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1. Low Dose Fractionated Radiation Therapy as a Chemo-Potentiator of Salvage Temozolomide (TMZ) for Recurrent Anaplastic Astrocytoma (AA) and Glioblastoma Multiforme (GBM): A Single-Arm Phase I/II Trial

Author

Lin, T.A., primary, Ke, S., additional, Hu, C., additional, Assadi, R.K., additional, Huang, J., additional, Kleinberg, L.R., additional, Mukherjee, D., additional, Weingart, J., additional, Holdhoff, M., additional, Grossman, S., additional, and Redmond, K.J., additional

Published
2023
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6. Abstract form for the Irish Journal of Medical Science v workshop on gastroduodenal pathology and Helicobacter pylori July 5th — 7th 1992 — Dublin, Ireland

Author

Logan, R. P. H., Gummett, P. A., Walker, M. M., Karim, Q. N., Baron, J. H., Misiewicz, J. J., Trieber, G., Walker, S., Klotz, U., Lozniewski, A., Weber, M., de Korwin, J. D., Floquet, J., Conroy, M. C., Burdin, J. C., Mannes, G. A., Bayerdörffer, E., Höchter, W., Weingart, J., Heldwein, W., Sommer, A., Müller-Lissner, S., Bomschein, W., Miehlke, S., Weinzierl, M., Ruckdeschel, G., von Wulffen, H., Köpcke, W., Stolte, M., Rune, S. J., Justesen, T., Hansen, J. M., Jensen, T. G., Eriksen, J., Thomsen, O. ø., Scheibel, J., Bonnevie, O., Bremmelgaard, A., Vilien, M., Knuhtsen, S., Elsborg, L., Hansen, J., Lauritsen, K., Wulff, H. R., Boixeda, D., Ballestero, S., Cantón, R., De Rafael, L., Martinm de Argila, C., Pozuelo, M. J., Sampedro, J., Baquero, F., Grigoriev, P. Ya., Isakov, V. A., Iakovenko, E. P., Hirschl, A. M., Brandstätter, G., Dragosics, B., Hentschel, E., Kundi, M., Rotter, M. L., Schütze, K., Taufer, M., Neri M, Susi D, Bovani I, Pindo R, Cuccurullo F., Coelho, L. G. V., Passos, M. C. F., Chausson, Y., Vieira, W. L. S., Castro, F. J., Franco, J. M. M., Fernandes, M. L. M., Castro, L. P., Jonas, C., De Koster, E., Van Gossum, M., Depierreux, M., Cheval, M., Deltenre, M., Schütz, E., Bethke, B., Lee, A., Hegedus, E., O’Rourke, J., Larsson, H., Sjöstedt, S., Veress, B., Nord, C. E., Sobala, G. M., George, R., Tompkins, D., Finlay, J., Manning, A., Sant, S., Xia, H. X., Daw, M., Gilvarry, J., Keane, C. T., O’Morain, C., Rubio, M. A., Hegarty, B., Blum, A. L., Sulser, E., Stadelmann, O., Munoz, N., Buiatti, E., Vivas, J., Oliver, W., Cano, E., Peraza, S., Castro, D., Sanchez, V., Andrade, O., Benz, M., Mendz, G. L., Hazell, S. L., Salmela, K. S., Roire, R. P., Hook-Nikanne, J., Kosunen, T. U., Salaspur, M., Luke, C. J., Reynolds, D. D. J., Penn, C. W., Bode, G., Mauch, F., Ditschuneit, H., Malfertheiner, P., Ferrero, Richard L., Agnes Labigne, Eaton, K. A., Krakowka, S., Mobley, H. L. T., Hu, Li-Tai, Foxall, P. A., Moran, A. P., Helander, I. M., Altman, C., Sobhani, I., Vissugaire, C., Migrant, M., Etienne, J. P., Sommi, P., Ricci, V., Fiocca, R., Cova, E., Figura, N., Romano, M., Ivey, K. J., Solcia, E., Ventura, U., Nilius, M., Schieffer, S., Hengels, K. J., Jablonowski, H., Strohmeyer, G., Cabrai, M. D., Barbosa, A. J. A., Lima