proving to play a valuable, though under-researched role in serving not just clients but also communities and funeral home staff. Funeral home social work fills gaps in after-death care and mental health and is distinct from palliative, hospice, end-of-life, and bereavement social work. Based on the experiences of funeral homes that employ social workers, this article argues that this innovation may bring new ideas to bridge some of the service gaps in after-death care in China and globally. This article outlines the support that will be needed from funeral homes, social work service agencies, and educational and research institutes to facilitate further development of funeral home mental health and social services and to promote the professionalization of funeral home social workers in China.
- Published
- 2018
19. Propagation of settlement in soft soils induced by tunneling
- Author
-
Xudong Wang, Pengpeng Ni, Shaowei Hu, Zheng Chen, and Weijia Tan
- Subjects
Linear fitting ,Settlement (structural) ,Building and Construction ,Geotechnical Engineering and Engineering Geology ,Compression (physics) ,Physics::Geophysics ,symbols.namesake ,Fourier transform ,Soil water ,symbols ,Geotechnical engineering ,Sensitivity (control systems) ,Elastic modulus ,Geology ,Quantum tunnelling - Abstract
In practice, it is vital to know the propagation law of settlement in soil induced by tunneling. In this paper, a novel two-dimensional subsurface settlement propagation model is established based on the stochastic medium theory. The governing equation is solved with the assumed settlement profile at the tunnel crown using the Fourier transform method. Subsequently, the sensitivity of the subsurface settlement to the model parameters B and N is discussed. A database containing 12 case histories is used to establish the relationship between the elastic modulus of soil and the model parameters B and N by the linear fitting method. Results show that the model parameters B and N can reflect the vertical propagation ability and the compression (or swelling) performance of the overlying soil, respectively. Finally, the applicability of the proposed model is demonstrated with a case study of tunneling in clays. It is concluded that the model presented in this paper is highly effective and convenient for use in practice.
- Published
- 2020
20. Analyzing the inertia of power grid systems comprising diverse conventional and renewable energy sources
- Author
-
Qiang Li, Bixing Ren, Weijia Tang, Dajiang Wang, Chenggen Wang, and Zhenhua Lv
- Subjects
Renewable energy sources ,Inertia response ,Virtual inertia control ,Frequency stability ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
The global pursuit of low-carbon technologies has led to the rapid development of renewable energy sources (RES), such as wind and solar power. The large-scale integration of RES into power grid systems can change the characteristics and forms of the system inertia. RES-heavy power systems exhibit lower inertia, compromising their frequency stability and rendering traditional inertia response mechanisms and analysis methods insufficient. This review compares the different inertias in traditional and future RES-heavy power systems, details the inertia response mechanisms of various types of devices, identifies deficiencies in the traditional inertia index when quantifying the inertia response capabilities of the equipment, and illustrates the necessity of exploring a generalized inertia index suitable for such systems. Furthermore, the influence mechanism of system inertia on frequency stability is analyzed, and the action mechanism and response time sequence of various types of devices in the system inertia response are described. The challenges in applying the traditional frequency stability analysis method to future RES-heavy power systems are also identified. This review can serve as a guide for developing power grid control systems and analysis methods to accommodate the increasing application of RES.
