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14 results on '"Weil, Erika L"'

2. Artificial Intelligence–Enabled Electrocardiogram for Atrial Fibrillation Identifies Cognitive Decline Risk and Cerebral Infarcts

Author

Weil, Erika L., Noseworthy, Peter A., Lopez, Camden L., Rabinstein, Alejandro A., Friedman, Paul A., Attia, Zachi I., Yao, Xiaoxi, Siontis, Konstantinos C., Kremers, Walter K., Christopoulos, Georgios, Mielke, Michelle M., Vemuri, Prashanthi, Jack, Clifford R., Jr., Gersh, Bernard J., Machulda, Mary M., Knopman, David S., Petersen, Ronald C., and Graff-Radford, Jonathan

Published
2022
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5. Abstract TP161: Predictors Of Undiagnosed Risk Factors For Cerebrovascular Ischemic Events: A Population-based Study

Author

Weil, Erika L, primary, Ding, Lili, additional, Khoury, Jane C, additional, Kissela, Brett M, additional, Alwell, Kathleen, additional, Woo, Daniel, additional, De Los Rios La Rosa, Felipe, additional, Mackey, Jason, additional, Ferioli, Simona, additional, Mistry, Eva, additional, Demel, Stacie L, additional, Coleman, Elisheva R, additional, Jasne, Adam S, additional, Slavin, Sabreena J, additional, Walsh, Kyle, additional, Star, Michael, additional, Haverbusch, Mary, additional, and Kleindorfer, Dawn O, additional

Published
2023
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10. AI-ECG for Atrial Fibrillation Identifies Cognitive Decline Risk and Cerebral Infarcts

Author

Weil, Erika L., Noseworthy, Peter A., Lopez, Camden L., Rabinstein, Alejandro A., Friedman, Paul A., Attia, Zachi I., Yao, Xiaoxi, Siontis, Konstantinos C., Kremers, Walter K., Christopoulos, Georgios, Mielke, Michelle, Vemuri, Prashanthi, Jack, Clifford R., Gersh, Bernard J., Machulda, Mary M., Knopman, David S., Petersen, Ronald C., and Graff-Radford, Jonathan

Subjects
Electrocardiography, Artificial Intelligence, Atrial Fibrillation, Humans, Cognitive Dysfunction, Cerebral Infarction, Article, Aged
Abstract

To investigate whether artificial intelligence-enabled electrocardiogram (AI-ECG) assessment of atrial fibrillation (AF) risk predicts cognitive decline and cerebral infarcts.This population-based study included sinus-rhythm ECG participants seen from November 29, 2004 through July 13, 2020, and a subset with brain magnetic resonance imaging (MRI) (October 10, 2011, through November 2, 2017). The AI-ECG score of AF risk calculated for participants was 0-1. To determine the AI-ECG-AF relationship with baseline cognitive dysfunction, we compared linear mixed-effects models with global and domain-specific cognitive z-scores from longitudinal neuropsychological assessments. The AI-ECG-AF score was logit transformed and modeled with cubic splines. For the brain-MRI subset, logistic regression evaluated correlation of the AI-ECG-AF score and the high-threshold, dichotomized AI-ECG-AF score with infarcts.Participants (N=3729; median age, 74.1 years) underwent cognitive analysis. Adjusting for age, sex, education, and APOE ɛ4-carrier status, the AI-ECG-AF score correlated with lower baseline and faster decline in global-cognitive z-scores (P=.009 and P=.01, respectively, non-linear-based spline-models tests) and attention z-scores (P.001 and P=.01, respectively). Sinus-rhythm-ECG participants (n=1373) underwent MRI. As a continuous measure, the AI-ECG-AF score correlated with infarcts but not after age and sex adjustment (P=.52). For dichotomized analysis, an AI-ECG-AF score greater than 0.5 correlated with infarcts (OR, 4.61; 95% CI, 2.45-8.55; P.001); even after age and sex adjustment (OR, 2.09; 95% CI, 1.06-4.07; P=.03).The AI-ECG-AF score correlated with worse baseline cognition and gradual global cognition and attention decline. High AF probability by AI-ECG-AF score correlated with MRI cerebral infarcts. However, most infarcts observed in our cohort were subcortical, suggesting that AI-ECG not only predicts AF but also detects other non-AF cardiac disease markers and correlates with small vessel cerebrovascular disease and cognitive decline.

Published
2022

13. Cerebral venous sinus thrombosis associated with spontaneous heparin-induced thrombocytopenia syndrome after total knee arthroplasty.

Author

Hwang, Steven R, Wang, Yuxiang, Weil, Erika L, Padmanabhan, Anand, Warkentin, Theodore E, and Pruthi, Rajiv K

Subjects
TOTAL knee replacement, VENOUS thrombosis, CRANIAL sinuses, ORTHOPEDIC surgery, SINUS thrombosis, THROMBOCYTOPENIA, SYNDROMES
Abstract

Spontaneous heparin-induced thrombocytopenia (HIT) syndrome, characterized by clinical and serologic features of HIT despite the absence of proximate heparin exposure, can be triggered by total knee arthroplasty (TKA). A 56-year-old female receiving aspirin thromboprophylaxis post-TKA presented with aphasia and thrombocytopenia on post-operative day 11. Imaging studies revealed cerebral venous sinus thrombosis (CVST) and intravenous bivalirudin was initiated. Her serum tested strong-positive for IgG anti-PF4/polyanion complexes and serotonin-release assay in the presence and absence of heparin; strong-positive IgG-specific chemiluminescent immunoassay; and moderate-positive latex immunoturbidimetric assay. Two 65 g doses of IVIG were administered. With the improvement of her platelet count, she was transitioned from bivalirudin to warfarin. At one-year follow-up, she remained free of recurrent thrombosis and neurologically stable with a normal platelet count. Previous reports of post-TKA spontaneous HIT syndrome include venous/arterial thrombosis and adrenal hemorrhage, and this report of CVST expands the clinical spectrum of this rare complication of orthopedic surgery. [ABSTRACT FROM AUTHOR]

Published
2021
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