Hr., G. F., Oliveira, C. A., Polak, J. M., Oderda, G., Villani, L., Altare, F., Morra, I., Miserendino, L., Ansaldi, N., Dixon, M. F., Wyatt, J. I., Axon, A. T. R., Beattie, S., Hamilton, H., Shabib, S., Cutz, E., Drumm, B., Sherman, P., Noach, L. A., Rolf, T., Bosma, N. B., Schwartz, M. P., Oosting, J., Rauws, E. A. J., Tytgat, G. N. J., Andrew, A., Nardone, G., d’Ormiento, F., Pontillo, M., Lobo, A. J., Uff, J. S., McNulty, C. N. M., Wilkinson, S. P., Suriani, R., Pallante, C., Ravizza, M., Galliano, D., Sallio, D., Malandrino, M., Oneglio, R., Colozza, M., Mazzucco, D., Gaia, E., Eidt, S., Vincent, P., Gottrand, F., Turck, D., Lecomte-Houcke, M., Leclerc, H., Bonvicini, F., Pretolani, S., Baraldini, M., Cilla, D., Baldinelli, S., Bazocchi, E., Acampora, P., Careddu, N., Brocchi, E., Gasbarrini, G., Joubert, M., Bazin, N., Thiaucourt, D., Protte, E., Gissler, C., Duprez, A., Merlin, P., Forestier, S., Labenz, J., Gyenes, E., Rühl, G. H., Börsch, G., Daskalopoulos, G., Carrick, J., Lian, R., Wagner, S., Bleck, J., Gebel, M., Bär, W., Manns, M., Lamouliatte, H., Bernard, P. H., Cayla, R., Vialette, G., Quinton, A., Mégraud, F., Lemaire, M., Quinten, A., De Mascarel, A., Webb, P., Forman, D., Knight, T., Wilson, A., Graves, S., Newell, D., Elder, J., Tonelli, E., Gatte, M. R. A., Ghironzi, G. C., Giulianelli, G., Bamford, K. B., Collins, J. S. A., Bickley, J., Johnston, B. T., Potts, S., Boston, V., Owen, R. J., Sloan, J., Basso, L., Lawlor, S., Clune, J., Szelényi, H., Stohmeyer, G., Macedo, G., Iglésias, I., Chaves, A. P., Loureiro, A., Katelaris, P. H., Seow, F., Lin, B., Napoli, J., Hones, D. B., Ngu, M. C., Akopyantz, Natalia S., Bukanov, Nikolay O., Westblom, T. Ulf, Berg, Douglas E., Nyst, J. F., Denis, P., Buset, M., De Reuck, M., Nielsen, H., Andersen, L. P., Birkholz, Sabine, Knipp, Ulrich, Nietzki, Claudia, Opferkuch, Wolfgang, Crabtree, J. E., Peichl, P., Lindly, I. J. D., Deusch, K., Seifirth, C., Funk, A., Dahie, I., Reut, K., Classen, M., Gionchetti, P., Vaira, D., Campieri, M., Bertinelli, E., Menegatti, M., Belluzzi, A., Briognola, C., Miglioli, M., Barbara, L., Tommaso, A. Di, Magistris, M. T. De, Bugnoli, M., Petracca, R., Covacci, A., Censini, S., Rappuoli, R., Abrignani, S., Territo, M. C., Smela, K. L., Reeve, J. R., Lee, T. D., Walsh, J. H., Armellini, D., Crabtree, J. E., Xiang, Z. Y., Mitchell, H. M., Hu, P. J., Li, Y. Y., Wang, Z. J., Zhao, S. M., Liu, Q., Chen, M., Du, G. G., Filipe, M. I., Reed, P. I., Craanen, M. E., Blok, P., Dekker, W., Colombo, E., Redaelli, D., Santangelo, M., Spinelli, M., Farinati, F., Valiante, F., Delia Libera, G., Germanà, B., Baffa, R., Rugge, M., Vianelo, F., Di Mario, F., Sipponen, Pentti, Rokkas, T., Popotheodorou, G., Kaldgeropoulos, N., Deprez, C., Galand, P., Fox, J. G., Wishnok, P., Murphy, J. C., Tannenbaum, S., Correa, P., Parsonnet, Julie, Macor, C., Da Broi, G. L., Avellinio, C., Reifen, R., Rasooly, I., Millson, M. E., Murphy, K., Thomas, J. E., Eastham, E. J., Malorgio, E., Dell’Olio, D., Kemmer, T. P., Dominguez-Munoz, J. E., Klingel, H., Gatto, M. R. A., Olivieri, R., Bayeli, R. F., Abate, L., De Gregorio, L., Aziz, J., Esposito, E., Basagni, C., Guilluy, R., Rousseau-Tsangaris, M., Brazier, J. L., Wadstiöm, Torkel, Tyszkiewicz, Tadeusz, Bergenzaun, Per, Olsson, Karin, Birac, C., Tall, F., Albenque, M., Labigne, A., Megraud, F., Feldman, R. A., Deeks, J., Glupczynski, Y., Burette, A., Goossens, H., Van den Boore, C., Butzler, J. P., Veldhuyzen van Zanten, S., Best, L., Benzanson, G., Haldane, D., Hazell, S., Mapstone, N. P., Lynch, D. A. F., Quirke, P., Taylor, D. E., Chang, N., Eaton, M., Stockdale, E., Salama, S. M., Thompson, L., Cockayne, A., Spiller, R. C., Leen, E., Sweeney, E., Klann, H., Hatz, R., Bornschein, W., Simon, T., Eimiller, A., Bolle, F., Schweikert, C., Köpeke, W., Moss, S. F., Bishop, A. E., Calam, J., Cahill, R. J., Xia, H., Solnick, J., and Tompkins, L.