- Published
- 2022
- Full Text
- View/download PDF
21. Mate Preference and Mating Behavior of Male Helicoverpa zea (Lepidoptera: Noctuidae) Infected with the Sexually Transmitted Insect Virus Hz-2V
- Author
-
John P. Burand and Weijia Tan
- Subjects
Gonad ,biology ,Physiology ,biology.organism_classification ,Virus ,Lepidoptera genitalia ,medicine.anatomical_structure ,Insect Science ,Botany ,medicine ,Noctuidae ,Helicoverpa zea ,Insect virus ,Mating ,Sexual contact - Abstract
The affect of Hz-2V (a.k.a. gonad-specific virus) virus infection on the reproductive physiology and behavior of infected adult Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) males was examined. Virus-infected males responded and flew to calling healthy and infected females at about the same rate. Although infected males were slower in approaching healthy females and attempting to mate compared with healthy males, infected males did make sexual contacts with females that could serve to transmit virus. Unlike matings with healthy males, which result in the cessation of calling, females that had made sexual contact with infected males continued to exhibit calling behavior and were receptive to mates. Although calling behavior of both healthy and infected females was inhibited by injecting extracts of reproductive tissues from healthy males, extracts of reproductive tissues from infected males inhibited female calling to a lesser degree and for an additional night compared with extracts from healthy males. The results presented here further demonstrate the ability of Hz-2V to alter the physiology and behavior of infected insects in ways that could serve to facilitate virus transmission.
- Published
- 2006
22. Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis
- Author
-
Leonardo Aliaga, Chunxing Yang, Linghua Qiu, Bin Yang, Weijia Tan, Tao Qiao, Hongyan Wang, Melissa J. Moore, Diane McKenna-Yasek, Thomas W. Smith, Lingtao Peng, Johnny Salameh, Huaibin Cai, Robert H. Brown, and Zuoshang Xu
- Subjects
Genetically modified mouse ,Central Nervous System ,Transgene ,Central nervous system ,Biology ,Pathogenesis ,Animals, Genetically Modified ,Mice ,mental disorders ,Paralysis ,medicine ,Animals ,Amyotrophic lateral sclerosis ,Gene knockdown ,Multidisciplinary ,Amyotrophic Lateral Sclerosis ,nutritional and metabolic diseases ,medicine.disease ,Spinal cord ,nervous system diseases ,DNA-Binding Proteins ,Disease Models, Animal ,medicine.anatomical_structure ,Phenotype ,PNAS Plus ,medicine.symptom ,Neuroscience - Abstract
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease that causes motor neuron degeneration, progressive motor dysfunction, paralysis, and death. Although multiple causes have been identified for this disease, >95% of ALS cases show aggregation of transactive response DNA binding protein (TDP-43) accompanied by its nuclear depletion. Therefore, the TDP-43 pathology may be a converging point in the pathogenesis that originates from various initial triggers. The aggregation is thought to result from TDP-43 misfolding, which could generate cellular toxicity. However, the aggregation as well as the nuclear depletion could also lead to a partial loss of TDP-43 function or TDP-43 dysfunction. To investigate the impact of TDP-43 dysfunction, we generated a transgenic mouse model for a partial loss of TDP-43 function using transgenic RNAi. These mice show ubiquitous transgene expression and TDP-43 knockdown in both the periphery and the central nervous system (CNS). Strikingly, these mice develop progressive neurodegeneration prominently in cortical layer V and spinal ventral horn, motor dysfunction, paralysis, and death. Furthermore, examination of splicing patterns of TDP-43 target genes in human ALS revealed changes consistent with TDP-43 dysfunction. These results suggest that the CNS, particularly motor neurons, possess a heightened vulnerability to TDP-43 dysfunction. Additionally, because TDP-43 knockdown predominantly occur in astrocytes in the spinal cord of these mice, our results suggest that TDP-43 dysfunction in astrocytes is an important driver for motor neuron degeneration and clinical phenotypes of ALS.
- Published
- 2014
23. Virtual Inertial Control Strategy Based on Fuzzy Logic Algorithm for PMSG Wind Turbines to Enhance Frequency Stability
- Author
-
Qun Li, Bixing Ren, Qiang Li, Dajiang Wang, Weijia Tang, Jianhui Meng, and Xiaolong Wu
- Subjects
PMSG ,wind turbines ,virtual inertial control ,fuzzy logic ,frequency support ,General Works - Abstract
With the increase of the penetration rate of wind power in the power grid, the high proportion of renewable energy and the high proportion of power electronic equipment in the power system will continuously reduce the inertia of the grid, and the frequency stability of the system will be seriously affected. The inertia of the system is an important parameter for system frequency regulation and stability calculation. For this reason, a virtual inertial control technology based on fuzzy logic control is proposed in this paper, which is used for wind turbines to participate in grid frequency regulation. In this method, based on power tracking, a fuzzy logic controller is designed to adjust the frequency adjustment coefficient adaptively, and fuzzy logic rules are used to optimize the power tracking curve online. Finally, by building a hardware-in-the-loop real-time simulation platform, the effectiveness of this method in providing system frequency support and improving the frequency response of the power grid is verified.