Published
1992
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7. Treatment

Author

Goodwin, C. S., Worsley, B., Pillai, E., Willems, V., Janisch, H. D., Langmaack, H., Sanchez, P., Alcalde, M., Lancho, A., Carpintero, P., Garcia, R., Pajares, J. M., Grigoriev, P. Ya., Isakov, V. A., Iakovenko, E. P., Iakovenko, A. V., Vogt, K., Hahn, H., Rehmann, I. H., Hedding-Eckerich, M., Blessing, J., Sobala, G. M., Lynch, D. A. F., Gallacher, B., Dixon, M. F., Axon, A. T. R., Bayerdörffer, E., Mannes, G., Sommer, A., Höchter, W., Weingart, J., Hatz, R., Miehlke, S., Lehn, N., Ruckdeschel, G., Dirschedl, P., Stolte, M., Adamek, R. J., Wegener, M., Birkholz, S., Opferkuch, W., Rühl, G. H., Wedmann, B., Labenz, J., Gyenes, E., R’hl, G. H., Börsch, G., Maieron, R., Rizzi, C., Zoratti, L., Andreoli, S., Da Broi, G. L., Beltrami, C. A., Chengyl, Zhuya, Yangiong, Mou, Jiesong, Hua, Zhenhua, Zhang, Bierti, L., Bolis, E. G., Di Battista, R., de Franchis, R., McAvinchey, D. J., Laurence, M., O’Riordan, J., Fantazi, M., Khawaja, M., Bologna, E, Stroppiana, M., Peyre, S., Pulitano’, R., Sategna-Guidetti, C., Martin, E., Alarcön, T., Sanz, J. C., Jimonez, M. I., López-Brea, M., Burette, A., Glupczynski, Y., Deprez, C., Di Mario, F., Ferrana, M., Battaglia, G., Dotto, P., Vianello, F., Grasso, G. A., Fiocca, R., Villiani, L., Luinetti, O., Gianatti, A., Boldorini, R., Lazzaroni, M., Bianchi Porro, G., Trespi, E., Perego, M., Alvisi, C., Cesana, B., Solcia, E., Logan, R. P. H., Greaves, R. R., Gummett, P. A., Walker, M. M., Karim, Q. N., Duggan, A. E., Baron, J. H., Misiewicz, J. J., Lohmarm, J., Porst, L. H. H., Schönlebe, J., Riedel, H., Catalano, F., Rizzo, G., Ayoubi Khajekini, M. T., Branciforte, G., Inserra, G., Liberti, A., Suriani, R., Pallante, C., Ravizza, M., Mazzucco, D., Galliano, D., Malandrino, M., Oneglio, R., Colozza, M., Gaia, E., Sallio, F., Colozza, D., Grandis, C., Forte, G. B., Bottiglieri, M. E., Durasco, R., Grimaldi, E., Rocco, P., Xia, H. X., Daw, M. A., Sant, S., Beattie, S., Keane, C. T., O’Morain, C. A., Larsson, H., Berglund, M. L., Tessaro, P., Schiavon, R., Contini, M. G., Ton, T., Norberto, L., Cassaro, M., Rugge, M., Guido, M., Baffa, R., Gloriosa, S., Turatello, F., Naccarato, R., Collins, R., O’Moram, C., Kemmer, T. P., Dominguez-Munoz, J. E., Klingel, H., Malfertheiner, P., McCarthy, C. J., McDermott, M., Hourihane, D., O’Morain, C., Droy-Lefiax, M. T., Forestier, B., Guillomain, D., Plique, O., Brugmann, D., Mégraud, F., Lamouliatte, H., Bernard, P. H., Cayla, R., Mégraud, M., de Mascarel, A., Quintonl, A., McLaren, A., McDowell, S. R., McColm, A. A., O’Malley, C., Bagshaw, J., Bouffant, F., Marelli, P., Cellini, L., Campa, M., Dainelli, B., Soldani, G., del Tacca, M., Ferrini, G., Larcinese, G., Semperlotti, N., Molnar, Gy., Fzentmihalyi, A., Takats, A., Gero, G., Penyige, J., Mark, Gy., Martínez-Gómez, J., García-Novo, D., Acuña-Quinõs, D., Gimeno, M., Vigneri, S., Termini, R., Scialabba, A., Pisciotta, G., Gusmaroli, R., Milesi, F., Mule, P., Menegatti, M., Reale, C., Holten, J., and Vaira, D.

Published
1992
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9. Endoskopie, Biopsie und Zytologie

Author

Ottenjann, R., Kühner, W., Weingart, J., Schwiegk, H., editor, Bläker, F., editor, Braun, W., editor, Bücheler, E., editor, Daum, R., editor, van Dongen, R. J. A. M., editor, Erbe, W., editor, Farthmann, E. H., editor, Filippini, L., editor, Franken, F. H., editor, Freyberger, H., editor, Gebbers, J.-O., editor, Haubrich, W. S., editor, Hölze, K. H., editor, Kühner, W., editor, Mohr, W., editor, Müller-Wieland, K., editor, Ottenjann, R., editor, Otto, H. F., editor, Roose, H. J., editor, Rumberger, E., editor, Schmiegel, W.-H., editor, Schreiber, H. W., editor, Schwilden, E.-D., editor, Soehendra, N., editor, Stelzner, F., editor, Thiele, H.-G., editor, Tijtgat, G. N., editor, Täger, B., editor, Weingart, J., editor, Winkler, R., editor, and Müller-Wieland, Kurt, editor

Published
1982
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10. Metastatic Atypical and Anaplastic Meningioma: A Case Series and Review of the Literature

Author

Kessler, Ra, Garzon-Muvdi, T, Yang, Wy, Weingart, J, Olivi, Alessandro, Huang, J, Brem, H, Lim, M, Olivi, A (ORCID:0000-0002-4489-7564), Kessler, Ra, Garzon-Muvdi, T, Yang, Wy, Weingart, J, Olivi, Alessandro, Huang, J, Brem, H, Lim, M, and Olivi, A (ORCID:0000-0002-4489-7564)

Abstract

BACKGROUND: Atypical (World Health Organization grade II) and anaplastic (World Health Organization grade III) meningiomas are rare, accounting for less than 5% of all meningiomas. Histologic grading has a significant impact on prognosis, risk of recurrence, and the need for adjuvant radiation or chemotherapy. Extracranial metastases are even more infrequent and occur in 0.1% of all cases.METHODS: Retrospective chart review of 168 patients with diagnosis of WHO grade II and III meningiomas was performed. Six patients with histologically confirmed metastatic disease were identified.RESULTS: We discuss the clinical, radiologic, and histopathologic clinical course of 6 patients with metastasis to the lung, liver, and spine from all patients with atypical or anaplastic meningioma treated at Johns Hopkins Hospital from 1993 to 2014.CONCLUSIONS: We reviewed the literature pertaining to this phenomenon and subsequently assessed the clinical benefits of adjuvant chemotherapeutic agents in patients with meningioma with metastatic disease.

Published
2017

13. Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord

Author

Wang, Y., Springer, S., Zhang, M., Mcmahon, K. W., Kinde, I., Dobbyn, L., Ptak, J., Brem, H., Chaichana, K., Gallia, G. L., Gokaslan, Z. L., Groves, M. L., Jallo, G. I., Lim, M., Olivi, Alessandro, Quinones-Hinojosa, A., Rigamonti, D., Riggins, G. J., Sciubba, D. M., Weingart, J. D., Wolinsky, J. -P., Ye, X., Oba-Shinjo, S. M., Marie, S. K. N., Holdhoff, M., Agrawal, N., Diaz, L. A., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Bettegowda, C., Olivi A. (ORCID:0000-0002-4489-7564), Wang, Y., Springer, S., Zhang, M., Mcmahon, K. W., Kinde, I., Dobbyn, L., Ptak, J., Brem, H., Chaichana, K., Gallia, G. L., Gokaslan, Z. L., Groves, M. L., Jallo, G. I., Lim, M., Olivi, Alessandro, Quinones-Hinojosa, A., Rigamonti, D., Riggins, G. J., Sciubba, D. M., Weingart, J. D., Wolinsky, J. -P., Ye, X., Oba-Shinjo, S. M., Marie, S. K. N., Holdhoff, M., Agrawal, N., Diaz, L. A., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Bettegowda, C., and Olivi A. (ORCID:0000-0002-4489-7564)

Abstract

Cell-free DNA shed by cancer cells has been shown to be a rich source of putative tumor-specific biomarkers. Because cell-free DNA from brain and spinal cord tumors cannot usually be detected in the blood, we studied whether the cerebrospinal fluid (CSF) that bathes the CNS is enriched for tumor DNA, here termed CSF-tDNA. We analyzed 35 primary CNS malignancies and found at least one mutation in each tumor using targeted or genome-wide sequencing. Using these patient-specific mutations as biomarkers, we identified detectable levels of CSF-tDNA in 74% [95% confidence interval (95% CI) = 57-88%] of cases. All medulloblastomas, ependymomas, and high-grade gliomas that abutted a CSF space were detectable (100% of 21 cases; 95% CI = 88-100%), whereas no CSF-tDNA was detected in patients whose tumors were not directly adjacent to a CSF reservoir (P < 0.0001, Fisher's exact test). These results suggest that CSF-tDNA could be useful for the management of patients with primary tumors of the brain or spinal cord.

Published
2015

14. Surgical outcomes of craniocervial junction meningiomas: A series of 22 consecutive patients

Author

Bydon, M., Martin Ma, T., Xu, R., Weingart, J., Olivi, Alessandro, Gokaslan, Z. L., Tamargo, R. J., Brem, H., Bydon, A., Olivi A. (ORCID:0000-0002-4489-7564), Bydon, M., Martin Ma, T., Xu, R., Weingart, J., Olivi, Alessandro, Gokaslan, Z. L., Tamargo, R. J., Brem, H., Bydon, A., and Olivi A. (ORCID:0000-0002-4489-7564)

Abstract

Objective We present our experience in managing craniocervical junction meningiomas and discuss various surgical approaches and outcomes. Methods We retrospectively reviewed 22 consecutive cases of craniocervical junction meningiomas operated on between August 1995 and May 2012. Results There were 15 female and 7 male patients (mean age: 54 years). Meningiomas were classified based on origin as spinocranial (7 cases) or craniospinal (15 cases). Additionally, the tumors were divided into anatomical location relative to the brainstem or spinal cord: there were 2 anterior tumors, 7 anterolateral, 12 lateral, and 1 posterolateral. Surgical approaches included the posterior midline suboccipital approach (9 cases), the far lateral approach (12 cases) and the lateral retrosigmoid approach (1 case). Gross-total resection was achieved in 45% of patients and subtotal in 55%. The most common post-operative complications were cranial nerve (CN) IX and X deficits. The mortality rate was 4.5%. There have been no recurrences to date with a mean follow-up was 46.5 months and the mean Karnofsky score at the last follow-up of 82.3. In this series, spinocranial tumors were detected at a smaller size (p = 0.0724) and treated earlier (p = 0.1398) than craniospinal tumors. They were associated with a higher rate of total resection (p = 0.0007), fewer post-operative CN IX or X deficits (p = 0.0053), and shorter hospitalizations (p = 0.08). Conclusion Our experience suggests that posterior midline suboccipital or far-lateral approaches with minimal condylar drilling and vertebral artery mobilization were suitable for most cases in this series. © 2013 Elsevier B.V. All rights reserved.