- Published
- 2022
- Full Text
- View/download PDF
24. Safety, tolerability, and pharmacokinetics of BAT8001 in patients with HER2‐positive breast cancer: An open‐label, dose‐escalation, phase I study
- Author
-
Ruoxi Hong, Wen Xia, Liye Wang, Kaping Lee, Qianyi Lu, Kuikui Jiang, Shengfeng Li, Jinquan Yu, Jin Wei, Weijia Tang, Danyang Zhou, Xin An, Jiajia Huang, Cong Xue, Xiwen Bi, Yanxia Shi, Zhongyu Yuan, Fei Xu, and Shusen Wang
- Subjects
BAT8001 ,antibody‐drug conjugate ,HER2‐postive ,breast cancer ,dose escalation ,maximum tolerated dose ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background The introductions of anti‐ human epidermal growth factor receptor‐2 (HER2) agents have significantly improved the treatment outcome of patients with HER2‐positive breast cancer. BAT8001 is a novel antibody‐drug conjugate targeting human epidermal growth factor receptor‐2 (HER2)‐expressing cells composed of a trastuzumab biosimilar linked to the drug‐linker Batansine. This dose‐escalation, phase I study was designed to assess the safety, tolerability, pharmacokinetics, and preliminary anti‐tumor activity of BAT8001 in patients with HER2‐positive locally advanced or metastatic breast cancer. Methods This trial was conducted in subjects with histologically confirmed HER2‐positive breast cancer (having evaluable lesions and an Eastern Cooperative Oncology Group performance status of 0 or 1) using a 3 + 3 design of escalating BAT8001 doses. Patients received BAT8001 intravenously in a 21‐day cycle, with dose escalation in 5 cohorts: 1.2, 2.4, 3.6, 4.8, and 6.0 mg/kg. The primary objective was to evaluate the safety and tolerability of BAT8001. Preliminary activity of BAT8001 was also assessed as a secondary objective. Results Between March 2017 to May 2018, 29 HER2‐positive breast cancer patients were enrolled. The observed dose‐limiting toxicities were grade 4 thrombocytopenia and grade 3 elevated transaminase. The maximum tolerated dose was determined to be 3.6 mg/kg. Grade 3 or greater adverse events (AEs) occurred in 14 (48.3%) of 29 patients, including thrombocytopenia in 12 (41.4%) patients, aspartate aminotransferase increased in 4 (13.8%) patients, γ‐glutamyl transferase increased in 2 (6.9%) patients, alanine aminotransferase increased in 2 (6.9%) patients, diarrhea in 2 (6.9%) patients. Objective response was observed in 12 (41.4%; 95% confidence interval [CI] = 23.5%‐61.1%) and disease control (including patients achieving objective response and stable disease) was observed in 24 (82.8%; 95% CI = 64.2%‐94.2%) patients. Conclusions BAT8001 demonstrated favorable safety profiles, with promising anti‐tumor activity in patients with HER2‐positive locally advanced or metastatic breast cancer. BAT8001 has the potential to provide a new therapeutic option in patients with metastatic HER2‐positive breast cancer.