Published
2014

16. LIST OF PARTICIPANTS

Author

Albegov, M., primary, Anderson, A., additional, Attas, V., additional, Baecher, G.B., additional, Bauer, L., additional, Bauerschmidt, R., additional, Belostotski, A.M., additional, Bergman, L., additional, Bonnaure, P., additional, Bonneau, N., additional, Bowie, S.H.U., additional, Brin, A., additional, Brinck, J.W., additional, Cameron, J., additional, Castaigne, R., additional, Clarke, A.M., additional, Clegg, M.W., additional, Dunham, K., additional, Englund, K.J., additional, Erdmann, R., additional, Fettweis, G.B., additional, Fiala, W., additional, Flynn, H., additional, Franěk, J., additional, Galli, R., additional, Gess, G., additional, Gouri, G.S., additional, Gros, J.G., additional, Grossling, B.F., additional, Harriss, R.C., additional, Herault, J.P., additional, Hirota, K., additional, Hoffmann, F., additional, Hubbert, M. King, additional, Hutber, F.W., additional, Kaufman, G.M., additional, Kausch, P., additional, Khazzoom, J.D., additional, Kuzovkin, I., additional, Löennroth, M., additional, Logigan, S., additional, Masseron, J., additional, Neu, H., additional, Odell, P., additional, Papousek, W., additional, Parikh, K.S., additional, Patyi, K., additional, Petras, L., additional, Polliart, A., additional, Pytlarz, T., additional, Roadifer, R.E., additional, Rozanov, Yu.A., additional, Rose, P.R., additional, Ross, W.A., additional, Roy, K.J., additional, Schanz, J.J., additional, Styrikovich, M., additional, Takei, M., additional, Tominaga, H., additional, Tuschak, T.S., additional, Uhrin, B., additional, Watson, M., additional, Weingart, J., additional, Wiegand, H., additional, Woite, J., additional, Häfele, W., additional, and Grenon, M., additional

Published
1979
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18. List of Participants

Author

AGNEW, P.A., primary, AL AZZAWI, A.R.H., additional, AL SARRAJ, Karawan, additional, AMADO, Pierre, additional, ARAFA, Salah, additional, AUDU, Mr, additional, BANNISTER, Scott, additional, BARNARD, G, additional, BARP, Bruno, additional, BENTZEN, Erik J., additional, BOA, Thomas W., additional, BOAK, David, additional, BREIDENBACH, H., additional, BROADBENT, S., additional, BURNESS, G M, additional, BURNETT, Norman, additional, BURSTOW, Frank, additional, BUTERA, F, additional, CAMERON, David A., additional, CAVE, Peter R., additional, CHANDLER, Charles, additional, CHOUDHURY, S H, additional, COUTTS, Tim J, additional, CRAWFORD, Mark, additional, EGHOLM, E., additional, DEAN, W F, additional, DONNELLY, Kevin, additional, EL, GAMMEL, additional, ELLIOT, George, additional, EMERY, Michael, additional, EVANS, F C, additional, EZEH, Chuks, additional, FAHAGALLA, M, additional, FLEMING, F W, additional, FRANCIS, E, additional, FRASER, A I, additional, GADDY, J.L., additional, GAIR, S, additional, GALT, Jean, additional, GANAPINI, Walter, additional, GARSIDE, A J, additional, GINN, G W C, additional, GIUFFRIDA, M, additional, GOLDING, Peter, additional, GRAINGER, W, additional, GRANT, S R, additional, GUNN, R, additional, HASSOON, H., additional, HAAHR, Jan, additional, HALLY, Martin, additional, HAMILTON, A R, additional, HANLON, Marion, additional, HANNA, Robert, additional, HARRISON, J D L, additional, HARDY, Mr, additional, HAUGHEY, Douglas, additional, HENDERSON, David M, additional, HOPE, D R, additional, IRVINE, James C, additional, JAMIESON, P, additional, JANUARY, M, additional, de JANUZZI, G Martino, additional, KAMAL, W A, additional, KANYI, D M, additional, KELLEDY, Elaine, additional, KERR, Andrew, additional, KIRKLAND, David, additional, KUROKAWA, K, additional, KWANT, Kees, additional, KYALAANI, F, additional, LEMMA, T, additional, LEWIS, A W, additional, LIDDELL, H, additional, de LIGT, J J, additional, LINDBERG, R, additional, LIPMAN, N, additional, LOCKERBIE, N, additional, LUNDSAGER, Per, additional, MacAULAY, D, additional, MacDONALD, John, additional, MacGREGOR, Kerr, additional, MacKAY, Ian, additional, McKELLAR, D R, additional, McLEAN, Darrell, additional, MacMILLAN, D, additional, McPHEE, W.R., additional, McPHERSON, D J, additional, McWHIRTER, W, additional, MAGUIRE, T, additional, MAGORIAN, D, additional, MARDON, R, additional, MARKS, B, additional, MARTIN, D J, additional, MAYS, I D, additional, MEYNELL, P J, additional, MILLAR, M, additional, MITCHELL, C P, additional, MOWLE, Alan, additional, MUNRO, J S, additional, NAUNTOFTE, Mr, additional, NGOKO, Nelson, additional, OBLADEN, N L, additional, OL'OTABA, S O, additional, OLSEN, H, additional, OTHIENO, H, additional, OTI, Mr, additional, PACETTI, Marco, additional, PEATFIELD, T, additional, POPE, I T, additional, POUND, B, additional, RADWAN, M S, additional, RATTO, C, additional, RIDDELL, John C, additional, REID, A U, additional, ROBERTSON, P, additional, SALUJA, G, additional, SARGENT, M, additional, SCOTT, R, additional, SCHNADT, L, additional, SEEBY, N, additional, SHANKS, DD, additional, SHRESTHA, S, additional, SMITH, H V, additional, SMITH, J, additional, SINTUNOWA, C, additional, SINGH, P N, additional, STEVENSON, W, additional, STRONG, S J, additional, SWET, C J, additional, THOMSON, J S, additional, TONKINSON, T, additional, TOWRIE, J, additional, URASSA, Dominic, additional, URQUHART, D C M, additional, VARDY, A, additional, VAN LIEROP, W E, additional, VAN de VUSSE, T, additional, VERHAART, P, additional, VIS, T, additional, VOLK, M, additional, WATES, N, additional, WATSON, G R, additional, WALDEMARIAM, K, additional, WASSERTHAL, W, additional, WEINGART, J, additional, WELSH, K, additional, WHITE, R, additional, WHITEHURST, B, additional, WILSON, T, additional, WILSON-GOUGH, A K, additional, WOODBRIDGE, K, additional, WOOLLEY, M V, additional, WYPER, Hilary, additional, ZAMBONI, F, additional, PROVEN, G., additional, HIMMEL, M., additional, and ROXBURGH, G., additional

Published
1982
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21. Podocalyxin-like protein is expressed in glioblastoma multiforme stem-like cells and is associated with poor outcome

Author

Binder, Z, Siu, I, Eberhart, C, Ap Rhys, C, Bai, R, Staedtke, V, Zhang, H, Smoll, N, Piantadosi, S, Piccirillo, S, Dimeco, F, Weingart, J, Vescovi, A, Olivi, A, Riggins, G, Gallia, G, Binder, ZA, Siu, IM, Eberhart, CG, Bai, RY, Smoll, NR, Piccirillo, SG, Weingart, JD, Riggins, GJ, Gallia, GL, VESCOVI, ANGELO LUIGI, Binder, Z, Siu, I, Eberhart, C, Ap Rhys, C, Bai, R, Staedtke, V, Zhang, H, Smoll, N, Piantadosi, S, Piccirillo, S, Dimeco, F, Weingart, J, Vescovi, A, Olivi, A, Riggins, G, Gallia, G, Binder, ZA, Siu, IM, Eberhart, CG, Bai, RY, Smoll, NR, Piccirillo, SG, Weingart, JD, Riggins, GJ, Gallia, GL, and VESCOVI, ANGELO LUIGI

Abstract

Glioblastoma multiforme (GBM) is the most common primary malignant adult brain tumor and is associated with poor survival. Recently, stem-like cell populations have been identified in numerous malignancies including GBM. To identify genes whose expression is changed with differentiation, we compared transcript profiles from a GBM oncosphere line before and after differentiation. Bioinformatic analysis of the gene expression profiles identified podocalyxin-like protein (PODXL), a protein highly expressed in human embryonic stem cells, as a potential marker of undifferentiated GBM stem-like cells. The loss of PODXL expression upon differentiation of GBM stem-like cell lines was confirmed by quantitative real-time PCR and flow cytometry. Analytical flow cytometry of numerous GBM oncosphere lines demonstrated PODXL expression in all lines examined. Knockdown studies and flow cytometric cell sorting experiments demonstrated that PODXL is involved in GBM stem-like cell proliferation and oncosphere formation. Compared to PODXL-negative cells, PODXL-positive cells had increased expression of the progenitor/stem cell markers Musashi1, SOX2, and BMI1. Finally, PODXL expression directly correlated with increasing glioma grade and was a marker for poor outcome in patients with GBM. In summary, we have demonstrated that PODXL is expressed in GBM stem-like cells and is involved in cell proliferation and oncosphere formation. Moreover, high PODXL expression correlates with increasing glioma grade and decreased overall survival in patients with GBM. © 2013 Binder et al.