- Published
- 2021
- Full Text
- View/download PDF
25. Infection with the insect virus Hz-2v alters mating behavior and pheromone production in female Helicoverpa zea moths
- Author
-
Woojin Kim, John P. Burand, Satoshi Nojima, Weijia Tan, and Wendell L. Roelofs
- Subjects
Male ,Time Factors ,media_common.quotation_subject ,Zoology ,mating behavior ,Insect Viruses ,Insect ,Reproductive physiology ,Moths ,Virus ,Pheromones ,Sexual Behavior, Animal ,pheromone ,Animals ,Helicoverpa zea ,Mating ,Insect virus ,media_common ,biology ,Ecology ,General Medicine ,Articles ,Hz-2V ,insect virus ,biology.organism_classification ,Infectious Disease Transmission, Vertical ,gonad specific virus ,Sex pheromone ,Insect Science ,Pheromone ,Female ,Vocalization, Animal - Abstract
The effect of Hz-2V virus infection on the reproductive physiology and behavior of infected Helicoverpa zea female moths was examined. In the absence of males, infected females exhibited calling behavior and called as often but for shorter periods on average than control females. As expected, control females mated with males for extend periods when they were present and did not call after mating, while virus-infected females made many frequent contacts with males and continued to call even after these contacts. Virus-infected females were found to produce five to seven times more pheromone than control females and attracted twice as many males as did control females in flight tunnel experiments. The ability of Hz-2V to alter the physiology and behavior of infected females observed here may serve to facilitate the transmission of virus in insect populations. Abbreviation: GSV gonad specific virus PSP pheromonestatic peptide
- Published
- 2004
26. Horizontal transmission of Hz-2V by virus infected Helicoverpa zea moths
- Author
-
John P. Burand, Weijia Tan, and Christopher P Rallis
- Subjects
Male ,biology ,viruses ,fungi ,Biological pest control ,Insect Viruses ,Moths ,biology.organism_classification ,Virology ,Virus ,Insect Vectors ,Lepidoptera genitalia ,Sexual Behavior, Animal ,Viral replication ,Abdomen ,Noctuidae ,Animals ,Helicoverpa zea ,Female ,Tissue Distribution ,Genitalia ,Mating ,Entomology ,Ecology, Evolution, Behavior and Systematics ,Horizontal transmission - Abstract
Helicoverpa zea female moths productively infected with Hz-2V have malformed reproductive tissues and are sterile. Virus replication in infected females occurs primarily in the reproductive tissues and culminates with the accumulation of virus-filled vesicles, which form plugs of virus covering the reproductive openings of these insects. The location of this large concentration of virus particles at the terminal abdominal segment of infected females suggests that it may serve as a source of virus that can be transmitted horizontally between moths during mating. In mating experiments it was found that healthy males are attracted to and attempt to mate with infected females, and that these males are able transmit Hz-2V to healthy females during subsequent matings, giving rise to virus infected progeny.
- Published
- 2003
27. Host plant effects on resistance to bifenthrin in silverleaf whitefly (Homoptera: Aleyrodidae)
- Author
-
David G. Riley and Weijia Tan
- Subjects
Hemiptera ,Insecticide Resistance ,Gossypium ,Insecticides ,Ecology ,Cucurbita ,Insect Science ,Pyrethrins ,Animals ,General Medicine ,Brassica ,Plants - Abstract
Effects of host plants on resistance to bifenthrin in the silverleaf whitefly, Bemisia argentifolii BellowsPerring, were determined by LC50 bioassay. In addition, inheritance of resistance to bifenthrin was investigated beginning with a single source of a bifenthrin-susceptible population. Overall, the resistance ratio between the bifenthrin-susceptible population and the selected bifenthrin-resistant population from the same source population was 915-fold after 1 yr in the greenhouse. Responses to bifenthrin among the susceptible and the resistant populations were changed when whiteflies were reared on three different host plants, i.e., cotton, cabbage, and squash. In the resistant populations, the LC50 value of whitefly fed on squash was increased as much as 7.5-fold, while the LC50 value of whitefly fed on cabbage was similar to cotton that served as the control plant. The host plant on which whiteflies feed appears to be an important factor in selection for resistance to bifenthrin, but these effects are crop specific. Based on an analysis using LC50 values of the reciprocal F1 cross on cotton, resistance of whitefly from a single-source whitefly population was inherited as an incompletely dominant factor. A model used to estimate loci numbers showed that resistance of whitefly to bifenthrin is probably controlled primarily by a few or a single locus. In addition, the difference in the ratio of LC50 values between males from unmated mother and males from mated mother was approximately fivefold, suggesting that insecticide resistance in whitefly males is in some way affected by mating.
- Published
- 2003
28. Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice
- Author
-
Tao Qiao, Weijia Tan, Melissa A. Beers, Hongyan Wang, Linghua Qiu, Zuoshang Xu, and Bin Yang
- Subjects
Vesicular Transport Proteins ,Clinical Neurology ,Mice, Transgenic ,lcsh:Geriatrics ,Biology ,Protein aggregation ,lcsh:RC346-429 ,Mice ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Superoxide Dismutase-1 ,0302 clinical medicine ,medicine ,Animals ,Humans ,Transgenic mice ,Motor neuron disease ,Neurodegeneration ,Amyotrophic lateral sclerosis ,VAPB ,Molecular Biology ,lcsh:Neurology. Diseases of the nervous system ,030304 developmental biology ,Motor Neurons ,0303 health sciences ,Superoxide Dismutase ,Amyotrophic Lateral Sclerosis ,Wild type ,Membrane Proteins ,Spinal muscular atrophy ,Motor neuron ,medicine.disease ,Cell biology ,lcsh:RC952-954.6 ,medicine.anatomical_structure ,Mutation ,Nerve Degeneration ,Unfolded protein response ,Neurology (clinical) ,ALS ,Neuroscience ,030217 neurology & neurosurgery ,Research Article - Abstract
Background A proline-to-serine substitution at position-56 (P56S) of vesicle-associated membrane protein-associated protein B (VAPB) causes a form of dominantly inherited motor neuron disease (MND), including typical and atypical amyotrophic lateral sclerosis (ALS) and a mild late-onset spinal muscular atrophy (SMA). VAPB is an integral endoplasmic reticulum (ER) protein and has been implicated in various cellular processes, including ER stress, the unfolded protein response (UPR) and Ca2+ homeostasis. However, it is unclear how the P56S mutation leads to neurodegeneration and muscle atrophy in patients. The formation of abnormal VAPB-positive inclusions by mutant VAPB suggests a possible toxic gain of function as an underlying mechanism. Furthermore, the amount of VAPB protein is reported to be reduced in sporadic ALS patients and mutant SOD1G93A mice, leading to the hypothesis that wild type VAPB plays a role in the pathogenesis of ALS without VAPB mutations. Results To investigate the pathogenic mechanism in vivo, we generated human wild type (wtVAPB) and mutant VAPB (muVAPB) transgenic mice that expressed the transgenes broadly in the CNS. We observed robust VAPB-positive aggregates in the spinal cord of muVAPB transgenic mice. However, we failed to find an impairment of motor function and motor neuron degeneration. We also did not detect any change in the endogenous VAPB level or evidence for induction of the unfolded protein response (UPR) and coaggregation of VAPA with muVAPB. Furthermore, we crossed these VAPB transgenic mice with mice that express mutant SOD1G93A and develop motor neuron degeneration. Overexpression of neither wtVAPB nor muVAPB modulated the protein aggregation and disease progression in the SOD1G93A mice. Conclusion Overexpression of VAPBP56S mutant to approximately two-fold of the endogenous VAPB in mouse spinal cord produced abundant VAPB aggregates but was not sufficient to cause motor dysfunction or motor neuron degeneration. Furthermore, overexpression of either muVAPB or wtVAPB does not modulate the course of ALS in SOD1G93A mice. These results suggest that changes in wild type VAPB do not play a significant role in ALS cases that are not caused by VAPB mutations. Furthermore, these results suggest that muVAPB aggregates are innocuous and do not cause motor neuron degeneration by a gain-of-toxicity, and therefore, a loss of function may be the underlying mechanism.