Published
2013

23. Stem Cells

Author

He, H., primary, Emmett, M. R., additional, Marshall, A. G., additional, Ji, Y., additional, Conrad, C. A., additional, Priebe, W., additional, Colman, H., additional, Lang, F. F., additional, Madden, T. L., additional, Kristoffersen, K., additional, Stockhausen, M.-T., additional, Poulsen, H. S., additional, Binder, Z. A., additional, Orr, B., additional, Lim, M., additional, Weingart, J. D., additional, Brem, H., additional, Olivi, A., additional, Riggins, G. J., additional, Gallia, G. L., additional, Litofsky, N. S., additional, Miller, D. C., additional, Rath, P., additional, Anthony, D. C., additional, Feng, Q., additional, Franklin, C., additional, Pei, L., additional, Free, A., additional, Kirk, M. D., additional, Shi, H., additional, Timmer, M., additional, Theiss, H., additional, Juerchott, K., additional, Ries, C., additional, Paron, I., additional, Franz, W., additional, Selbig, J., additional, Guo, K., additional, Tonn, J. C., additional, Schichor, C., additional, Zhou, Y.-H., additional, Hu, Y., additional, Pioli, P. D., additional, Rajneesh, K., additional, Limoli, C. L., additional, Yu, L., additional, Hess, K. R., additional, Linskey, M. E., additional, Faber, F., additional, Jaeger, D., additional, Thorsteinsdottir, J., additional, Albrecht, V., additional, Tonn, J.-C., additional, Price, R., additional, Song, J., additional, Zimmerman, P., additional, Duale, H., additional, Rivera, A., additional, Kaur, B., additional, Parada, L., additional, Cook, C., additional, Chiocca, E. A., additional, Kwon, C.-H., additional, Munoz, D. M., additional, Guha, A., additional, Estrada-Bernal, A., additional, Van Brocklyn, J. R., additional, Gu, C., additional, Mahasenan, K. V., additional, Joshi, K., additional, Gupta, S., additional, Mattson, A., additional, Li, C., additional, Nakano, I., additional, Chi, A. S., additional, Rheinbay, E., additional, Wakimoto, H., additional, Gillespie, S., additional, Kasif, S., additional, Rabkin, S. D., additional, Martuza, R. L., additional, Bernstein, B. E., additional, Skirboll, S. L., additional, Wurdak, H., additional, Zhu, S., additional, Romero, A., additional, Lorger, M., additional, Watson, J., additional, Chiang, C.-y., additional, Zhang, J., additional, Natu, V. S., additional, Lairson, L. L., additional, Walker, J. R., additional, Trussell, C. M., additional, Harsh, G. R., additional, Vogel, H., additional, Felding-Habermann, B., additional, Orth, A. P., additional, Miraglia, L. J., additional, Rines, D. R., additional, Schultz, P. G., additional, Hide, T., additional, Takezaki, T., additional, Nakamura, H., additional, Makino, K., additional, Kuratsu, J.-i., additional, Kondo, T., additional, Yao, J., additional, Kim, Y.-W., additional, Koul, D., additional, Almeida, J. S., additional, Weinstein, J. N., additional, Alfred Yung, W. K., additional, Miyazaki, T., additional, Chaudhury, A. R., additional, Wong, A. J., additional, Del Vecchio, C., additional, Mitra, S., additional, Han, S.-Y., additional, Holgado-Madruga, M., additional, Gupta, P., additional, Golebiewska, A., additional, Brons, N. H., additional, Bjerkvig, R., additional, Niclou, S. P., additional, Ramm, P., additional, Vollmann-Zwerenz, A., additional, Beier, C., additional, Aigner, L., additional, Bogdahn, U., additional, Kalbitzer, H. R., additional, Hau, P., additional, Sanzey, M., additional, Vallar, L., additional, Tamura, K., additional, Aoyagi, M., additional, Ando, N., additional, Ogishima, T., additional, Yamamoto, M., additional, Ohno, K., additional, Perin, A., additional, Fung, K. H., additional, Longatti, P., additional, Guiot, M.-C., additional, Del Maestro, R. F., additional, Rossi, S., additional, Stechishin, O., additional, Weiss, S., additional, Stifani, S., additional, Goodman, L., additional, Gao, F., additional, Gumin, J., additional, Ezhilarasan, R., additional, Love, P., additional, George, A., additional, Lang, F., additional, Aldape, K., additional, Sulman, E. P., additional, Soeda, A., additional, Lee, D.-H., additional, Shaffrey, M. E., additional, Oldfield, E. H., additional, Park, D. M., additional, Dietrich, J., additional, Han, R., additional, Noble, M., additional, Yang, M. Y., additional, Liu, X., additional, Madhankumar, A. B., additional, Sheehan, J., additional, Slagle-Webb, B., additional, Connor, J. R., additional, Fu, J., additional, Shen, R.-J., additional, Kaluzova, M., additional, Machaidze, R., additional, Nduom, E. N. K., additional, Burden, C. T., additional, Hadjipanayis, C. G., additional, Lei, L., additional, Sonabend, A., additional, Guarnieri, P., additional, Ludwig, T., additional, Rosenfeld, S., additional, Bruce, J., additional, Canoll, P., additional, Vaillant, B. D., additional, Bhat, K., additional, Balasubramaniyam, V., additional, Wang, S., additional, Sulman, E., additional, Goodman, L. D., additional, Love, P. N., additional, Soules, M., additional, Zhu, T., additional, Flack, C., additional, Talsma, C., additional, Hamm, L., additional, Muraszko, K., additional, Fan, X., additional, Matsuoka, Y., additional, Kawano, Y., additional, Kobayashi, D., additional, Kumagai, J., additional, Frank, R. T., additional, Najbauer, J., additional, Aboody, K. S., additional, Metz, M., additional, Garcia, E., additional, Aramburo, S., additional, Valenzuela, V., additional, Gutova, M., additional, Annala, A. J., additional, Barish, M., additional, Danks, M., additional, Kim, S. U., additional, Portnow, J., additional, Hofstetter, C., additional, Gursel, D., additional, Mubita, L., additional, Holland, E., additional, Boockvar, J., additional, Monje, M., additional, Freret, M., additional, Masek, M., additional, Edwards, M. S., additional, Fisher, P. G., additional, and Beachy, P., additional

Published
2010
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24. Tumor Models (In Vivo/In Vitro)

Author

Doucette, T. A., primary, Kong, L.-Y., additional, Yang, Y., additional, Wei, J., additional, Wang, J., additional, Fuller, G. N., additional, Heimberger, A. B., additional, Rao, G., additional, Ajewung, N., additional, Kamnasaran, D., additional, Katz, A. M., additional, Amankulor, N., additional, Squatrito, M., additional, Hambardzumyan, D., additional, Holland, E. C., additional, Poschl, J., additional, Lorenz, A., additional, Von Bueren, A., additional, Li, S., additional, Peraud, A., additional, Tonn, J.-C., additional, Herms, J., additional, Xiang, M., additional, Rutkowski, S., additional, Kretzschmar, H., additional, Schuller, U., additional, Studebaker, A., additional, Raffel, C., additional, Aoki, Y., additional, Hashizume, R., additional, Ozawa, T., additional, Gupta, N., additional, James, C. D., additional, Navis, A. C., additional, Hamans, B. C., additional, Claes, A., additional, Heerschap, A., additional, Wesseling, P., additional, Jeuken, J. W., additional, Leenders, W. P., additional, Agudelo, P. A., additional, Williams, S., additional, Nowicki, M. O., additional, Johnson, J., additional, Li, P. K., additional, Chiocca, E. A., additional, Lannutti, J. J., additional, Lawler, S. E., additional, Viapiano, M. S., additional, Bergeron, J., additional, Aliaga, A., additional, Bedell, B., additional, Soderquist, C., additional, Sonabend, A., additional, Lei, L., additional, Crisman, C., additional, Yun, J. P., additional, Sisti, J., additional, Castelli, M., additional, Bruce, J. N., additional, Canoll, P., additional, Kirsch, M., additional, Stelling, A., additional, Salzer, R., additional, Krafft, C., additional, Schackert, G., additional, Steiner, G., additional, Balvers, R. K., additional, van den Hengel, S. K., additional, Wakimoto, H., additional, Hoeben, R. C., additional, Leenstra, S., additional, Dirven, C. M., additional, Lamfers, M. L., additional, Sabha, N. S., additional, Agnihotri, S., additional, Wolf, A., additional, von Deimling, A., additional, Croul, S., additional, Guha, A., additional, Trojahn, U. S., additional, Lenferink, A., additional, O'Connor-McCourt, M., additional, Kanai, R., additional, Curry, W. T., additional, Yip, S., additional, Barnard, Z. R., additional, Mohapatra, G., additional, Stemmer-Rachamimov, A. O., additional, Martuza, R. L., additional, Rabkin, S. D., additional, Binder, Z. A., additional, Salmasi, V., additional, Lim, M., additional, Weingart, J., additional, Brem, H., additional, Olivi, A., additional, Riggins, G. J., additional, Gallia, G. L., additional, Rong, Y., additional, Zhang, Z., additional, Gang, C., additional, Tucker-Burden, C., additional, Van Meir, E., additional, Brat, D. J., additional, Kloezeman, J. J., additional, Kleijn, A., additional, French, P. J., additional, Spoor, J. K., additional, Bazzoli, E., additional, Fomchenko, E. I., additional, Schultz, N., additional, Brennan, C., additional, DeAngelis, L. M., additional, Nimer, S. D., additional, Mohyeldin, A., additional, Hsu, W., additional, Shah, S. R., additional, Adams, H., additional, Shah, P., additional, Katuri, L., additional, Kosztowski, T., additional, Loeb, D. M., additional, Wolinsky, J.-P., additional, Gokaskan, Z. L., additional, Quinones-Hinojosa, A., additional, Daphu, I. K., additional, Immervoll, H., additional, Bjerkvig, R., additional, Thorsen, F., additional, Caretti, V., additional, Idema, S., additional, Zondervan, I., additional, Meijer, D. H., additional, Lagerweij, T., additional, Barazas, M., additional, Vos, W., additional, Hamans, B., additional, van der Stoop, P., additional, Hulleman, E., additional, van der Valk, P., additional, Bugiani, M., additional, Vandertop, W. P., additional, Noske, D., additional, Kaspers, G. J., additional, Molthoff, C., additional, Wurdinger, T., additional, Chow, L. M., additional, Endersby, R., additional, Zhu, X., additional, Rankin, S., additional, Qu, C., additional, Zhang, J., additional, Ellison, D. W., additional, Baker, S. J., additional, Tabar, V., additional, LaFaille, F., additional, and Studer, L., additional

Published
2010
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25. New energy technologies for buildings

Author

Schoen, R, Hirshberg, A, and Weingart, J

Subjects
Energy Production And Conversion
Abstract

The principal objective of the present work is to identify a variety of strategic approaches which could significantly enhance the rate of commercial development and deployment of total energy systems, fuel cells, and solar conversion. Emphasis is on the need for integration of research, conference, legislation, federal program, and industrial program aspects, leading to a fruitful feedback and follow-through process involving new energy technologies. The discussions are on a general, lay level. Recommendations made feature (1) action which improves the environment for innovation and change, (2) action which decreases risk and creates positive incentives, and (3) action which reflects the distance a particular technology is from commercialization and widespread use, as determined by its position on a development/diffusion scale.

Published
1975

27. Pilzbesiedlung bei Kolitiden

Author

Höchter, W., primary, Seeliger, H. P. R., additional, Keilig, W., additional, Hemmer, E., additional, Weingart, J., additional, and Ottenjann, R., additional

Published
2008
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38. 2572

Author

Hales, R., primary, Shokek, O., additional, Burger, P., additional, Paynter, N., additional, Cohen, K., additional, Carson, B., additional, Weingart, J., additional, Song, D., additional, and Wharam, M., additional

Published
2006
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42. Are guidelines followed in Helicobacter pylori diagnosis and therapy? An inquiry among gastroenterologists, referring physicians and patients in Munich

Author

Fritz, N., primary, Birkner, B., additional, Schusdziarra, V., additional, Borlinghaus, K.-P., additional, Burlefinger, R., additional, Dettmer, A., additional, Heldwein, W., additional, Henke, M., additional, Höchter, W., additional, Janetschek, P., additional, Kunze, R., additional, Schatke, W., additional, Strauch, M., additional, Struppler, C., additional, Weingart, J., additional, and Rösch, T., additional

Published
2000
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