- Published
- 2013
29. Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.
- Author
-
Chunxing Yang, Hongyan Wang, Tao Qiao, Bin Yang, Aliaga, Leonardo, Linghua Qiu, Weijia Tan, Salameh, Johnny, McKenna-Yasek, Diane M., Smith, Thomas, Lingtao Peng, Moore, Melissa J., Brown Jr., Robert H., Huaibin Cai, and Zuoshang Xu
- Subjects
AMYOTROPHIC lateral sclerosis ,CENTRAL nervous system abnormality diagnosis ,TREATMENT of central nervous system cancer ,PHENOTYPES ,CELLS ,GENOTYPE-environment interaction - Abstract
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease that causes motor neuron degeneration, progressive motor dysfunction, paralysis, and death. Although multiple causes have been identified for this disease, >95% of ALS cases show aggregation of transactive response DNA binding protein (TDP-43) accompanied by its nuclear depletion. Therefore, the TDP-43 pathology may be a converging point in the pathogenesis that originates from various initial triggers. The aggregation is thought to result from TDP-43 misfolding, which could generate cellular toxicity. However, the aggregation as well as the nuclear depletion could also lead to a partial loss of TDP-43 function or TDP-43 dysfunction. To investigate the impact of TDP-43 dysfunction, we generated a transgenic mouse model for a partial loss of TDP-43 function using transgenic RNAi. These mice show ubiquitous transgene expression and TDP-43 knockdown in both the periphery and the central nervous system (CNS). Strikingly, these mice develop progressive neurodegeneration prominently in cortical layer V and spinal ventral horn, motor dysfunction, paralysis, and death. Furthermore, examination of splicing patterns of TDP-43 target genes in human ALS revealed changes consistent with TDP-43 dysfunction. These results suggest that the CNS, particularly motor neurons, possess a heightened vulnerability to TDP-43 dysfunction. Additionally, because TDP-43 knockdown predominantly occur in astrocytes in the spinal cord of these mice, our results suggest that TDP-43 dysfunction in astrocytes is an important driver for motor neuron degeneration and clinical phenotypes of ALS. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
30. The Dynamic Change and Effect of Rainfall Induced Groundwater Flow
- Author
-
Yuqiong He, Rong Sun, Zemin Xu, and Weijia Tang
- Subjects
road engineering ,rainfall-induce ,flow distribution ,effect ,slope stability ,Hydraulic engineering ,TC1-978 ,Water supply for domestic and industrial purposes ,TD201-500 - Abstract
This study aims to analyze the groundwater flow changes caused by rainfall and its influence on slope stability. Taking the slope in Dingjiafen, Chuxiong, Yunnan, China as the study area, the study monitored the data of rainfall and drew upon the calculation module of ArcGIS to predict the change of the groundwater flow and water level fluctuation in the soil. In this way, the visual simulation of groundwater flow distribution of the slope was realized; and the influence of groundwater flow distribution caused by rainfall seepage on the slope’s stability was also analyzed. The results indicate that: (1) the rainfall recharge rate is affected by the thickness of the soil layer, the slope, the rainfall intensity, and the initial water content of the soil; (2) the seepage flow of rainfall in per unit time is positively correlated with the soil layer thickness of the slope; (3) the groundwater is repeatedly raised, maintained, and dissipated by periodic rainfall which destroys the structure of the soil; and (4) the rainfall reduces the cohesion and internal friction angle of the soil resulting in the “muddy water softening effect” in the weak zone.
- Published
- 2021
- Full Text
- View/download PDF
31. Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice.
- Author
-
Linghua Qiu, Tao Qiao, Melissa Beers, Weijia Tan, Hongyan Wang, Bin Yang, and Zuoshang Xu
- Subjects
AMYOTROPHIC lateral sclerosis ,MOTOR neuron diseases ,NEURODEGENERATION ,SPINAL muscular atrophy ,ENDOPLASMIC reticulum - Abstract
Background: A proline-to-serine substitution at position-56 (P56S) of vesicle-associated membrane protein-associated protein B (VAPB) causes a form of dominantly inherited motor neuron disease (MND), including typical and atypical amyotrophic lateral sclerosis (ALS) and a mild late-onset spinal muscular atrophy (SMA). VAPB is an integral endoplasmic reticulum (ER) protein and has been implicated in various cellular processes, including ER stress, the unfolded protein response (UPR) and Ca
2+ homeostasis. However, it is unclear how the P56S mutation leads to neurodegeneration and muscle atrophy in patients. The formation of abnormal VAPB-positive inclusions by mutant VAPB suggests a possible toxic gain of function as an underlying mechanism. Furthermore, the amount of VAPB protein is reported to be reduced in sporadic ALS patients and mutant SOD1G93A mice, leading to the hypothesis that wild type VAPB plays a role in the pathogenesis of ALS without VAPB mutations. Results: To investigate the pathogenic mechanism in vivo, we generated human wild type (wtVAPB) and mutant VAPB (muVAPB) transgenic mice that expressed the transgenes broadly in the CNS. We observed robust VAPB-positive aggregates in the spinal cord of muVAPB transgenic mice. However, we failed to find an impairment of motor function and motor neuron degeneration. We also did not detect any change in the endogenous VAPB level or evidence for induction of the unfolded protein response (UPR) and coaggregation of VAPA with muVAPB. Furthermore, we crossed these VAPB transgenic mice with mice that express mutant SOD1G93A and develop motor neuron degeneration. Overexpression of neither wtVAPB nor muVAPB modulated the protein aggregation and disease progression in the SOD1G93A mice. Conclusion: Overexpression of VAPBP56S mutant to approximately two-fold of the endogenous VAPB in mouse spinal cord produced abundant VAPB aggregates but was not sufficient to cause motor dysfunction or motor neuron degeneration. Furthermore, overexpression of either muVAPB or wtVAPB does not modulate the course of ALS in SOD1G93A mice. These results suggest that changes in wild type VAPB do not play a significant role in ALS cases that are not caused by VAPB mutations. Furthermore, these results suggest that muVAPB aggregates are innocuous and do not cause motor neuron degeneration by a gain-of-toxicity, and therefore, a loss of function may be the underlying mechanism. [ABSTRACT FROM AUTHOR]- Published
- 2013
- Full Text
- View/download PDF
32. Mate Preference and Mating Behavior of Male Helicoverpa zea (Lepidoptera: Noctuidae) Infected with the Sexually Transmitted Insect Virus Hz-2V.
- Author
-
Burand, John P. and Weijia Tan
- Subjects
- *
HELIOTHIS zea , *VIRUS diseases , *ANIMAL sexual behavior , *INFECTIOUS disease transmission , *VIRUSES - Abstract
The affect of Hz-2V (a.k.a. gonad-specific virus) virus infection on the reproductive physiology and behavior of infected adult Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) males was examined. Virus-infected males responded and flew to calling healthy and infected females at about the same rate. Although infected males were slower in approaching healthy females and attempting to mate compared with healthy males, infected males did make sexual contacts with females that could serve to transmit virus. Unlike matings with healthy males, which result in the cessation of calling, females that had made sexual contact with infected males continued to exhibit calling behavior and were receptive to mates. Although calling behavior of both healthy and infected females was inhibited by injecting extracts of reproductive tissues from healthy males, extracts of reproductive tissues from infected males inhibited female calling to a lesser degree and for an additional night compared with extracts from healthy males. The results presented here further demonstrate the ability of Hz-2V to alter the physiology and behavior of infected insects in ways that could serve to facilitate virus transmission. [ABSTRACT FROM AUTHOR]
- Published
- 2006
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.